Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation

scientific article published in Scientific Reports

Identifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-35432-1
P932PMC publication ID6250670
P698PubMed publication ID30467359

P50authorGianluca D'AbroscaQ60976349
Paolo Vincenzo PedoneQ60976351
P2093author name stringLuciano Pirone
Roberto Fattorusso
Emilia Maria Pedone
Gaetano Malgieri
Ilaria Baglivo
Joshua Edison Pitzer
Roy Martin Roop
P2860cites workH-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact proteinQ27640081
The H-NS dimerization domain defines a new fold contributing to DNA recognitionQ27640522
The prokaryotic Cys2His2 zinc-finger adopts a novel fold as revealed by the NMR structure of Agrobacterium tumefaciens Ros DNA-binding domainQ27648878
H-NS forms a superhelical protein scaffold for DNA condensationQ27664196
C68 from the Sulfolobus islandicus plasmid-virus pSSVx is a novel member of the AbrB-like transcription factor familyQ27666459
Structural basis for recognition of AT-rich DNA by unrelated xenogeneic silencing proteinsQ27670439
Indirect DNA Readout by an H-NS Related Protein: Structure of the DNA Complex of the C-Terminal Domain of LerQ27675789
Protein secondary structure prediction based on position-specific scoring matricesQ27860483
The prokaryotic zinc-finger: structure, function and comparison with the eukaryotic counterpartQ28085030
H-NS mediates the silencing of laterally acquired genes in bacteriaQ28490022
A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaTQ28548172
Protein oligomers studied by solid-state NMR--the case of the full-length nucleoid-associated protein histone-like nucleoid structuring protein.Q51060085
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques.Q52132803
MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein?Q52597474
The regulatory protein MucR binds to a short DNA region located upstream of the mucR coding region in Rhizobium meliloti.Q54565706
Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS.Q54578667
Multimeric Self-assembly Equilibria Involving the Histone-like Protein H-NS: A THERMODYNAMIC STUDYQ56838392
Structural Zn(II) Implies a Switch from Fully Cooperative to Partly Downhill Folding in Highly Homologous ProteinsQ57956898
Molecular strategies to replace the structural metal site in the prokaryotic zinc finger domainQ60127355
NMR assignments of the DNA binding domain of Ml4 protein from Mesorhizobium lotiQ60127416
A Novel Type of Zinc Finger DNA Binding Domain in theAgrobacteriumtumefaciensTranscriptional Regulator Ros†Q60127434
The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domainQ89310714
Brucella melitensis MucR, an orthologue of Sinorhizobium meliloti MucR, is involved in resistance to oxidative, detergent, and saline stresses and cell envelope modifications.Q42286087
Zinc(II) complexes of ubiquitin: speciation, affinity and binding featuresQ42618007
Molecular analysis of the Rhizobium meliloti mucR gene regulating the biosynthesis of the exopolysaccharides succinoglycan and galactoglucanQ42684629
High-affinity DNA binding sites for H-NS provide a molecular basis for selective silencing within proteobacterial genomesQ42734633
MucR Is Required for Transcriptional Activation of Conserved Ion Transporters to Support Nitrogen Fixation of Sinorhizobium fredii in Soybean NodulesQ42772967
The effects of MucR on expression of type IV secretion system, quorum sensing system and stress responses in Brucella melitensisQ42774011
The Sinorhizobium fredii HH103 MucR1 Global Regulator Is Connected With the nod Regulon and Is Required for Efficient Symbiosis With Lotus burttii and Glycine max cv. WilliamsQ42774150
Time-resolved assembly of a nucleoprotein complex between Shigella flexneri virF promoter and its transcriptional repressor H-NS.Q43040765
An experimentally tested scenario for the structural evolution of eukaryotic Cys2His2 zinc fingers from eubacterial ros homologsQ43821264
Deciphering the zinc coordination properties of the prokaryotic zinc finger domain: The solution structure characterization of Ros87 H42A functional mutantQ44551205
The ferrous iron transporter FtrABCD is required for the virulence of Brucella abortus 2308 in miceQ45091061
Towards understanding the molecular recognition process in prokaryotic zinc-finger domainQ45897497
Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability.Q47133480
The Rhizobium leguminosarum bv. trifolii RosR: transcriptional regulator involved in exopolysaccharide production.Q48078594
H-NS, the genome sentinelQ50074672
Oligomerization of the chromatin-structuring protein H-NS.Q50120784
Fine-tuning of galactoglucan biosynthesis in Sinorhizobium meliloti by differential WggR (ExpG)-, PhoB-, and MucR-dependent regulation of two promotersQ29346921
Sinorhizobium meliloti regulator MucR couples exopolysaccharide synthesis and motilityQ29346924
The structural role of the zinc ion can be dispensable in prokaryotic zinc-finger domainsQ30397217
Mariner mutagenesis of Brucella melitensis reveals genes with previously uncharacterized roles in virulence and survivalQ33266939
Rhizobium leguminosarum bv. trifolii rosR is required for interaction with clover, biofilm formation and adaptation to the environment.Q33744535
Identification of genes in the RosR regulon of Rhizobium etliQ33994082
High-order oligomerization is required for the function of the H-NS family member MvaT in Pseudomonas aeruginosaQ34297693
Complex Regulation of Symbiotic Functions Is Coordinated by MucR and Quorum Sensing in Sinorhizobium melilotiQ34484314
Integrated circuits: how transcriptional silencing and counter-silencing facilitate bacterial evolutionQ35070419
H-NS in Gram-negative bacteria: a family of multifaceted proteinsQ35579488
H-NS: a universal regulator for a dynamic genomeQ35752413
Transcriptome profiling of a Rhizobium leguminosarum bv. trifolii rosR mutant reveals the role of the transcriptional regulator RosR in motility, synthesis of cell-surface components, and other cellular processesQ35881196
Agrobacterium transcriptional regulator Ros is a prokaryotic zinc finger protein that regulates the plant oncogene iptQ36069140
H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule ExperimentsQ36146713
Regulation of Ti plasmid virulence genes by a chromosomal locus of Agrobacterium tumefaciensQ36279312
ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cellsQ36588882
Putative quorum-sensing regulator BlxR of Brucella melitensis regulates virulence factors including the type IV secretion system and flagella.Q36594589
BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suisQ36646623
Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.Q36804708
Silencing of xenogeneic DNA by H-NS-facilitation of lateral gene transfer in bacteria by a defense system that recognizes foreign DNA.Q36851768
H-NS family members function coordinately in an opportunistic pathogenQ36999879
The Regulatory Protein RosR Affects Rhizobium leguminosarum bv. trifolii Protein Profiles, Cell Surface Properties, and Symbiosis with CloverQ37194913
DNA bridging and antibridging: a role for bacterial nucleoid-associated proteins in regulating the expression of laterally acquired genesQ37389789
The chromatin-associated protein H-NS alters DNA topology in vitroQ37627511
The Sinorhizobium meliloti MucR protein, which is essential for the production of high-molecular-weight succinoglycan exopolysaccharide, binds to short DNA regions upstream of exoH and exoY.Q37881293
Zinc to cadmium replacement in the prokaryotic zinc-finger domain.Q38310799
Selective silencing of foreign DNA with low GC content by the H-NS protein in SalmonellaQ38312504
Nature and mechanism of the in vivo oligomerization of nucleoid protein H-NS.Q38323021
rosR, a determinant of nodulation competitiveness in Rhizobium etliQ38348206
Versatility of global transcriptional regulators in alpha-Proteobacteria: from essential cell cycle control to ancillary functionsQ38385326
Brucella melitensis cyclic di-GMP phosphodiesterase BpdA controls expression of flagellar genesQ38629084
H-NS: an overarching regulator of the Vibrio cholerae life cycleQ38919200
Analysis of the Ros repressor of Agrobacterium virC and virD operons: molecular intercommunication between plasmid and chromosomal genesQ39928933
The virC and virD operons of the Agrobacterium Ti plasmid are regulated by the ros chromosomal gene: analysis of the cloned ros geneQ39941301
Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.Q40746737
Cell cycle transition from S-phase to G1 in Caulobacter is mediated by ancestral virulence regulators.Q42057422
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectBrucella abortusQ11353905
P304page(s)17238
P577publication date2018-11-22
P1433published inScientific ReportsQ2261792
P1476titleIdentifying the region responsible for Brucella abortus MucR higher-order oligomer formation and examining its role in gene regulation
P478volume8

Reverse relations

cites work (P2860)
Q96229909Structural Insight of the Full-Length Ros Protein: A Prototype of the Prokaryotic Zinc-Finger Family
Q104064581The change of conditions does not affect Ros87 downhill folding mechanism

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