| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/S41579-018-0020-5 |
| P698 | PubMed publication ID | 29769653 |
| P50 | author | Deborah J. Lenschow | Q85543822 |
| P2093 | author name string | Yi-Chieh Perng | |
| P2860 | cites work | Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency | Q24294718 |
| E1-L2 activates both ubiquitin and FAT10 | Q24294748 | ||
| Negative regulation of protein phosphatase 2Cbeta by ISG15 conjugation | Q24298148 | ||
| Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15 | Q24301430 | ||
| Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme | Q24301649 | ||
| Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification | Q24304218 | ||
| ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity | Q24318462 | ||
| ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway | Q24318890 | ||
| IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage | Q24337202 | ||
| UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity | Q24337310 | ||
| Interferon regulatory factor 3 and CREB-binding protein/p300 are subunits of double-stranded RNA-activated transcription factor DRAF1. | Q24522348 | ||
| Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways | Q24531725 | ||
| Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein | Q24536345 | ||
| Identification of interferon-stimulated gene 15 as an antiviral molecule during Sindbis virus infection in vivo | Q24537289 | ||
| Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I | Q24556673 | ||
| The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein | Q24562149 | ||
| Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation | Q24563471 | ||
| Systematic and quantitative assessment of the ubiquitin-modified proteome | Q24634631 | ||
| ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response | Q24648592 | ||
| Protein ISGylation modulates the JAK-STAT signaling pathway | Q24672739 | ||
| Negative regulation of ISG15 E3 ligase EFP through its autoISGylation | Q24677656 | ||
| ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP | Q24681258 | ||
| ISG15 counteracts Listeria monocytogenes infection | Q35933408 | ||
| Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness. | Q35989977 | ||
| Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes | Q36018543 | ||
| Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis | Q36019386 | ||
| Chemosensitivity is controlled by p63 modification with ubiquitin-like protein ISG15. | Q36068315 | ||
| Biochemical and Structural Insights into the Preference of Nairoviral DeISGylases for Interferon-Stimulated Gene Product 15 Originating from Certain Species | Q36076825 | ||
| Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators | Q36114328 | ||
| Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation | Q36424059 | ||
| ISG15 deficiency and increased viral resistance in humans but not mice | Q27317417 | ||
| Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease | Q27683898 | ||
| UBP43 (USP18) specifically removes ISG15 from conjugated proteins | Q27863712 | ||
| High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction | Q27863761 | ||
| ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. | Q27863896 | ||
| Proteomic identification of proteins conjugated to ISG15 in mouse and human cells | Q27863897 | ||
| The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase | Q27863905 | ||
| Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells | Q27863910 | ||
| HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets | Q27863927 | ||
| ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus | Q27865223 | ||
| ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells | Q27865244 | ||
| Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein | Q27865245 | ||
| Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein | Q27865248 | ||
| Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling | Q28504645 | ||
| IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses | Q28507005 | ||
| Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication. | Q28609759 | ||
| Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport | Q28609810 | ||
| Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs | Q28609836 | ||
| ISG15: a ubiquitin-like enigma | Q28612249 | ||
| Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays | Q28646554 | ||
| The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme | Q28768791 | ||
| Zika virus infects cells lining the blood-retinal barrier and causes chorioretinal atrophy in mouse eyes | Q29365715 | ||
| Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling | Q29614206 | ||
| An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis | Q29618105 | ||
| Protein Interferon-Stimulated Gene 15 Conjugation Delays but Does Not Overcome Coronavirus Proliferation in a Model of Fulminant Hepatitis | Q30049307 | ||
| Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome | Q30090228 | ||
| A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other Etiologies. | Q30250910 | ||
| Herpes Simplex Virus and Interferon Signaling Induce Novel Autophagic Clusters in Sensory Neurons | Q30744548 | ||
| ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins. | Q30829791 | ||
| Vaccinia virus E3 protein prevents the antiviral action of ISG15 | Q33349449 | ||
| Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication. | Q33588390 | ||
| Immunoregulatory properties of ISG15, an interferon-induced cytokine | Q33610088 | ||
| Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins | Q33706912 | ||
| ISG15 in Host Defense Against Candida albicans Infection in a Mouse Model of Fungal Keratitis | Q33792940 | ||
| Nedd4 regulates egress of Ebola virus-like particles from host cells | Q36464448 | ||
| ISG15 Is Upregulated in Respiratory Syncytial Virus Infection and Reduces Virus Growth through Protein ISGylation. | Q36694038 | ||
| Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity | Q36757129 | ||
| Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease | Q36923194 | ||
| UBE1L causes lung cancer growth suppression by targeting cyclin D1. | Q37089020 | ||
| Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification | Q37201724 | ||
| Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes | Q37206449 | ||
| Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin | Q37224705 | ||
| Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins | Q37261013 | ||
| ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding | Q37300449 | ||
| Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus | Q37565034 | ||
| Exosomes contribute to the transmission of anti-HIV activity from TLR3-activated brain microvascular endothelial cells to macrophages | Q37643710 | ||
| The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference | Q37712257 | ||
| Interferon-stimulated gene 15 and the protein ISGylation system | Q37824472 | ||
| The antiviral activities of ISG15. | Q38149665 | ||
| The Type I IFN response to infection with Mycobacterium tuberculosis requires ESX-1-mediated secretion and contributes to pathogenesis | Q38304495 | ||
| MERS-CoV papain-like protease has deISGylating and deubiquitinating activities | Q38315802 | ||
| Glycoprotein 90K, downregulated in advanced colorectal cancer tissues, interacts with CD9/CD82 and suppresses the Wnt/beta-catenin signal via ISGylation of beta-catenin | Q38342968 | ||
| Restriction of Human Cytomegalovirus Replication by ISG15, a Host Effector Regulated by cGAS-STING Double-Stranded-DNA Sensing | Q38716285 | ||
| STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling. | Q38717767 | ||
| Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18. | Q38739880 | ||
| Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. | Q38801652 | ||
| Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. | Q38868287 | ||
| UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells | Q38967400 | ||
| Structural basis of the specificity of USP18 toward ISG15. | Q38976984 | ||
| ISG15 functions as an interferon-mediated antiviral effector early in the murine norovirus life cycle | Q38988141 | ||
| Interferon-mediated ISG15 conjugation restricts dengue virus 2 replication | Q39001034 | ||
| ISG15: In Sickness and in Health | Q39020195 | ||
| The impact of ISGylation during Mycobacterium tuberculosis infection in mice. | Q39021236 | ||
| Disease tolerance and immunity in host protection against infection | Q39065203 | ||
| ISG15 facilitates cellular antiviral response to dengue and west nile virus infection in vitro | Q39085625 | ||
| A negative feedback of the HIF-1α pathway via interferon-stimulated gene 15 and ISGylation | Q39093186 | ||
| Interferon-Stimulated Gene 15 Conjugation Stimulates Hepatitis B Virus Production Independent of Type I Interferon Signaling Pathway In Vitro. | Q39170332 | ||
| Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation | Q39228289 | ||
| Beyond ISGlylation: Functions of Free Intracellular and Extracellular ISG15. | Q39280448 | ||
| Influenza A virus NS1 protein prevents activation of NF-kappaB and induction of alpha/beta interferon | Q39593618 | ||
| ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment | Q39784912 | ||
| Modulation of alpha interferon anti-hepatitis C virus activity by ISG15. | Q39816395 | ||
| The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response. | Q39855775 | ||
| Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species. | Q40229759 | ||
| Retinoic acid-induced protein ISGylation is dependent on interferon signal transduction | Q40285814 | ||
| Camptothecin induces the ubiquitin-like protein, ISG15, and enhances ISG15 conjugation in response to interferon. | Q40463160 | ||
| Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway | Q40556308 | ||
| Proteasomes modulate conjugation to the ubiquitin-like protein, ISG15. | Q40690946 | ||
| Reexamination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43-deficient mice | Q40701351 | ||
| Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3. | Q40749748 | ||
| Characterization of specific DNA-binding factors activated by double-stranded RNA as positive regulators of interferon alpha/beta-stimulated genes | Q41283879 | ||
| The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection | Q41454651 | ||
| Direct induction of interferon-gamma- and interferon-alpha/beta-inducible genes by double-stranded RNA. | Q41681306 | ||
| Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection. | Q41881005 | ||
| Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection | Q41893512 | ||
| ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection | Q41908871 | ||
| Isg15 controls p53 stability and functions. | Q41980692 | ||
| Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy | Q42197083 | ||
| The Mechanism of Budding of Retroviruses From Cell Membranes | Q42593601 | ||
| Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63 | Q42737885 | ||
| Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. | Q42749928 | ||
| mHERC6 is the essential ISG15 E3 ligase in the murine system | Q42802538 | ||
| Inhibition of hepatitis C virus replication by IFN-mediated ISGylation of HCV-NS5A. | Q42920114 | ||
| ISG15 governs mitochondrial function in macrophages following vaccinia virus infection. | Q43294926 | ||
| Identification of a ubiquitin family protein as a novel neutrophil chemotactic factor | Q44577790 | ||
| Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis. | Q45345094 | ||
| Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway | Q46828227 | ||
| LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation. | Q47210749 | ||
| Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor | Q47444950 | ||
| Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis B. | Q47589759 | ||
| Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulating type I IFN signaling. | Q50089068 | ||
| Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator. | Q51442060 | ||
| Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. | Q53350223 | ||
| A human 15-kDa IFN-induced protein induces the secretion of IFN-gamma | Q67701306 | ||
| Interferon-induced proteins. Purification and characterization of a 15,000-dalton protein from human and bovine cells induced by interferon | Q70675872 | ||
| Precursor processing of pro-ISG15/UCRP, an interferon-beta-induced ubiquitin-like protein | Q78151565 | ||
| The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation | Q80500093 | ||
| Properties of the ISG15 E1 enzyme UbE1L | Q81453919 | ||
| Crystal structure of the interferon-induced ubiquitin-like protein ISG15 | Q81786381 | ||
| Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population | Q33815694 | ||
| The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process | Q33826592 | ||
| Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. | Q33826676 | ||
| The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15. | Q33919690 | ||
| ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation | Q34058142 | ||
| Human rhinovirus-induced ISG15 selectively modulates epithelial antiviral immunity | Q34064995 | ||
| IFN-induced 15-kDa protein is released from human lymphocytes and monocytes | Q34091306 | ||
| Interferon stimulated gene 15 constitutively produced by melanoma cells induces e-cadherin expression on human dendritic cells. | Q34133693 | ||
| HERC6 is the main E3 ligase for global ISG15 conjugation in mouse cells | Q34137392 | ||
| Molecular characterization of the interferon-induced 15-kDa protein. Molecular cloning and nucleotide and amino acid sequence | Q34165574 | ||
| The interferon-inducible 15-kDa ubiquitin homolog conjugates to intracellular proteins | Q34248463 | ||
| A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses | Q34261516 | ||
| Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia | Q34300055 | ||
| Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15. | Q34335062 | ||
| The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase | Q34345166 | ||
| Conjugation of the 15-kDa interferon-induced ubiquitin homolog is distinct from that of ubiquitin | Q34370290 | ||
| Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin | Q34396930 | ||
| In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. | Q34404800 | ||
| Interferon-stimulated genes: a complex web of host defenses | Q34405609 | ||
| Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance | Q34458906 | ||
| UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation | Q34590516 | ||
| Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus | Q34593578 | ||
| The human cytomegalovirus UL26 protein antagonizes NF-κB activation | Q34594875 | ||
| Ovarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses | Q34725292 | ||
| Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics | Q34984025 | ||
| Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice | Q34992604 | ||
| Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation | Q35002436 | ||
| Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. | Q35121255 | ||
| The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages | Q35543082 | ||
| SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme | Q35660049 | ||
| Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs | Q35837862 | ||
| Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon | Q35852773 | ||
| Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-alpha /beta | Q35894501 | ||
| Identification and characterization of a novel ISG15-ubiquitin mixed chain and its role in regulating protein homeostasis | Q35903273 | ||
| P433 | issue | 7 | |
| P304 | page(s) | 423-439 | |
| P577 | publication date | 2018-07-01 | |
| P1433 | published in | Nature Reviews Microbiology | Q1071797 |
| P1476 | title | ISG15 in antiviral immunity and beyond | |
| P478 | volume | 16 |
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