ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis

scientific article published on 10 September 2019

ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/S41419-019-1919-0
P932PMC publication ID6737032
P698PubMed publication ID31506423

P50authorGuo-Wei ZhangQ92893175
P2093author name stringJia Xu
Lei Zhou
Xue-Mei Chen
Zhi-Wei Li
Jie-Hui Tan
Qi-Xin Mo
Rong-Chang Cao
Su-Bing Li
Su-Ying Zhou
Zhao-Chang Qi
P2860cites workPancreatoscopy-Directed Electrohydraulic Lithotripsy for Pancreatic Ductal Stones in Painful Chronic Pancreatitis Using SpyGlass.Q39135052
Genetic risk in chronic pancreatitis: the misfolding-dependent pathwayQ39398523
Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout miceQ40167265
Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrestQ40246328
ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiationQ41931284
A carboxyl ester lipase (CEL) mutant causes chronic pancreatitis by forming intracellular aggregates that activate apoptosisQ42275500
Mitochondrial dysfunction and apoptosis of acinar cells in chronic pancreatitisQ46502471
ATF6 knockdown decreases apoptosis, arrests the S phase of the cell cycle, and increases steroid hormone production in mouse granulosa cellsQ47886362
Perturbation of proteasome function by bortezomib leading to ER stress-induced apoptotic cell death in cholangiocarcinomaQ47955863
Sirtuin-3 (SIRT3) protects pancreatic β-cells from endoplasmic reticulum (ER) stress-induced apoptosis and dysfunction.Q51622010
Mechanism of membrane pore formation by human gasdermin-DQ57805428
Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling PathwayQ58568578
A novel p.Ser282Pro variant is associated with autosomal dominant hereditary pancreatitisQ60609832
Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitisQ24658116
Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOPQ28216242
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signalsQ28646129
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitisQ30528817
Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell deathQ33654180
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent PathwayQ33843764
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesisQ34192744
Endoplasmic reticulum stress is chronically activated in chronic pancreatitisQ34283421
The epidemiology of pancreatitis and pancreatic cancerQ34341477
Alcohol and Smoking as Risk Factors in an Epidemiology Study of Patients With Chronic PancreatitisQ34594385
Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detectionQ34620078
Pathogenesis of chronic pancreatitis: an evidence-based review of past theories and recent developmentsQ35956897
Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stressQ36300434
Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitisQ36775826
Loss of acinar cell IKKα triggers spontaneous pancreatitis in miceQ36793423
Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Q36927073
Mechanisms of parenchymal injury and signaling pathways in ectatic ducts of chronic pancreatitis: implications for pancreatic carcinogenesisQ37421292
Chronic pancreatitis: genetics and pathogenesisQ37488219
Genetics and pathogenesis of chronic pancreatitis: the 2012 updateQ38022995
Endoplasmic reticulum stress in immunityQ38286013
ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulationQ38869861
P433issue9
P921main subjectchronic pancreatitisQ1996053
P304page(s)662
P577publication date2019-09-10
P1433published inCell Death and DiseaseQ2197222
P1476titleATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis
P478volume10

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cites work (P2860)
Q98159125ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis
Q92068835Ambroxol Improves Neuronal Survival and Reduces White Matter Damage through Suppressing Endoplasmic Reticulum Stress in Microglia after Intracerebral Hemorrhage
Q101573973EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis

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