DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer

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DNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1106015503
P356DOI10.1186/S13148-018-0539-3
P932PMC publication ID6080402
P698PubMed publication ID30081950

P50authorRowaida Z TahaQ57903071
Eyad ElkordQ47163713
P2093author name stringSalman M Toor
Varun Sasidharan Nair
Hibah Shaath
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
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DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.Q55425717
CpG island methylator phenotype in cancerQ81080870
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A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencingQ33268624
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Intratumoral FoxP3+Helios+ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal CancerQ33729278
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Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigensQ34788858
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DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA MethyltransferasesQ37575781
Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?Q38245387
Cancer Statistics, 2017.Q39038674
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Immune Checkpoints as a Target for Colorectal Cancer Treatment.Q39387816
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.Q39867000
PD-L1 expression in colorectal cancer is associated with microsatellite instability, BRAF mutation, medullary morphology and cytotoxic tumor-infiltrating lymphocytesQ40745198
Epigenetic changes in colorectal cancerQ41973340
Immune checkpoint inhibitors in cancer therapy: a focus on T-regulatory cellsQ49851572
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmolecular biologyQ7202
colorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)104
P577publication date2018-08-06
P1433published inClinical EpigeneticsQ18620113
P1476titleDNA methylation and repressive histones in the promoters of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, PD-L1, and galectin-9 genes in human colorectal cancer
P478volume10

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cites work (P2860)
Q93264969Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Q99638160Genome-wide DNA methylation analysis by MethylRad and the transcriptome profiles reveal the potential cancer-related lncRNAs in colon cancer
Q90677742Immunogenic cell death in colon cancer prevention and therapy
Q64057809Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer
Q64120108PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Q98224804Role of Epigenetic Modifications in Inhibitory Immune Checkpoints in Cancer Development and Progression
Q92310206Systematic analysis of differentially methylated expressed genes and site-specific methylation as potential prognostic markers in head and neck cancer

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