Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

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Tight regulation of unstructured proteins: from transcript synthesis to protein degradation is …
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scholarly articleQ13442814

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P819ADS bibcode2008Sci...322.1365G
P356DOI10.1126/SCIENCE.1163581
P932PMC publication ID2803065
P698PubMed publication ID19039133
P5875ResearchGate publication ID23502903

P50authorMatthias FutschikQ37376165
Mohan Madan BabuQ56084741
Sarah TeichmannQ19501099
P2093author name stringJörg Gsponer
P2860cites workUbiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathwayQ40115992
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activityQ42512304
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasomeQ43816254
Proteasomal degradation of tau proteinQ44163168
Coupled folding and binding with alpha-helix-forming molecular recognition elementsQ48122045
Cell cycle-dependent caspase-like activity that cleaves p27KIP1 is the β1 subunit of the 20S proteasomeQ61043686
Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of LifeQ22061741
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinasesQ24294546
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2Q24294568
Protein misfolding, functional amyloid, and human diseaseQ28131732
Adapting proteostasis for disease interventionQ28131818
Intrinsically disordered proteinQ28191444
Alpha-synuclein and neurodegenerative diseasesQ28204386
Intrinsic disorder in cell-signaling and cancer-associated proteinsQ28207698
TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancerQ28256844
Divorcing ARF and p53: an unsettled caseQ28258356
NF-kappaB dictates the degradation pathway of IkappaBalphaQ28588231
The importance of intrinsic disorder for protein phosphorylationQ28776125
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversityQ28910326
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigmQ29615865
Control of stochasticity in eukaryotic gene expressionQ29615955
The interplay between structure and function in intrinsically unstructured proteins.Q30350853
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteinsQ33262919
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.Q33292483
20S proteasomes and protein degradation "by default".Q33998904
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapyQ34763495
Oncogenic re-wiring of cellular signaling pathwaysQ36745360
Intrinsic disorder in transcription factorsQ36882145
P433issue5906
P407language of work or nameEnglishQ1860
P304page(s)1365-1368
P577publication date2008-11-01
P1433published inScienceQ192864
P1476titleTight regulation of unstructured proteins: from transcript synthesis to protein degradation
P478volume322

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