Mechanism of membrane pore formation by human gasdermin-D

scientific article published on 13 June 2018

Mechanism of membrane pore formation by human gasdermin-D is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.15252/EMBJ.201798321
P932PMC publication ID6043855
P698PubMed publication ID29898893

P50authorSebastian HillerQ37619301
Daniel Jobst MullerQ54877794
Estefania MulvihillQ87907775
P2093author name stringLorenzo Sborgi
Stefania A Mari
Moritz Pfreundschuh
P2860cites workMembrane lipids: where they are and how they behaveQ24653084
Pyroptotic cell death defends against intracellular pathogensQ27022620
Conformational changes during pore formation by the perforin-related protein pleurotolysinQ27313232
Pore-forming activity and structural autoinhibition of the gasdermin familyQ27709423
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Structural basis of pore formation by the bacterial toxin pneumolysinQ28246818
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretionQ28270330
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane poresQ28511994
Pro-inflammatory programmed cell deathQ29300293
Pyroptosis: host cell death and inflammationQ29615594
Plasticity of listeriolysin O pores and its regulation by pH and unique histidine [corrected].Q30152954
Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membraneQ30163889
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell deathQ30370004
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell deathQ30833912
Assembly mechanism of the oligomeric streptolysin O pore: the early membrane lesion is lined by a free edge of the lipid membrane and is extended gradually during oligomerizationQ32097271
Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infectionQ34036902
Revisiting caspases in sepsisQ34662282
Perforin oligomers form arcs in cellular membranes: a locus for intracellular delivery of granzymes.Q34675229
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.Q34678595
Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.Q35240727
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytesQ36266939
Current trends in inflammatory and immunomodulatory mediators in sepsisQ36628592
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranesQ37102414
Multiparametric imaging of biological systems by force-distance curve-based AFM.Q38132326
Mechanisms and functions of inflammasomesQ38214128
Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores.Q38494808
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterolQ38724298
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.Q38835006
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell deathQ38835009
Inflammasomes: mechanism of assembly, regulation and signallingQ38862650
Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family FunctionsQ39135386
Imaging modes of atomic force microscopy for application in molecular and cell biology.Q39223922
Incomplete pneumolysin oligomers form membrane pores.Q40223553
Real-time visualization of perforin nanopore assembly.Q40343450
Unraveling the Pore-Forming Steps of Pneumolysin from Streptococcus pneumoniae.Q40468791
The gasdermin-D pore: Executor of pyroptotic cell deathQ42323433
Quantitative imaging of the electrostatic field and potential generated by a transmembrane protein pore at subnanometer resolutionQ45741395
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.Q47035972
Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1 beta-converting enzyme precursorQ47855030
Multiparametric high-resolution imaging of native proteins by force-distance curve-based AFM.Q48315684
Directly Observing the Lipid-Dependent Self-Assembly and Pore-Forming Mechanism of the Cytolytic Toxin Listeriolysin O.Q51797727
Formation of Solid-Supported Lipid Bilayers: An Integrated ViewQ57366502
Imaging and Quantifying Chemical and Physical Properties of Native Proteins at Molecular Resolution by Force-Volume AFMQ57825361
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectmolecular biologyQ7202
P304page(s)e98321
P577publication date2018-06-13
P1433published inThe EMBO JournalQ1278554
P1476titleMechanism of membrane pore formation by human gasdermin-D
P478volume37

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cites work (P2860)
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Q92655305Cell Death and Liver Disease
Q100504574Emerging insights on the role of gasdermins in infection and inflammatory diseases
Q91868002Excessive Iodine Promotes Pyroptosis of Thyroid Follicular Epithelial Cells in Hashimoto's Thyroiditis Through the ROS-NF-κB-NLRP3 Pathway
Q57492013From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?
Q106518156GSDMD (1-275) binds PIPs
Q106518171GSDMD (1-275) binds cardiolipin
Q106518162GSDMD forms ring‐shaped oligomers
Q106518161GSDMD oligomerizes into arc-, slit-shaped structures
Q106518172GSDME (1-270) binds cardiolipin
Q94496417GSDME-Dependent Incomplete Pyroptosis Permits Selective IL-1α Release under Caspase-1 Inhibition
Q92702300Gasdermin D (GSDMD) as a new target for the treatment of infection
Q58614135Gasdermin-d Played a Critical Role in the Cyclic Stretch-Induced Inflammatory Reaction in Human Periodontal Ligament Cells
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Q96640576Jack of all trades inhibits inflammation (in sober people)
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Q92823870Membrane perforation by the pore-forming toxin pneumolysin
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Q58606423Seeing and sensing single G protein-coupled receptors by atomic force microscopy
Q57285666The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia
Q91130446The gasdermins, a protein family executing cell death and inflammation
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