A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells

scientific article published in Nature

A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1042202214
P356DOI10.1038/336544A0
P698PubMed publication ID2904653

P2093author name stringSchaffner W
Matthias P
Müller MM
Ruppert S
P2860cites workMutational analysis of the immunoglobulin heavy chain promoter regionQ37411997
Use of a protein-blotting procedure and a specific DNA probe to identify nuclear proteins that recognize the promoter region of the transferrin receptor geneQ37534767
In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancersQ38348647
Homeo boxes in the study of developmentQ39462903
The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activityQ40879101
Discrete elements within the SV40 enhancer region display different cell-specific enhancer activities.Q41338677
Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2.Q41347892
Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitroQ41424983
Isolation and analysis of cDNA and genomic clones of fibronectin and its receptorQ41832789
A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domainQ42650828
Transcription Factor OTF-1 Is Functionally Identical to the DNA Replication Factor NF-IIIQ44126643
Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b geneQ45283630
Divergent homeo box proteins recognize similar DNA sequences in Drosophila.Q52456495
Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoterQ57071439
An enhancer-like sequence within the Xenopus U2 gene promoter facilitates the formation of stable transcription complexesQ57378225
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genesQ59066385
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genesQ59067785
Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elementsQ59070373
An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activityQ59094880
The SV40 enhancer can be dissected into multiple segments, each with a different cell type specificityQ69816464
A 100-kD HeLa cell octamer binding protein (OBP100) interacts differently with two separate octamer-related sequences within the SV40 enhancerQ69816471
The yeast regulatory gene PHO2 encodes a homeo boxQ69917363
Sp1 transcription factor binds DNA and activates transcription even when the binding site is CpG methylatedQ70226586
Interaction of cell-type-specific nuclear proteins with immunoglobulin VH promoter region sequencesQ70306748
Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitroQ70366236
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAsQ22066003
Genomic sequencingQ24594942
A new method for sequencing DNAQ24605576
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A simple and very efficient method for generating cDNA librariesQ27860461
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencingQ27860941
Rapid similarity searches of nucleic acid and protein data banksQ28270448
Isolation of a recombinant copy of the gene encoding C/EBPQ28565641
In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophageQ29616562
Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNAQ29620537
Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteinsQ30412414
Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor.Q33930252
Multiple DNA sequence elements are necessary for the function of an immunoglobulin heavy chain promoterQ34359857
OVEC, a versatile system to study transcription in mammalian cells and cell-free extractsQ34703535
Sequences closely related to an immunoglobulin gene promoter/enhancer element occur also upstream of other eukaryotic and of prokaryotic genesQ35057079
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequenceQ36258756
Cloning of a Lymphoid-Specific cDNA Encoding a Protein Binding the Regulatory Octamer DNA MotifQ36454242
Affinity purification of sequence-specific DNA binding proteinsQ37394403
P433issue6199
P407language of work or nameEnglishQ1860
P304page(s)544-551
P577publication date1988-12-01
P1433published inNatureQ180445
P1476titleA cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells
P478volume336

Reverse relations

cites work (P2860)
Q41684954'E-boxes' as promoter elements in B cell lines and untransformed B lymphocytes
Q332903901-Aminocyclopropane-1-carboxylate synthase in tomato is encoded by a multigene family whose transcription is induced during fruit and floral senescence
Q34303119A CACGTG motif of the Antirrhinum majus chalcone synthase promoter is recognized by an evolutionarily conserved nuclear protein
Q28585539A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
Q24634609A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain
Q33575964A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor
Q24318898A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues
Q24317715A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor
Q38325341A novel POU family transcription factor is closely related to Brn-3 but has a distinct expression pattern in neuronal cells
Q24315271A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2
Q33921920A novel upstream element compensates for an ineffectual octamer motif in an immunoglobulin V kappa promoter
Q41305696A silencer and an adjacent positive element interact to modulate the activity of the human insulin promoter
Q35016297A simple method to renature DNA-binding proteins separated by SDS-polyacrylamide gel electrophoresis
Q38342131A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position
Q40819029A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter
Q36773951Activation of octamer-containing promoters by either octamer-binding transcription factor 1 (OTF-1) or OTF-2 and requirement of an additional B-cell-specific component for optimal transcription of immunoglobulin promoters.
Q37062002Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein
Q41236557An autoregulatory enhancer element of the Drosophila homeotic gene Deformed
Q36731893Analysis of Oct2-isoform expression in lipopolysaccharide-stimulated B lymphocytes.
Q41683573Analysis of abnormal expression of G-CSF gene in a novel tumor cell line (KHC 287) elaborating G-CSF, IL-1 and IL-6 with co-amplification of c-myc and c-ki-ras
Q40447774Anti-OTF-1 antibodies inhibit NFIII stimulation of in vitro adenovirus DNA replication
Q24533589Assembly requirements of PU.1-Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers
Q24601319Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins
Q38339734Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements
Q38302908B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1.
Q36604444B cell development and immunoglobulin transcription in Oct-1-deficient mice
Q59059941B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation
Q40678198BLyF, a novel cell-type- and stage-specific regulator of the B-lymphocyte gene mb-1
Q36726471Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary-gland-specific nuclear factor
Q28620968Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes
Q24564107Brn-3.0: a POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs
Q24291231CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression
Q71609649Cell differentiation in vitro and the expression of Oct-2 protein and oct-2 RNA
Q36382408Cell size regulation, a mechanism that controls cellular RNA accumulation: consequences on regulation of the ubiquitous transcription factors Oct1 and NF-Y and the liver-enriched transcription factor DBP.
Q41566088Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter
Q48941969Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals.
Q33866711Cell-specific transcriptional control of the mouse DNA-binding protein mC/EBP.
Q38142292Characterization of a DNA-binding protein system which is inversely correlated with class II expression
Q28646103Characterization of a negative retinoic acid response element in the murine Oct4 promoter
Q24559695Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution
Q40689345Chicken HDAC2 down-regulates IgM light chain gene promoter activity.
Q36959388Chicken beta B1-crystallin gene expression: presence of conserved functional polyomavirus enhancer-like and octamer binding-like promoter elements found in non-lens genes
Q33246568Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome
Q24294398Cloning and characterization of a human c-myc promoter-binding protein
Q42809816Cloning and characterization of the chick Oct binding factor OBF-1.
Q36826781Cloning and characterization of the murine B-cell specific transcriptional coactivator Bob1.
Q41521004Cloning and tissue-specific expression of the gene for mouse C-reactive protein
Q29620250Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells
Q24635381Cloning of cDNAs coding for human HMG I and HMG Y proteins: both are capable of binding to the octamer sequence motif
Q28508568Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers
Q24596982Cloning, chromosomal localization and expression pattern of the POU domain gene Oct-11
Q32058411Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse
Q41434010Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma × T cell hybrids
Q33590388Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm.
Q33411695DNA binding properties of YB-1 and dbpA: binding to double-stranded, single-stranded, and abasic site containing DNAs
Q58450390DNA-binding domain ancestry
Q35804675Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated
Q35785980Demonstration of a divergent transcript from the bidirectional heavy chain immunoglobulin promoter VH441 in B-cells
Q41543354Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions
Q42818478Differential expression of subspecies of polyomavirus and murine leukemia virus enhancer core binding protein, PEBP2, in various hematopoietic cells
Q40791425Differential transactivation potential of Oct1 and Oct2 is determined by additional B cell-specific activities
Q38304688Displacement of an E-box-binding repressor by basic helix-loop-helix proteins: implications for B-cell specificity of the immunoglobulin heavy-chain enhancer
Q44258345Dissection of functional domains of the pituitary-specific transcription factor GHF-1.
Q40505363Distribution and characterization of helix-loop-helix enhancer-binding proteins from pancreatic beta cells and lymphocytes
Q48239230Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming.
Q41347892Drosophila homoeotic genes encode transcriptional activators similar to mammalian OTF-2.
Q36719499Drosophila proliferating cell nuclear antigen (cyclin) gene: structure, expression during development, and specific binding of homeodomain proteins to its 5'-flanking region
Q41082106Enhancer activation by a single type of transcription factor shows cell type dependence
Q68355311Eukaryotic transcription factors
Q41690369Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling?
Q36464686Expression and Activity of the Transcription Factor SCIP during Glial Differentiation and Myelination
Q49058843Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity
Q28277007Expression of a large family of POU-domain regulatory genes in mammalian brain development
Q48078650Expression patterns of novel genes encoding homeodomain leucine-zipper proteins in Arabidopsis thaliana.
Q41204949Extinction of Ig genes expression in myeloma x fibroblast somatic cell hybrids is accompanied by repression of the oct-2 gene encoding a B-cell specific transcription factor
Q41577622Extinction of Oct-3/4 Gene Expression in Embryonal Carcinoma × Fibroblast Somatic Cell Hybrids is Accompanied by Changes in the Methylation Status, Chromatin Structure, and Transcriptional Activity of the Oct-3/4 Upstream Region
Q43182464Extinction of T cell receptor alpha-chain gene expression accompanied by loss of the lymphoid enhancer-binding factor 1 (LEF-1) in murine somatic cell hybrids
Q37837345From human autoantibodies to the fetal antibody repertoire to B cell malignancy: it's a small world after all.
Q40421477Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice
Q40522431Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms
Q28138243Functional interaction between Oct-1 and retinoid X receptor
Q38311057Functional interaction between different isoforms of the Oct-2 transcription factor expressed in neuronal cells
Q41595934Functional interference between the ubiquitous and constitutive octamer transcription factor 1 (OTF-1) and the glucocorticoid receptor by direct protein-protein interaction involving the homeo subdomain of OTF-1
Q24678821Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression
Q28247692Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23–q25) and mouse chromosome 3 near Egf
Q39716358Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1
Q40447891Genetic analysis of transcription factors implicated in B lymphocyte development.
Q36774107Helix-loo-helix proteins in the regulation of immunoglobulin gene transcription
Q33920748Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1
Q33409717Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences
Q24568349High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
Q58989608Homoeo boxes, POU proteins and the limits to promiscuity
Q41606947Housekeeping Na,K-ATPase alpha 1 subunit gene promoter is composed of multiple cis elements to which common and cell type-specific factors bind
Q24561490Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene
Q24293962Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues
Q44430992I-POU: a POU-domain protein that inhibits neuron-specific gene activation
Q24561560Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
Q39682683Identification and functional characterization of BTas transactivator as a DNA-binding protein
Q36708461Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2.
Q36717517Identification of an octamer-binding site in the human kappa light-chain enhancer
Q36761913Identification of an octamer-binding site in the mouse kappa light-chain immunoglobulin enhancer
Q41098489Identification of factors regulating the expression of the human glucocerebrosidase gene
Q38343022Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene
Q45850803Immediate early protein of pseudorabies virus is a general transactivator but stimulates only suboptimally utilized promoters. A clue to specificity?
Q34306285Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene
Q42601474In vitro binding to the leucine tRNA gene identifies a novel yeast homeobox gene
Q42479628Independent promoters regulate the expression of two amino terminally distinct forms of latent transforming growth factor-beta binding protein-1 (LTBP-1) in a cell type-specific manner
Q40398799Inhibition of herpes simplex virus infection by ectopic expression of neuronal splice variants of the Oct-2 transcription factor
Q28587910Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer
Q29543470Interaction of Oct-1 with TFIIB
Q41082082Interference and synergism of glucocorticoid receptor and octamer factors.
Q38299790Involvement of the Ets family factor PU.1 in the activation of immunoglobulin promoters
Q33291709Isolation and characterization of the gene encoding EF-1αO, an elongation factor 1-α expressed during early development of Xenopus laevis
Q24317240Isolation of the human genomic brain-2/N-Oct 3 gene (POUF3) and assignment to chromosome 6q16
Q38337624Liver-specific gene expression: A-activator-binding site, a promoter module present in vitellogenin and acute-phase genes
Q40517596Lymphoid-specific transcriptional activation by components of the IgH enhancer: studies on the E2/E3 and octanucleotide elements
Q34320901Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box
Q38356590Mapping of the transcriptional repression domain of the lymphoid-specific transcription factor oct-2A.
Q35068608Mapping the transactivation domain of the Oct-6 POU transcription factor
Q53435594Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc.
Q36687242Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells
Q33831064Molecular mechanisms of extinction: old findings and new ideas
Q40928375Molecular principles of Oct2-mediated gene activation in B cells
Q67871563Mouse chromosome 7
Q35675706Mouse chromosome 7.
Q40530633Multiple Oct2 isoforms are generated by alternative splicing
Q48270366Multiple elements in the promoter of granulocyte colony-stimulating factor gene regulate its constitutive expression in human carcinoma cells
Q24300369Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
Q38342198Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors
Q38348953N-myc oncogene expression in neuroblastoma is driven by Sp1 and Sp3
Q42482263NF-κB-dependent signals control BOB.1/OBF.1 and Oct2 transcriptional activity in B cells
Q28508721New type of POU domain in germ line-specific protein Oct-4
Q48157917Novel DNA binding proteins participate in the regulation of human neurofilament H gene expression
Q34183708Novel mechanisms of class II major histocompatibility complex gene regulation
Q24313516OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins
Q36574089OCA-B is a functional analog of VP16 but targets a separate surface of the Oct-1 POU domain
Q74261398Oct proteins are qualitative rather than quantitative regulators of kappa transcription
Q28620476Oct-1 and Oct-2 potentiate functional interactions of a transcription factor with the proximal sequence element of small nuclear RNA genes
Q25255861Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation
Q34041038Oct-2 facilitates functional preinitiation complex assembly and is continuously required at the promoter for multiple rounds of transcription
Q28506545Oct-4: a germline-specific transcription factor mapping to the mouse t-complex
Q24556538Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain
Q40655422Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity
Q38356251Octamer binding factors and their coactivator can activate the murine PU.1 (spi-1) promoter.
Q40819050Octamer binding proteins confer transcriptional activity in early mouse embryogenesis
Q33569207Octamer transcription factors bind to two different sequence motifs of the immunoglobulin heavy chain promoter
Q36722675Octamer-binding proteins in diverse hemopoietic cells.
Q38316492Overlapping positive and negative regulatory elements determine lens-specific activity of the delta 1-crystallin enhancer
Q40535937POU domain transcription factors from different subclasses stimulate adenovirus DNA replication
Q41082612POU proteins bend DNA via the POU-specific domain
Q67525041POU-specific domain of Oct-2 factor confers 'octamer' motif DNA binding specificity on heterologous Antennapedia homeodomain
Q39677670Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells.
Q38314158Phosphorylation of Oct-2 at sites located in the POU domain induces differential down-regulation of Oct-2 DNA-binding ability
Q24629845Positive and negative elements regulate a melanocyte-specific promoter
Q41644824Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene
Q72911892Production of recombinant antibodies in lymphoid and non-lymphoid cells
Q28620733Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter
Q35910996Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration
Q24604697Purification of early-B-cell factor and characterization of its DNA-binding specificity
Q41350631RNA polymerase II C-terminal domain required for enhancer-driven transcription
Q36665511Reconstitution of transcriptional activation domains by reiteration of short peptide segments reveals the modular organization of a glutamine-rich activation domain
Q36230644Regulated expression of mouse mammary tumor proviral genes in cells of the B lineage.
Q36317476Regulation of JC virus by the POU-domain transcription factor Tst-1: implications for progressive multifocal leukoencephalopathy
Q38356344Regulation of human involucrin promoter activity by POU domain proteins
Q36572865Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.
Q28249579Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
Q42129614Regulatory elements controlling pituitary-specific expression of the human prolactin gene
Q40447847Regulatory elements involved in the bidirectional activity of an immunoglobulin promoter
Q41736670Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages
Q41431521Repression of a herpes simplex virus immediate-early promoter by the Oct-2 transcription factor is dependent on an inhibitory region at the N terminus of the protein
Q39882501Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma
Q36811375Segments of the POU domain influence one another's DNA-binding specificity
Q28592898Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding
Q36700925Simian virus 40 (SV40) T-antigen transcriptional activation mediated through the Oct/SPH region of the SV40 late promoter
Q40506234Stringent integrity requirements for both trans-activation and DNA-binding in a trans-activator, Oct3
Q45948452Structural analyses of human developmentally regulated Vh3 genes.
Q34765130Structure-function analysis of the DNA binding domain ofSaccharomyces cerevisiaeABF1
Q38340482Target Detection Assay (TDA): a versatile procedure to determine DNA binding sites as demonstrated on SP1 protein
Q40873369Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation
Q35851233The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct-2 factors, leading to differential promoter activation
Q28259912The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction
Q41670378The B-cell and neuronal forms of the octamer-binding protein Oct-2 differ in DNA-binding specificity and functional activity
Q41213754The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication
Q41543532The DNA binding specificity of the bipartite POU domain and its subdomains
Q40653846The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins
Q47356708The Oct-1 homoeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16.
Q36665493The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription
Q36562262The POU domain of SCIP/Tst-1/Oct-6 is sufficient for activation of an acetylcholine receptor promoter
Q24610899The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP
Q27930788The SNF5 protein of Saccharomyces cerevisiae is a glutamine- and proline-rich transcriptional activator that affects expression of a broad spectrum of genes
Q52211686The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos.
Q35889925The VP16 paradox: herpes simplex virus VP16 contains a long-range activation domain but within the natural multiprotein complex activates only from promoter-proximal positions
Q42066326The basic helix-loop-helix-zipper domain of TFE3 mediates enhancer-promoter interaction
Q33919795The cell type-specific octamer transcription factor OTF-2 has two domains required for the activation of transcription
Q77741483The different alternatively spliced isoforms of the Oct-2 transcription factor repress the involucrin promoter in a cell type-specific manner
Q44315513The domain model for eukaryotic DNA organization. 2: A molecular basis for constraints on development and evolution
Q37816327The early expression of some human autoantibody-associated heavy chain variable region genes is controlled by specific regulatory elements
Q36820980The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription
Q36732192The gene encoding the transcription factor SCIP has features of an expressed retroposon
Q35891939The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11
Q36675781The immunoglobulin heavy chain locus contains another B-cell-specific 3' enhancer close to the alpha constant region
Q41387568The inhibitory domain in the Oct-2 transcription factor represses gene activity in a cell type-specific and promoter-independent manner
Q40421568The murine Hox-2.4 promoter contains a functional octamer motif
Q46881141The novel Solanum tuberosum calcium dependent protein kinase, StCDPK3, is expressed in actively growing organs
Q41082602The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer
Q40527591The octamer binding factor Oct6: cDNA cloning and expression in early embryonic cells
Q38333663The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons
Q33591163The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein
Q36729328The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.
Q33743837The role of POU domain proteins in the regulation of mammalian pituitary and nervous system development.
Q24564741The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein
Q40453618The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.
Q37149425The transcriptional coactivator Bob1 promotes the development of follicular T helper cells via Bcl6
Q36720218The ubiquitous octamer-binding protein(s) is sufficient for transcription of immunoglobulin genes
Q36013163The weak, fine-tuned binding of ubiquitous transcription factors to the II-2 enhancer contributes to its T cell-restricted activity
Q41656802Three individual regulatory elements of the promoter positively activate the transcription of the murine gene encoding granulocyte colony-stimulating factor
Q24556539Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity
Q36500778Towards a molecular understanding of T-cell differentiation
Q35036645Transactivation of the human papilloma virus 16 octamer motif by the octamer binding protein Oct-2 requires both the N and C terminal activation domains
Q33919791Transcription factor Oct-2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non-lymphoid (HeLa) cells
Q41652229Transcription factor requirements for U2 snRNA-encoding gene activation in B lymphoid cells
Q34784369Transcription factors interacting with herpes simplex virus alpha gene promoters in sensory neurons
Q72550639Transcription factors: an overview
Q41748770Transcription of the promoter of the rat NF-1 gene depends on the integrity of an Sp1 recognition site.
Q38289155Transcriptional activation and repression, two properties of the lymphoid-specific transcription factor Oct-2a
Q46076067Transcriptional controls underlying Schwann cell differentiation and myelination
Q35850917Transcriptional regulatory elements of the RAS2 gene of Saccharomyces cerevisiae
Q37639988Transformation by homeobox genes can be mediated by selective transcriptional repression.
Q41854472Transforming growth factor beta and cyclosporin A inhibit the inducible activity of the interleukin-2 gene in T cells through a noncanonical octamer-binding site
Q28575317Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0
Q36678035Two cis-DNA elements involved in myeloid-cell-specific expression and gamma interferon (IFN-gamma) activation of the human high-affinity Fc gamma receptor gene: a novel IFN regulatory mechanism
Q72080558Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3
Q34209930Two diverged human homeobox genes involved in the differentiation of human hematopoietic progenitors map to chromosome 1, bands q41-42.1
Q24293444Two members of an HNF1 homeoprotein family are expressed in human liver
Q42633662Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription
Q40531520Xenopus laevis Oct-1 does not bind to certain histone H2B gene promoter octamer motifs for which a novel octamer-binding factor has high affinity
Q36363138YB-1 DNA-binding protein represses interferon gamma activation of class II major histocompatibility complex genes
Q40404963Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis
Q24596854cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif
Q33198212dOct2, a Drosophila Oct transcription factor that functions in yeast
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