Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants

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Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/GUTJNL-2012-302448
P698PubMed publication ID22580415
P5875ResearchGate publication ID224949669

P2093author name stringSumit Paliwal
D Nageshwar Reddy
G Venkat Rao
Giriraj Ratan Chandak
Shivaram Prasad Singh
K Radha Mani
Seema Bhaskar
Varghese Thomas
P2860cites workChymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogenQ38290039
Mutations of the cystic fibrosis gene in patients with chronic pancreatitisQ38502091
Clinical profile of idiopathic chronic pancreatitis in North IndiaQ38907565
Trypsinogen copy number mutations in patients with idiopathic chronic pancreatitisQ39222848
Cathepsin B gene polymorphism Val26 is not associated with idiopathic chronic pancreatitis in European patientsQ42410004
The role of intracellular calcium signaling in premature protease activation and the onset of pancreatitis.Q42856794
A synonymous codon change in the LMNA gene alters mRNA splicing and causes limb girdle muscular dystrophy type 1BQ43074501
Mutations in the pancreatic secretory trypsin inhibitor gene (PSTI/SPINK1) rather than the cationic trypsinogen gene (PRSS1) are significantly associated with tropical calcific pancreatitisQ43074804
The G191R variant in the PRSS2 gene does not play a role in protection against tropical calcific pancreatitis.Q47825234
Detection of a large genomic deletion in the pancreatic secretory trypsin inhibitor (SPINK1) gene.Q54593532
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen geneQ24311652
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitisQ24645261
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YQ24675338
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitisQ28145585
A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groupsQ28279242
SIFT: Predicting amino acid changes that affect protein functionQ29547211
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitisQ30815377
Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cellsQ33764920
Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence informationQ34609519
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitisQ34732835
Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variantsQ34978483
Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitisQ35596502
Association of cathepsin B gene polymorphisms with tropical calcific pancreatitisQ35768923
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minimaQ37066299
P433issue11
P407language of work or nameEnglishQ1860
P921main subjecttropical pancreatitisQ55783556
P304page(s)1602-1606
P577publication date2012-05-12
P1433published inGutQ5621669
P1476titleComprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants
P478volume62

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cites work (P2860)
Q40798375Association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute and chronic pancreatitis: A case-control study from India
Q36251687CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis
Q26775406Caldecrin: A pancreas-derived hypocalcemic factor, regulates osteoclast formation and function
Q38805333Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.
Q37591305Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice
Q55126870Changing phenotype and disease behaviour of chronic pancreatitis in India: evidence for gene-environment interactions.
Q86874923Characterization of two deletions of the CTRC locus
Q40906883Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
Q34283421Endoplasmic reticulum stress is chronically activated in chronic pancreatitis
Q48247460Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.
Q33843764Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Q34667122Genetic and phenotypic heterogeneity in tropical calcific pancreatitis
Q36933359Genetic risk factors for pancreatic disorders
Q34508844Genetics of acute and chronic pancreatitis: An update
Q40103441Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis
Q37256871Hereditary pancreatitis of 3 Chinese children: Case report and literature review
Q26739600Hereditary pancreatitis: current perspectives
Q33815473High Prevalence of Serine Protease Inhibitor Kazal Type 1 Gene Variations Detected by Whole Gene Sequencing in Patients with Fibrocalculous Pancreatic Diabetes.
Q38757404Identification of a functional enhancer variant within the chronic pancreatitis-associated SPINK1 c.101A>G (p.Asn34Ser)-containing haplotype
Q40012446Idiopathic chronic calcific pancreatitis in a child: An uncommon entity
Q37638790Insights into the genetic risk factors for the development of pancreatic disease
Q91901662Mediastinal Pseudocyst and Cardiac Tamponade Due to Massive Pericardial Effusion in Pediatric Chronic Calcific Pancreatitis
Q35837145Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Q37602778New insights into the pathogenesis of pancreatitis
Q37231509PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis
Q35565390The Common Chymotrypsinogen C (CTRC) Variant G60G (C.180T) Increases Risk of Chronic Pancreatitis But Not Recurrent Acute Pancreatitis in a North American Population.

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