Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes

scientific article published in PLoS ONE

Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0202513
P932PMC publication ID6195259
P698PubMed publication ID30339683

P50authorAndrew E. FirthQ37368648
Alberto VianelliQ63891865
P2093author name stringNicola Chirico
Robert Belshaw
Olga Blinkova
David Karlin
Yiming Bao
Angelo Pavesi
P2860cites workDirect detection of alternative open reading frames translation products in human significantly expands the proteomeQ21132658
Gapped BLAST and PSI-BLAST: a new generation of protein database search programsQ24545170
ViralZone: a knowledge resource to understand virus diversityQ24608854
A viral assembly factor promotes AAV2 capsid formation in the nucleolusQ24630650
NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteinsQ24676525
Detecting overlapping coding sequences in virus genomesQ25255657
Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4Q27348186
The evolution of genome compression and genomic novelty in RNA virusesQ27481078
Size selective recognition of siRNA by an RNA silencing suppressorQ27642862
A novel influenza A virus mitochondrial protein that induces cell death.Q27863709
Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usageQ28205745
Characterization of the NSP6 protein product of rotavirus gene 11Q28238136
Reprogramming the genetic code: The emerging role of ribosomal frameshifting in regulating cellular gene expressionQ28601053
Detection of a fourth orbivirus non-structural proteinQ28743968
Origins of genes: "big bang" or continuous creation?Q28775832
Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular DynamicsQ30384425
Concomitant emergence of the antisense protein gene of HIV-1 and of the pandemic.Q30393522
A first look at ARFome: dual-coding genes in mammalian genomesQ33285032
The origin of a novel gene through overprinting in Escherichia coliQ33316861
Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcriptsQ33322942
Overlapping messages and survivabilityQ33340723
IS1414, an Escherichia coli insertion sequence with a heat-stable enterotoxin gene embedded in a transposase-like geneQ33591956
The leader protein of Theiler's virus inhibits immediate-early alpha/beta interferon productionQ33853304
MicroRNA-binding viral protein interferes with Arabidopsis developmentQ33900664
An out-of-frame overlapping reading frame in the ataxin-1 coding sequence encodes a novel ataxin-1 interacting proteinQ34037160
Functional characterization of coat protein and V2 involved in cell to cell movement of Cotton leaf curl Kokhran virus-DabawaliQ34081439
Identification and characterization of a novel non-structural protein of bluetongue virusQ34126290
Observation of dually decoded regions of the human genome using ribosome profiling dataQ34272114
Detection of functional overlapping genes: simulation and case studiesQ34274599
Evolution of viral proteins originated de novo by overprintingQ34289647
Tobamovirus evolution: gene overlaps, recombination, and taxonomic implicationsQ34410124
Stability and evolution of overlapping genesQ34510162
Evasion of antiviral innate immunity by Theiler's virus L* protein through direct inhibition of RNase LQ34795484
Viral proteins originated de novo by overprinting can be identified by codon usage: application to the "gene nursery" of DeltaretrovirusesQ34961642
RefSeq: an update on mammalian reference sequencesQ35047930
Evolution and structural organization of the C proteins of paramyxovirinaeQ35108545
FRESCo: finding regions of excess synonymous constraint in diverse virusesQ35223162
NCBI viral genomes resourceQ35254405
Deciphering poxvirus gene expression by RNA sequencing and ribosome profilingQ35611968
Evolution of new functions de novo and from preexisting genesQ35663923
Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry siteQ35837090
Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprintingQ35871463
Transcriptional slippage in the positive-sense RNA virus family PotyviridaeQ36004263
Functional Segregation of Overlapping Genes in HIV.Q36226848
Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 directionQ36401203
Death of a dogma: eukaryotic mRNAs can code for more than one proteinQ36443272
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
An overlapping essential gene in the PotyviridaeQ36557983
The P1N-PISPO trans-Frame Gene of Sweet Potato Feathery Mottle Potyvirus Is Produced during Virus Infection and Functions as an RNA Silencing SuppressorQ36694008
Gene overlapping and size constraints in the viral worldQ36923458
The effect of gene overlapping on the rate of RNA virus evolutionQ37003107
TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorderQ37178764
Bioinformatic evidence for a stem-loop structure 5'-adjacent to the IGR-IRES and for an overlapping gene in the bee paralysis dicistrovirusesQ37422410
KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional featuresQ37488130
Control of gene expression by translational recoding.Q37975583
Non-canonical translation in RNA virusesQ38005664
A novel interaction between the human papillomavirus type 16 E2 and E1--E4 proteins leads to stabilization of E2.Q38350138
Ribosome Profiling as a Tool to Decipher Viral ComplexityQ38766711
The Andes hantavirus NSs protein is expressed from the viral small mRNA by a leaky scanning mechanismQ39430510
The N-terminus of Bunyamwera orthobunyavirus NSs protein is essential for interferon antagonismQ39709693
Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP2b, GP3, and GP4) of equine arteritis virusQ39752506
The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 proteinQ40027289
A single chicken anemia virus protein induces apoptosisQ40037868
Molecular evolution in papova viruses and in bacteriophagesQ40130352
Interaction of Sesbania mosaic virus (SeMV) RNA-dependent RNA polymerase (RdRp) with the p10 domain of polyprotein 2a and its implications in SeMV replication.Q40467050
A novel naturally occurring hybrid gene encoded by a plant RNA virus facilitates long distance virus movementQ40790028
The C-terminal domain of rotavirus NSP5 is essential for its multimerization, hyperphosphorylation and interaction with NSP6.Q40899934
Interactions of the borna disease virus P, N, and X proteins and their functional implications.Q41043684
Properties of the adeno-associated virus assembly-activating proteinQ41167414
Mapping overlapping functional elements embedded within the protein-coding regions of RNA virusesQ41895260
Powerful sequence similarity search methods and in-depth manual analyses can identify remote homologs in many apparently "orphan" viral proteinsQ41909051
The MPI Bioinformatics Toolkit for protein sequence analysisQ42551891
Overlapping genes produce proteins with unusual sequence properties and offer insight into de novo protein creationQ42570606
Detection of signature sequences in overlapping genes and prediction of a novel overlapping gene in hepatitis G virusQ42623482
Constrained evolution with respect to gene overlap of hepatitis B virusQ42651913
Patterns of nucleotide difference in overlapping and non-overlapping reading frames of papillomavirus genomesQ42657502
Bioinformatic analysis suggests that a conserved ORF in the waikaviruses encodes an overlapping geneQ42658197
The phosphorylated form of the ORF3 protein of hepatitis E virus interacts with its non-glycosylated form of the major capsid protein, ORF2.Q42673813
The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.Q42691537
The structure of the flock house virus B2 protein, a viral suppressor of RNA interference, shows a novel mode of double-stranded RNA recognitionQ43205663
Evolution of overlapping genesQ44976752
Identification of the interaction and interaction domains of chicken anemia virus VP2 and VP3 proteinsQ45325332
VP2 of Chicken Anaemia Virus Interacts with Apoptin for Down-regulation of Apoptosis through De-phosphorylated Threonine 108 on ApoptinQ45325403
Potential evolutionary influences on overlapping reading frames in the bovine leukemia virus pXBL regionQ45408106
Sequence analysis of Potato leafroll virus isolates reveals genetic stability, major evolutionary events and differential selection pressure between overlapping reading frame productsQ45732078
Simultaneous expression of recombinant baculovirus-encoded chicken anaemia virus (CAV) proteins VP1 and VP2 is required for formation of the CAV-specific neutralizing epitopeQ45751924
Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virusQ45791146
Overlapping genes in bacteriophage phiX174Q48417689
What is principal component analysis?Q51891406
Why genes overlap in viruses.Q55053051
Crystal structure of p19 ? a universal suppressor of RNA silencingQ56926966
A maximum-likelihood approach to analyzing nonoverlapping and overlapping reading framesQ72117439
On the informational content of overlapping genes in prokaryotic and eukaryotic virusesQ73382871
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)e0202513
P577publication date2018-10-19
P1433published inPLOS OneQ564954
P1476titleOverlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes
P478volume13

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cites work (P2860)
Q89737056A case for a negative-strand coding sequence in a group of positive-sense RNA viruses
Q99407070Are Antisense Proteins in Prokaryotes Functional?
Q90032387Asymmetric evolution in viral overlapping genes is a source of selective protein adaptation
Q95839248New insights into the evolutionary features of viral overlapping genes by discriminant analysis
Q92756067The HIV-1 Antisense Protein ASP Is a Transmembrane Protein of the Cell Surface and an Integral Protein of the Viral Envelope
Q92921538The Potyviruses: An Evolutionary Synthesis Is Emerging

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