Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

scientific article published in Nature

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1012041829
P356DOI10.1038/NATURE02446
P698PubMed publication ID15034593

P50authorJitka A ViragQ59683766
Kishore PasumarthiQ72249210
P2093author name stringDavid A Williams
Charles E Murry
Michael Rubart
Loren J Field
Hans Reinecke
Hidehiro Nakajima
Joshua D Dowell
Mark H Soonpaa
Veronica Poppa
Stephen H Bartelmez
Hisako O Nakajima
Gillian Bradford
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Chimerism of the transplanted heartQ77452324
Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human heartsQ77885470
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cellsQ24672061
Generalized potential of adult neural stem cellsQ28145509
Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cellQ28188430
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytesQ28209232
Bone marrow cells regenerate infarcted myocardiumQ28210640
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)Q28216990
Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humansQ31113632
Physiological Coupling of Donor and Host Cardiomyocytes After Cellular TransplantationQ31141231
Cardiomyocyte regeneration from circulating bone marrow cells in miceQ31148531
From marrow to brain: expression of neuronal phenotypes in adult mice.Q33926766
Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrowQ33926770
Myocyte and myogenic stem cell transplantation in the heartQ35131739
Myofibroblast and endothelial cell proliferation during murine myocardial infarct repairQ35843221
Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarctionQ36349782
Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac graftingQ45711148
Immune response to green fluorescent protein: implications for gene therapyQ45861644
Muscle regeneration by bone marrow-derived myogenic progenitorsQ45885806
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo.Q46003277
Transdifferentiation of Blood-Derived Human Adult Endothelial Progenitor Cells Into Functionally Active CardiomyocytesQ60723059
Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardiumQ72321699
Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patientsQ73106026
Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heartQ73927431
Cardiomyocytes of noncardiac origin in myocardial biopsies of human transplanted heartsQ74397725
P433issue6983
P407language of work or nameEnglishQ1860
P304page(s)664-668
P577publication date2004-03-21
P1433published inNatureQ180445
P1476titleHaematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
P478volume428

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Q35201621Embryonic stem cell-derived cardiomyocyte heterogeneity and the isolation of immature and committed cells for cardiac remodeling and regeneration
Q36995124Embryonic stem cells attenuate myocardial dysfunction and inflammation after surgical global ischemia via paracrine actions
Q37388612Embryonic stem cells in cardiac repair and regeneration
Q80833914Embryonic stem cells pace the heart
Q36920724Emerging Concepts in Paracrine Mechanisms in Regenerative Cardiovascular Medicine and Biology
Q34239856Empowering adult stem cells for myocardial regeneration
Q42090077Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis
Q35985560Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance.
Q37325660Endothelial progenitor cells: implications for cardiovascular disease
Q36387870Endothelial-cardiomyocyte interactions in cardiac development and repair
Q34508414Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts
Q35747710Engineered myocardial tissues constructed in vivo using cardiomyocyte-like cells derived from bone marrow mesenchymal stem cells in rats
Q36804669Engineering stem cells for therapy
Q59064296Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia
Q24677311Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium
Q39848465Engraftment of mesenchymal stem cells into dystrophin-deficient mice is not accompanied by functional recovery
Q39864941Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy
Q36121810Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair
Q43593323Epicardial progenitor cells in cardiac regeneration and neovascularisation
Q38930599Epicardium-Derived Heart Repair.
Q37513850Establishing Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs
Q46568661Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia
Q39864835Estrogen receptor alpha supports cardiomyocytes indirectly through post-infarct cardiac c-kit+ cells
Q50868250Evaluating the role of autologous mesenchymal stem cell seeded on decellularized pericardium in the treatment of myocardial infarction: an animal study.
Q37273936Evidence that bone marrow cells do not contribute to the alveolar epithelium
Q40018932Evolution of the c-kit-positive cell response to pathological challenge in the myocardium
Q47438101Evolving cell-based therapies for heart failure patients
Q37358894Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis.
Q59795422Exosomes: Basic Biology and Technological Advancements Suggesting Their Potential as Ischemic Heart Disease Therapeutics
Q45831019Expansion of Umbilical Cord Blood Aldehyde Dehydrogenase Expressing Cells Generates Myeloid Progenitor Cells that Stimulate Limb Revascularization
Q28073078Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery
Q38195538Extra- and intracellular factors regulating cardiomyocyte proliferation in postnatal life.
Q38292668Extracellular vesicles: potential roles in regenerative medicine
Q36942196FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin + G-CSF therapy after acute myocardial infarction
Q33842934FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes.
Q27309113Fetal myocardium in the kidney capsule: an in vivo model of repopulation of myocytes by bone marrow cells
Q37120596Finding Expandable Induced Cardiovascular Progenitor Cells
Q55229425Forging the Fate of Cellular Therapies for Cardiovascular Disease.
Q35221817Formation of human myocardium in the rat heart from human embryonic stem cells
Q36569726From cardiac repair to cardiac regeneration--ready to translate?
Q49423373Functional Tissue Engineering: A Prevascularized Cardiac Muscle Construct for Validating Human Mesenchymal Stem Cells Engraftment Potential In Vitro
Q50977973Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation.
Q35539690Functional and transcriptomic recovery of infarcted mouse myocardium treated with bone marrow mononuclear cells.
Q51621930Functional impact of targeted closed-chest transplantation of bone marrow cells in rats with acute myocardial ischemia/reperfusion injury.
Q50648691Functional properties of cells obtained from human cord blood CD34+ stem cells and mouse cardiac myocytes in coculture.
Q38000518Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy.
Q51712826Fusion of circulating blood cells with solid-organ tissue cells in clinical stem cell transplants: a potential therapeutic model?
Q81424114G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Q37176449G-CSF- and erythropoietin-based cell therapy: a promising strategy for angiomyogenesis in myocardial infarction
Q36227832G-CSF/SCF reduces inducible arrhythmias in the infarcted heart potentially via increased connexin43 expression and arteriogenesis
Q38660472Gaining myocytes or losing fibroblasts: Challenges in cardiac fibroblast reprogramming for infarct repair
Q35606632Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1).
Q26865425Gene and cell therapies for the failing heart to prevent sudden arrhythmic death
Q36675432Gene and cell therapy for chronic ischaemic heart disease
Q37470623Gene and cell therapy for heart failure
Q39136745Generation of induced cardiac progenitor cells via somatic reprogramming
Q36982525Genesis of myocardial repair with cardiac progenitor cells and tissue engineering
Q34298871Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy
Q37156670Genetic enhancement of stem cell engraftment, survival, and efficacy
Q37010620Genetic modification of stem cells for transplantation
Q39871712Genomic profiling of developing cardiomyocytes from recombinant murine embryonic stem cells reveals regulation of transcription factor clusters
Q36540656Getting to the heart of myocardial stem cells and cell therapy
Q53318735Global contractility increment in nonischemic dilated cardiomyopathy after free wall-only intramyocardial injection of autologous bone marrow mononuclear cells: an insight over stem cells clinical mechanism of action.
Q38160044Global search for right cell type as a treatment modality for cardiovascular disease
Q35644254Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes
Q53055138Granulocyte-colony stimulating factor reduces cardiomyocyte apoptosis and ameliorates diastolic dysfunction in Otsuka Long-Evans Tokushima Fatty rats.
Q40250950Granulocyte-colony-stimulating factor in acute myocardial infarction: future perspectives after FIRSTLINE-AMI and REVIVAL-2.
Q33781018Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts
Q38018889Harnessing the potential of adult cardiac stem cells: lessons from haematopoiesis, the embryo and the niche
Q36029669Healing a broken heart with stem cells
Q57395528Heart failure and regenerative cardiology
Q33605156Heart failure management: the present and the future
Q24562846Heart regeneration
Q38654054Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics
Q89870117Heart regeneration in mouse and human: A bioengineering perspective
Q34390677Heart regeneration: Past, present and future
Q36606663Heart repair and stem cells
Q46296118Heart valve and myocardial tissue engineering
Q43077724Hearty slices to plan for future health
Q36824005Hematopoietic stem cells are pluripotent and not just "hematopoietic".
Q37194059Hematopoietic stem cells: ex-vivo expansion and therapeutic potential for myocardial ischemia
Q42742754Heterogeneity of engrafted bone-lining cells after systemic and local transplantation
Q93270242Heterogenetic parabiosis between healthy and dystrophic mice improve the histopathology in muscular dystrophy
Q35848474Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines.
Q37353891Human Umbilical Cord Blood for Transplantation Therapy in Myocardial Infarction
Q41871049Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells
Q36882814Human cardiospheres as a source of multipotent stem and progenitor cells
Q50525938Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process.
Q35085099Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver
Q40434564Human embryoid body-derived stem cells in co-culture with bladder smooth muscle and urothelium
Q36804578Human embryonic stem cell-derived cardiomyocytes: inducing strategies.
Q37911584Human embryonic stem cell-derived vascular smooth muscle cells in therapeutic neovascularisation
Q37023827Human embryonic stem cells and cardiac repair
Q40353752Human embryonic stem cells: towards therapies for cardiac disease. Derivation of a Dutch human embryonic stem cell line
Q37554356Human heart valve-derived scaffold improves cardiac repair in a murine model of myocardial infarction
Q53629452Human mesenchymal stem cells do not differentiate into cardiomyocytes in a cardiac ischemic xenomodel.
Q34051561Human peripheral blood-derived CD31+ cells have robust angiogenic and vasculogenic properties and are effective for treating ischemic vascular disease
Q37924272Human pluripotent stem cell-based approaches for myocardial repair: from the electrophysiological perspective
Q39847147Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents.
Q35874256Human stem cells shape the future of cardiac regeneration research
Q33807191Human umbilical cord blood mononuclear cell transplantation in rats with intrinsic sphincter deficiency
Q37262399Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo.
Q37075151Hunt for pluripotent stem cell -- regenerative medicine search for almighty cell
Q37247304Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction
Q37830101Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion
Q46323076Hypoxic preconditioning protects rat hearts against ischaemia-reperfusion injury: role of erythropoietin on progenitor cell mobilization
Q27334319ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
Q50710399Identification of interventricular septum precursor cells in the mouse embryo.
Q36124315Identity deception: not a crime for a stem cell
Q37242779Imaging gene expression in human mesenchymal stem cells: from small to large animals
Q36656791Imaging stem cells implanted in infarcted myocardium
Q35879474Immuno-modification of enhancing stem cells targeting for myocardial repair.
Q51714776Impact of different bone marrow cell preparations on left ventricular remodelling after experimental myocardial infarction.
Q42548551Implantation of a three-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction
Q33781650Improved mobilization of the CD34(+) and CD133(+) bone marrow-derived circulating progenitor cells by freshly isolated intracoronary bone marrow cell transplantation in patients with ischemic heart disease
Q38088809Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell-derived cardiomyocytes
Q35163294Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway
Q31028296Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells
Q33753521Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
Q38840533Improving stem cell therapy in cardiovascular diseases: the potential role of microRNA.
Q28069954Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?
Q34993682In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging
Q35855818In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function.
Q35621666In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium
Q37120197Increased cardiac myocyte progenitors in failing human hearts
Q48154865Increases in plasma Tβ4 after intracardiac cell therapy in chronic ischemic heart failure is associated with symptomatic improvement
Q38203865Induced pluripotent stem cells for post-myocardial infarction repair: remarkable opportunities and challenges.
Q51743757Inflammatory responses after intracoronary mononuclear BM cell therapy in swine.
Q47904355Influence of in vitro biomimicked stem cell 'niche' for regulation of proliferation and differentiation of human bone marrow-derived mesenchymal stem cells to myocardial phenotypes: serum starvation without aid of chemical agents and prevention of s
Q42027651Initial clinical outcomes of intracoronary infusion of autologous progenitor cells in patients with acute myocardial infarction.
Q37294345Injectable cardiac tissue engineering for the treatment of myocardial infarction
Q33433387Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy
Q37606016Innate regeneration in the aging heart: healing from within
Q41288382Innervating sympathetic neurons regulate heart size and the timing of cardiomyocyte cell cycle withdrawal
Q33734315Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue
Q33327638Intracoronary autologous bone marrow-derived mononuclear cell transplantation improves coronary collateral vessel formation and recruitment capacity in patients with ischemic cardiomyopathy: a combined hemodynamic and scintigraphic approach
Q34332467Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial
Q37598908Intracoronary blood- or bone marrow-derived cell transplantation in patients with ischemic heart disease
Q34318046Intracoronary delivery of bone-marrow-derived stem cells
Q33258314Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis
Q39836735Intramyocardial Peptide Nanofiber Injection Improves Postinfarction Ventricular Remodeling and Efficacy of Bone Marrow Cell Therapy in Pigs
Q47895605Intramyocardial delivery of bone marrow mononuclear cells and mechanical assist device implantation in patients with end-stage cardiomyopathy
Q40191474Intratracheal transplantation of alveolar type II cells reverses bleomycin-induced lung fibrosis
Q42659946Is biological repair of heart on the horizon?
Q44948306Is heart regeneration on the right track?
Q37408693Is stem cell-based therapy going on or out for cardiac disease?
Q42456173Ischaemia/reperfusion induced cardiac stem cell homing to the injured myocardium by stimulating stem cell factor expression via NF-kappaB pathway
Q39109413Ischemia/Reperfusion
Q36691627Isolation and expansion of resident cardiac progenitor cells.
Q35882798It is all in the blood: the multifaceted contribution of circulating progenitor cells in diabetic complications
Q38140885JAK-STAT signaling in cardiomyogenesis of cardiac stem cells
Q34292542Label-free enrichment of functional cardiomyocytes using microfluidic deterministic lateral flow displacement
Q34090699LateTIME: a phase-II, randomized, double-blinded, placebo-controlled, pilot trial evaluating the safety and effect of administration of bone marrow mononuclear cells 2 to 3 weeks after acute myocardial infarction
Q33611657Learning from Mother Nature: Innovative Tools to Boost Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects
Q37778540Lessons for cardiac regeneration and repair through development
Q33328467Lineage tracing of cardiac explant derived cells.
Q51808978Liver repopulation trial using bone marrow cells in a retrorsine-induced chronic hepatocellular injury model.
Q37043528Logistics of stem cell isolation, preparation and delivery for heart repair: concerns of clinicians, manufacturers, investors and public health.
Q41665176Lost and found: cardiac stem cell therapy revisited
Q59057872Lost in translation
Q37506545Lost in translation: what is limiting cardiomyoplasty and can tissue engineering help?
Q34962330MSCs transplantation with application of G-CSF reduces apoptosis or increases VEGF in rabbit model of myocardial infarction
Q39295052Macrophages modulate the viability and growth of human mesenchymal stem cells
Q52789420Mammalian Heart Regeneration: The Race to the Finish Line.
Q27024992Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes
Q40508379Mechanical derivation of functional myotubes from adipose-derived stem cells.
Q93147053Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate
Q90617296Mesenchymal Stem Cell-Derived Extracellular Vesicles in Tissue Regeneration
Q26785404Mesenchymal Stem Cells for Cardiac Regenerative Therapy: Optimization of Cell Differentiation Strategy
Q36972669Mesenchymal stem cell administration at coronary artery reperfusion in the rat by two delivery routes: a quantitative assessment
Q38069136Mesenchymal stem cells and kidney repair
Q38816740Mesenchymal stem cells and vascular regeneration.
Q41983710Mesenchymal stem cells are recruited to striated muscle by NFAT/IL-4-mediated cell fusion
Q37884436Mesenchymal stem cells for cardiovascular regeneration
Q44592644Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation
Q30494495Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections
Q37296154Metabolic modulation and cellular therapy of cardiac dysfunction and failure
Q34907048Microarray-based characterization of a colony assay used to investigate endothelial progenitor cells and relevance to endothelial function in humans
Q41683501Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone
Q36477618Minimally invasive cell-seeded biomaterial systems for injectable/epicardial implantation in ischemic heart disease
Q45871851Mobilization of haematopoietic and non-haematopoietic cells by granulocyte-colony stimulating factor and vascular endothelial growth factor gene therapy in patients with stable severe coronary artery disease
Q30477168Molecular Imaging of Stem Cell Transplantation in Myocardial Disease
Q47363128Molecular medicine: the writing is on the vessel wall
Q37808269Molecular physiology of cardiac regeneration
Q50660744Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction.
Q54569449Morphological and molecular characterization of novel population of CXCR4+ SSEA-4+ Oct-4+ very small embryonic-like cells purified from human cord blood: preliminary report.
Q54217535Most of the Dust Has Settled: cKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes In Vivo.
Q36225111Multiple stem cell populations contribute to the formation of the myocardium
Q37002713Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Q63364496Multipotent Progenitor Cells in Regenerative Cardiovascular Medicine
Q64992007Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.
Q42853310Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment
Q42407370Multipotent stem cells in cardiac regenerative therapy
Q28085334Multipotent stem cells of the heart-do they have therapeutic promise?
Q37157338MyoCell, a cell-based, autologous skeletal myoblast therapy for the treatment of cardiovascular diseases
Q52730089Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.
Q48247352Myocardial Regeneration via Progenitor Cell-Derived Exosomes
Q35727937Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition.
Q38632039Myocardial infarction: stem cell transplantation for cardiac regeneration.
Q38045804Myocardial regeneration of the failing heart
Q34402223Myocardial regeneration with bone-marrow-derived stem cells
Q36247746Myocardial regenerative properties of macrophage populations and stem cells.
Q35168352Myocardial remodeling: cellular and extracellular events and targets
Q37176440Myocardial repair: from salvage to tissue reconstruction
Q33635730Myocardial survival signaling in response to stem cell transplantation
Q37578552Myocardial tissue engineering: the quest for the ideal myocardial substitute
Q36304191Myocardial-cell replacement: the science, the clinic and the future
Q35733632Myocyte proliferation in the developing heart
Q88540277Myoediting: Toward Prevention of Muscular Dystrophy by Therapeutic Genome Editing
Q38074105Natural ECM as biomaterial for scaffold based cardiac regeneration using adult bone marrow derived stem cells.
Q39022829Natural killer cells in inflammatory heart disease.
Q38738993Navigating the labyrinth of cardiac regeneration
Q36949077Neoangiogenesis with endothelial precursors for the treatment of ischemia
Q79898170Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization
Q57176905New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications
Q38048838New cell therapies in cardiology.
Q37783802New therapies for the failing heart: trans-genes versus trans-cells.
Q46197643New tissue for failing hearts
Q28306609Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells
Q37907966Noninvasive stem cell tracking
Q36666478Nuclear imaging in cardiac cell therapy
Q35841708On how Rac controls hematopoietic stem cell activity
Q61799559On the Choice of the Extracellular Vesicles for Therapeutic Purposes
Q41389712One-day kinetics of myocardial engraftment after intracoronary injection of bone marrow mononuclear cells in patients with acute and chronic myocardial infarction
Q93069246Optimization of Timing and Times for Administration of Atorvastatin-Pretreated Mesenchymal Stem Cells in a Preclinical Model of Acute Myocardial Infarction
Q36054643Optimized protocol for immunostaining of experimental GFP-expressing and human hearts
Q38982831Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology
Q37997980Organ repair and regeneration: an overview.
Q27023325Origin of cardiomyocytes in the adult heart
Q37488050Over-expression of HSP47 augments mouse embryonic stem cell smooth muscle differentiation and chemotaxis
Q36415354Overview of recent advances in molecular cardiology
Q90670550Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis
Q51011615Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium.
Q29620571Paracrine mechanisms in adult stem cell signaling and therapy
Q38107063Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives.
Q42854848Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine
Q50528333Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart.
Q38596702Pathophysiology of Myocardial Infarction
Q28071643Peripheral blood mononuclear cell secretome for tissue repair
Q37467729Perspectives on Trypanosoma cruzi-induced heart disease (Chagas disease).
Q26765883Pharmacological Therapy in the Heart as an Alternative to Cellular Therapy: A Place for the Brain Natriuretic Peptide?
Q46770537Phenotypic characteristics of hybrid cells produced by cell fusion of porcine adrenal chromaffin cells with human mesenchymal stem cells: a preliminary study
Q50773050Phenotypic characterization and preclinical production of human lineage-negative cells for regenerative stem cell therapy.
Q37969874Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
Q56777886Plasticity and cardiovascular applications of multipotent adult progenitor cells
Q36667445Plasticity and tissue regenerative potential of bone marrow-derived cells
Q33875374Pluripotent stem cell derived cardiomyocytes for cardiac repair
Q36855438Pluripotent stem cells for cardiac regeneration: overview of recent advances & emerging trends
Q30497438Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization
Q37016190Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure
Q53236739Positron emission tomography for the evaluation and treatment of cardiomyopathy.
Q39069601Possible Muscle Repair in the Human Cardiovascular System
Q28306800Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
Q38160455Potential and clinical utility of stem cells in cardiovascular disease.
Q36523923Potential of stem-cell-based therapies for heart disease
Q37382220Pre-transplantation specification of stem cells to cardiac lineage for regeneration of cardiac tissue
Q36850078Preconditioning c-Kit-positive Human Cardiac Stem Cells with a Nitric Oxide Donor Enhances Cell Survival through Activation of Survival Signaling Pathways
Q37668953Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration
Q34276744Preservation of myocardial structure is enhanced by pim-1 engineering of bone marrow cells
Q50657450Pressure-induced cardiac overload induces upregulation of endothelial and myocardial progenitor cells.
Q39440985Pro-angiogenic potential of human chorion-derived stem cells: in vitro and in vivo evaluation
Q37595834Progenitor cell therapy for heart disease
Q40457855Progenitor cell therapy of ischemic heart disease: the new frontier.
Q36108608Progenitor/stem cell transplantation for repair of myocardial infarction: Hype or hope?
Q26823933Programming and reprogramming a human heart cell
Q36327823Progress and prospects: cell based regenerative therapy for cardiovascular disease.
Q59086575Prometheus unbound
Q41214335Promises and pitfalls in cell replacement therapy for heart failure
Q94503644Promoting Cardiac Regeneration and Repair Using Acellular Biomaterials
Q35639798Protein localization in the plant Golgi apparatus and the trans-Golgi network
Q38629150Proteomics of cell-cell interactions in health and disease.
Q54619692Purified human bone marrow multipotent mesenchymal stem cells regenerate infarcted myocardium in experimental rats.
Q38143802Quo Vadis medycyno regeneracyjna?: Quo Vadis Regenerative Medicine?
Q37807086REVIEW: Stem Cell Therapy in Cardiovascular Disorders
Q33361149Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone
Q37444118Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction
Q38147034Recent advances in heart regeneration
Q36312990Recent advances in primary percutaneous intervention for acute myocardial infarction
Q39526666Recent progress in therapeutic angiogenesis
Q34784347Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice.
Q38032473Regenerating cardiac cells: insights from the bench and the clinic
Q27687840Regenerating functional heart tissue for myocardial repair
Q36497191Regenerating new heart with stem cells
Q91691962Regenerating the field of cardiovascular cell therapy
Q22251075Regenerating the heart
Q36038854Regeneration of the heart
Q36462071Regenerative medicine for cardiovascular disorders-new milestones: adult stem cells
Q38075104Regenerative medicine for the treatment of heart disease
Q38174769Regenerative therapy for cardiovascular disease
Q35222931Rejuvenation: an integrated approach to regenerative medicine
Q37104058Repairing damaged myocardium: evaluating cells used for cardiac regeneration
Q37774067Resident cardiac progenitor cells: at the heart of regeneration.
Q36406482Resident progenitors and bone marrow stem cells in myocardial renewal and repair
Q53419687Retention of nanoparticles-labeled bone marrow mononuclear cells in the isolated ex vivo perfused heart after myocardial infarction in animal model.
Q34041306Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices.
Q37932621Retrograde delivery of stem cells: promising delivery strategy for myocardial regenerative therapy.
Q37766134Review of stem cell-based therapy for the treatment of cardiovascular disease
Q37976449Revisiting cardiovascular regeneration with bone marrow-derived angiogenic and vasculogenic cells
Q91905110Role of Adult Tissue-Derived Pluripotent Stem Cells in Bone Regeneration
Q37689954Role of endothelial progenitor cells during ischemia-induced vasculogenesis and collateral formation
Q36294424Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart
Q37687409Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy
Q82530867SCIPIO brings new momentum to cardiac cell therapy
Q52731083SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells.
Q42393097SDF-1:CXCR4 Axis Is Fundamental for Tissue Preservation and Repair
Q90362748STAT3 for Cardiac Regenerative Medicine: Involvement in Stem Cell Biology, Pathophysiology, and Bioengineering
Q80322388Searching for reputability: first randomised study on bone-marrow transplantation in the heart
Q37868851Selecting the optimal cell for kidney regeneration: fetal, adult or reprogrammed stem cells.
Q51632340Sex of muscle stem cells does not influence potency for cardiac cell therapy.
Q40167706Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart
Q38315476Short-term intermittent administration of CXCR4 antagonist AMD3100 facilitates myocardial repair in experimental myocardial infarction
Q34827093Single cell gene profiling revealed heterogeneity of paracrine effects of bone marrow cells in mouse infarcted hearts
Q33823725Small intestinal submucosa gel as a potential scaffolding material for cardiac tissue engineering.
Q35945147Some notes on stem cell therapy in cardiovascular diseases
Q36426360Sources of cardiomyocytes for stem cell therapy: an update
Q51067725Stem Cell Banking and Its Impact on Cardiac Regenerative Medicine.
Q57951496Stem Cell Therapy for the Broken Heart: Mini-Organ Transplantation
Q35125820Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box.
Q39329517Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases.
Q39190689Stem Cells in Cardiovascular Medicine: the Road to Regenerative Therapies
Q50075212Stem Cells in Regenerative Cardiology
Q85240790Stem and progenitor cell-based therapy approaches: current developments on treatment of acute myocardial infarction and chronic ischemic cardiomyopathy
Q37045472Stem cell differentiation: cardiac repair
Q35002029Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine
Q34479264Stem cell factor receptor induces progenitor and natural killer cell-mediated cardiac survival and repair after myocardial infarction.
Q37991028Stem cell mediated cardiovascular repair
Q33708216Stem cell paracrine actions and tissue regeneration
Q36362598Stem cell research: future implications for internal medicine
Q38098219Stem cell stimulation of endogenous myocyte regeneration
Q37087315Stem cell therapies in cardiovascular disease A "realistic" appraisal.
Q34441749Stem cell therapy and breast cancer treatment: review of stem cell research and potential therapeutic impact against cardiotoxicities due to breast cancer treatment
Q26801514Stem cell therapy and tissue engineering for correction of congenital heart disease
Q34129904Stem cell therapy for cardiac dysfunction
Q37401003Stem cell therapy for cardiac repair
Q37544884Stem cell therapy for cardiac repair: benefits and barriers
Q36836349Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology
Q37877423Stem cell therapy for heart diseases
Q40097837Stem cell therapy for heart failure: the science and current progress.
Q39850212Stem cell therapy for ischemic heart disease
Q36529988Stem cell therapy for ischemic heart disease: beginning or end of the road?
Q35980614Stem cell therapy for the heart
Q37070968Stem cell therapy in acute myocardial infarction
Q46963373Stem cell therapy in postinfarction chronic coronary heart disease
Q35087066Stem cell therapy. Use of differentiated pluripotent stem cells as replacement therapy for treating disease
Q38225999Stem cell therapy: challenges ahead
Q33348580Stem cell therapy: pieces of the puzzle
Q36368239Stem cell transplantation for the treatment of myocardial infarction
Q34315088Stem cell treatment of the heart: a review of its current status on the brink of clinical experimentation
Q35128063Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation
Q38050281Stem cell-based therapy for ischemic heart disease.
Q51726662Stem cell-derived cardiomyocytes after bone marrow and heart transplantation.
Q37293765Stem cell-mediated natural tissue engineering
Q36228883Stem cells
Q36842866Stem cells and cardiac regeneration
Q37766151Stem cells and cardiac repair: a critical analysis
Q57635832Stem cells and cardiovascular tissue repair: Mechanism, methods, and clinical applications
Q35910261Stem cells and muscle diseases.
Q37991771Stem cells and regenerative medicine - future perspectives
Q35832759Stem cells and repair of the heart.
Q36428648Stem cells and their potential relevance to paediatric cardiology
Q38072245Stem cells and their role in renal ischaemia reperfusion injury
Q36124846Stem cells as future therapy in cardiology
Q38273056Stem cells for cardiac regeneration and possible roles of the transforming growth factor-β superfamily
Q33352048Stem cells for cardiac repair in acute myocardial infarction
Q38124263Stem cells for cardiac repair: an introduction
Q35109987Stem cells for cardiac repair: status, mechanisms, and new strategies
Q36225214Stem cells for cardiomyocyte regeneration: state of the art.
Q37261623Stem cells for heart cell therapies
Q36446920Stem cells for the ischaemic heart
Q40006145Stem cells from in- or outside of the heart: isolation, characterization, and potential for myocardial tissue regeneration
Q39750538Stem cells in heart failure
Q33863225Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
Q37183624Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies.
Q29614416Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
Q36254634Stem cells: From embryology to cellular therapy? An appraisal of the present state of art.
Q38467240Stem-cell angiogenesis and regeneration of the heart: review of a saga of 2 decades.
Q82265727Stem-cell therapy after acute myocardial infarction: the focus should be on those at risk
Q37089732Stem-cell therapy for cardiac disease
Q37164041Stem-cell-based therapy and lessons from the heart
Q37255265Stemming heart failure with cardiac- or reprogrammed-stem cells
Q34372277Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction
Q36380582Strategies for developing therapeutic application of human embryonic stem cells.
Q37162061Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation
Q46970615Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure
Q37345060Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction
Q40054505Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy
Q36663081Surgically relevant aspects of stem cell paracrine effects
Q27024287Systems-based technologies in profiling the stem cell molecular framework for cardioregenerative medicine
Q40476983THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential.
Q47644462TRPC3-mediated Ca2+ signals as a promising strategy to boost therapeutic angiogenesis in failing hearts: The role of autologous endothelial colony forming cells
Q89801635Targeting Age-Related Pathways in Heart Failure
Q36642702Targeting angiogenesis versus myogenesis with cardiac cell therapy
Q37220758Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction
Q38234910Targeting pleiotropic signaling pathways to control adult cardiac stem cell fate and function.
Q47862843Telomere-independent cellular senescence in human fetal cardiomyocytes
Q37776212Teratomas from pluripotent stem cells: A clinical hurdle
Q39067173The ATP-Binding Cassette Transporter BCRP1/ABCG2 Plays a Pivotal Role in Cardiac Repair After Myocardial Infarction Via Modulation of Microvascular Endothelial Cell Survival and Function
Q52322793The Delta Opioid Peptide DADLE Represses Hypoxia-Reperfusion Mimicked Stress Mediated Apoptotic Cell Death in Human Mesenchymal Stem Cells in Part by Downregulating the Unfolded Protein Response and ROS along with Enhanced Anti-Inflammatory Effect.
Q39095681The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away
Q38746402The Heart and Great Vessels
Q92128776The Immunomodulatory Functions of Mesenchymal Stromal/Stem Cells Mediated via Paracrine Activity
Q58998678The Systems Biology of Stem Cell Released Molecules—Based Therapeutics
Q61443241The biochemical and electrophysiological profiles of amniotic fluid-derived stem cells following Wnt signaling modulation cardiac differentiation
Q36836344The birth of 'regenerative pharmacology': a clinical perspective
Q36174197The bone marrow--cardiac axis of myocardial regeneration
Q30493876The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction
Q34026411The combination of angiotensin II and 5-azacytidine promotes cardiomyocyte differentiation of rat bone marrow mesenchymal stem cells
Q38375149The duality of chemokines in heart failure
Q35079018The effect of bone marrow mononuclear stem cell therapy on left ventricular function and myocardial perfusion.
Q26746647The emerging role of viral vectors as vehicles for DMD gene editing
Q36559150The future of cell therapy for myocardial regeneration
Q37790961The future of regenerating the myocardium
Q35092172The heterogeneous murine corneal stromal cell populations in vitro.
Q36944120The immature heart: the roles of bone marrow stromal stem cells in growth and myocardial repair
Q37096652The immune system and cardiac repair.
Q44113705The importance of understanding the molecular mechanism of stem cell-induced cardiac tissue repair
Q36769987The magic behind stem cells
Q34629634The mouse as a model system to study cardiac regeneration
Q38033889The need for standardized protocols for future clinical trials of cell therapy
Q37839779The origin of interstitial myofibroblasts in chronic kidney disease
Q37567542The possible use of stem cells in regenerative medicine: dream or reality?
Q37988002The regenerative potential of angiotensin AT2 receptor in cardiac repair.
Q34405511The role of stem cells in cardiac regeneration.
Q37067647The role of stem cells in the post-MI patient
Q33278687The stem cell continuum: cell cycle, injury, and phenotype lability
Q36667426The stem cell continuum: considerations on the heterogeneity and plasticity of marrow stem cells
Q35874253The strength of plasticity: stem cells for cardiac repair
Q28247457The stuttering progress of cell therapy for heart disease
Q37053163The therapeutic potential of stem cells in heart disease
Q51167242The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.
Q39580194The use of stem cells for the repair of cardiac tissue in ischemic heart disease
Q36406459The utility of magnetic resonance imaging in cardiac tissue regeneration trials
Q47763374Therapeutic Potential of Hematopoietic Stem Cell-Derived Exosomes in Cardiovascular Disease.
Q37608469Therapeutic angiogenesis for coronary artery disease: clinical trials of proteins, plasmids, adenovirus and stem cells
Q81140463Therapeutic angiogenesis gains a leg to stand on
Q36847077Therapeutic angiogenesis with bone marrow--derived stem cells
Q36909360Therapeutic potential of adult progenitor cells in cardiovascular disease
Q42121480Therapeutic potential of human adipose stem cells in a rat myocardial infarction model
Q28295270Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
Q38013063Thymosin β4 and cardiac regeneration: are we missing a beat?
Q38857237Tissue Engineering Strategies for Myocardial Regeneration: Acellular Versus Cellular Scaffolds?
Q40199212Tissue engineering approaches for the development of a contractile cardiac patch.
Q37788417Tissue regeneration potential in human umbilical cord blood
Q33537670Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling
Q29394460Towards regenerative therapy for cardiac disease
Q37946759Towards the generation of patient-specific patches for cardiac repair.
Q84570135Transcoronary bone marrow-derived progenitor cells in a child with myocardial infarction: first pediatric experience
Q40334464Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation
Q38267322Transcutaneous measurement of glomerular filtration rate in small rodents: through the skin for the win?
Q26860340Translating stem cell research to cardiac disease therapies: pitfalls and prospects for improvement
Q35995055Translational aspects of cardiac cell therapy
Q52729630Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types.
Q42379231Transplantation of Isl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function.
Q81228975Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study
Q42824750Transplantation of microencapsulated cells expressing VEGF improves angiogenesis in implanted xenogeneic acellular dermis on wound
Q34702508Transplantation of microencapsulated genetically modified xenogeneic cells augments angiogenesis and improves heart function
Q46097112Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction
Q37625948Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle.
Q50747193Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure.
Q64243699Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility
Q59091693US government halts heart stem-cell study
Q87297024Ultrasound targeted microbubble destruction promotes angiogenesis and heart function by inducing myocardial microenvironment change
Q36438947Ultrastructural evidence of exosome secretion by progenitor cells in adult mouse myocardium and adult human cardiospheres
Q61479658Umbilical Cord Blood-Derived Stem Cells Spontaneously Express Cardiomyogenic Traits
Q83220060Umbilical cord blood cell transplantation for myocardial regeneration
Q50664911Umbilical cord blood-derived progenitor cells enhance muscle regeneration in mouse hindlimb ischemia model.
Q36804511Umbilical cord-derived stem cells for tissue therapy: current and future uses
Q33683767Unchain my heart: the scientific foundations of cardiac repair
Q57823657Undeniable Evidence That the Adult Mammalian Heart Lacks an Endogenous Regenerative Stem Cell
Q36126866Update on the use of stem cells for cardiac disease
Q39926156Use of ferumoxides for stem cell labeling
Q53486196Uterine cells-an immunoprivileged cell source for therapy-but are they for everyone?
Q45127736Vascular endothelial growth factor stimulates skeletal muscle regeneration in vivo
Q35215645Very small embryonic-like (VSEL) stem cells in adult organs and their potential role in rejuvenation of tissues and longevity
Q37155637Very small embryonic-like (VSEL) stem cells: purification from adult organs, characterization, and biological significance
Q37824871Very small embryonic-like stem cells: biology and therapeutic potential for heart repair
Q83144947[Embryonic stem cells. Future perspectives]
Q53608261[Future perspectives in the treatment of heart failure: from cell transplantation to cardiac regeneration].
Q80260743[Investigation in stem cells]
Q81567481[Regenerative medicine with adult stem cells]
Q82930966[Stem cell therapy for the regeneration of heart muscle]
Q84563741[Surgical intramyocardial stem cell therapy for chronic ischemic heart failure]
Q36484631beta(1)- and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: comparison with failing and non-failing adult human heart
Q34004496c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes.
Q46798182c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair.
Q38313140c-kit(+) cells: the tell-tale heart of cardiac regeneration?
Q34021586c-kit+ cells minimally contribute cardiomyocytes to the heart
Q36170830c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart
Q27315833c-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling
Q41950391mRNA-mediated gene delivery into human progenitor cells promotes highly efficient protein expression.
Q34013292p27 kip1 haplo-insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK activation

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