Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model

scientific article published in Scientific Reports

Valproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-018-34915-5
P932PMC publication ID6220313
P698PubMed publication ID30405207

P50authorBin-Nan WuQ58672165
P2093author name stringKuang-I Cheng
Jun-Yih Chen
Yung-Shun Juan
Li-Wen Chu
Su-Ling Hsieh
P2860cites workSpinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis.Q51072965
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Effect of Progesterone Therapy on TNF-α and iNOS Gene Expression in Spinal Cord Injury Model.Q51701456
Regulation of the NR2B-CREB-CRTC1 Signaling Pathway Contributes to Circadian Pain in Murine Model of Chronic Constriction Injury.Q53325722
Valproic acid preserves motoneurons following contusion in organotypic spinal cord slice culture.Q53736174
Xanthine derivative KMUP-1 reduces inflammation and hyperalgesia in a bilateral chronic constriction injury model by suppressing MAPK and NFκB activation.Q54364707
Morphological and Physiological Plasticity of Spinal Lamina II GABA Neurons Is Induced by Sciatic Nerve Chronic Constriction Injury in Mice.Q54966963
Células gliais satélite de gânglios sensitivos: o seu papel na dorQ60690322
Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-kappaB DNA binding activity and COX-2 mRNAQ80753306
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Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in miceQ38671373
Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cellsQ39022519
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The Diverse Roles of Microglia in the Neurodegenerative Aspects of Central Nervous System (CNS) Autoimmunity.Q39154769
Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerveQ39366176
Asiatic Acid Prevents the Deleterious Effects of Valproic Acid on Cognition and Hippocampal Cell Proliferation and SurvivalQ39744411
Regenerative potential of targeting glycogen synthase kinase-3 signaling in neural tissuesQ41977968
Astrocytic tight junctions control inflammatory CNS lesion pathogenesisQ42644144
Signaling pathways regulating dose-dependent dual effects of TNF-α on primary cultured Schwann cellsQ43692533
Neuroprotective and anti-inflammatory activities of atorvastatin in a rat chronic constriction injury modelQ44225729
Valproic acid down‐regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase‐1 and ‐2 in rat brainQ44402831
The effects of electroacupuncture on the extracellular signal-regulated kinase 1/2/P2X3 signal pathway in the spinal cord of rats with chronic constriction injuryQ45252424
Intrathecal administration of clonidine attenuates spinal neuroimmune activation in a rat model of neuropathic pain with existing hyperalgesia.Q46034893
Cell protective mechanism of valproic acid in lethal hemorrhagic shockQ46461770
Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in ratsQ47962120
Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signalingQ47978199
Atorvastatin prevents neuroinflammation in chronic constriction injury rats through nuclear NFκB downregulation in the dorsal root ganglion and spinal cordQ48085576
Adrenomedullin mediates tumor necrosis factor-α-induced responses in dorsal root ganglia in ratsQ48733160
All guns blazing: management and survival of massive valproic acid overdose - case report and literature reviewQ49177996
Neurotrauma and inflammation: CNS and PNS responsesQ27001219
Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in ratsQ27324438
Minimal NF-κB activity in neuronsQ28294910
Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosisQ28484135
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaQ29620385
Apigenin inhibits TNFα/IL-1α-induced CCL2 release through IKBK-epsilon signaling in MDA-MB-231 human breast cancer cellsQ33602761
Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injuryQ33782828
The history of valproate in clinical neuroscienceQ33974000
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsyQ34150830
The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivationQ34442409
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.Q34554719
Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?Q34714351
Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-κB in rats with trigeminal neuropathic pain.Q35189130
The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injuryQ35283038
Valproate Inhibits Methamphetamine Induced Hyperactivity via Glycogen Synthase Kinase 3β Signaling in the Nucleus Accumbens CoreQ35647946
Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradationQ35660728
G-CSF attenuates neuroinflammation and stabilizes the blood-brain barrier via the PI3K/Akt/GSK-3β signaling pathway following neonatal hypoxia-ischemia in rats.Q35842220
Glial cells: old cells with new twistsQ37027769
AKT activation controls cell survival in response to HDAC6 inhibitionQ37412534
Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat.Q37731721
Evaluation of anticonvulsants for possible use in neuropathic pain.Q37921343
GSK-3 Mouse Models to Study Neuronal Apoptosis and NeurodegenerationQ37959957
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectneuronitisQ17157137
P304page(s)16457
P577publication date2018-11-07
P1433published inScientific ReportsQ2261792
P1476titleValproate reduces neuroinflammation and neuronal death in a rat chronic constriction injury model
P478volume8

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cites work (P2860)
Q92131087Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice
Q93175296HDAC Inhibition by Valproic Acid Induces Neuroprotection and Improvement of PD-like Behaviors in LRRK2 R1441G Transgenic Mice
Q90220373Morin Alleviates Vincristine-Induced Neuropathic Pain via Nerve protective Effect and Inhibition of NF-κB Pathway in Rats

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