Hypoxia, Metabolism and Immune Cell Function.

scientific article published on 15 May 2018

Hypoxia, Metabolism and Immune Cell Function. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/BIOMEDICINES6020056
P932PMC publication ID6027519
P698PubMed publication ID29762526

P2093author name stringChristian Stockmann
Ewelina Krzywinska
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Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells.Q31118586
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Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasisQ33685179
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Hypoxia modulates human eosinophil functionQ34023169
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammationQ34028645
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Why does ARNT2 behave differently from ARNT?Q34122467
A membrane protease regulates energy production in macrophages by activating hypoxia-inducible factor-1 via a non-proteolytic mechanismQ34144698
Plasmacytoid dendritic cells: recent progress and open questionsQ34162925
Th17/Treg imbalance induced by increased incidence of atherosclerosis in patients with systemic lupus erythematosus (SLE).Q50864077
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Need (more than) two to Tango: Multiple tools to adapt to changes in oxygen availability.Q52372277
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?Q52668399
Hypoxia affects dendritic cell survival: role of the hypoxia-inducible factor-1α and lipopolysaccharide.Q53257878
Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease.Q54453217
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.Q54709609
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Antigen presentation by dendritic cells in vivoQ58757885
The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritisQ83163543
HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitisQ83763046
Disturbed Th17/Treg balance in patients with rheumatoid arthritisQ84644585
Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitisQ85666783
Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.Q36858877
Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosisQ36862166
Hypoxia-inducible factor 1 (HIF-1) pathwayQ36966537
TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogensQ36967641
Hypoxia inducible factor (HIF) function in innate immunity and infectionQ37009862
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.Q37200886
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.Q37489023
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.Q37491480
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response systemQ37510481
Interdependence of hypoxic and innate immune responsesQ37586121
Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammationQ37633213
Gsk3 is a metabolic checkpoint regulator in B cellsQ37643807
Regulation of plasmacytoid dendritic cell development.Q37690000
Impact of Metabolism on T-Cell Differentiation and Function and Cross Talk with Tumor MicroenvironmentQ37694431
Basophils: new players in the cytokine networkQ37788426
Basophils in allergic immune responsesQ37950600
Neutrophil function: from mechanisms to diseaseQ37973773
Immune regulatory function of B cells.Q37973774
Lymph node homing of T cells and dendritic cells via afferent lymphaticsQ37998206
Cross-presentation by dendritic cellsQ38025870
Role of hypoxia inducible factor-1α for interferon synthesis in mouse dendritic cellsQ38077750
The integration of T cell migration, differentiation and functionQ38100061
Tumor-associated macrophages: functional diversity, clinical significance, and open questionsQ38105286
TH2, allergy and group 2 innate lymphoid cellsQ38107790
Oxygen sensing, hypoxia-inducible factors, and disease pathophysiologyQ38128383
Functional extracellular eosinophil granules: a bomb caught in a trapQ38153632
Mast cell progenitors: origin, development and migration to tissuesQ38193606
Development and function of dendritic cell subsetsQ38212449
The biology of innate lymphoid cellsQ38319907
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cellsQ38347067
Glucose, glycolysis and lymphocyte responsesQ38563943
Targeting Th17 Effector Cytokines for the Treatment of Autoimmune DiseasesQ38584529
Heterogeneity and diversity of group 3 innate lymphoid cells: new cells on the blockQ38606216
miR-210 and hypoxic microvesicles: Two critical components of hypoxia involved in the regulation of killer cells function.Q38622260
Immunometabolism: Cellular Metabolism Turns Immune RegulatorQ38624726
Mast cells in asthma--state of the art.Q38633155
Innate lymphoid cells: major players in inflammatory diseasesQ38643190
Similarities in the Metabolic Reprogramming of Immune System and EndotheliumQ38645730
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cellsQ38714538
Hypoxia impairs anti-viral activity of natural killer (NK) cells but has little effect on anti-fibrotic NK cell functions in hepatitis C virus infectionQ38841745
A guide to immunometabolism for immunologists.Q38891307
Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg ActivityQ38917327
Hypoxia-inducible factors: key regulators of myeloid cells during inflammationQ38947313
HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxiaQ38948917
The hypoxia-inducible factor (HIF) couples immunity with metabolismQ38975324
HIF-mediated innate immune responses: cell signaling and therapeutic implicationsQ38989126
Formation of Neutrophil Extracellular Traps under Low Oxygen Level.Q39117515
Constitutive Glycolytic Metabolism Supports CD8(+) T Cell Effector Memory Differentiation during Viral Infection.Q39194568
MYC and HIF in shaping immune response and immune metabolismQ39211916
What Fuels Natural Killers? Metabolism and NK Cell ResponsesQ39249602
Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.Q39321728
Oxygen Metabolism and Innate Immune Responses in the Gut.Q39433728
von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylaseQ39593358
Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxiaQ39698671
Nitric oxide causes macrophage migration via the HIF-1-stimulated small GTPases Cdc42 and Rac1.Q39838660
Innate lymphoid cells at the interface between obesity and asthma.Q40062668
TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance.Q40412394
Hypoxic tumor-derived microvesicles negatively regulate NK cell function by a mechanism involving TGF-β and miR23a transferQ40437768
Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophagesQ40544126
Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell ActivitiesQ40693797
Cutting Edge: Hypoxia-Inducible Factor 1 Negatively Regulates Th1 FunctionQ40731073
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tensionQ41052822
Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activityQ41486353
Neutrophils as Components of Mucosal Homeostasis.Q41597529
HIF1α and metabolic reprogramming in inflammation.Q41678886
The immune diet: meeting the metabolic demands of lymphocyte activationQ41898658
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cellsQ42419970
HIF-1alpha expression regulates the bactericidal capacity of phagocytesQ42876119
Involvement of hypoxia-inducible factor-1 HiF(1alpha) in IgE-mediated primary human basophil responsesQ43273725
Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch RecombinationQ43286092
Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axisQ43685111
Expression of proinflammatory cytokines via HIF-1alpha and NF-kappaB activation on desferrioxamine-stimulated HMC-1 cellsQ43763430
Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alphaQ44606435
Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and functionQ44869825
Life with oxygenQ45345070
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesisQ45737030
All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis.Q45991876
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.Q46017879
Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defenseQ46197286
Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.Q46373208
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsisQ46377120
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory MacrophagesQ46485595
Dendritic cell reprogramming by the hypoxic environmentQ47249620
Regulation of immunity and inflammation by hypoxia in immunological nichesQ47708732
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migrationQ47844444
Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms.Q48025116
Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK CellsQ48239332
Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune diseaseQ49212691
Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue Protection-Linking the Nutritional State to Barrier Immunity.Q49630984
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.Q49917932
Mast cells, basophils and eosinophils: From allergy to cancerQ50081347
Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophilsQ34217833
B-cell biology and developmentQ34331269
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.Q34364808
Succinate: a metabolic signal in inflammationQ34393631
Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2.Q34393801
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseasesQ34658996
Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious DiseasesQ34726144
Activation-specific metabolic requirements for NK Cell IFN-γ productionQ35071267
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cellsQ35102340
HIF transcription factors, inflammation, and immunityQ35137138
Antigen-specific transforming growth factor β-induced Treg cells, but not natural Treg cells, ameliorate autoimmune arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance.Q35190507
Autophagic degradation of GZMB/granzyme B: a new mechanism of hypoxic tumor cell escape from natural killer cell-mediated lysisQ35319841
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.Q35404457
The role of the macrophage in sentinel responses in intestinal immunityQ35545583
Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27.Q35592657
miR-141 and miR-200a, Revelation of New Possible Players in Modulation of Th17/Treg Differentiation and Pathogenesis of Multiple Sclerosis.Q35621616
IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania InfectionQ35653927
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demandQ35690181
Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α.Q35765467
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsionQ35776328
Characterization of Th17 and FoxP3(+) Treg Cells in Paediatric Psoriasis PatientsQ35871966
The role of HIF-1alpha in myeloid cell inflammationQ36175335
The Role of IL-17 and Th17 Lymphocytes in Autoimmune DiseasesQ36249305
Integration of oxygen signaling at the consensus HRE.Q36290265
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzymeQ36349700
Regulation of the chemokine receptor CXCR4 by hypoxiaQ36371842
Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activityQ36402484
B Cells, Antibodies, and MoreQ36432935
Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expressionQ36672331
IL-10-producing regulatory B cells (B10 cells) in autoimmune diseaseQ36760499
Eosinophils: singularly destructive effector cells or purveyors of immunoregulation?Q36811733
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil functionQ36823821
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P577publication date2018-05-15
P1433published inBiomedicinesQ50816265
P1476titleHypoxia, Metabolism and Immune Cell Function.
P478volume6

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cites work (P2860)
Q91961385Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans
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