Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells

scientific article

Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/GUT.2009.198903
P932PMC publication ID2848392
P698PubMed publication ID19951900
P5875ResearchGate publication ID40044986

P2093author name stringMiklós Sahin-Tóth
Richárd Szmola
P2860cites workGain-of-function mutations associated with hereditary pancreatitis enhance autoactivation of human cationic trypsinogenQ46911281
Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene.Q51796788
Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis.Q53276855
Reduced pancreatic volume and beta-cell area in patients with chronic pancreatitis.Q53383717
That which does not kill me makes me stronger: adapting to chronic ER stressQ81405125
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen geneQ24311652
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitisQ24645261
Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanismQ24650338
Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitisQ24658116
Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YQ24675338
Biochemical models of hereditary pancreatitisQ24675973
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitisQ28138406
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitisQ28145585
Clinical and genetic characteristics of hereditary pancreatitis in EuropeQ28250117
A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitisQ30815377
Pathways to injury in chronic pancreatitis: decoding the role of the high-risk SPINK1 N34S haplotype using meta-analysisQ33328503
Association of rare chymotrypsinogen C (CTRC) gene variations in patients with idiopathic chronic pancreatitisQ34732835
Glucocorticoids increase amylase mRNA levels, secretory organelles, and secretion in pancreatic acinar AR42J cellsQ36212907
Endoplasmic reticulum stress signaling in diseaseQ36610455
Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.Q36805212
Minigene analysis of intronic variants in common SPINK1 haplotypes associated with chronic pancreatitis.Q37181595
From endoplasmic-reticulum stress to the inflammatory responseQ37225354
Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitisQ37395316
Secretagogues differentially activate endoplasmic reticulum stress responses in pancreatic acinar cellsQ40223778
Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradationQ41110653
Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomeraseQ41617941
Cell death in pancreatitis: caspases protect from necrotizing pancreatitisQ46091205
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendoplasmic reticulumQ79927
P304page(s)365-372
P577publication date2009-11-30
P1433published inGutQ5621669
P1476titlePancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells
P478volume59

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cites work (P2860)
Q42725781A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis
Q31814814A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Q38963298Asparagine-linked glycosylation of human chymotrypsin C is required for folding and secretion but not for enzyme activity
Q37725572Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency
Q39571536Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
Q37591305Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice
Q27693296Chymotrypsin C mutations in chronic pancreatitis
Q40906883Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk
Q39334642Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants
Q43633901Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis
Q38802376Endoplasmic reticulum stress is activated in acute pancreatitis
Q34283421Endoplasmic reticulum stress is chronically activated in chronic pancreatitis
Q36927073Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.
Q33843764Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Q34667122Genetic and phenotypic heterogeneity in tropical calcific pancreatitis
Q37842752Genetic basis of chronic pancreatitis in Asia Pacific region
Q39398523Genetic risk in chronic pancreatitis: the misfolding-dependent pathway
Q34358474Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis
Q38822781Karyopherin Alpha 2 Promotes the Inflammatory Response in Rat Pancreatic Acinar Cells Via Facilitating NF-κB Activation.
Q36793423Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice
Q97548636Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice
Q35837145Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.
Q37918238Molecular mechanisms of pancreatic injury
Q39305127Pancreatic Disorders
Q36775826Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis
Q38034035Pathogenic mechanisms of acute pancreatitis
Q38840155Pathophysiological mechanisms in acute pancreatitis: Current understanding
Q37802876Proteomic analysis of zymogen granules.
Q36122718SEC23B is required for the maintenance of murine professional secretory tissues
Q38776190TRAM1 protects AR42J cells from caerulein-induced acute pancreatitis through ER stress-apoptosis pathway
Q36174524Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis

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