Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.

scientific article published on 08 January 2014

Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.538884
P8608Fatcat IDrelease_vn3ojwytfjhuzj4hg2vdcduj7m
P932PMC publication ID3931037
P698PubMed publication ID24403079

P50authorMiklós Sahin-TóthQ38318675
Evette S. RadiskyQ56027708
P2093author name stringAndrás Szabó
P2860cites workPeptide-bond hydrolysis equilibria in native proteins. Conversion of virgin into modified soybean trypsin inhibitorQ72499538
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitisQ24645261
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YQ24675338
Biochemical models of hereditary pancreatitisQ24675973
A clogged gutter mechanism for protease inhibitorsQ27639422
Structure of a serine protease poised to resynthesize a peptide bondQ27643959
Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinQ27649308
Structural evidence for standard-mechanism inhibition in metallopeptidases from a complex poised to resynthesize a peptide bondQ27673839
Protein inhibitors of proteinasesQ29619496
Structural determinants of limited proteolysisQ30403966
Structural and kinetic determinants of protease substratesQ33703882
Studies of intestinal digestion and absorption in the humanQ33732020
High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residuesQ33880616
Mechanisms of intestinal calcium absorptionQ35042228
Intestinal enterokinase deficiency. A newly-recognized disorder of protein digestion.Q35148327
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin CQ36016998
Synthesis of peptide bonds by proteinases. Addition of organic cosolvents shifts peptide bond equilibriums toward synthesisQ39225669
Enzymic resynthesis of the hydrolyzed peptide bond(s) in ribonuclease SQ39237337
Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activationQ39477680
Digestion and Absorption of ProteinQ39722823
Human cationic trypsinogen. Role of Asn-21 in zymogen activation and implications in hereditary pancreatitisQ41734787
The structural aspects of limited proteolysis of native proteinsQ41738009
Expression of recombinant proteins with uniform N-terminiQ42219434
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.Q43246426
Human cationic trypsinogen. Arg(117) is the reactive site of an inhibitory surface loop that controls spontaneous zymogen activation.Q43826802
Thermodynamics and kinetics of the reactive site peptide-bond hydrolysis in bovine pancreatic secretory trypsin inhibitor (Kazal)Q44175495
Affinity purification of recombinant trypsinogen using immobilized ecotin.Q46011088
Gain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogenQ46911281
Calcium Solubility, Intestinal Sojourn Time and Paracellular Permeability Codetermine Passive Calcium Absorption in RatsQ54701353
Structural basis of the activation and action of trypsinQ56172518
Fate of pancreatic enzymes during small intestinal aboral transit in humansQ68975753
Metabolism of 131I-labelled human pancreatic cationic trypsin after intraduodenal administrationQ69568889
The binding of Ca2 to trypsinogen and its relation to the mechanism of activationQ72300241
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectzymogenQ245759
P304page(s)4753-4761
P577publication date2014-01-08
P1433published inJournal of Biological ChemistryQ867727
P1476titleZymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation
P478volume289

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cites work (P2860)
Q30394859An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis
Q33843764Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Q35837145Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Q37065823Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis

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