Tertiary Lymphoid Structures: Autoimmunity Goes Local

scientific article published on 12 September 2018

Tertiary Lymphoid Structures: Autoimmunity Goes Local is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2018.01952
P932PMC publication ID6143705
P698PubMed publication ID30258435

P50authorSerena ColafrancescoQ61146517
Saba NayarQ109774294
P2093author name stringFrancesca Barone
Elena Pipi
Charlotte Smith
David H Gardner
P2860cites workCXCR5⁺ T helper cells mediate protective immunity against tuberculosisQ24628780
Resistance to rituximab therapy and local BAFF overexpression in Sjögren's syndrome-related myoepithelial sialadenitis and low-grade parotid B-cell lymphomaQ24644580
Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver diseaseQ24669792
B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissueQ24669900
B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selectionQ24796794
How Follicular Dendritic Cells Shape the B-Cell AntigenomeQ26742173
Regulation of germinal center B-cell differentiationQ26766726
Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissuesQ26778348
Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: a critical reviewQ26782025
Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular CellsQ27302285
In vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-diseaseQ27307168
Mast cell modulation of the vascular and lymphatic endotheliumQ27687421
Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come TogetherQ28067648
Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic InflammationQ28068106
High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and RegulationQ28069933
Tertiary Lymphoid Organs in Central Nervous System AutoimmunityQ28071379
Ectopic Lymphoid Structures: Powerhouse of AutoimmunityQ28071579
Potential of Cells and Cytokines/Chemokines to Regulate Tertiary Lymphoid Structures in Human DiseasesQ28071670
Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the ColonQ28071695
Tertiary Lymphoid Structures in Cancers: Prognostic Value, Regulation, and Manipulation for Therapeutic InterventionQ28073895
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid OrgansQ28079346
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
In situ diversification of the antibody repertoire in chronic Lyme arthritis synoviumQ28236584
The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitantsQ28249961
Structure and function of the spleenQ28264813
B-cell tolerance checkpoints in health and autoimmunityQ28296605
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responsesQ28510184
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Germinal centersQ29616234
The germinal center responseQ35680329
Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid.Q35691047
Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patchesQ35748193
Novel expression of vascular endothelial growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cellsQ35791588
Rheumatoid arthritis: symptoms, diagnosis, and managementQ35821503
Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glandsQ35840846
Ectopic lymphoid neogenesis in psoriatic arthritisQ35953359
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organsQ36055624
CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis.Q36095617
Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune DiseaseQ36097332
B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary DiseaseQ36128542
Physiological and molecular mechanisms of lymphocyte homingQ36135230
Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammationQ36174679
Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.Q36180696
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue.Q36220292
Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated GlycansQ36221190
Inducible tertiary lymphoid structures, autoimmunity, and exocrine dysfunction in a novel model of salivary gland inflammation in C57BL/6 miceQ36253046
CELLULAR ORIGIN OF RHEUMATOID FACTORQ36264407
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancerQ36285953
Lymphangiogenesis in development and human diseaseQ36342355
Chronic inflammation caused by lymphotoxin is lymphoid neogenesisQ36366337
CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitisQ36370272
High endothelial venules (HEVs) in human melanoma lesions: Major gateways for tumor-infiltrating lymphocytesQ36373347
B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissueQ36392366
Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptorQ36401399
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivityQ36403525
Lymphoid organ development: from ontogeny to neogenesisQ36426808
Stromal niches, plasma cell differentiation and survival.Q36450001
Germinal-center organization and cellular dynamicsQ36459345
Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow.Q36503878
Is defective lymphatic drainage a trigger for lymphoid neogenesis?Q36571605
Interleukin-7 induced immunopathology in arthritisQ36622402
Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and functionQ36630985
Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndromeQ60548246
CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjogren's Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid OrganizationQ60810847
Activation-Induced Cytidine Deaminase Expression in Follicular Dendritic Cell Networks and Interfollicular Large B Cells Supports Functionality of Ectopic Lymphoid Neogenesis in Autoimmune Sialoadenitis and MALT Lymphoma in Sjogren's SyndromeQ60810867
Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndromeQ60810881
Systematic microanatomical analysis of CXCL13 and CCL21in situ production and progressive lymphoid organization in rheumatoid synovitisQ60810884
Agalactosyl IgG in aggregates from the rheumatoid jointQ61912627
Demonstration of lymphatics in human synovial tissueQ67844637
Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis. Comparison with rheumatoid synovium and tonsillar lymphoid tissueQ68092724
Clonally related IgM rheumatoid factors undergo affinity maturation in the rheumatoid synovial tissueQ68112569
Kinetic study of a galactosyltransferase in the B cells of patients with rheumatoid arthritisQ68382167
Identification of cells infiltrating the minor salivary glands in patients with Sjögren's syndromeQ69127340
The effects of oxygen free radicals on the carbohydrate moiety of IgGQ69334332
Salivary gland immunoglobulin and rheumatoid factor synthesis in Sjögren's syndrome. Natural history and response to treatmentQ69377489
Reduced B-cell galactosyltransferase activity in rheumatoid arthritisQ69911135
Galactosylation of IgG associated oligosaccharides: reduction in patients with adult and juvenile onset rheumatoid arthritis and relation to disease activityQ69917731
Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosisQ70245284
Rheumatoid myositis. Clinical and histologic features and possible pathogenesisQ70367133
Decreased B-cell galactosyltransferase activity in rheumatoid arthritisQ70398376
Aberrant expression pattern of the SS-B/La antigen in the labial salivary glands of patients with Sjögren's syndromeQ71098355
V-gene repertoire and hypermutation of rheumatoid factors produced in rheumatoid synovial inflammation and immunized healthy donorsQ71556172
Local synthesis of IgM and IgM rheumatoid factor in rheumatoid pleuritisQ71770349
Variable region gene usage of human monoclonal rheumatoid factors derived from healthy donors following immunizationQ72119406
The development of dermatitis infiltrated by gamma delta T cells in IL-7 transgenic miceQ72782828
Detection of glycosylation abnormality in rheumatoid IgG using N-acetylglucosamine-specific Psathyrella velutina lectinQ72842709
Autoantibody activity of IgG rheumatoid factor increases with decreasing levels of galactosylation and sialylationQ73019497
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognitionQ36694143
BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphomaQ36762885
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.Q36768842
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursorsQ36775342
Rheumatoid factor isotypes in serum and salivary fluid of patients with primary Sjögren's syndromeQ36777586
CD4⁺ follicular helper T cell infiltration predicts breast cancer survivalQ36966923
Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitisQ37053099
Ectopic lymphoid tissues and local immunityQ37075235
T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.Q37123859
A role for gut-associated lymphoid tissue in shaping the human B cell repertoireQ37125768
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid StructuresQ37189681
Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16Q37245752
Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defenceQ37282246
Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs.Q37282551
Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.Q37309590
Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndromeQ37384819
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpointQ37395827
Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomasQ37578581
Lymphatic vessels and tertiary lymphoid organsQ37602241
Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling.Q37700808
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responsesQ37761265
Pathogenetic mechanisms in the initiation and perpetuation of Sjögren's syndromeQ37777643
New insights into the development of lymphoid tissuesQ37779724
Stromal cell-immune cell interactionsQ37809072
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organsQ37810779
Role of the lymphatic system in the pathogenesis of Crohn's diseaseQ37872180
Transitional B cells: how well are the checkpoints for specificity understood?Q37905695
The lymphatic vasculature in diseaseQ37953774
How T cells earn the follicular rite of passageQ37961194
Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypesQ37963475
Ectopic lymphoid neogenesis and lymphoid chemokines in Sjogren's syndrome: at the interplay between chronic inflammation, autoimmunity and lymphomagenesis.Q37972338
Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.Q37996599
IgM memory B cells: a mouse/human paradox.Q38000487
Tertiary lymphoid organs in infection and autoimmunityQ38012568
The role of non-hematopoietic stromal cells in the persistence of inflammationQ38075556
Embryonic hematopoiesis.Q38138223
Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced NeuroinflammationQ40775503
Follicular Helper T CellsQ40780566
Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritisQ40942545
Intraclonal generation of antibody mutants in germinal centresQ41172275
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.Q41584831
A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis.Q41701035
Ig gene analysis reveals altered selective pressures on Ig-producing cells in parotid glands of primary Sjögren's syndrome patientsQ41713174
Germinal center reaction: antigen affinity and presentation explain it all.Q41835569
A chemokine-dependent stromal induction mechanism for aberrant lymphocyte accumulation and compromised lymphatic return in rheumatoid arthritisQ41838799
Use of Toll-Like Receptor Agonists to Induce Ectopic Lymphoid Structures in Myasthenia Gravis Mouse Models.Q41848000
Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centersQ41873772
Twin studies on the effect of genetic factors on serum agalactosyl immunoglobulin G levelsQ41932195
The chemokine receptor CXCR5 is pivotal for ectopic mucosa-associated lymphoid tissue neogenesis in chronic Helicobacter pylori-induced inflammationQ42202704
Emergence and Evolution of Secondary Lymphoid OrgansQ42275091
Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stromaQ42392661
Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease.Q42461189
Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosaQ42593095
Evolution of ectopic lymphoid neogenesis and in situ autoantibody production in autoimmune nonobese diabetic mice: cellular and molecular characterization of tertiary lymphoid structures in pancreatic isletsQ42936052
Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutationQ42944652
Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas.Q43036855
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patientsQ43205818
Terminal monosaccharide screening of synovial immunoglobulins G and A for the early detection of rheumatoid arthritisQ43264757
Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravisQ43699039
Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodiesQ43772895
Tertiary lymphoid organ development coincides with determinant spreading of the myelin-specific T cell responseQ43887998
Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune diseaseQ44118287
Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluidQ44136305
Selective infiltration of B cells committed to the production of monoreactive rheumatoid factor in synovial tissue of patients with rheumatoid arthritisQ44822843
Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.Q44999948
The presence of citrullinated proteins is not specific for rheumatoid synovial tissueQ45141270
Epstein-Barr virus persistence and infection of autoreactive plasma cells in synovial lymphoid structures in rheumatoid arthritis.Q45353333
Molecular characterization of B cell clonal expansions in the liver of chronically hepatitis C virus-infected patientsQ45736807
Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs.Q45850882
AID constrains germinal center size by rendering B cells susceptible to apoptosis.Q45991820
Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cellsQ46098675
The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeuticsQ46414452
Clinical features distinguishing lymphoma development in primary Sjögren's Syndrome--a retrospective cohort studyQ46512541
Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunityQ46625270
Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.Q46655434
Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tensionQ46915063
Spoiling for a Fight: B Lymphocytes As Initiator and Effector Populations within Tertiary Lymphoid Organs in Autoimmunity and Transplantation.Q47110972
Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor ImmunityQ47195254
Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune DiseaseQ47220975
Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis.Q47357498
Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.Q47365613
Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndromeQ47389814
Ectopic CD40 ligand expression on B cells triggers intestinal inflammationQ47643935
Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.Q47700104
Molecular IgV(H) analysis demonstrates highly somatic mutated B cells in synovialitis of osteoarthritis: a degenerative disease is associated with a specific, not locally generated immune responseQ47907395
Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lungQ47925227
Evidence for a selected humoral immune response encoded by VH4 family genes in the synovial membrane of a patient with rheumatoid arthritis (RA).Q48059669
The B lymphocyte in rheumatoid arthritis: analysis of rearranged Vx genes from B cells infiltrating the synovial membraneQ48070203
Maturation of the immune response in germinal centersQ48194763
BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis.Q48195816
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.Q48200750
B cells in the pathogenesis of primary Sjögren syndromeQ48507544
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cellsQ34501407
Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosisQ34538912
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritisQ34550475
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.Q34574913
Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndromeQ34577213
Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis.Q34586903
Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunityQ34590424
Regulatory T cells interfere with the development of bronchus-associated lymphoid tissueQ34610191
Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemiaQ34746694
Monitoring cellular movement in vivo with photoconvertible fluorescence protein "Kaede" transgenic miceQ34802242
Fc-glycosylation of IgG1 is modulated by B-cell stimuliQ34994340
Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in miceQ35009518
Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells.Q35013206
Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profilingQ35070183
In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritisQ35070813
Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjögren's syndromeQ35082778
Deciphering the stromal and hematopoietic cell network of the adventitia from non-aneurysmal and aneurysmal human aortaQ35108490
Tertiary Lymphoid Structure-Associated B Cells are Key Players in Anti-Tumor ImmunityQ35110486
Ectopic Germinal Center Formation in Rheumatoid SynovitisQ35119934
Reassessing the function of immune-complex retention by follicular dendritic cellsQ35209478
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone lossQ35311994
Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjogren's syndromeQ35449868
Characterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjögren syndrome: comparison with tonsillar lymphoid folliclesQ35547069
Immunoglobulin synthesis by salivary gland lymphoid cells in Sjögren's syndromeQ35573939
Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survivalQ35620266
B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesionsQ35637396
Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centersQ35669109
Molecular structure of the La and Ro autoantigens and their use in autoimmune diagnosticsQ38207468
Ectopic lymphoid-like structures in infection, cancer and autoimmunityQ38221815
Phenotype and functions of memory Tfh cells in human bloodQ38226748
Type I and type II Fc receptors regulate innate and adaptive immunityQ38232105
Sjögren Syndrome-associated lymphomas: an update on pathogenesis and managementQ38260354
The binding of synovial tissue-derived human monoclonal immunoglobulin M rheumatoid factor to immunoglobulin G preparations of differing galactose contentQ38305712
Galactose terminating oligosaccharides of IgG in patients with primary Sjögren's syndromeQ38328454
Binding specificities of a polyreactive and a monoreactive human monoclonal IgG rheumatoid factor: role of oligosaccharidesQ38351692
Stromal cells in chronic inflammation and tertiary lymphoid organ formationQ38415281
Characterization of intra-graft B cells during renal allograft rejectionQ38426194
IL-17 increases cadherin-11 expression in a model of autoimmune experimental arthritis and in rheumatoid arthritisQ38471885
Thymic stromal lymphopoietin as a novel mediator amplifying immunopathology in rheumatic disease.Q38545128
Tertiary Lymphoid Structures: An Anti-tumor School for Adaptive Immune Cells and an Antibody Factory to Fight Cancer?Q38635910
Immunoglobulin characteristics and RNAseq data of FcRL4+ B cells sorted from synovial fluid and tissue of patients with rheumatoid arthritisQ38701167
The Emerging Importance of IgG Fab Glycosylation in Immunity.Q38724772
High-throughput analysis of immunoglobulin G glycosylationQ38797703
Salivary Gland Pathology in Sjögren's SyndromeQ38901467
Implication of Epstein-Barr virus infection in disease-specific autoreactive B cell activation in ectopic lymphoid structures of Sjögren's syndrome.Q38956613
Germinal Center B Cell DynamicsQ38960786
Germinal centers: programmed for affinity maturation and antibody diversificationQ39088982
Stromal networking: cellular connections in the germinal centreQ39188164
Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune diseaseQ39251627
The prevalence of lymphoid follicles in Helicobacter pylori associated gastritis in patients with ulcers and non-ulcer dyspepsiaQ39646520
Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity.Q39728088
Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritisQ39788236
Tertiary intratumor lymphoid tissue in colo-rectal cancerQ39799097
IgG subclass and vaccination stimulus determine changes in antigen specific antibody glycosylation in mice.Q40108236
Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian CancerQ40111767
Signals and signs for lymphocyte responsesQ40620206
Malignant lymphoma in primary Sjögren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's SyndromeQ40634492
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitmentQ40725945
Autoantibodies to La/SSB in patients with primary Sjögren's syndrome (pSS) are associated with upregulation of La/SSB mRNA in minor salivary gland biopsies (MSGs)Q73239406
The B lymphocyte in rheumatoid arthritis: recirculation of B lymphocytes between different joints and bloodQ73262658
Ongoing Ig gene hypermutation in salivary gland mucosa-associated lymphoid tissue-type lymphomasQ73292535
Adventitial infiltrates associated with advanced atherosclerotic plaques: structural organization suggests generation of local humoral immune responsesQ73444129
In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serumQ73486207
Lymphomas in patients with Sjogren's syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with virusesQ73516588
Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomasQ73537019
"Lymphoid" chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjögren's syndrome patients: possible participation in lymphoid structure formationQ73565836
The glycosylation of IgA produced by murine B cells is altered by Th2 cytokinesQ73648144
Coexistence of different B-cell clones in consecutive lesions of low-grade MALT lymphoma of the salivary gland in Sjögren's diseaseQ73733122
Newly-formed lymph nodes in the submucosa in chronic inflammatory bowel diseaseQ73768616
Analysis of VH gene rearrangements from synovial B cells of patients with rheumatoid arthritis reveals infiltration of the synovial membrane by memory B cellsQ74080705
Differential glycosylation of two glycoproteins synthesized by murine B cells in response to IL-4 plus IL-5Q74126955
Lymphoid neogenesis in rheumatoid synovitisQ74147962
Analysis of V(H)-D-J(H) gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sjögren's syndromeQ74456111
Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndromeQ74714965
Evolution of autoantibody responses via somatic hypermutation outside of germinal centersQ74813307
VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSEQ76969494
Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndromeQ77179303
Functional analysis of rheumatoid factor-producing B cells from the synovial fluid of rheumatoid arthritis patientsQ77742360
Functional B-cell response in intrahepatic lymphoid follicles in chronic hepatitis CQ77933533
B lymphocyte galactosyltransferase protein levels in normal individuals and in patients with rheumatoid arthritisQ77937154
Ro/SS-A-reactive B lymphocytes in salivary glands and peripheral blood of patients with Sjögren's syndromeQ77953449
Anti-cyclic citrullinated peptide antibody determination in the synovial fluid of patients with rheumatoid arthritis: comment on the article by Caspi et alQ80016129
Recruitment and activation of naive T cells in the islets by lymphotoxin beta receptor-dependent tertiary lymphoid structureQ80171529
B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosisQ80358551
Tumour necrosis factor blockade increases lymphangiogenesis in murine and human arthritic jointsQ80442904
Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesisQ80706974
A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21Q80833012
Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13Q80833035
Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjögren's syndrome and healthy subjectsQ81255342
Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal centerQ81767216
Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophagesQ81811357
Synovial fluid levels of anti-cyclic citrullinated peptide antibodies and IgA rheumatoid factor in rheumatoid arthritis, psoriatic arthritis, and osteoarthritisQ82490820
An important role of lymphatic vessels in the control of UVB-induced edema formation and inflammationQ82519880
Tertiary lymphoid organs in renal allografts can be associated with donor-specific tolerance rather than rejectionQ83014796
Stromal activation and formation of lymphoid-like stroma in chronic lung allograft dysfunctionQ83930980
Characteristics of the minor salivary gland infiltrates in Sjögren's syndromeQ84847752
IL-17A Is Elevated in End-Stage Chronic Obstructive Pulmonary Disease and Contributes to Cigarette Smoke-induced Lymphoid NeogenesisQ87058446
Changes of glycosylation of IgG in rheumatoid arthritis patients treated with methotrexateQ87291258
Rheumatoid arthritisQ87726283
Production of immunoglobulin and rheumatoid factor by lymphoid cells in rheumatoid pericardiumQ93605766
IgA rheumatoid factor synthesis by dissociated synovial cells. Characterization and relationship to IgM rheumatoid factor synthesisQ93644153
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosisQ48949792
Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD.Q49108090
Role of B Cell-Activating Factor in Chronic Obstructive Pulmonary DiseaseQ49120393
Role of CXCL13 in cigarette smoke-induced lymphoid follicle formation and chronic obstructive pulmonary diseaseQ49123591
Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation.Q49130159
Sweet SIGNs: IgG glycosylation leads the way in IVIG-mediated resolution of inflammationQ50193260
In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.Q50463818
The significance of lymphoid follicles in the interpretation of gastric biopsy specimens.Q50771565
Germinal centres in diagnostic labial gland biopsies of patients with primary Sjögren's syndrome are not predictive for parotid MALT lymphoma development.Q50889934
Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients.Q50892871
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer.Q50993488
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer.Q50996147
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.Q51052357
Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection.Q51060341
Vagal innervation is required for the formation of tertiary lymphoid tissue in colitis.Q51617066
[Rheumatoid arthritis as a connective tissue disease].Q51737827
Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.Q51985115
Abnormal B cell differentiation in primary Sjögren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with Serum IgG concentration.Q52013073
Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.Q52013904
Significantly depressed percentage of CD27+ (memory) B cells among peripheral blood B cells in patients with primary Sjögren's syndrome.Q52017364
T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.Q52580164
Control of the T follicular helper-germinal center B-cell axis by CD8⁺ regulatory T cells limits atherosclerosis and tertiary lymphoid organ development.Q52656274
Stereotypic rheumatoid factors that are frequently expressed in mucosa-associated lymphoid tissue-type lymphomas are rare in the labial salivary glands of patients with Sjögren's syndrome.Q53162209
Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome.Q53548268
Immunglobulin classes, subclasses and complexes of IgG rheumatoid factor in rheumatoid plasma cellsQ54271534
B cell survival in intragraft tertiary lymphoid organs after rituximab therapy.Q54528998
Identification of transitional type II B cells in the salivary glands of patients with Sjögren's syndrome.Q54595044
Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis.Q55096337
Lymphoma and Lymphomagenesis in Primary Sjögren's Syndrome.Q55446969
Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cellsQ55970268
Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid StructuresQ56965922
Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic miceQ57212152
Plasmacytoid Dendritic Cells Play a Key Role in Promoting Atherosclerosis in Apolipoprotein E–Deficient MiceQ57231901
Clonality of B-cells in portal lymphoid infiltrates of HCV-infected liversQ57426204
Nodular lymphoid lesion of the liver: an immune-mediated disorder mimicking low-grade malignant lymphomaQ57649393
Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt's lymphoma and mucosa-associated lymphoid tissue lymphomaQ58025679
The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgMQ58234633
Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritisQ58234756
Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgGQ59067758
Chronic Rejection Triggers the Development of an Aggressive Intragraft Immune Response through Recapitulation of Lymphoid OrganogenesisQ59387561
Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjögren's syndromeQ60548216
Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjögren's syndromeQ60548229
The nature of small-airway obstruction in chronic obstructive pulmonary diseaseQ29618682
Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltratesQ30090232
Ectopic lymphoid neogenesis in rheumatic autoimmune diseasesQ30235935
Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β ReceptorsQ30279169
Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humansQ30475578
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporterQ30498133
Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesisQ30524332
Structural studies on IgG oligosaccharides of patients with primary Sjögren's syndromeQ31136020
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritisQ32045081
Human IgG Fc-binding phage antibodies constructed from synovial fluid CD38+ B cells of patients with rheumatoid arthritis show the imprints of an antigen-dependent process of somatic hypermutation and clonal selectionQ33185912
Novel ganglioside antigen identified by B cells in human medullary breast carcinomas: the proof of principle concerning the tumor-infiltrating B lymphocytesQ33221145
Interleukin 7-induced lymphoid neogenesis in arthritis: recapitulation of a fetal developmental programme?Q33369489
Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesionsQ33372911
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- miceQ33399367
Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synoviumQ33399862
Proposed diagnostic criteria for rheumatoid arthritisQ33570530
Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.Q33597563
Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritisQ33611035
Chemokines and B-cell homing to follicles.Q33681306
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer RegressionQ33694988
Sputum autoantibodies in patients with established rheumatoid arthritis and subjects at risk of future clinically apparent diseaseQ33789860
CD4+CXCR5+ follicular helper T cells in salivary gland promote B cells maturation in patients with primary Sjogren's syndromeQ33802835
Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonalQ33849715
Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signalingQ33869955
Follicular stromal cells and lymphocyte homing to follicles.Q34067358
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndromeQ34108411
The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysisQ34122715
Lymphotoxin-alpha contributes to lymphangiogenesisQ34184735
Anti-CCP antibodies: the past, the present and the futureQ34190363
The development of inducible bronchus-associated lymphoid tissue depends on IL-17.Q34191942
Chemokines determine local lymphoneogenesis and a reduction of circulating CXCR4+ T and CCR7 B and T lymphocytes in thyroid autoimmune diseases.Q34204159
In vitro synthesis of immunoglobulin by rheumatoid synovial membraneQ34272996
Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.Q34320316
Pathogenesis of aphthoid ulcers in Crohn's disease: correlative findings by magnifying colonoscopy, electron microscopy, and immunohistochemistryQ34409692
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P407language of work or nameEnglishQ1860
P921main subjectB-cellQ188930
autoantibodyQ785022
follicular dendritic cellQ2631550
humoral immunityQ1142875
neoplasmQ1216998
tertiary lymphoid structureQ54928327
P304page(s)1952
P577publication date2018-09-12
P1433published inFrontiers in ImmunologyQ27723748
P1476titleTertiary Lymphoid Structures: Autoimmunity Goes Local
P478volume9

Reverse relations

cites work (P2860)
Q57795383B Cells Caught in the Act: Class Switching to IgA in Lung Lymphoid Follicles in COPD
Q89847251Chemokine CXCL13 in serum, CSF and blood-CSF barrier function: evidence of compartment restriction
Q89840605Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma
Q93065024Immunology of the ageing kidney
Q90127592Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System

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