Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice

scientific article published on 18 June 2019

Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI.INSIGHT.129717
P932PMC publication ID6675558
P698PubMed publication ID31211695

P50authorMiklós Sahin-TóthQ38318675
Eszter HegyiQ90043970
P2093author name stringAndrea Geisz
Balázs Csaba Németh
Zsanett Jancsó
P2860cites workChymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme YQ24675338
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent PathwayQ33843764
Early trypsinogen activation in acute pancreatitis.Q33953449
The epidemiology of pancreatitis and pancreatic cancerQ34341477
Conditionally immortalized colonic epithelial cell line from a Ptk6 null mouse that polarizes and differentiates in vitroQ34420694
Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin CQ36016998
Why does pancreatic overstimulation cause pancreatitis?Q36632168
Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary PancreatitisQ37065823
Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loopQ37099760
Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in miceQ37591305
CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injuryQ37699664
Chymotrypsin C (caldecrin) stimulates autoactivation of human cationic trypsinogenQ38290039
Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitisQ40103441
Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.Q40414683
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
Intra-acinar trypsinogen activation mediates early stages of pancreatic injury but not inflammation in mice with acute pancreatitisQ41628354
Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expressionQ43161315
Variation feature of receptor binding sites of H1N1 influenza hemagglutinin in different hostsQ44989044
Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.Q50034038
Metamizol Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice.Q52148725
A preclinical model of chronic pancreatitis driven by trypsinogen autoactivationQ59806147
Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitisQ79856720
Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in miceQ90473602
Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in MiceQ90750780
Elevated intracellular trypsin exacerbates acute pancreatitis and chronic pancreatitis in miceQ92819652
P433issue14
P304page(s)e129717
P577publication date2019-06-18
P1433published inJCI insightQ27727187
P1476titleNatural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice
P478volume4

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cites work (P2860)
Q89962204Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice
Q97548636Loss of chymotrypsin-like protease (CTRL) alters intrapancreatic protease activation but not pancreatitis severity in mice

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