Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins

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Proteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins is …
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P356DOI10.3389/FMICB.2018.02738
P932PMC publication ID6262318
P698PubMed publication ID30524389

P50authorAkhil Chandra BanerjeaQ44593096
P2093author name stringSneh Lata
Ritu Mishra
P2860cites workHIV-1 Vpr protein directly loads helicase-like transcription factor (HLTF) onto the CRL4-DCAF1 E3 ubiquitin ligase.Q47592848
Reassessment of the capacity of the HIV-1 Env cytoplasmic domain to trigger NF-κB activation.Q49900491
p14ARF is capable of promoting HIV-1 tat degradation.Q53483321
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5.Q53637010
Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.Q54649040
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
The endogenous Mus81-Eme1 complex resolves Holliday junctions by a nick and counternick mechanismQ79120277
Intrinsic disorder and function of the HIV-1 Tat proteinQ84182175
ISG15 in antiviral immunity and beyondQ88701533
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradationQ21089617
Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting stepsQ21131559
Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particlesQ21559507
Manipulation of dendritic cell function by virusesQ21710678
HIV-1 induced bystander apoptosisQ22241221
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 buddingQ24291784
The Protein Network of HIV BuddingQ24294993
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteinsQ24296475
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus buddingQ24299705
T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restrictionQ24300389
Identification of host proteins required for HIV infection through a functional genomic screenQ24306298
Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomainQ24306855
Modulation of HIV-1 Rev protein abundance and activity by polyubiquitination with unconventional Lys-33 branchingQ24309503
Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensingQ24318920
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by NefQ24338889
Ubiquitin is covalently attached to the p6Gag proteins of human immunodeficiency virus type 1 and simian immunodeficiency virus and to the p12Gag protein of Moloney murine leukemia virusQ24523226
Interaction of the human immunodeficiency virus type 1 Vpr protein with the nuclear pore complex.Q24523667
Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylasesQ24530147
Analysis of human immunodeficiency virus type 1 Gag ubiquitinationQ24531968
The trans-Golgi network-associated human ubiquitin-protein ligase POSH is essential for HIV type 1 productionQ24557498
Myristoylation-dependent replication and assembly of human immunodeficiency virus 1Q24559906
Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle releaseQ24563651
The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cellsQ24564509
Memory and the NMDA receptorsQ24603015
Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1Q24609814
ESCRT-III protein requirements for HIV-1 buddingQ24627115
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag)Q24633537
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradationQ24643067
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanismQ24644811
Human immunodeficiency virus vpr product is a virion-associated regulatory proteinQ24649600
DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrestQ24671784
Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycleQ24680705
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1Q24681112
Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrateQ24683820
Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activityQ24685633
The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycleQ24685965
Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAVQ27649242
Structural Basis of HIV-1 Activation by NF-κB—A Higher-Order Complex of p50:RelA Bound to the HIV-1 LTRQ27657031
The DDB1-DCAF1-Vpr-UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destructionQ27727807
Proteasomes can degrade a significant proportion of cellular proteins independent of ubiquitinationQ27932737
A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoterQ28190014
CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoformsQ28191684
AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus BuddingQ28204548
HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egressQ28207991
Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF ComplexQ28210666
20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1Q28238115
Complete nucleotide sequence of the AIDS virus, HTLV-IIIQ28259080
Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complexQ28270521
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motifQ28276184
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNAQ28279502
A genomic and functional inventory of deubiquitinating enzymesQ28284911
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNAQ28286261
Nucleotide sequence of the AIDS virus, LAVQ28286313
Polyubiquitin chains: polymeric protein signalsQ28294396
A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73Q28305429
HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activationQ28306470
Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesQ28477489
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene productQ29615049
PDZ domain proteins of synapsesQ29616399
Histone ubiquitination: triggering gene activityQ29617523
Control of RNA initiation and elongation at the HIV-1 promoterQ29620157
Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.Q30379978
HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membraneQ30815492
HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligaseQ33290831
Proteasomal degradation of TRIM5alpha during retrovirus restrictionQ33337129
Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal traffickingQ33455505
Host cell factors in HIV replication: meta-analysis of genome-wide studiesQ33455551
Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase MachineryQ33567848
HIV-1 Tat regulates cyclin B1 by promoting both expression and degradationQ33613221
Biochemical and functional interactions between HIV-1 Tat protein and TAR RNA.Q33635863
Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.Q33700568
Characterization of E3 ligases involved in lysosomal sorting of the HIV-1 restriction factor BST2.Q33743176
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathwayQ33782459
The human immunodeficiency virus rev protein is a nuclear phosphoproteinQ34534125
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeatQ34563887
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptorQ34647751
Requirements for the selective degradation of CD4 receptor molecules by the human immunodeficiency virus type 1 Vpu protein in the endoplasmic reticulum.Q34701164
Lysine 144, a ubiquitin attachment site in HIV-1 Nef, is required for Nef-mediated CD4 down-regulationQ34784600
Tight regulation of unstructured proteins: from transcript synthesis to protein degradationQ34890013
HIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.Q35015138
ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteractionQ35579416
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.Q35665886
Interferon targeted genes in host defenseQ35675514
Serine Phosphorylation of HIV-1 Vpu and Its Binding to Tetherin Regulates Interaction with Clathrin AdaptorsQ35758867
The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradationQ35776289
HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest.Q35837172
Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.Q35890940
HIV-1 Vpu utilizes both cullin-RING ligase (CRL) dependent and independent mechanisms to downmodulate host proteinsQ35895988
Ubiquitination of BST-2 protein by HIV-1 Vpu protein does not require lysine, serine, or threonine residues within the BST-2 cytoplasmic domainQ35922462
Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugsQ36168643
PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic densityQ36394413
Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophagesQ36400526
HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitinationQ36436143
Multiple NF-κB sites in HIV-1 subtype C long terminal repeat confer superior magnitude of transcription and thereby the enhanced viral predominanceQ36492916
HIV-1 pathogenesis: the virusQ36526530
The ubiquitin-proteasome pathway in viral infectionsQ36538328
Host restriction factors in retroviral infection: promises in virus-host interactionQ36548179
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.Q36633274
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cellsQ36651389
Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytesQ36685112
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4Q36687143
APOBEC3G is degraded by the proteasomal pathway in a Vif-dependent manner without being polyubiquitylatedQ36726563
Deubiquitination in virus infectionQ36732782
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminusQ36793300
Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu proteinQ36830393
HIV-1 Tat mediates degradation of RON receptor tyrosine kinase, a regulator of inflammationQ36877203
Inhibition of β-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cellsQ39552474
Function of ubiquitin (Ub) specific protease 15 (USP15) in HIV-1 replication and viral protein degradation.Q39557790
BIM(EL), an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation.Q39580598
β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 releaseQ39594626
Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G.Q39608648
Polyubiquitination of APOBEC3G is essential for its degradation by HIV-1 Vif.Q39741166
Functions of Linear Ubiquitin Chains in the NF-κB Pathway : Linear Polyubiquitin in NF-κB Signaling.Q39794933
Human immunodeficiency virus type 1 Vpr induces apoptosis following cell cycle arrestQ39880367
ISGylation - a key to lock the cell gates for preventing the spread of threatsQ40079195
Ubiquitination of human immunodeficiency virus type 1 Gag is highly dependent on Gag membrane associationQ40112050
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome systemQ40121880
Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu proteinQ40143694
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcriptionQ40272529
HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stressesQ40400941
Cell cycle arrest in G2/M promotes early steps of infection by human immunodeficiency virusQ40435980
Ubiquitination of APOBEC3G by an HIV-1 Vif-Cullin5-Elongin B-Elongin C complex is essential for Vif functionQ40444285
Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradationQ40485830
Expression of HIV-1 accessory protein Vif is controlled uniquely to be low and optimal by proteasome degradationQ40514892
HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradationQ40551410
The Vif protein of human immunodeficiency virus type 1 is posttranslationally modified by ubiquitinQ40580159
HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly SitesQ40677862
The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.Q40816820
Cooperative interaction between HIV-1 regulatory proteins Tat and Vpr modulates transcription of the viral genomeQ40863490
HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivoQ41071784
HIV-1 Rev downregulates Tat expression and viral replication via modulation of NAD(P)H:quinine oxidoreductase 1 (NQO1).Q41172672
The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathwayQ41748165
Role of interferon-stimulated gene ISG-15 in the interferon-omega-mediated inhibition of human immunodeficiency virus replicationQ44004509
Viruses and the 26S proteasome: hacking into destructionQ44310046
The Vif Protein of HIV Triggers Degradation of the Human Antiretroviral DNA Deaminase APOBEC3GQ44653976
NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP.Q44692715
Human immunodeficiency virus-1 Nef suppresses Hsp70-mediated Tat activationQ45362793
Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins.Q47138132
The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cellsQ33782776
Kinetic analysis of human immunodeficiency virus type 1 assembly reveals the presence of sequential intermediatesQ33806395
The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulationQ33815533
The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding processQ33826592
Regulation of Apobec3F and human immunodeficiency virus type 1 Vif by Vif-Cul5-ElonB/C E3 ubiquitin ligaseQ33908716
Ubiquitin in chainsQ33925675
Gag proteins of the highly replicative MN strain of human immunodeficiency virus type 1: posttranslational modifications, proteolytic processings, and complete amino acid sequencesQ33930053
Degradation of oxidized proteins by the 20S proteasome.Q33941917
Taking a bite: proteasomal protein processingQ33958918
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.Q33962101
p53 proteasomal degradation: poly-ubiquitination is not the whole storyQ33989179
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.Q33991996
20S proteasomes and protein degradation "by default".Q33998904
HIV-1 Vpr redirects host ubiquitination pathwayQ34059218
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasmQ34060474
Ubiquitin in retrovirus assembly: actor or bystander?Q34087687
The nuclear factor NF-kappaB pathway in inflammationQ34114512
HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradationQ34140089
Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu.Q34146128
Identification and characterization of the human mus81-eme1 endonucleaseQ34193657
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infectionQ34242229
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseQ34288376
Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal regionQ34363381
Human immunodeficiency virus type 1 Vif is efficiently packaged into virions during productive but not chronic infectionQ34465108
The gag gene products of human immunodeficiency virus type 1: alignment within the gag open reading frame, identification of posttranslational modifications, and evidence for alternative gag precursorsQ36881276
HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophagesQ36904912
Curcumin inhibits HIV-1 by promoting Tat protein degradationQ36990763
Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradationQ37010047
MDM2 is a novel E3 ligase for HIV-1 Vif.Q37069041
Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletionQ37115275
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 buddingQ37116827
The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infectionQ37126033
A crescent-shaped ALIX dimer targets ESCRT-III CHMP4 filaments.Q37235659
HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal DegradationQ37371813
HIV accessory proteins versus host restriction factorsQ37375080
The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction FactorQ37415400
CD4 and BST-2/tetherin proteins retro-translocate from endoplasmic reticulum to cytosol as partially folded and multimeric moleculesQ37428581
NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A-Ubiquitin Ligase Signaling Pathway.Q37504979
HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanismQ37529530
Antiviral activity of innate immune protein ISG15.Q37579660
Cellular & molecular basis of HIV-associated neuropathogenesis.Q37582716
Immune regulator ABIN1 suppresses HIV-1 transcription by negatively regulating the ubiquitination of Tat.Q37638282
Host factors mediating HIV-1 replicationQ37922877
The antiviral activities of ISG15.Q38149665
HIV-1 Vpr Protein Induces Proteasomal Degradation of Chromatin-associated Class I HDACs to Overcome Latent Infection of Macrophages.Q38265455
Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev.Q38332969
Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.Q38626145
HIV-1 Tat potently stabilises Mdm2 and enhances viral replicationQ38705008
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat proteinQ38712887
HIV-1 Vpu Downmodulates ICAM-1 Expression, Resulting in Decreased Killing of Infected CD4+ T Cells by NK CellsQ38718438
Core Binding Factor β Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated DegradationQ38739726
SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).Q38761101
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaksQ38774142
G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.Q38947343
The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.Q39155657
LC3C Contributes to Vpu-Mediated Antagonism of BST2/Tetherin Restriction on HIV-1 Release through a Non-canonical Autophagy Pathway.Q39158488
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.Q39315034
Structure and Function of Viral Deubiquitinating Enzymes.Q39381317
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)2738
P577publication date2018-01-01
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleProteasomal Degradation Machinery: Favorite Target of HIV-1 Proteins
P478volume9

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cites work (P2860)
Q89985542Dengue NS5 modulates expression of miR-590 to regulate ubiquitin-specific peptidase 42 in human microglia
Q98733271Dengue Virus Degrades USP33-ATF3 Axis via Extracellular Vesicles to Activate Human Microglial Cells

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