Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial

scientific article published on 24 September 2018

Efficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial is …
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scholarly articleQ13442814

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P356DOI10.1136/BMJOPEN-2018-022448
P932PMC publication ID6157558
P698PubMed publication ID30249630

P50authorSin Gon KimQ60321492
P2093author name stringNam Hoon Kim
Soo Heon Kwak
Min Kyong Moon
Soo Lim
Juneyoung Lee
Jun Sung Moon
Yong-Ho Lee
Ho Chan Cho
P2860cites workManagement of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).Q22241288
Insulin Secretory Capacity and Insulin Resistance in Korean Type 2 Diabetes Mellitus PatientsQ26740228
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) GroupQ27860882
Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ28262769
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesQ29547541
Effects of intensive glucose lowering in type 2 diabetesQ29547736
10-year follow-up of intensive glucose control in type 2 diabetesQ29615973
Glucose control and vascular complications in veterans with type 2 diabetesQ29619213
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapyQ29620534
The natural history of type 2 diabetes. Implications for clinical practiceQ33752751
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.Q33864120
A Novel Therapeutic Agent for Type 2 Diabetes Mellitus: SGLT2 InhibitorQ34161881
Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on HypoglycemiaQ36108419
beta-cell failure in diabetes and preservation by clinical treatmentQ36757992
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetesQ37139427
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2016 EXECUTIVE SUMMARY.Q41000321
Dual add-on therapy in type 2 diabetes poorly controlled with metformin monotherapy: a randomized double-blind trial of saxagliptin plus dapagliflozin addition versus single addition of saxagliptin or dapagliflozin to metforminQ41685708
Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada. Introduction.Q44391845
Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell functionQ45124452
Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.Q46576386
Relation of glycemic control to diabetic microvascular complications in diabetes mellitusQ70880944
The association of glycemia and cause-specific mortality in a diabetic populationQ72855277
Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 DiabetesQ86057577
Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetesQ86623452
Comparison of empagliflozin and glimepiride as add-on to metformin in patients with type 2 diabetes: a 104-week randomised, active-controlled, double-blind, phase 3 trialQ88117871
P433issue9
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)e022448
P577publication date2018-09-24
P1433published inBMJ OpenQ17003470
P1476titleEfficacy and tolerability of novel triple combination therapy in drug-naïve patients with type 2 diabetes from the TRIPLE-AXEL trial: protocol for an open-label randomised controlled trial
P478volume8

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