Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

scientific article published in Science

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.1129594
P698PubMed publication ID16888140

P50authorJeffrey RavetchQ1359564
Falk NimmerjahnQ1394084
P2093author name stringYoshikatsu Kaneko
P2860cites workLack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicityQ30835165
P433issue5787
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P1104number of pages4
P304page(s)670-673
P577publication date2006-08-01
P1433published inScienceQ192864
P1476titleAnti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
P478volume313

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cites work (P2860)
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Q61813265IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age
Q58572561IgG Glyco-Engineering to Improve IVIg Potency
Q98177698IgG Suppresses Antibody Responses to Sheep Red Blood Cells in Double Knock-Out Mice Lacking Complement Factor C3 and Activating Fcγ-Receptors
Q64118813IgG and Fcγ Receptors in Intestinal Immunity and Inflammation
Q88445153IgG and leukocytes: Targets of immunomodulatory α2,6 sialic acids
Q33378924IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions
Q40108236IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.
Q34368678IgG subclasses and allotypes: from structure to effector functions
Q34036447IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring.
Q38115691IgG-Fc N-glycosylation at Asn297 and IgA O-glycosylation in the hinge region in health and disease
Q38013479IgG-Fc glycoengineering in non-mammalian expression hosts
Q36213225IgG4 can induce an M2-like phenotype in human monocyte-derived macrophages through FcγRI.
Q28512966Immune complexes regulate bone metabolism through FcRγ signalling
Q55094703Immune modulation of i.v. immunoglobulin in women with reproductive failure.
Q28069362Immune recruitment or suppression by glycan engineering of endogenous and therapeutic antibodies
Q33381036Immune regulation by B cells and antibodies a view towards the clinic.
Q34468348Immunoglobulin G (IgG) Fab glycosylation analysis using a new mass spectrometric high-throughput profiling method reveals pregnancy-associated changes
Q55055409Immunoglobulin G Fc N-glycan profiling in patients with gastric cancer by LC-ESI-MS: relation to tumor progression and survival.
Q86421496Immunoglobulin G Fc N-glycosylation in Guillain-Barré syndrome treated with intravenous immunoglobulin
Q55290367Immunoglobulin G Fragment Crystallizable Glycosylation After Hematopoietic Stem Cell Transplantation Is Dissimilar to Donor Profiles.
Q33518916Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study
Q27681704Immunoglobulin G1 Fc Domain Motions: Implications for Fc Engineering
Q38994739Immunoglobulin Glycosylation Effects in Allergy and Immunity
Q58861272Immunoglobulines intraveineuses dans les maladies auto-immunes et inflammatoires : au-delà d’une simple substitution
Q64091767Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity
Q34289043Immunological challenges of cardiac transplantation: the need for better animal models to answer current clinical questions
Q42920927Immunological intervention in human diseases
Q88650321Immunological responses to influenza vaccination: lessons for improving vaccine efficacy
Q64928515Immunomodulation in Primary Immune Thrombocytopenia: A Possible Role of the Fc Fragment of Romiplostim?
Q33393823Immunomodulatory drugs and their application to the management of canine immune-mediated disease
Q33576327Immunotherapy of malignant disease with tumor antigen-specific monoclonal antibodies
Q24634395Immunotherapy of systemic sclerosis
Q92613729Impact of Fc N-glycan sialylation on IgG structure
Q38818688Impact of Glycosylation on Effector Functions of Therapeutic IgG
Q38762019Impact of IgG Fc-Oligosaccharides on Recombinant Monoclonal Antibody Structure, Stability, Safety, and Efficacy.
Q97883509Impact of Plasma Membrane Domains on IgG Fc Receptor Function
Q90535599Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells
Q37140095Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy
Q48134110Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies.
Q37342888Improved tumor immunity using anti-tyrosinase related protein-1 monoclonal antibody combined with DNA vaccines in murine melanoma
Q39279968Improving Antibody-Based Cancer Therapeutics Through Glycan Engineering.
Q59132146Improving Immunotherapy Through Glycodesign
Q40602343In planta protein sialylation through overexpression of the respective mammalian pathway
Q28547176In vitro glycoengineering of IgG1 and its effect on Fc receptor binding and ADCC activity
Q38202547In vivo kinetics and biodistribution analysis of neoglycoproteins: effects of chemically introduced glycans on proteins
Q40114596In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques
Q82908543In vivo veritas: the surprising roles of Fc receptors in immunity
Q41880662In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap
Q27485310Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis
Q34208137Increased sialylation of anti-Thomsen-Friedenreich antigen (CD176) antibodies in patients with gastric cancer: a diagnostic and prognostic potential
Q58861264Indications et mécanismes d’action des immunoglobulines intraveineuses dans les pathologies auto-immunes et inflammatoires systémiques
Q26781290Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity
Q27010099Infection, inflammation and host carbohydrates: a Glyco-Evasion Hypothesis
Q37754703Inflammation and arthritis: perspectives of the glycobiologist
Q35670608Inflammatory bowel disease associates with proinflammatory potential of the immunoglobulin G glycome
Q26796413Inflammatory etiopathogenesis of systemic lupus erythematosus: an update
Q64925019Influence of N-glycosylation on effector functions and thermal stability of glycoengineered IgG1 monoclonal antibody with homogeneous glycoforms.
Q64253803Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza Virus
Q51081577Integrated Genome and Protein Editing Swaps α-2,6 Sialylation for α-2,3 Sialic Acid on Recombinant Antibodies from CHO.
Q54977678Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes.
Q37679918Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance
Q84979117Intramolecular Glycan–Protein Interactions in Glycoproteins
Q38346284Intravenous Immunoglobulin and Immunomodulation of B-Cell - in vitro and in vivo Effects
Q22241424Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease
Q36959840Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.
Q33270749Intravenous immune globulin in hereditary inclusion body myopathy: a pilot study
Q27000371Intravenous immunoglobulin and Alzheimer's disease: what now?
Q33420267Intravenous immunoglobulin as clinical immune-modulating therapy
Q38308436Intravenous immunoglobulin in neurology--mode of action and clinical efficacy
Q36302368Intravenous immunoglobulin in the management of lupus nephritis.
Q37487547Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways
Q86017374Intravenous immunoglobulin replacement therapy in common variable immunodeficiency induces B cell depletion through differentiation into apoptosis-prone CD21(low) B cells
Q37573529Intravenous immunoglobulin therapy for autoimmune diseases
Q37873722Intravenous immunoglobulin therapy in rheumatic diseases
Q33405903Intravenous immunoglobulin therapy: how does IgG modulate the immune system?
Q37773248Intravenous immunoglobulin-based immunotherapy: an arsenal of possibilities for patients and science
Q37732919Intravenous immunoglobulin-induced IL-33 is insufficient to mediate basophil expansion in autoimmune patients
Q38133405Intravenous immunoglobulin-mediated immunosuppression and the development of an IVIG substitute
Q36757383Intravenous immunoglobulin: an update on the clinical use and mechanisms of action.
Q38304255Intravenous immunoglobulins (IVIG) in systemic sclerosis: a challenging yet promising future
Q37578120Intravenous immunoglobulins in systemic lupus erythematosus: from the bench to the bedside
Q36384725Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion.
Q37626118Intravenous immunoglobulins--understanding properties and mechanisms
Q39933128Intravenous immunoglobulins. Current understanding and future directions.
Q35965959Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry
Q37774870Involvement of aberrant glycosylation in thyroid cancer
Q35951417Isotype-specific glycosylation analysis of mouse IgG by LC-MS.
Q42372965Kinetics of N-Glycan Release from Human Immunoglobulin G (IgG) by PNGase F: All Glycans Are Not Created Equal
Q35167400Lack of protection following passive transfer of polyclonal highly functional low-dose non-neutralizing antibodies
Q27671018Lanthanide binding and IgG affinity construct: Potential applications in solution NMR, MRI, and luminescence microscopy
Q64266918Lectin microarray profiling and monosaccharide analysis of bovine milk immunoglobulin G oligosaccharides during the first 10 days of lactation
Q39642938Lectin-Based Biosensor Strategy for Electrochemical Assay of Glycan Expression on Living Cancer Cells
Q36673623Lectins: carbohydrate-specific reagents and biological recognition molecules
Q37252443Lessons learnt from many years of experience using anti-D in humans for prevention of RhD immunization and haemolytic disease of the fetus and newborn
Q34574913Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Q81041251Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production
Q34803358Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn
Q93379659Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus
Q37578785Low-affinity Fcgamma receptors, autoimmunity and infection
Q37281976MALDI-TOF-MS reveals differential N-linked plasma- and IgG-glycosylation profiles between mothers and their newborns.
Q44031303MS in the analysis of biosimilars
Q99711567MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation
Q33382862Macrophages activated by C-reactive protein through Fc gamma RI transfer suppression of immune thrombocytopenia
Q36670335Making autoantibodies safe
Q37290930Mammalian glycosylation in immunity
Q33815783Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice
Q35771248Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.
Q35108694Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes
Q34247694Mass spectrometry in the analysis of N-linked and O-linked glycans
Q79375472Massive gastrointestinal haemorrhage in isolated intestinal Henoch-Schonlein purpura with response to intravenous immunoglobulin infusion
Q42375731Massive immune response against IVIg interferes with response against other antigens in mice: A new mode of action?
Q36260924Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome
Q38161574Mechanisms and potential therapeutic targets in allergic inflammation: recent insights.
Q33740580Mechanisms of Autoantibody-Induced Pathology.
Q37737994Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy.
Q38335199Mechanisms of action of Ig preparations: immunomodulatory and anti-inflammatory effects
Q39119704Mechanisms of action of intravenous immunoglobulin
Q33389428Mechanisms of action of intravenous immunoglobulins
Q30371304Mechanisms of tolerance induction in allergic disease: integrating current and emerging concepts.
Q35292040Membrane adsorbers comprising grafted glycopolymers for targeted lectin binding
Q41940868Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses
Q36821157Microarrays in infection and immunity
Q50237001Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact
Q37558341Microscale Measurements of Michaelis-Menten Constants of Neuraminidase with Nanogel Capillary Electrophoresis for the Determination of the Sialic Acid Linkage
Q93052135Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo
Q90608974Model-Driven Engineering of N-Linked Glycosylation in Chinese Hamster Ovary Cells
Q41677985Modulating IgG effector function by Fc glycan engineering.
Q37860624Modulation of antibody effector function
Q39590627Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose
Q51749017Modulation of mAb quality attributes using microliter scale fed-batch cultures.
Q39062945Modulators of IgG penetration through the blood-brain barrier: Implications for Alzheimer's disease immunotherapy
Q37511739Molecular analysis of an alternative N-glycosylation machinery by functional transfer from Actinobacillus pleuropneumoniae to Escherichia coli.
Q59047780Molecular and Cellular Pathways of Immunoglobulin G Activity In Vivo
Q38135285Molecular basis for downregulation of C5a-mediated inflammation by IgG1 immune complexes in allergy and asthma
Q26825548Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
Q36922576Monoclonal antibodies - a proven and rapidly expanding therapeutic modality for human diseases
Q24655389Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization
Q37181031Monoclonal antibodies for cancer immunotherapy
Q35866472Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants
Q63362959Multi-isotype Glycoproteomic Characterization of Serum Antibody Heavy Chains Reveals Isotype- and Subclass-Specific -Glycosylation Profiles
Q34270155Multifarious roles of sialic acids in immunity
Q28390264Multifocal motor neuropathy, multifocal acquired demyelinating sensory and motor neuropathy, and other chronic acquired demyelinating polyneuropathy variants
Q58761454Multiple Roles of Glycans in Hematological Malignancies
Q35747533Multiple mechanisms of immune suppression by B lymphocytes
Q40054832Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation
Q37484223Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG
Q36133312N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical
Q42973099N-linked glycosylation selectively regulates autonomous precursor BCR function
Q36249961NMR characterization of immunoglobulin G Fc glycan motion on enzymatic sialylation
Q50497045Nanoscale reversed-phase liquid chromatography-mass spectrometry of permethylated N-glycans.
Q37895956Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
Q36797342Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity
Q35170050Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model
Q94701607Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita
Q40130027Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists
Q92133744Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity
Q39320387New Insights into Pericarditis: Mechanisms of Injury and Therapeutic Targets
Q41173378New advances in the treatment of neurological diseases using high dose intravenous immunoglobulins
Q27652073New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2·1-Å resolution
Q33900595New paradigms for functional HIV-specific nonneutralizing antibodies
Q41042837Noninvasive Imaging of Dendrimer‐Type N‐Glycan Clusters: In Vivo Dynamics Dependence on Oligosaccharide Structure
Q37409360Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
Q52608527Novel Concepts of Altered Immunoglobulin G Galactosylation in Autoimmune Diseases.
Q35075181Novel blocking human IgG directed against the pentapeptide repeat motifs of Neisseria meningitidis Lip/H.8 and Laz lipoproteins
Q34307304Novel data analysis tool for semiquantitative LC-MS-MS2 profiling of N-glycans
Q37979848Novel roles for the IgG Fc glycan
Q37290692Novel targets for immunotherapy in glomerulonephritis
Q90736495On enzymatic remodeling of IgG glycosylation; unique tools with broad applications
Q34253508On the perplexingly low rate of transport of IgG2 across the human placenta
Q48987144One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates
Q52547591One-pot enzymatic glycan remodeling of a therapeutic monoclonal antibody by endoglycosidase S (Endo-S) from Streptococcus pyogenes.
Q37113941Opportunities to exploit non-neutralizing HIV-specific antibody activity
Q28831266Optimal Synthetic Glycosylation of a Therapeutic Antibody
Q28831364Optimal Synthetic Glycosylation of a Therapeutic Antibody
Q90649263Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention
Q33926907Passively administered pooled human immunoglobulins exert IL-10 dependent anti-inflammatory effects that protect against fatal HSV encephalitis
Q42846834Perioperative Infliximab Application Ameliorates Acute Rejection Associated Inflammation After Intestinal Transplantation
Q60956631Perspective on the Development and Validation of Ab Reagents to Fish Immune Proteins for the Correct Assessment of Immune Function
Q42118646Pharmacokinetics of Monoclonal Antibodies.
Q34080417Physicochemical and biological characterization of 1E10 anti-idiotype vaccine.
Q42113781Physicochemical and biological characterization of SB2, a biosimilar of Remicade® (infliximab).
Q34275537Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics
Q40078229Plant-produced anti-dengue virus monoclonal antibodies exhibit reduced antibody-dependent enhancement of infection activity.
Q36808629Polarized immune responses differentially regulate cancer development
Q36620451Post-translational modifications in the context of therapeutic proteins
Q38246996Post-translational structural modifications of immunoglobulin G and their effect on biological activity
Q55250588Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways.
Q47132349Pro-inflammatory State in Monoclonal Gammopathy of Undetermined Significance and in Multiple Myeloma Is Characterized by Low Sialylation of Pathogen-Specific and Other Monoclonal Immunoglobulins
Q35873009Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid
Q36571261Production and characterization of mouse monoclonal antibodies recognizing multiple subclasses of human IgG.
Q46250133Production of IgGs with a human-like sialylation in CHO cells.
Q36213335Production of α2,6-sialylated IgG1 in CHO cells
Q38408253Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis
Q43125937Profile of Jeffrey Ravetch. Interview by Philip Downey
Q46608396Profiling N-linked oligosaccharides from IgG by high-performance anion-exchange chromatography with pulsed amperometric detection
Q63443148Profiling and genetic control of the murine immunoglobulin G glycome
Q91844287Profiling of Naturally Occurring Antibodies to the Thomsen-Friedenreich Antigen in Health and Cancer: The Diversity and Clinical Potential
Q55491567Promoter methylation of the MGAT3 and BACH2 genes correlates with the composition of the immunoglobulin G glycome in inflammatory bowel disease.
Q35262648Prophylactic anti-D preparations display variable decreases in Fc-fucosylation of anti-D.
Q36592223Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation.
Q35590264Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs
Q38593866Protective role of mouse IgG1 in cryoglobulinaemia; insights from an animal model and relevance to human pathology.
Q98466487Protein Glycoengineering: An Approach for Improving Protein Properties
Q58861270Protein destabilizing agents induce polyreactivity and enhanced immunomodulatory activity in IVIg preparations
Q37168156Protein-glycan interactions in the control of innate and adaptive immune responses
Q42748675Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins
Q33934663Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry
Q37999739Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach
Q35232337Rapid comparison of a candidate biosimilar to an innovator monoclonal antibody with advanced liquid chromatography and mass spectrometry technologies
Q33378989Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets
Q33379309Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.
Q38050998Recent advances in technology supporting biopharmaceutical production from mammalian cells
Q92837603Recognition of the human antibody-mediated platelet destruction in adult ITP patients by C-reactive protein
Q42144247Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22.
Q38957490Regulation of antibody effector functions through IgG Fc N-glycosylation
Q37877263Regulation of immunity and inflammation by intravenous immunoglobulin: relevance to solid organ transplantation
Q51774594Regulation of leukocyte recruitment by the long pentraxin PTX3.
Q27015093Regulatory B cells: an exciting target for future therapeutics in transplantation
Q38233691Regulatory functions of B cells in allergic diseases
Q40223873Repeat application of microneedles does not alter skin appearance or barrier function and causes no measurable disturbance of serum biomarkers of infection, inflammation or immunity in mice in vivo.
Q46364522Reply to Bayry et al.: The anti-inflammatory activity of sialylated IgG Fcs.
Q42971141Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc.
Q57253422Reply to — IVIG pluripotency and the concept of Fc-sialylation: challenges to the scientist
Q37778732Research and development of next generation of antibody-based therapeutics
Q34315442Restricted motion of the conserved immunoglobulin G1 N-glycan is essential for efficient FcγRIIIa binding
Q34555935Reversibility of membrane N-glycome of HeLa cells upon treatment with epigenetic inhibitors
Q38258905Review: intravenous immunoglobulin and B cells: when the product regulates the producer
Q40461706Rituximab in Combination With Bortezomib, Plasmapheresis, and High-Dose IVIG to Treat Antibody-Mediated Renal Allograft Rejection.
Q34724042Role of glycosylation in structure and stability of Erythrina corallodendron lectin (EcorL): a molecular dynamics study
Q36739762Role of monoclonal antibodies in tumor-specific immunity
Q57253408Role of sialylation in the anti-inflammatory activity of intravenous immunoglobulin - F(ab')₂ versus Fc sialylation
Q35164415Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation
Q49972870SHIP negatively regulates type II immune responses in mast cells and macrophages
Q42917889Self and nonself recognition with bacterial and animal glycans, surveys by synthetic chemistry
Q46360891Separation of nonfucosylated antibodies with immobilized FcγRIII receptors
Q45999306Serum glycosylation characterization of osteonecrosis of the femoral head by mass spectrometry.
Q58864656Shortage of human intravenous immunoglobulin—reasons and possible solutions
Q38283308Should development of Alzheimer's disease-specific intravenous immunoglobulin be considered?
Q37586575Sialic acid level reflects the disturbances of glycosylation and acute-phase reaction in rheumatic diseases
Q48726112Sialic acid linkage-specific permethylation for improved profiling of protein glycosylation by MALDI-TOF MS.
Q41888076Sialic acid on herpes simplex virus type 1 envelope glycoproteins is required for efficient infection of cells
Q43789293Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model
Q55347406Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis.
Q48210931Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy
Q37085836Sialylated immunoglobulin G can neutralize influenza virus infection through receptor mimicry
Q42316355Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury
Q51370563Sialylation and desialylation dynamics of monocytes upon differentiation and polarization to macrophages.
Q90171001Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
Q36768842Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.
Q36352180Sialylation determines the nephritogenicity of IgG3 cryoglobulins
Q58004245Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)
Q36266469Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity
Q57253368Sialylation of anti-histone immunoglobulin G autoantibodies determines their capabilities to participate in the clearance of late apoptotic cells
Q33399238Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin.
Q35959088Sialyltransferase and Neuraminidase Levels/Ratios and Sialic Acid Levels in Peripheral Blood B Cells Correlate with Measures of Disease Activity in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Pilot Study
Q58612152Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody
Q37117619Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
Q53081892Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies.
Q35158352Site-specific modification of ED-B-targeting antibody using intein-fusion technology
Q92173365Small-molecule control of antibody N-glycosylation in engineered mammalian cells
Q47286747Solid-Phase Enzymatic Remodeling Produces High Yields of Single Glycoform Antibodies
Q47110972Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.
Q63433108Streptococcal Endo-β--Acetylglucosaminidase Suppresses Antibody-Mediated Inflammation
Q27684721Structural Characterization of Anti-Inflammatory Immunoglobulin G Fc Proteins
Q38615376Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.
Q26824272Structural and functional characteristics of bovine milk protein glycosylation
Q34619043Structural and functional characterization of the trifunctional antibody catumaxomab
Q27675205Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans
Q47846522Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody
Q36624176Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa
Q38615372Structural mechanism of high affinity FcγRI recognition of immunoglobulin G.
Q35031336Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.
Q89473460Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
Q42364603Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health
Q34107337Substrate specificity of cytoplasmic N-glycosyltransferase
Q50193260Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammation
Q38239288Sweet and sour: the role of glycosylation for the anti-inflammatory activity of immunoglobulin G.
Q38851112Sweet but dangerous - the role of immunoglobulin G glycosylation in autoimmunity and inflammation.
Q33414406Sweetened antibodies against humoral autoimmunity: sialylated antibodies are required for IVIg-mediated therapy
Q33265617Synthetic antibodies as therapeutics
Q37123859T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.
Q91838076TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
Q55234556Targeting B Cells and Plasma Cells in Autoimmune Diseases.
Q38207937Targeting B cells and autoantibodies in the therapy of autoimmune diseases
Q33758483Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice.
Q52370705Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues.
Q27002843Targeting the Fc receptor in autoimmune disease
Q36516810The "sweet" side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation
Q37206320The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study
Q95513710The Author Replies
Q50129712The B cell response to citrullinated antigens in the development of rheumatoid arthritis.
Q60047547The Clinical Value of Autoantibodies in Rheumatoid Arthritis
Q92921343The Contribution of IgG Glycosylation to Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement-Dependent Cytotoxicity (CDC) in Hashimoto's Thyroiditis: An in Vitro Model of Thyroid Autoimmunity
Q33430624The Elements Steering Pathogenesis in IgG-Mediated Alloimmune Diseases
Q38724772The Emerging Importance of IgG Fab Glycosylation in Immunity.
Q88669457The Glycoscience of Immunity
Q37293581The Golgi CMP-sialic acid transporter: A new CHO mutant provides functional insights
Q33931736The IgG-specific endoglycosidase EndoS inhibits both cellular and complement-mediated autoimmune hemolysis
Q90460486The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange
Q33740762The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains
Q35818105The Pathogenicity of Anti-β2GP1-IgG Autoantibodies Depends on Fc Glycosylation
Q59360845The Potential Role of Fc-Receptor Functions in the Development of a Universal Influenza Vaccine
Q39088502The Role and Function of Fcγ Receptors on Myeloid Cells
Q57019841The Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses
Q28395318The Role of Posttranslational Protein Modifications in Rheumatological Diseases: Focus on Rheumatoid Arthritis
Q36021825The Structural Role of Antibody N-Glycosylation in Receptor Interactions
Q38066414The advantage of specific intravenous immunoglobulin (sIVIG) on regular IVIG: experience of the last decade
Q24676548The antiinflammatory activity of IgG: the intravenous IgG paradox
Q64926950The association between subclass-specific IgG Fc N-glycosylation profiles and hypertension in the Uygur, Kazak, Kirgiz, and Tajik populations.
Q38117686The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies
Q37091308The case for immunomodulatory approaches in treating HSV encephalitis
Q37638949The challenge and promise of glycomics
Q36213158The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development
Q38182645The expanding role of therapeutic antibodies
Q37027166The growth and potential of human antiviral monoclonal antibody therapeutics.
Q90027632The history of IgG glycosylation and where we are now
Q42116482The immunoglobulin G1 N-glycan composition affects binding to each low affinity Fc γ receptor
Q36670313The impact of microcarrier culture optimization on the glycosylation profile of a monoclonal antibody
Q36976399The isotype repertoire of antibodies against novel UH-RA peptides in rheumatoid arthritis.
Q36819920The mast cell IgG receptors and their roles in tissue inflammation
Q38615385The multiple facets of FcRn in immunity.
Q37664865The other side of immunoglobulin G: suppressor of inflammation
Q38206946The pathogenic potential of autoreactive antibodies in rheumatoid arthritis.
Q38824186The potential of intravenous immunoglobulins for cancer therapy: a road that is worth taking?
Q38268922The protective role of immunoglobulins in fungal infections and inflammation
Q36906422The regulatory power of glycans and their binding partners in immunity
Q28075279The role of genetics and antibodies in sepsis
Q38218832The role of glycosylation in IBD.
Q37995919The role of sialic acid as a modulator of the anti-inflammatory activity of IgG.
Q38029304The sweet tooth of biopharmaceuticals: importance of recombinant protein glycosylation analysis.
Q94452368The trinity of COVID-19: immunity, inflammation and intervention
Q41170285Therapeutic Potential of Intravenous Immunoglobulin in Acute Brain Injury
Q38149195Therapeutic antibodies as a treatment option for dengue fever
Q39729881Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils.
Q36950457Therapeutic potential of deglycosylated antibodies.
Q37807782Therapeutic use of immunoglobulins
Q37780677Tolerance: an overview and perspectives
Q42687289Total synthesis of the 2,6-sialylated immunoglobulin G glycopeptide fragment in homogeneous form.
Q30419992Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress
Q92229013Transcriptome alteration spectrum in rat lung induced by radiotherapy
Q40762677Translating Inhibitory Fc Receptor Biology into Novel Therapeutic Approaches
Q26991899Translating basic mechanisms of IgG effector activity into next generation cancer therapies
Q41967328Treatment of Antibody-Mediated Renal Allograft Rejection: Improving Step by Step
Q37557375Treatment of chronic inflammatory demyelinating polyneuropathy: from molecular bases to practical considerations.
Q53816522Treatment of inclusion body myositis: is low-dose intravenous immunoglobulin the solution?
Q26822442Treatment of spinal cord injury with intravenous immunoglobulin G: preliminary evidence and future perspectives
Q37974990Treatment of systemic lupus erythematosus: new advances in targeted therapy
Q35063963Treatment response in Kawasaki disease is associated with sialylation levels of endogenous but not therapeutic intravenous immunoglobulin G
Q57640701Treatment with Low Doses of Polyclonal Immunoglobulin Improves B Cell Function During Immune Reconstitution in a Murine Model
Q36781300Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
Q38232105Type I and type II Fc receptors regulate innate and adaptive immunity
Q30394129Ubiquitous Importance of Protein Glycosylation
Q89901292Understanding the role of antibody glycosylation through the lens of severe viral and bacterial diseases
Q93078490Understudied Factors Influencing Fc-Mediated Immune Responses against Viral Infections
Q27670877Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose
Q36253487Unusual transglycosylation activity of Flavobacterium meningosepticum endoglycosidases enables convergent chemoenzymatic synthesis of core fucosylated complex N-glycopeptides
Q36632113Use of mouse models to study the mechanisms and consequences of RBC clearance.
Q38547311Using glyco-engineering to produce therapeutic proteins.
Q91694478Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer
Q55091658Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability.
Q35656099Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections
Q39067348Will sialylation change intravenous immunoglobulin therapy in the future?
Q38055447With or without sugar? (A)glycosylation of therapeutic antibodies
Q85397964[Glycosylation-dependent effector function of IgG antibodies]
Q45964401[Optimizing therapy in patients with severe autoimmune blistering skin diseases].
Q83179107[The significance of intravenous immunoglobulin in treatment of immune-mediated polyneuropathies]
Q54102494[Use of intravenous polyclonal immunoglobulins in autoimmune and inflammatory disorders].
Q38615353bIgG time for large eaters: monocytes and macrophages as effector and target cells of antibody-mediated immune activation and repression.

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