Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

scientific article published on 26 May 2015

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M114.618439
P932PMC publication ID4498067
P698PubMed publication ID26013824

P50authorMiklós Sahin-TóthQ38318675
Heiko WittQ90796906
P2093author name stringAndrás Szabó
Eszter Hegyi
Maren Ludwig
Renata Szépeová
P2860cites workHuman Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin InhibitorsQ24295201
Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluidQ24301887
Molecular cloning and expression of human caldecrinQ24312209
Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistanceQ24312765
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitisQ24645261
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YQ24675338
The role of ecotin dimerization in protease inhibitionQ27631754
Crystal structure reveals basis for the inhibitor resistance of human brain trypsinQ27637610
Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsinQ27649308
Determinants of Affinity and Proteolytic Stability in Interactions of Kunitz Family Protease Inhibitors with MesotrypsinQ27664637
The P 2 ′ residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activityQ27671330
Long-range Electrostatic Complementarity Governs Substrate Recognition by Human Chymotrypsin C, a Key Regulator of Digestive Enzyme ActivationQ27676497
Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitorsQ27679201
Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin.Q30367678
The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsinQ33581987
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cellsQ33764920
High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residuesQ33880616
Trypsinogen variants in pancreatic juice of healthy volunteers, chronic alcoholics, and patients with pancreatitis and cancer of the pancreasQ34476170
Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.Q34503091
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitisQ34732835
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin CQ36016998
Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.Q37596314
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogenQ38290039
Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variantsQ39334642
Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis riskQ40906883
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coliQ42144510
Robust autoactivation, chymotrypsin C independence and diminished secretion define a subset of hereditary pancreatitis-associated cationic trypsinogen mutants.Q42145402
Sequence determination of eglin C using combined microtechniques of amino acid analysis, peptide isolation, and automatic Edman degradationQ42260195
Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.Q43246426
Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitisQ45140102
Affinity purification of recombinant trypsinogen using immobilized ecotin.Q46011088
CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?Q46039599
Effects of chronic alcohol abuse on exocrine pancreatic secretion in manQ70044313
Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteasesQ70445331
Arazoformyl peptide surrogates as spectrophotometric kinetic assay substrates for carboxypeptidase AQ71543383
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furinQ73270037
CHYMOTRYPSIN C. I. ISOLATION OF THE ZYMOGEN AND THE ACTIVE ENZYME: PRELIMINARY STRUCTURE AND SPECIFICITY STUDIESQ77193324
CHYMOTRYPSIN C. II. ENZYMATIC SPECIFICITY TOWARD SEVERAL POLYPEPTIDESQ77193331
Active forms of chymotrypsin C isolated from autolyzed porcine pancreas glandsQ93611004
P433issue28
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)17282-17292
P577publication date2015-05-26
P1433published inJournal of Biological ChemistryQ867727
P1476titleMesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis
P478volume290

Reverse relations

cites work (P2860)
Q38805333Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.
Q38875996Clinical chronic pancreatitis
Q33843764Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Q97548636Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice
Q37231509PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis
Q33591558PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast