| scholarly article | Q13442814 |
| review article | Q7318358 |
| P6179 | Dimensions Publication ID | 1085569530 |
| P356 | DOI | 10.1007/S10620-017-4601-3 |
| P932 | PMC publication ID | 5487703 |
| P698 | PubMed publication ID | 28536777 |
| P50 | author | Eszter Hegyi | Q90043970 |
| Miklós Sahin-Tóth | Q38318675 | ||
| P2093 | author name string | Miklós Sahin-Tóth | |
| Eszter Hegyi | |||
| P2860 | cites work | Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene | Q24311652 |
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| Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis | Q79144290 | ||
| Hereditary pancreatitis caused by triplication of the trypsinogen locus | Q79314164 | ||
| Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3 | Q79802965 | ||
| Functional analysis of eight missense mutations in the SPINK1 gene | Q83463602 | ||
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| A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis | Q28138105 | ||
| SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis | Q28138406 | ||
| Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis | Q28145585 | ||
| The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families | Q28266223 | ||
| A conservative assessment of the major genetic causes of idiopathic chronic pancreatitis: data from a comprehensive analysis of PRSS1, SPINK1, CTRC and CFTR genes in 253 young French patients | Q30000783 | ||
| Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis | Q30528817 | ||
| A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis | Q30815377 | ||
| Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen | Q33261846 | ||
| Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysis | Q33328503 | ||
| Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death | Q33654180 | ||
| Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells | Q33764920 | ||
| Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. | Q34274288 | ||
| Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitis | Q34732835 | ||
| Assessing the pathological relevance of SPINK1 promoter variants | Q35304061 | ||
| The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population. | Q35565390 | ||
| Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis. | Q35837145 | ||
| Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C | Q36016998 | ||
| Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis | Q36775826 | ||
| Whole exome sequencing identifies multiple, complex etiologies in an idiopathic hereditary pancreatitis kindred | Q36836323 | ||
| Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis. | Q36927073 | ||
| Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis | Q37065823 | ||
| Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop | Q37099760 | ||
| Comprehensive screening for PRSS1, SPINK1, CFTR, CTRC and CLDN2 gene mutations in Chinese paediatric patients with idiopathic chronic pancreatitis: a cohort study | Q37172601 | ||
| Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis. | Q37181595 | ||
| PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis | Q37231509 | ||
| Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis | Q37395316 | ||
| Intracellular autoactivation of human cationic trypsinogen mutants causes reduced trypsinogen secretion and acinar cell death | Q37446172 | ||
| Variants in CPA1 are strongly associated with early onset chronic pancreatitis | Q37540036 | ||
| CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis | Q37583400 | ||
| Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. | Q37596314 | ||
| Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis | Q37629167 | ||
| Genetic prevalence and characteristics in children with recurrent pancreatitis | Q37957666 | ||
| Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogen | Q38290039 | ||
| Analysis of PRSS1 and SPINK1 mutations in Korean patients with idiopathic and familial pancreatitis | Q38498428 | ||
| Genophenotypic Analysis of Pediatric Patients With Acute Recurrent and Chronic Pancreatitis | Q38832770 | ||
| SPINK1 Promoter Variants in Chronic Pancreatitis | Q38837070 | ||
| Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitis | Q39222848 | ||
| Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants | Q39334642 | ||
| Limited contribution of the SPINK1 N34S mutation to the risk and severity of alcoholic chronic pancreatitis: a report from the United States | Q39437846 | ||
| Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation | Q39477680 | ||
| Functional significance of SPINK1 promoter variants in chronic pancreatitis. | Q40314070 | ||
| Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk | Q40906883 | ||
| Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation | Q41110653 | ||
| The tetra-aspartate motif in the activation peptide of human cationic trypsinogen is essential for autoactivation control but not for enteropeptidase recognition | Q41837429 | ||
| Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation | Q41886614 | ||
| Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants. | Q42145402 | ||
| Brand new SPINK1 and CFTR mutations in a child with acute recurrent pancreatitis: a case report | Q42256357 | ||
| [-215G>A; IVS3+2T>C] mutation in the SPINK1 gene causes exon 3 skipping and loss of the trypsin binding site | Q42844578 | ||
| Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis | Q43626455 | ||
| Association and differential role of PRSS1 and SPINK1 mutation in early-onset and late-onset idiopathic chronic pancreatitis in Chinese subjects. | Q43968341 | ||
| Two human trypsinogens. Purification, molecular properties, and N-terminal sequences | Q44455238 | ||
| Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis | Q44562481 | ||
| Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis | Q44727697 | ||
| Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study | Q44741070 | ||
| CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated? | Q46039599 | ||
| A loss-of-function p.G191R variant in the anionic trypsinogen (PRSS2) gene in Japanese patients with pancreatic disorders | Q46217528 | ||
| Mutations in the serine protease inhibitor Kazal Type 1 (SPINK1) gene in Japanese patients with pancreatitis | Q46568542 | ||
| Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice | Q46637445 | ||
| High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis | Q46905124 | ||
| Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis | Q48120455 | ||
| Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639. | Q48149884 | ||
| Clarifying the clinical relevance of SPINK1 intronic variants in chronic pancreatitis | Q48271163 | ||
| Genetic and electrophysiological characteristics of recurrent acute pancreatitis. | Q51685014 | ||
| Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. | Q51796788 | ||
| The contribution of the SPINK1 c.194+2T>C mutation to the clinical course of idiopathic chronic pancreatitis in Chinese patients. | Q54290065 | ||
| A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. | Q54572661 | ||
| Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene. | Q54593532 | ||
| Frequency of CFTR, SPINK1, and cathepsin B gene mutation in North Indian population: connections between genetics and clinical data. | Q55311728 | ||
| Pancreatic Cancer Cell Lines Heterozygous for the SPINK1 p.N34S Haplotype Exhibit Diminished Expression of the Variant Allele. | Q55394233 | ||
| Co-inheritance of a novel deletion of the entire SPINK1 gene with a CFTR missense mutation (L997F) in a family with chronic pancreatitis | Q57263763 | ||
| Common variants atPRSS1–PRSS2andCLDN2–MORC4loci associate with chronic pancreatitis in Japan | Q60609859 | ||
| N34S Mutation in the SPINK1 Gene Is Not Associated With Alternative Splicing | Q60609873 | ||
| A Loss of Function Polymorphism (G191R) of Anionic Trypsinogen (PRSS2) Confers Protection Against Chronic Pancreatitis | Q61052873 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial | Q6936496 |
| P433 | issue | 7 | |
| P921 | main subject | enzyme | Q8047 |
| regulation of gene expression | Q411391 | ||
| chronic pancreatitis | Q1996053 | ||
| genetic predisposition to disease | Q64843122 | ||
| P304 | page(s) | 1692-1701 | |
| P577 | publication date | 2017-05-23 | |
| 2017-07-01 | |||
| P1433 | published in | Digestive Diseases and Sciences | Q15716711 |
| P1476 | title | Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway | |
| P478 | volume | 62 |
| Q99555974 | A Paper-Based Near-Infrared Optical Biosensor for Quantitative Detection of Protease Activity Using Peptide-Encapsulated SWCNTs |
| Q59806147 | A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation |
| Q90044620 | ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis |
| Q57456168 | Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Recurrent Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop |
| Q46881127 | Analysis of the Impact of Known SPINK1 Missense Variants on Pre-mRNA Splicing and/or mRNA Stability in a Full-Length Gene Assay |
| Q92917206 | CaMKII/proteasome/cytosolic calcium/cathepsin B axis was present in tryspin activation induced by nicardipine |
| Q90602547 | Channelopathy of the Pancreas Causes Chronic Pancreatitis |
| Q98474838 | Chronic pancreatitis |
| Q90750780 | Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice |
| Q99710688 | Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis |
| Q93000610 | Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B |
| Q89962204 | Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice |
| Q39398523 | Genetic risk in chronic pancreatitis: the misfolding-dependent pathway |
| Q90473602 | Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice |
| Q89517074 | Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation |
| Q97548636 | Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice |
| Q92845915 | Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice |
| Q50034038 | Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis. |
| Q64243510 | Novel Pathogenic Variant p.Glu190Lys in a Case of Chronic Pancreatitis |
| Q93084777 | Observational longitudinal multicentre investigation of acute pancreatitis (GOULASH PLUS): follow-up of the GOULASH study, protocol |
| Q92535394 | Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers |
| Q58690866 | SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis |
| Q48295919 | Severe infantile isolated exocrine pancreatic insufficiency caused by the complete functional loss of the SPINK1 gene |
| Q99243102 | Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding |
| Q64239617 | Toward a clinical diagnostic pipeline for SPINK1 intronic variants |
| Q49407408 | Trypsin Binding with Copper Ions Scavenges Superoxide: Molecular Dynamics-Based Mechanism Investigation |
| Q90255282 | Trypsin activity governs increased susceptibility to pancreatitis in mice expressing human PRSS1R122H |
| Q57286529 | Trypsinogen isoforms in the ferret pancreas |
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