High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes

scientific article published on 18 September 2007

High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKM712
P932PMC publication ID2094087
P698PubMed publication ID17881364
P5875ResearchGate publication ID5962453

P50authorBenjamin LangQ30513195
Sylvie RimskyQ42734712
Mohan Madan BabuQ56084741
Claudio O GualerziQ121401404
Cynthia L PonQ121401444
P2093author name stringNicolas Blot
Malcolm Buckle
Marcel Geertz
Emeline Bouffartigues
Andrew Travers
Georgi Muskhelishvili
Stefano Stella
Ramesh Mavathur
P2860cites workBase-stacking and base-pairing contributions into thermal stability of the DNA double helixQ22065979
RegulonDB (version 5.0): Escherichia coli K-12 transcriptional regulatory network, operon organization, and growth conditionsQ25257226
H-NS mediates the silencing of laterally acquired genes in bacteriaQ28490022
Suppression of FNR-dependent transcription activation at the Escherichia coli nir promoter by Fis, IHF and H-NS: modulation of transcription initiation by a complex nucleo-protein assembly.Q30327164
Bacterial chromatin organization by H-NS protein unravelled using dual DNA manipulationQ33263766
Multiple control of flagellum biosynthesis in Escherichia coli: role of H-NS protein and the cyclic AMP-catabolite activator protein complex in transcription of the flhDC master operonQ33993289
H-NS-Dependent regulation of flagellar synthesis is mediated by a LysR family proteinQ33994555
Repression of bacterial motility by a novel fimbrial gene productQ34081623
The global regulatory hns gene negatively affects adhesion to solid surfaces by anaerobically grown Escherichia coli by modulating expression of flagellar genes and lipopolysaccharide productionQ34306480
How to become a uropathogen: comparative genomic analysis of extraintestinal pathogenic Escherichia coli strainsQ35036510
Transcriptional regulation of the yghJ-pppA-yghG-gspCDEFGHIJKLM cluster, encoding the type II secretion pathway in enterotoxigenic Escherichia coliQ35634240
Structure of the histone-like protein H-NS and its role in regulation and genome superstructureQ35737936
H-NS: a universal regulator for a dynamic genomeQ35752413
A common topology for bacterial and eukaryotic transcription initiation?Q36724672
A molecular mechanism for the repression of transcription by the H-NS proteinQ38291337
Structural basis for preferential binding of H-NS to curved DNA.Q38302758
Escherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymeraseQ38308470
Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome.Q38309827
Homeostatic regulation of supercoiling sensitivity coordinates transcription of the bacterial genomeQ38312050
Selective silencing of foreign DNA with low GC content by the H-NS protein in SalmonellaQ38312504
The virF promoter in Shigella: more than just a curved DNA stretchQ38345190
Reciprocal transcriptional and posttranscriptional growth-phase-dependent expression of sfh, a gene that encodes a paralogue of the nucleoid-associated protein H-NS.Q39111071
An architectural role of the Escherichia coli chromatin protein FIS in organising DNA.Q39516058
Fine-structure deletion analysis of the transcriptional silencer of the proU operon of Salmonella typhimuriumQ39837835
How is osmotic regulation of transcription of the Escherichia coli proU operon achieved? A review and a modelQ41397370
H-NS antagonism in Shigella flexneri by VirB, a virulence gene transcription regulator that is closely related to plasmid partition factors.Q42058447
Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS.Q42662171
The histone-like nucleoid structuring protein H-NS represses the Escherichia coli bgl operon downstream of the promoterQ47814123
Interplay between global regulators of Escherichia coli: effect of RpoS, Lrp and H-NS on transcription of the gene osmC.Q47848431
An H-NS-like stealth protein aids horizontal DNA transmission in bacteriaQ50074297
The H-NS protein represses transcription of the eltAB operon, which encodes heat-labile enterotoxin in enterotoxigenic Escherichia coli, by binding to regions downstream of the promoter.Q54488218
Interactions of the nucleoid-associated DNA-binding protein H-NS with the regulatory region of the osmotically controlled proU operon of Escherichia coli.Q54638049
H-NS cooperative binding to high-affinity sites in a regulatory element results in transcriptional silencingQ63430392
Chemical determinants of DNA bending at adenine-thymine tractsQ69394090
An extended role for the nucleoid structuring protein H-NS in the virulence gene regulatory cascade of Shigella flexneriQ78816863
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)6330-6337
P577publication date2007-09-18
P1433published inNucleic Acids ResearchQ135122
P1476titleHigh-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomes
P478volume35

Reverse relations

cites work (P2860)
Q53471267A new target for the old regulator: H-NS suppress T6SS secretory protein EvpP, the major virulence factor in the fish pathogen Edwardsiella tarda.
Q33659856A proteomic analysis reveals differential regulation of the σ(S)-dependent yciGFE(katN) locus by YncC and H-NS in Salmonella and Escherichia coli K-12.
Q64992212A putative curved DNA region upstream of rcsA in Escherichia coli plays a key role in transcriptional regulation by H-NS.
Q58728313A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity
Q42045404AatA is a novel autotransporter and virulence factor of avian pathogenic Escherichia coli
Q50288424Altered Distribution of RNA Polymerase Lacking the Omega Subunit within the Prophages along the Escherichia coli K-12 Genome.
Q41775452An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions
Q37990287Architectural organization in E. coli nucleoid
Q84825966Architecture of the Escherichia coli nucleoid
Q38354049Bacterial histone-like proteins: roles in stress resistance
Q28235450Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response
Q41334372Bacterial-Chromatin Structural Proteins Regulate the Bimodal Expression of the Locus of Enterocyte Effacement (LEE) Pathogenicity Island in Enteropathogenic Escherichia coli.
Q35739170BpaB and EbfC DNA-binding proteins regulate production of the Lyme disease spirochete's infection-associated Erp surface proteins
Q34122629BpaB, a novel protein encoded by the Lyme disease spirochete's cp32 prophages, binds to erp Operator 2 DNA
Q35111368Bridged filaments of histone-like nucleoid structuring protein pause RNA polymerase and aid termination in bacteria
Q36911549Characterization of the ospZ promoter in Shigella flexneri and its regulation by VirB and H-NS.
Q24634543Chromosome organization by a nucleoid-associated protein in live bacteria
Q92049179Coherent Domains of Transcription Coordinate Gene Expression During Bacterial Growth and Adaptation
Q38701091Considerations on bacterial nucleoids
Q44448553Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium.
Q64241132CrfC Protein, a Nucleoid Partition Factor, Localizes to Nucleoid Poles via the Activities of Specific Nucleoid-Associated Proteins
Q88076871DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression
Q39310921DNA supercoiling is a fundamental regulatory principle in the control of bacterial gene expression
Q27021341DNA thermodynamics shape chromosome organization and topology
Q89531327Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model
Q64122811Density of σ70 promoter-like sites in the intergenic regions dictates the redistribution of RNA polymerase during osmotic stress in Escherichia coli
Q33621541Differential effects and interactions of endogenous and horizontally acquired H-NS-like proteins in pathogenic Escherichia coli
Q33466737Differential regulation of horizontally acquired and core genome genes by the bacterial modulator H-NS.
Q42113114Direct and indirect effects of H-NS and Fis on global gene expression control in Escherichia coli
Q92785357Early fate of exogenous promoters in E. coli
Q54270927Effect of promoter-upstream sequence on σ38-dependent stationary phase gene transcription.
Q37800563Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression
Q34486085Function of the Histone-Like Protein H-NS in Motility of Escherichia coli: Multiple Regulatory Roles Rather than Direct Action at the Flagellar Motor
Q42168572Functions of the Hha and YdgT proteins in transcriptional silencing by the nucleoid proteins, H-NS and StpA, in Escherichia coli
Q38338657Gene clusters reflecting macrodomain structure respond to nucleoid perturbations.
Q39418355Gene regulation by H-NS as a function of growth conditions depends on chromosomal position in Escherichia coli
Q46189959Gene silencing and large-scale domain structure of the E. coli genome.
Q54329564Gene silencing by H-NS from distal DNA site.
Q41475410Genes on a Wire: The Nucleoid-Associated Protein HU Insulates Transcription Units in Escherichia coli
Q34789412Genome-scale analysis of escherichia coli FNR reveals complex features of transcription factor binding.
Q34572484Genomic analysis of the regulatory elements and links with intrinsic DNA structural properties in the shrunken genome of Buchnera
Q45943343Genomic analysis reveals epistatic silencing of "expensive" genes in Escherichia coli K-12.
Q37248338Genomic islands: tools of bacterial horizontal gene transfer and evolution
Q36146713H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments
Q29346604H-NS binding and repression of the ctx promoter in Vibrio cholerae
Q42587144H-NS binds with high affinity to the Tn10 transpososome and promotes transpososome stabilization
Q37264621H-NS is a negative regulator of the two hemolysin/cytotoxin gene clusters in Vibrio anguillarum
Q42041830H-NS is a novel transcriptional modulator of the ribonucleotide reductase genes in Escherichia coli
Q36970729H-NS plays a role in expression of Acinetobacter baumannii virulence features.
Q35943182H-NS regulation of IraD and IraM antiadaptors for control of RpoS degradation
Q61821275H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing
Q28078849H-NS, Its Family Members and Their Regulation of Virulence Genes in Shigella Species
Q92572722High-Resolution Mapping of the Escherichia coli Chromosome Reveals Positions of High and Low Transcription
Q34297693High-order oligomerization is required for the function of the H-NS family member MvaT in Pseudomonas aeruginosa
Q41888233Histone and TK0471/TrmBL2 form a novel heterogeneous genome architecture in the hyperthermophilic archaeon Thermococcus kodakarensis
Q89511205Horizontally Acquired Homologs of Xenogeneic Silencers: Modulators of Gene Expression Encoded by Plasmids, Phages and Genomic Islands
Q54273780IHF is a trans-acting factor implicated in the regulation of the proU P2 promoter.
Q54293552Identification of high-specificity H-NS binding site in LEE5 promoter of enteropathogenic Esherichia coli (EPEC).
Q59328846Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation
Q58700745Impact of Chromosomal Architecture on the Function and Evolution of Bacterial Genomes
Q27675789Indirect DNA Readout by an H-NS Related Protein: Structure of the DNA Complex of the C-Terminal Domain of Ler
Q28267896Induction of the ferritin gene (ftnA) of Escherichia coli by Fe(2+)-Fur is mediated by reversal of H-NS silencing and is RyhB independent
Q44557392Influence of mobile DNA-protein-DNA bridges on DNA configurations: coarse-grained Monte-Carlo simulations
Q49906658Insights into transcriptional silencing and anti-silencing in Shigella flexneri: a detailed molecular analysis of the icsP virulence locus
Q34905294Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism.
Q36747405Integration host factor positively regulates virulence gene expression in Vibrio cholerae
Q38114847Integration of syntactic and semantic properties of the DNA code reveals chromosomes as thermodynamic machines converting energy into information
Q35805938Interaction of the histone-like nucleoid structuring protein and the general stress response regulator RpoS at Vibrio cholerae promoters that regulate motility and hemagglutinin/protease expression
Q42380111Mechanism of environmentally driven conformational changes that modulate H-NS DNA-bridging activity
Q41210610MgaSpn and H-NS: Two Unrelated Global Regulators with Similar DNA-Binding Properties.
Q47133480Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability.
Q36878446Molecular Characterization of the Vacuolating Autotransporter Toxin in Uropathogenic Escherichia coli
Q52597474MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?
Q36672112New insights into transcriptional regulation by H-NS
Q36093140Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing
Q35227911Oligomerization mechanisms of an H-NS family protein, Pmr, encoded on the plasmid pCAR1 provide a molecular basis for functions of H-NS family members
Q35893892P1 Ref Endonuclease: A Molecular Mechanism for Phage-Enhanced Antibiotic Lethality
Q33916703Phage encoded H-NS: a potential achilles heel in the bacterial defence system
Q34113865Post-transcriptional global regulation by CsrA in bacteria
Q64123090Predicting the mechanism and rate of H-NS binding to AT-rich DNA
Q34743860Promoters of Escherichia coli versus promoter islands: function and structure comparison
Q35094995RNA-seq analysis identifies new genes regulated by the histone-like nucleoid structuring protein (H-NS) affecting Vibrio cholerae virulence, stress response and chemotaxis.
Q92254163Reconstruction of transcriptional regulatory networks of Fis and H-NS in Escherichia coli from genome-wide data analysis
Q36631364Regulation of Expression of Uropathogenic Escherichia coli Nonfimbrial Adhesin TosA by PapB Homolog TosR in Conjunction with H-NS and Lrp
Q43173259Regulation of expression of the region 3 promoter of the Escherichia coli K5 capsule gene cluster involves H-NS, SlyA, and a large 5' untranslated region
Q33825930Regulation of pga operon expression and biofilm formation in Actinobacillus pleuropneumoniae by sigmaE and H-NS
Q41911369Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription factors, and the divergent yjjP gene by H-NS and LeuO.
Q39098419Regulation systems of protease and hemolysin production in Vibrio vulnificus
Q48032066Replication fork passage drives asymmetric dynamics of a critical nucleoid-associated protein in Caulobacter.
Q36197536Repression by H-NS of genes required for the biosynthesis of the Vibrio cholerae biofilm matrix is modulated by the second messenger cyclic diguanylic acid
Q38701806Rv3852 (H-NS) of Mycobacterium tuberculosis Is Not Involved in Nucleoid Compaction and Virulence Regulation
Q37431786Sequence-specific recognition of DNA by the C-terminal domain of nucleoid-associated protein H-NS.
Q33983666Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties
Q35213505SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12.
Q41897597Spatial organization of DNA sequences directs the assembly of bacterial chromatin by a nucleoid-associated protein
Q55356316StpA and Hha stimulate pausing by RNA polymerase by promoting DNA-DNA bridging of H-NS filaments.
Q96229909Structural Insight of the Full-Length Ros Protein: A Prototype of the Prokaryotic Zinc-Finger Family
Q37648787Structural and functional map of a bacterial nucleoid
Q27670439Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteins
Q54980882Structure and Properties of DNA Molecules Over The Full Range of Biologically Relevant Supercoiling States.
Q58286649Structure and function of archaeal histones
Q40376693The DNA sequence-dependence of nucleosome positioning in vivo and in vitro
Q33405760The HU regulon is composed of genes responding to anaerobiosis, acid stress, high osmolarity and SOS induction
Q37122992The Histone-Like Nucleoid Structuring Protein (H-NS) Is a Negative Regulator of the Lateral Flagellar System in the Deep-Sea Bacterium Shewanella piezotolerans WP3.
Q34595063The Intimin-Like Protein FdeC Is Regulated by H-NS and Temperature in Enterohemorrhagic Escherichia coli
Q58286818The Major Architects of Chromatin: Architectural Proteins in Bacteria, Archaea and Eukaryotes
Q30365649The T4 phage DNA mimic protein Arn inhibits the DNA binding activity of the bacterial histone-like protein H-NS.
Q42881926The Treponema denticola AtcR LytTR domain-containing response regulator interacts with three architecturally distinct promoter elements: implications for understanding the molecular signaling mechanisms that drive the progression of periodontal dise
Q35827107The histone-like nucleoid structuring protein (H-NS) is a repressor of Vibrio cholerae exopolysaccharide biosynthesis (vps) genes
Q36044716The nucleoid-associated proteins H-NS and FIS modulate the DNA supercoiling response of the pel genes, the major virulence factors in the plant pathogen bacterium Dickeya dadantii.
Q37080380The pneumococcal MgaSpn virulence transcriptional regulator generates multimeric complexes on linear double-stranded DNA
Q39310951The regulatory role of DNA supercoiling in nucleoprotein complex assembly and genetic activity.
Q33750107The transcriptional regulator Rok binds A+T-rich DNA and is involved in repression of a mobile genetic element in Bacillus subtilis.
Q43040765Time-resolved assembly of a nucleoprotein complex between Shigella flexneri virF promoter and its transcriptional repressor H-NS.
Q33769087Transcription of AAT•ATT triplet repeats in Escherichia coli is silenced by H-NS and IS1E transposition
Q37143621Transcription termination controls prophage maintenance in Escherichia coli genomes
Q35221516Upstream binding of idling RNA polymerase modulates transcription initiation from a nearby promoter

Search more.