Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

scientific article (publication date: 22 October 1999)

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1006/JMBI.1999.3110
P3181OpenCitations bibliographic resource ID878078
P698PubMed publication ID10550212
P5875ResearchGate publication ID12751097

P2093author name stringWright PE
Dyson HJ
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectprotein structureQ735188
P304page(s)321-31
P577publication date1999-10-22
P1433published inJournal of Molecular BiologyQ925779
P1476titleIntrinsically unstructured proteins: re-assessing the protein structure-function paradigm
P478volume293

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Q42847536Energetic rationale for an unexpected and abrupt reversal of guanidinium chloride-induced unfolding of peptide deformylase
Q45285817Energetics of structural transitions of the addiction antitoxin MazE: is a programmed bacterial cell death dependent on the intrinsically flexible nature of the antitoxins?
Q22061727Energy landscape of a peptide consisting of alpha-helix, 3(10)-helix, beta-turn, beta-hairpin, and other disordered conformations
Q28509483Engineering of metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1
Q47807596Enhanced Sampling of Intrinsic Structural Heterogeneity of the BH3-Only Protein Binding Interface of Bcl-xL.
Q38475866Enhanced and effective conformational sampling of protein molecular systems for their free energy landscapes
Q26747086Enhanced conformational sampling to visualize a free-energy landscape of protein complex formation
Q46348230Enhancer of rudimentary homologue interacts with scaffold attachment factor B at the nuclear matrix to regulate SR protein phosphorylation.
Q46166238Ensemble characterization of an intrinsically disordered FG-Nup peptide and its F>A mutant in DMSO-d6.
Q30010207Ensemble modeling of protein disordered states: experimental restraint contributions and validation
Q28087125Entropic clocks in the service of electrical signaling: 'Ball and chain' mechanisms for ion channel inactivation and clustering
Q90639936Epitope Mapping and Fine Specificity of Human T and B Cell Responses for Novel Candidate Blood-Stage Malaria Vaccine P27A
Q44210367Equilibrium unfolding and conformational plasticity of troponin I and T.
Q39005050Erythropoietin and co.: intrinsic structure and functional disorder
Q33908831Essential amino acids of the hantaan virus N protein in its interaction with RNA.
Q30976509Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins
Q30392517Estimation of Position Specific Energy as a Feature of Protein Residues from Sequence Alone for Structural Classification
Q29048164Evaluation of disorder predictions in CASP9
Q39006906Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates
Q38826569Evidence for a Strong Correlation Between Transcription Factor Protein Disorder and Organismic Complexity.
Q47362690Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.
Q33479542Evidence for the concerted evolution between short linear protein motifs and their flanking regions
Q35037936Evolution and disorder
Q58697064Evolution of In Silico Strategies for Protein-Protein Interaction Drug Discovery
Q36627901Evolution of disorder in Mediator complex and its functional relevance
Q36111480Evolution of the Twist Subfamily Vertebrate Proteins: Discovery of a Signature Motif and Origin of the Twist1 Glycine-Rich Motifs in the Amino-Terminus Disordered Domain.
Q36254589Evolutionarily Conserved Sequence Features Regulate the Formation of the FG Network at the Center of the Nuclear Pore Complex
Q51099642Evolutionarily conserved and conformationally constrained short peptides might serve as DNA recognition elements in intrinsically disordered regions.
Q90593521Evolutionary Analysis of the Lysine-Rich N-terminal Cytoplasmic Domains of the Gastric H+,K+-ATPase and the Na+,K+-ATPase
Q61807386Evolutionary Features in the Structure and Function of Bacterial Toxins
Q35492670Evolutionary and structural annotation of disease-associated mutations in human aminoacyl-tRNA synthetases
Q91933571Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome
Q42211815Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life
Q57976405Exclusively Heteronuclear13C-Detected Amino-Acid-Selective NMR Experiments for the Study of Intrinsically Disordered Proteins (IDPs)
Q57796342Expanded Interactome of the Intrinsically Disordered Protein Dss1
Q30384195Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum
Q34197530Expanding the proteome: disordered and alternatively folded proteins
Q52310580Exploration of nucleoprotein α-MoRE and XD interactions of Nipah and Hendra viruses.
Q46759832Exploring CP12 binding proteins revealed aldolase as a new partner for the phosphoribulokinase/glyceraldehyde 3-phosphate dehydrogenase/CP12 complex--purification and kinetic characterization of this enzyme from Chlamydomonas reinhardtii
Q38706805Exploring Short Linear Motifs Using the ELM Database and Tools.
Q88538166Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii
Q41220497Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding
Q37612363Exploring the dark foldable proteome by considering hydrophobic amino acids topology.
Q41359500Exploring the sequence-structure-function relationship for the intrinsically disordered βγ-crystallin Hahellin
Q43107662Exploring tryptophan dynamics in acid-induced molten globule state of bovine alpha-lactalbumin: a wavelength-selective fluorescence approach
Q33437376Expression, Purification, and Characterization of Interleukin-11 Orthologues.
Q34412809Extended binding site on fibronectin for the functional upstream domain of protein F1 of Streptococcus pyogenes.
Q28208096Extended disordered proteins: targeting function with less scaffold
Q38779757Extracting structural information from charge-state distributions of intrinsically disordered proteins by non-denaturing electrospray-ionization mass spectrometry
Q34804941Extraordinarily slow binding of guanosine to the Tetrahymena group I ribozyme: implications for RNA preorganization and function
Q64098998Extreme Fuzziness: Direct Interactions between Two IDPs
Q57444244FAT: a novel domain in PIK-related kinases
Q27316103FFPred 3: feature-based function prediction for all Gene Ontology domains
Q89545394FTIP: An Accurate and Efficient Method for Global Protein Surface Comparison
Q35622155Fairy "tails": flexibility and function of intrinsically disordered extensions in the photosynthetic world
Q33276249False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Q37312800Finding Our Way in the Dark Proteome
Q45326386First experimental assessment of protein intrinsic disorder involvement in an RNA virus natural adaptive process
Q37171908Five and four dimensional experiments for robust backbone resonance assignment of large intrinsically disordered proteins: application to Tau3x protein
Q36501662Flexibility and small pockets at protein-protein interfaces: New insights into druggability.
Q64883675Flexibility of the "rigid" classics or rugged bottom of the folding funnels of myoglobin, lysozyme, RNase A, chymotrypsin, cytochrome c, and carboxypeptidase A1.
Q47675885Flexibility vs Preorganization: Direct Comparison of Binding Kinetics for a Disordered Peptide and Its Exact Preorganized Analogues.
Q92609993Flexible loop and helix 2 domains of TCTP are the functional domains of dimerized TCTP
Q30351593Flexible nets. The roles of intrinsic disorder in protein interaction networks.
Q24797048Flexible peptides and cytoplasmic gels
Q36833903FlgM proteins from different bacteria exhibit different structural characteristics
Q34019126Flipping the switch: the structural basis for signaling through the CRIB motif
Q30393337Fluctuations of backbone torsion angles obtained from NMR-determined structures and their prediction
Q34321761Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'.
Q33929677Folding and signaling share the same pathway in a photoreceptor
Q30377510Folding by numbers: primary sequence statistics and their use in studying protein folding
Q79086585Folding for binding or binding for folding?
Q73327910Folding minimal sequences: the lower bound for sequence complexity of globular proteins
Q36132363Folding of Intrinsically Disordered Protein Phosphatase 1 Regulatory Proteins
Q28361570Folding units in calcium vector protein of amphioxus: Structural and functional properties of its amino- and carboxy-terminal halves
Q74575210Formation and implications of a ternary complex of profilin, thymosin beta 4, and actin
Q37863858FrankSum: new feature selection method for protein function prediction
Q87135307Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics
Q90683085Free-energy landscape of molecular interactions between endothelin 1 and human endothelin type B receptor: fly-casting mechanism
Q46522186From Fuzzy to Function: The New Frontier of Protein-Protein Interactions
Q49935761From a highly-disordered to a metastable state: Uncovering insights of α-synuclein.
Q30482453From genomics to proteomics
Q43459132Frustration-induced protein intrinsic disorder.
Q41104557Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells
Q47276758Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions
Q36101573Functional advantages of dynamic protein disorder
Q30360720Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.
Q36986347Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions
Q30375717Functional aspects of protein flexibility.
Q42061600Functional dissection of an intrinsically disordered protein: understanding the roles of different domains of Knr4 protein in protein-protein interactions
Q30155121Functional fragments of disorder in outer membrane β barrel proteins
Q45732230Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA.
Q24292209Functional organization of the yeast proteome by systematic analysis of protein complexes
Q28085662Functional roles of transiently and intrinsically disordered regions within proteins
Q27655500Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion
Q37173128Functionality and the evolution of marginal stability in proteins: inferences from lattice simulations
Q38659937Functionality of Intrinsic Disorder in Tumor Necrosis Factor-α and its Receptors
Q37373601Functionalization of a nanopore: the nuclear pore complex paradigm
Q22061730Fuzziness: linking regulation to protein dynamics
Q26801450Fuzzy complexes: Specific binding without complete folding
Q50922689Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Q40954956GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins.
Q42004836Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods.
Q51723393Generating artificial homologous proteins according to the representative family character in molecular mechanics properties--an attempt in validating an underlying rule of protein evolution.
Q37283552Generation of a flexible loop structural ensemble and its application to induced-fit structural changes following ligand binding
Q45053413Genes encoding intrinsic disorder in Eukaryota have high GC content
Q34353364Genome-scale prediction of proteins with long intrinsically disordered regions
Q92457010Genome-wide identification, expression analysis and functional study of the GRAS gene family in Tartary buckwheat (Fagopyrum tataricum)
Q35467878Genome-wide survey of natural selection on functional, structural, and network properties of polymorphic sites in Saccharomyces paradoxus
Q29615737GlobPlot: Exploring protein sequences for globularity and disorder
Q50598201Globular-disorder transition in proteins: a compromise between hydrophobic and electrostatic interactions?
Q22676705Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Q34221808H-Prune through GSK-3β interaction sustains canonical WNT/β-catenin signaling enhancing cancer progression in NSCLC
Q64992963HIV Vaccine Mystery and Viral Shell Disorder.
Q39215152HIV-1 Tat Binding to PCAF Bromodomain: Structural Determinants from Computational Methods
Q35191557HMGA proteins: flexibility finds a nuclear niche?
Q28201754HMGI/Y proteins: flexible regulators of transcription and chromatin structure
Q36526195Helix formation and the unfolded state of a 52-residue helical protein
Q47163099Hidden α-helical propensity segments within disordered regions of the transcriptional activator CHOP.
Q47215441High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules.
Q57976419High-Resolution Characterization of Intrinsic Disorder in Proteins: Expanding the Suite of 13C-Detected NMR Spectroscopy Experiments to Determine Key Observables
Q54644975High-dimensionality 13C direct-detected NMR experiments for the automatic assignment of intrinsically disordered proteins.
Q41098679High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations
Q30417432High-throughput characterization of intrinsic disorder in proteins from the Protein Structure Initiative
Q33224737Histone structure and nucleosome stability
Q30422597Homepeptide repeats: implications for protein structure, function and evolution
Q36281781Homology modeling and molecular dynamics simulations of lymphotactin
Q85478769How Closely Related Are Conformations of Protein Ions Sampled by IM-MS to Native Solution Structures?
Q52309841How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein?
Q50540318How disorder influences order and vice versa--mutual effects in fusion proteins containing an intrinsically disordered and a globular protein.
Q38944980How disordered is my protein and what is its disorder for? A guide through the "dark side" of the protein universe
Q38732930How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication
Q37951586How random are intrinsically disordered proteins? A small angle scattering perspective
Q35596437How round is a protein? Exploring protein structures for globularity using conformal mapping
Q50559161How to Predict Disorder in a Protein of Interest.
Q37756001Hub promiscuity in protein-protein interaction networks
Q43057992Human full-length Securin is a natively unfolded protein
Q28910375Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation
Q24528120Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol
Q38055634Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins
Q46430110Hydrogen-exchange strategies applied to energetics of intermediate processes in protein folding
Q42237982Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators
Q38494386IDEAL in 2014 illustrates interaction networks composed of intrinsically disordered proteins and their binding partners
Q38426249IDEAL: Intrinsically Disordered proteins with Extensive Annotations and Literature
Q90010481IDPpi: Protein-Protein Interaction Analyses of Human Intrinsically Disordered Proteins
Q47227239IDPs in macromolecular complexes: the roles of multivalent interactions in diverse assemblies.
Q55518742IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding.
Q34989882Identification and functions of usefully disordered proteins
Q41965811Identification of Atg3 as an intrinsically disordered polypeptide yields insights into the molecular dynamics of autophagy-related proteins in yeast
Q28910206Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin
Q38740701Identification of a novel transcript isoform of the TTLL12 gene in human cancers
Q43904668Identification of a substrate recognition site on Ubc9.
Q36640580Identification of intrinsic order and disorder in the DNA repair protein XPA.
Q52411803Identification of protein functions from a molecular surface database, eF-site.
Q79359154Identification of specific functional subdomains within the linker histone H10 C-terminal domain
Q37314442Identification of the copper(II) coordinating residues in the prion protein by metal-catalyzed oxidation mass spectrometry: evidence for multiple isomers at low copper(II) loadings
Q42847528Identification of transient hub proteins and the possible structural basis for their multiple interactions
Q24624622Identification, analysis, and prediction of protein ubiquitination sites
Q40068041Identifying DNA-binding proteins using structural motifs and the electrostatic potential
Q40823789Identifying Similar Patterns of Structural Flexibility in Proteins by Disorder Prediction and Dynamic Programming
Q41633838Identifying intrinsically disordered protein regions likely to undergo binding-induced helical transitions
Q92263182Immunogenicity of a recombinant fusion construct composed of intrinsically unstructured, low polymorphic segments derived from merozoite surface protein 2 and trophozoite exported protein 1
Q38908481Immunogenicity of dimorphic and C-terminal fragments of Plasmodium falciparum MSP2 formulated with different adjuvants in mice
Q41897467Importance of the proline-rich multimerization domain on the oligomerization and nucleic acid binding properties of HIV-1 Vif
Q30332782Improved amino acid flexibility parameters
Q40470834Improved validation of IDP ensembles by one-bond Cα-Hα scalar couplings.
Q35538193Improving protein order-disorder classification using charge-hydropathy plots
Q44567650Improving the chemical shift dispersion of multidimensional NMR spectra of intrinsically disordered proteins
Q41388956In Silico Molecular Characterization of Cysteine Protease YopT from Yersinia pestis by Homology Modeling and Binding Site Identification
Q47355906In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib.
Q50864208In various protein complexes, disordered protomers have large per-residue surface areas and area of protein-, DNA- and RNA-binding interfaces.
Q47246041InSiDDe: A Server for Designing Artificial Disordered Proteins
Q37836386Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
Q33295214Inferring function using patterns of native disorder in proteins
Q90333278Influence of Hyperglycemic Conditions on Self-Association of the Alzheimer's Amyloid β (Aβ1-42) Peptide
Q30380392Influence of sequence changes and environment on intrinsically disordered proteins.
Q36554344Inherent relationships among different biophysical prediction methods for intrinsically disordered proteins
Q34162531Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein
Q34358236Insight into role of selection in the evolution of polyglutamine tracts in humans
Q38375901Insights from the Shell Proteome: Biomineralization to Adaptation
Q26768540Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
Q35899015Insights into Unfolded Proteins from the Intrinsic ϕ/ψ Propensities of the AAXAA Host-Guest Series
Q33443462Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.
Q34989920Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance
Q52053619Integrated graphical analysis of protein sequence features predicted from sequence composition.
Q37073450Integrating folding kinetics and protein function: biphasic kinetics and dual binding specificity in a WW domain
Q41814829Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: a tight complex implying one binding site
Q44881244Interaction of SDS with Na+/K+-ATPase: SDS-solubilized enzyme retains partial structure and function
Q64943644Interactions of Casein and Polypeptides in Multilayer Films Studied by FTIR and Molecular Dynamics.
Q42565088Interactions of TolB with the translocation domain of colicin E9 require an extended TolB box.
Q44137579Interactions of the 18.5-kDa isoform of myelin basic protein with Ca(2+)-calmodulin: in vitro studies using fluorescence microscopy and spectroscopy
Q38005623Interactions via intrinsically disordered regions: what kind of motifs?
Q27650152Interconversion between two unrelated protein folds in the lymphotactin native state
Q47270597Interfacial Properties of NTAIL, an Intrinsically Disordered Protein
Q51412572Interplay between binding affinity and kinetics in protein-protein interactions.
Q34442046Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein
Q37153744Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.
Q37746939Interpretation of biomolecular NMR spin relaxation parameters.
Q38614473Interpreting functional effects of coding variants: challenges in proteome-scale prediction, annotation and assessment
Q35656792Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region
Q46692539Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies
Q55066708Intrinsic Disorder and Posttranslational Modifications: The Darker Side of the Biological Dark Matter.
Q50559158Intrinsic Disorder and Semi-disorder Prediction by SPINE-D.
Q47351608Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.
Q33292127Intrinsic Disorder in Transmembrane Proteins: Roles in Signaling and Topology Prediction
Q92543673Intrinsic Disorder-Based Emergence in Cellular Biology: Physiological and Pathological Liquid-Liquid Phase Transitions in Cells
Q35632957Intrinsic disorder and functional proteomics
Q34201884Intrinsic disorder and protein multibinding in domain, terminal, and linker regions
Q35850129Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins
Q30402803Intrinsic disorder here, there, and everywhere, and nowhere to escape from it.
Q51574262Intrinsic disorder in S100 proteins.
Q37114136Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses
Q37649609Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients
Q28207698Intrinsic disorder in cell-signaling and cancer-associated proteins
Q33417626Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis
Q30395169Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis
Q42210557Intrinsic disorder in putative protein sequences
Q34594105Intrinsic disorder in scaffold proteins: getting more from less
Q30399043Intrinsic disorder in spondins and some of their interacting partners
Q31090109Intrinsic disorder in the Protein Data Bank
Q36882145Intrinsic disorder in transcription factors
Q33252616Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes
Q41077744Intrinsic disorder: signaling via highly specific but short-lived association
Q41678532Intrinsic dynamics of the partly unstructured PX domain from the Sendai virus RNA polymerase cofactor P.
Q34051941Intrinsic protein disorder in human pathways
Q47171932Intrinsic protein disorder reduces small-scale gene duplicability
Q28910370Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2
Q39172489Intrinsically Disordered Regions in Serum Albumin: What Are They For?
Q58061261Intrinsically disordered C-terminal segments of voltage-activated potassium channels: a possible fishing rod-like mechanism for channel binding to scaffold proteins
Q40488052Intrinsically disordered caldesmon binds calmodulin via the "buttons on a string" mechanism
Q28910465Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress
Q28191444Intrinsically disordered protein
Q35228279Intrinsically disordered proteins (IDPs) in trypanosomatids.
Q38007557Intrinsically disordered proteins and novel strategies for drug discovery
Q92697805Intrinsically disordered proteins and structured proteins with intrinsically disordered regions have different functional roles in the cell
Q35135581Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders
Q37600691Intrinsically disordered proteins and their environment: effects of strong denaturants, temperature, pH, counter ions, membranes, binding partners, osmolytes, and macromolecular crowding
Q57908356Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates
Q24631733Intrinsically disordered proteins in a physics-based world
Q35510300Intrinsically disordered proteins in cellular signalling and regulation.
Q57354509Intrinsically disordered proteins in crowded milieu: when chaos prevails within the cellular gumbo
Q47142042Intrinsically disordered proteins in the nucleus of human cells
Q38002804Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery
Q37932415Intrinsically disordered regions as affinity tuners in protein-DNA interactions
Q37528149Intrinsically disordered regions of p53 family are highly diversified in evolution
Q21560973Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations
Q29614784Intrinsically unstructured proteins
Q37893583Intrinsically unstructured proteins and neurodegenerative diseases: conformational promiscuity at its best
Q22061731Intrinsically unstructured proteins and their functions
Q100738796Investigating the trade-off between folding and function in a multidomain Y-family DNA polymerase
Q90079877Investigation into Early Steps of Actin Recognition by the Intrinsically Disordered N-WASP Domain V
Q89982899Investigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1
Q64079382Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins
Q44792787Ion mobility spectrometry focusing on speciation analysis of metals/metalloids bound to carbonic anhydrase.
Q30415349Is a malleable protein necessarily highly dynamic? The hydrophobic core of the nuclear coactivator binding domain is well ordered
Q34989900Is polyproline II a major backbone conformation in unfolded proteins?
Q44040157IsUnstruct: prediction of the residue status to be ordered or disordered in the protein chain by a method based on the Ising model
Q44238564Isolation and characterization of T4 bacteriophage gp17 terminase, a large subunit multimer with enhanced ATPase activity
Q30881310Isolation and characterization of cDNAs expressed in the early stages of flavonol-induced pollen germination in petunia
Q54412578Janus chaperones: assistance of both RNA- and protein-folding by ribosomal proteins.
Q44458262Kinetic modulation of a disordered protein domain by phosphorylation
Q42677967Kinetic studies and structural models of the association of E. coli sigma(70) RNA polymerase with the lambdaP(R) promoter: large scale conformational changes in forming the kinetically significant intermediates
Q33409291Kinetics of contact formation and end-to-end distance distributions of swollen disordered peptides
Q40308402Kinetics of protein-DNA interaction: facilitated target location in sequence-dependent potential
Q37383647Knitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy
Q39096488Knockdown of prothymosin α leads to apoptosis and developmental defects in zebrafish embryos.
Q48251022Large-scale aggregation analysis of eukaryotic proteins reveals an involvement of intrinsically disordered regions in protein folding
Q30393021Large-scale analysis of intrinsic disorder flavors and associated functions in the protein sequence universe
Q37383520Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome
Q33398192Large-scale prediction of long disordered regions in proteins using random forests
Q30353929Length-dependent prediction of protein intrinsic disorder.
Q46151834Leucine-rich hydrophobic clusters promote folding of the N-terminus of the intrinsically disordered transactivation domain of p53.
Q33728497Library of disordered patterns in 3D protein structures.
Q91817045Life in Phases: Intra- and Inter- Molecular Phase Transitions in Protein Solutions
Q37373866Linking folding and binding
Q38619152Liquid-liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau.
Q43480027Long live structural biology
Q37791308Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age.
Q43259863Long-lived conformational isomerism of protein dimers: the role of the free energy of subunit association
Q36694319Looking at the carcinogenicity of human insulin analogues via the intrinsic disorder prism
Q52942751Loopy proteins appear conserved in evolution.
Q28346049Low-complexity regions in Plasmodium falciparum proteins
Q40091428M1 RNA is important for the in-cell solubility of its cognate C5 protein: Implications for RNA-mediated protein folding
Q33597596MARCKS phosphorylation is modulated by a peptide mimetic of MARCKS effector domain leading to increased radiation sensitivity in lung cancer cell lines
Q47313553MFIB: a repository of protein complexes with mutual folding induced by binding.
Q50062976MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth.
Q92663669Macromolecular Interactions of Disordered Proteins
Q47926089Malaria vaccine: why is it taking so long?
Q34066027Malleable machines take shape in eukaryotic transcriptional regulation
Q30430063Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
Q38056343Mass spectrometry methods for intrinsically disordered proteins.
Q33282752Maximum entropy reconstruction of joint phi, psi-distribution with a coil-library prior: the backbone conformation of the peptide hormone motilin in aqueous solution from phi and psi-dependent J-couplings
Q30398335Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain
Q36001147Measuring the Elasticity of Poly-l-Proline Helices with Terahertz Spectroscopy.
Q40210194Mechanism of coupled folding and binding of an intrinsically disordered protein
Q28477146Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP
Q34544246Mechanistic insights into mammalian stress granule dynamics.
Q37110326Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin requires changes in secondary structures
Q34132153Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains
Q44026039Methionine oxidation inhibits fibrillation of human alpha-synuclein in vitro
Q38442694Methods for protein complex prediction and their contributions towards understanding the organisation, function and dynamics of complexes.
Q22061750Micelle-induced folding of spinach thylakoid soluble phosphoprotein of 9 kDa and its functional implications
Q90153550Microsecond Simulation of the Proteoglycan-like Region of Carbonic Anhydrase IX and Design of Chemical Inhibitors Targeting pH Homeostasis in Cancer Cells
Q27313374Microsecond molecular dynamics simulations of intrinsically disordered proteins involved in the oxidative stress response
Q92021476Microstructure and in-depth proteomic analysis of Perna viridis shell
Q54764736Microtubule-associated protein (MAP) 4 interacts with microtubules in an intrinsically disordered manner.
Q34708119Mining alpha-helix-forming molecular recognition features with cross species sequence alignments
Q64268295Misprediction of Structural Disorder in Halophiles
Q34278790MobiDB: a comprehensive database of intrinsic protein disorder annotations.
Q57329073Modeling Protein Folding Pathways
Q30400966Modeling disordered protein interactions from biophysical principles
Q33553759Modular Organization of Residue-Level Contacts Shapes the Selection Pressure on Individual Amino Acid Sites of Ribosomal Proteins
Q30379187Modularity of intrinsic disorder in the human proteome.
Q64087496Modulation of Disordered Proteins with a Focus on Neurodegenerative Diseases and Other Pathologies
Q91663732Modulation of p53 Transactivation Domain Conformations by Ligand Binding and Cancer-Associated Mutations
Q42154324Modulation of the structural integrity of helix F in apomyoglobin by single amino acid replacements
Q36832884Molecular "negativity" may underlie multiple sclerosis: role of the myelin basic protein family in the pathogenesis of MS.
Q36615930Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
Q24301910Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division
Q37200897Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT).
Q34095287Molecular biology of HMGA proteins: hubs of nuclear function
Q53153274Molecular dynamics simulations show altered secondary structure of clawless in binary complex with DNA providing insights into aristaless-clawless-DNA ternary complex formation.
Q34098005Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseases
Q43710118Molecular interactions of the Gbeta binding domain of the Ste20p/PAK family of protein kinases. An isolated but fully functional Gbeta binding domain from Ste20p is only partially folded as shown by heteronuclear NMR spectroscopy.
Q43859311Molecular mechanics of cardiac titin's PEVK and N2B spring elements.
Q45233445Molecular mechanism of multispecific recognition of Calmodulin through conformational changes
Q38453820Molecular recognition features (MoRFs) in three domains of life
Q37746989Molecular simulations of protein disorder
Q35755852Molecular-docking study of malaria drug target enzyme transketolase in Plasmodium falciparum 3D7 portends the novel approach to its treatment
Q35613650Monte Carlo study of substrate-induced folding and refolding of lattice proteins
Q48050089More than just tails: intrinsic disorder in histone proteins
Q37770057Multicolor single-molecule FRET to explore protein folding and binding
Q38077753Multifarious roles of intrinsic disorder in proteins illustrate its broad impact on plant biology
Q34056519Multifunctionality of the linker histones: an emerging role for protein-protein interactions
Q31034789Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations
Q44495415Multiple sclerosis: an important role for post-translational modifications of myelin basic protein in pathogenesis.
Q51958292Multiple time scale dynamics of distance fluctuations in a semiflexible polymer: a one-dimensional generalized Langevin equation treatment.
Q36048325Multiple-Localization and Hub Proteins
Q33737866Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes
Q33966744Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality
Q31149517Mutual induced fit binding of Xenopus ribosomal protein L5 to 5S rRNA.
Q27637572Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
Q37246459Mutual synergistic protein folding in split intein
Q57284426N transverse relaxation measurements for the characterization of µs-ms dynamics are deteriorated by the deuterium isotope effect on N resulting from solvent exchange
Q37488240NMR and EPR studies of membrane transporters
Q91816134NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins
Q24792064NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain
Q30979050NMR relaxation studies on the hydrate layer of intrinsically unstructured proteins
Q46854196NMR spectroscopic studies of intrinsically disordered proteins at near-physiological conditions
Q43623358NMR spin relaxation methods for characterization of disorder and folding in proteins
Q27646493NMR structural analysis of cadmium sensing by winged helix repressor CmtR
Q35207504NORSp: Predictions of long regions without regular secondary structure
Q56993044NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
Q57694316Nanoelectronic detection of breast cancer biomarker
Q36528645Nanoimaging for protein misfolding and related diseases
Q40439451Native globular actin has a thermodynamically unstable quasi-stationary structure with elements of intrinsic disorder
Q30160415Natively unfolded domains in endocytosis: hooks, lines and linkers.
Q39011544Natively unfolded proteins: An overview
Q29616416Natively unfolded proteins: a point where biology waits for physics
Q34665088Natively unstructured regions in proteins identified from contact predictions
Q34534029Natural tri- to hexapeptides self-assemble in water to amyloid beta-type fiber aggregates by unexpected alpha-helical intermediate structures
Q33929602Net charge per residue modulates conformational ensembles of intrinsically disordered proteins
Q90219347Network mapping of the conformational heterogeneity of SOD1 by deploying statistical cluster analysis of FTIR spectra
Q34648491Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
Q46506077New Insight in Copper-Ion Binding to Human Islet Amyloid: The Contribution of Metal-Complex Speciation To Reveal the Polypeptide Toxicity
Q44063793New force field on modeling intrinsically disordered proteins.
Q89849097New technologies to analyse protein function: an intrinsic disorder perspective
Q92659488Nipah shell disorder, modes of infection, and virulence
Q44428923Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers
Q80194726Nm23-H1/NDP kinase folding intermediates and cancer: a hypothesis
Q58062013Nonequilibrium NMR Methods for Monitoring Protein and RNA Folding
Q33892231Nonlinear protein degradation and the function of genetic circuits
Q33747704Nonnative interactions in coupled folding and binding processes of intrinsically disordered proteins
Q31814779Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells
Q44985651Novel sensors of the regulatory switch on the regulatory light chain of smooth muscle Myosin
Q37891686Novel strategies for drug discovery based on Intrinsically Disordered Proteins (IDPs)
Q37851243Nuclear magnetic resonance analysis of protein-DNA interactions
Q34313193Nuclear magnetic resonance methods for elucidation of structure and dynamics in disordered states
Q29871437Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein
Q34115619Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2.
Q34051068Occurrence of disordered patterns and homorepeats in eukaryotic and bacterial proteomes
Q40068957On the Helix Propensity in Generalized Born Solvent Descriptions of Modeling the Dark Proteome
Q91826372On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins
Q31129225On the importance of polar interactions for complexes containing intrinsically disordered proteins
Q41906667On the intrinsic disorder status of the major players in programmed cell death pathways
Q46186165On the potential of using peculiarities of the protein intrinsic disorder distribution in mitochondrial cytochrome b to identify the source of animal meats
Q36631429On the properties and sequence context of structurally ambivalent fragments in proteins
Q30844532On the role of residue phosphorylation in 14-3-3 partners: AANAT as a case study
Q51081890Opposing Intermolecular Tuning of Ca2+ Affinity for Calmodulin by Neurogranin and CaMKII Peptides.
Q30435828Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles
Q42847498Optimal region of average side-chain entropy for fast protein folding
Q37369361Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1
Q26739978Order, Disorder, and Everything in Between
Q30411543Ordered and disordered proteins as nanomaterial building blocks
Q34981100Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology
Q37223265Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain.
Q34118594Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand
Q50224082Out-of-equilibrium biomolecular interactions monitored by picosecond fluorescence in microfluidic droplets.
Q28587046Overexpression of peroxisomal testis-specific 1 protein induces germ cell apoptosis and leads to infertility in male mice
Q30368988Overview of protein structural and functional folds.
Q54110028PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer.
Q43586302PAS domain receptor photoactive yellow protein is converted to a molten globule state upon activation
Q33800245PB1-F2 influenza A virus protein adopts a beta-sheet conformation and forms amyloid fibers in membrane environments
Q45222808PELPK1 (At5g09530) contains a unique pentapeptide repeat and is a positive regulator of germination in Arabidopsis thaliana
Q33902242PONDR-FIT: a meta-predictor of intrinsically disordered amino acids
Q64079336PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ
Q52655128PRR4: A novel downregulated gene in laryngeal cancer.
Q41730413Papillomavirus binding factor (PBF) is an intrinsically disordered protein with potential participation in osteosarcoma genesis, in silico evidence
Q28073739ParB Partition Proteins: Complex Formation and Spreading at Bacterial and Plasmid Centromeres
Q91709607Paradoxes and wonders of intrinsic disorder: Stability of instability
Q45324112Parallel Tempering of Dark Matter from the Ebola Virus Proteome: Comparison of CHARMM36m and CHARMM22 Force Fields with Implicit Solvent.
Q33531518Parameterization of disorder predictors for large-scale applications requiring high specificity by using an extended benchmark dataset
Q33909288Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases
Q30851150Peptide Conformation Analysis Using an Integrated Bayesian Approach
Q90737238Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins
Q22061729Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence Disorder
Q35888187Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case.
Q42724139Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin
Q47224852Phosphorylation of an intrinsically disordered region of Ets1 shifts a multi-modal interaction ensemble to an auto-inhibitory state
Q37130781Phylogenetic and Structural Analysis of the Pluripotency Factor Sex-Determining Region Y box2 Gene of Camelus dromedarius (cSox2).
Q58114522Physical Background of the Disordered Nature of "Mutual Synergetic Folding" Proteins
Q38189746Physicochemical bases for protein folding, dynamics, and protein-ligand binding
Q28728669Physicochemical biology: conquered boundaries and new horizons
Q34014387Physicochemical mechanisms of protein regulation by phosphorylation
Q26823798Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
Q35060442Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains
Q35874419Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus.
Q73637421Plasticity of secondary structure in the N-terminal region of beta-dystroglycan
Q41849419Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro
Q37208923Population size dependence of fitness effect distribution and substitution rate probed by biophysical model of protein thermostability.
Q91820539Position-, disorder-, and salt-dependent diffusion in binding-coupled-folding of intrinsically disordered proteins
Q28141258Post-translational hydroxylation at the N-terminus of the prion protein reveals presence of PPII structure in vivo
Q28088517Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease
Q47710367Potential functions of LEA proteins from the brine shrimp Artemia franciscana - anhydrobiosis meets bioinformatics
Q37209109Potential implications of availability of short amino acid sequences in proteins: an old and new approach to protein decoding and design
Q34075054Potential use of non-classical pathways for the transport of macromolecular drugs
Q41824624Potentials of mean force for the interaction of blocked alanine dipeptide molecules in water and gas phase from MD simulations
Q42431942PrDOS: prediction of disordered protein regions from amino acid sequence
Q34442149Predicted and measured disorder in peripherin/rds, a retinal tetraspanin
Q51121458Predicting DNA-binding sites of proteins based on sequential and 3D structural information.
Q47422786Predicting intrinsic disorder from amino acid sequence
Q37549950Predicting intrinsic disorder in proteins: an overview
Q31104427Predicting mostly disordered proteins by using structure-unknown protein data
Q34439776Predicting properties of intrinsically unstructured proteins
Q51373131Predicting protein oxidation sites with feature selection and analysis approach.
Q22061741Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life
Q48104723Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins.
Q35051967Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission
Q43644496Prediction of active sites of enzymes by maximum relevance minimum redundancy (mRMR) feature selection
Q33267899Prediction of amyloidogenic and disordered regions in protein chains
Q48347994Prediction of disordered regions in proteins based on the meta approach.
Q34272402Prediction of disordered regions in proteins from position specific score matrices
Q35669411Prediction of lysine ubiquitylation with ensemble classifier and feature selection
Q45759852Prediction of protein amidation sites by feature selection and analysis.
Q21145360Prediction of protein binding regions in disordered proteins
Q28483826Prediction of protein cleavage site with feature selection by random forest
Q47596342Prediction of protein disorder based on IUPred
Q28480439Prediction of protein domain with mRMR feature selection and analysis
Q34102974Prediction of protein modification sites of pyrrolidone carboxylic acid using mRMR feature selection and analysis
Q36330083Prediction of protein relative enthalpic stability from molecular dynamics simulations of the folded and unfolded states
Q28482815Prediction of protein-protein interaction sites by random forest algorithm with mRMR and IFS
Q38647905Predictions of Backbone Dynamics in Intrinsically Disordered Proteins Using De Novo Fragment-Based Protein Structure Predictions
Q33561335Predictors of natively unfolded proteins: unanimous consensus score to detect a twilight zone between order and disorder in generic datasets
Q35970945Preferred peptide backbone conformations in the unfolded state revealed by the structure analysis of alanine-based (AXA) tripeptides in aqueous solution
Q34082751Prepaying the entropic cost for allosteric regulation in KIX
Q38968261Presence and utility of intrinsically disordered regions in kinases
Q97681217Presence of intrinsically disordered proteins can inhibit the nucleation phase of amyloid fibril formation of Aβ(1-42) in amino acid sequence independent manner
Q42994014Prevalence of intrinsic disorder in the hepatitis C virus ARFP/Core+1/S protein
Q37030888Privileged scaffolds targeting reverse-turn and helix recognition.
Q30993418Probing conformational disorder in neurotensin by two-dimensional solid-state NMR and comparison to molecular dynamics simulations
Q37439424Probing early events in ferrous cytochrome c folding with time-resolved natural and magnetic circular dichroism spectroscopies
Q35118034Probing protein disorder and complexity at single-molecule resolution
Q33732362Probing protein flexibility reveals a mechanism for selective promiscuity
Q37847124Probing structural transitions in both structured and disordered proteins using site-directed spin-labeling EPR spectroscopy.
Q34098982Probing structural transitions in the intrinsically disordered C-terminal domain of the measles virus nucleoprotein by vibrational spectroscopy of cyanylated cysteines
Q41905582Probing the urea dependence of residual structure in denatured human alpha-lactalbumin
Q56890940Production of recombinant human growth hormone conjugated with a transcytotic peptide in Pichia pastoris for effective oral protein delivery
Q42567400Proline-rich salivary proteins have extended conformations
Q36857096Properties, functions, and drug targeting of the multifunctional nucleocapsid protein of the human immunodeficiency virus.
Q47371568Prosystemin, a prohormone that modulates plant defense barriers, is an intrinsically disordered protein.
Q92454652Proteasome Activation to Combat Proteotoxicity
Q30376386Protein Misfolding in Lipid-Mimetic Environments.
Q33321436Protein abundance profiling of the Escherichia coli cytosol
Q34225700Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
Q33481211Protein disorder in the human diseasome: unfoldomics of human genetic diseases
Q37369375Protein disorder is positively correlated with gene expression in Escherichia coli
Q33247791Protein disorder prediction by condensed PSSM considering propensity for order or disorder
Q34189827Protein disorder: conformational distribution of the flexible linker in a chimeric double cellulase
Q37572718Protein dynamics and motions in relation to their functions: several case studies and the underlying mechanisms
Q36137498Protein dynamics and the diversity of an antibody response.
Q38509224Protein dynamics: from rattling in a cage to structural relaxation
Q43104940Protein flexibility and intrinsic disorder
Q41842857Protein flexibility, not disorder, is intrinsic to molecular recognition
Q43187852Protein folding and misfolding on surfaces.
Q46826884Protein folding intermediates of invasin protein IbeA from Escherichia coli
Q30420136Protein folding: a problem with multiple solutions
Q31926188Protein functional epitopes: hot spots, dynamics and combinatorial libraries
Q37241586Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses
Q37950254Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.
Q36675634Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii
Q33373579Protein intrinsic disorder toolbox for comparative analysis of viral proteins
Q41026093Protein intrinsic disorder within the Potyvirus genus: from proteome-wide analysis to functional annotation.
Q24534031Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion
Q37409309Protein recognition and selection through conformational and mutually induced fit.
Q28068775Protein stability: a crystallographer's perspective
Q35101254Protein structural modularity and robustness are associated with evolvability.
Q30422019Protein structure networks
Q34749909Protein surface salt bridges and paths for DNA wrapping
Q42158098Proteins with RNA chaperone activity: a world of diverse proteins with a common task-impediment of RNA misfolding
Q38257180Proteins without unique 3D structures: biotechnological applications of intrinsically unstable/disordered proteins
Q42673758Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?
Q36926540Proteome-wide discovery of evolutionary conserved sequences in disordered regions
Q34135482Proteomic analysis of potential keratan sulfate, chondroitin sulfate A, and hyaluronic acid molecular interactions
Q39572472Proteomics of Mycoplasma genitalium: identification and characterization of unannotated and atypical proteins in a small model genome
Q30400560Proteus: a random forest classifier to predict disorder-to-order transitioning binding regions in intrinsically disordered proteins
Q42073011Protonation-dependent conformational variability of intrinsically disordered proteins.
Q33294377Purification of CREB to apparent homogeneity: removal of truncation products and contaminating nucleic acid
Q42958947Putting proteins in context: scientific illustrations bring together information from diverse sources to provide an integrative view of the molecular biology of cells
Q21999552Quantifying the mechanisms of domain gain in animal proteins
Q36967812Quantifying the topography of the intrinsic energy landscape of flexible biomolecular recognition
Q64093485Quo Vadis Biomolecular NMR Spectroscopy?
Q36100522RNA polymerase II inhibitors dissociate antigenic peptide generation from normal viral protein synthesis: a role for nuclear translation in defective ribosomal product synthesis?
Q81609870Rapid assessment of protein structural stability and fold validation via NMR
Q24289194Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses
Q35554097Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.
Q38007407Recent progress in NMR spectroscopy: toward the study of intrinsically disordered proteins of increasing size and complexity
Q34141716Recognition between flexible protein molecules: induced and assisted folding
Q33989616Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain
Q52282024Recognition of the intrinsically flexible addiction antidote MazE by a dromedary single domain antibody fragment. Structure, thermodynamics of binding, stability, and influence on interactions with DNA.
Q51595638Reduced amino acid alphabet is sufficient to accurately recognize intrinsically disordered protein.
Q36446093Regulation of Escherichia coli SOS mutagenesis by dimeric intrinsically disordered umuD gene products.
Q36967218Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits
Q36413937Regulation of protein phosphatase 1 by intrinsically disordered proteins
Q34567970Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes
Q35621355Regulation of the c-Abl and Bcr-Abl tyrosine kinases
Q32186098Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain
Q42623293Relating protein conformational changes to packing efficiency and disorder
Q36818806Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer
Q90492960Reporting on the future of integrative structural biology ORAU workshop
Q90352806Residual Structure Accelerates Binding of Intrinsically Disordered ACTR by Promoting Efficient Folding upon Encounter
Q37255426Residual structure within the disordered C-terminal segment of p21(Waf1/Cip1/Sdi1) and its implications for molecular recognition.
Q34130185Residual structures, conformational fluctuations, and electrostatic interactions in the synergistic folding of two intrinsically disordered proteins
Q30392495Resonance assignment of disordered protein with repetitive and overlapping sequence using combinatorial approach reveals initial structural propensities and local restrictions in the denatured state.
Q34378120Retro-MoRFs: identifying protein binding sites by normal and reverse alignment and intrinsic disorder prediction
Q38218411Retrospective on the all-in-one retroviral nucleocapsid protein
Q45245698Reversible dimerization of acid-denatured ACBP controlled by helix A4.
Q38034245Revisiting ligand-induced conformational changes in proteins: essence, advancements, implications and future challenges.
Q30409086Rigidity, secondary structure, and the universality of the boson peak in proteins
Q58002465Role for NMR in structural genomics
Q36727341Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300
Q57961910Role of histidine for charge regulation of unstructured peptides at interfaces and in bulk
Q37922607Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
Q36331739Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1
Q36650544Role of peripherin/rds in vertebrate photoreceptor architecture and inherited retinal degenerations
Q37306581Role of synucleins in Alzheimer's disease
Q37587111Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation
Q107341671SARS-CoV-2 NSP1 C-terminal (residues 131–180) is an intrinsically disordered region in isolation
Q104451368SARS-CoV-2 NSP1 C-terminal region (residues 130-180) is an intrinsically disordered region
Q40308499SAXS study of the PIR domain from the Grb14 molecular adaptor: a natively unfolded protein with a transient structure primer?
Q33978783SPA: Short peptide analyzer of intrinsic disorder status of short peptides
Q24620741SPINE-D: accurate prediction of short and long disordered regions by a single neural-network based method
Q90337998SPOT-Disorder2: Improved Protein Intrinsic Disorder Prediction by Ensembled Deep Learning
Q51276233Search for identical octapeptides in unrelated proteins: Structural plasticity revisited.
Q89701040Secondary mutation-induced alternative splicing suppresses RNA splicing defect of the jing he sheng1 mutant
Q34439134Secondary structure and dynamics of an intrinsically unstructured linker domain
Q48044298Self-referring DNA and protein: a remark on physical and geometrical aspects
Q92631742Sequence Effects on Size, Shape, and Structural Heterogeneity in Intrinsically Disordered Proteins
Q35110852Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins
Q29616420Sequence complexity of disordered protein
Q47306170Sequence fingerprints distinguish erroneous from correct predictions of intrinsically disordered protein regions
Q30424441Sequence repeats and protein structure.
Q51673743Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations.
Q92028346Sequence-Specific DNA Binding by Noncovalent Peptide-Azocyclodextrin Dimer Complex as a Suitable Model for Conformational Fuzziness
Q73774451Sequence-specific 1H, 15N and 13C resonance assignments of the inhibitory prodomain of human furin
Q25257115Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins
Q98458635Shell disorder analysis suggests that pangolins offered a window for a silent spread of an attenuated SARS-CoV-2 precursor among humans
Q41157592Shell disorder, immune evasion and transmission behaviors among human and animal retroviruses
Q21263144Short Linear Motifs recognized by SH2, SH3 and Ser/Thr Kinase domains are conserved in disordered protein regions
Q34982184Simulating disorder-order transitions in molecular recognition of unstructured proteins: where folding meets binding
Q30427325Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.
Q46033026Single-molecule fluorescence studies of intrinsically disordered proteins.
Q36555388Single-residue posttranslational modification sites at the N-terminus, C-terminus or in-between: To be or not to be exposed for enzyme access
Q30330026Site-specific molecular design and its relevance to pharmacogenomics and chemical biology.
Q36273763Six- and seven-dimensional experiments by combination of sparse random sampling and projection spectroscopy dedicated for backbone resonance assignment of intrinsically disordered proteins
Q34314714Slow, reversible, coupled folding and binding of the spectrin tetramerization domain
Q35784396Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells
Q28479168Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes
Q53650419Solution NMR studies of an intrinsically unstructured protein within a dilute, 75 kDa eukaryotic protein assembly; probing the practical limits for efficiently assigning polypeptide backbone resonances.
Q27667329Solution Structure of the mSin3A PAH2–Pf1 SID1 Complex: A Mad1/Mxd1-Like Interaction Disrupted by MRG15 in the Rpd3S/Sin3S Complex
Q35866822Solution model of the intrinsically disordered polyglutamine tract-binding protein-1.
Q89634156Solution of Levinthal's Paradox and a Physical Theory of Protein Folding Times
Q27630794Solution structure and backbone dynamics of the DNA-binding domain of mouse Sox-5
Q40219967Solution studies and structural model of the extracellular domain of the human amyloid precursor protein
Q89843916Specific Conformational Dynamics and Expansion Underpin a Multi-Step Mechanism for Specific Binding of p27 with Cdk2/Cyclin A
Q44042490Specific and intrinsic sequence patterns extracted by deep learning from intra-protein binding and non-binding peptide fragments
Q42151102Specificity and affinity quantification of flexible recognition from underlying energy landscape topography
Q36626411Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments
Q35189399Speeding molecular recognition by using the folding funnel: the fly-casting mechanism
Q57976414Speeding up sequence specific assignment of IDPs
Q30355526Spritz: a server for the prediction of intrinsically disordered regions in protein sequences using kernel machines.
Q43058028Stability of HAMLET--a kinetically trapped alpha-lactalbumin oleic acid complex
Q33913778Stabilization of the spectrin-like domains of nesprin-1α by the evolutionarily conserved "adaptive" domain
Q55059374Stable folding intermediates prevent fast interconversion between the closed and open states of Mad2 through its denatured state.
Q51362509Stochastic simulation of structural properties of natively unfolded and denatured proteins.
Q27676730Structural Basis for Molecular Interactions Involving MRG Domains: Implications in Chromatin Biology
Q28910175Structural Characterization by NMR of the Natively Unfolded Extracellular Domain of β-Dystroglycan: Toward the Identification of the Binding Epitope for α-Dystroglycan
Q47316588Structural Characterization of Highly Flexible Proteins by Small-Angle Scattering
Q92409822Structural Characterization of N-WASP Domain V Using MD Simulations with NMR and SAXS Data
Q51684046Structural Characterization of the Intrinsically Disordered Protein p53 Using Raman Spectroscopy.
Q47591898Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry
Q27640497Structural analysis of Bacillus subtilis SPP1 phage helicase loader protein G39P
Q27690266Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain
Q38656166Structural and dynamic properties of the C-terminal region of the Escherichia coli RNA chaperone Hfq: integrative experimental and computational studies
Q26825355Structural and energetic basis of allostery
Q35295410Structural basis for inhibition of the MDM2:p53 interaction by an optimized MDM2-binding peptide selected with mRNA display
Q35954007Structural basis for protein phosphatase 1 regulation and specificity
Q27641812Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii
Q56762917Structural biology of hepatitis C virus
Q57071963Structural biology: Breaking the protein rules
Q44930085Structural biology: Signalling from disordered proteins
Q38779747Structural characterizations of phosphorylatable residues in transmembrane proteins from Arabidopsis thaliana
Q43572388Structural consequences of site-directed mutagenesis in flexible protein domains: NMR characterization of the L(55,56)S mutant of RhoGDI.
Q40373998Structural details on mdm2-p53 interaction
Q34114315Structural disorder and dynamics of elastin
Q47401954Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins.
Q39393201Structural disorder in plant proteins: where plasticity meets sessility
Q59350859Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)
Q35333283Structural disorder of folded proteins: isotope-edited 2D IR spectroscopy and Markov state modeling
Q33640276Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment
Q36346815Structural disorder within the replicative complex of measles virus: functional implications
Q47562775Structural disorder: a tool for housekeeping proteins performing tissue-specific interactions
Q34680376Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins
Q34116108Structural diversity in free and bound states of intrinsically disordered protein phosphatase 1 regulators
Q41436984Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation.
Q63610098Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion
Q54544087Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB.
Q54454823Structural flexibility of intrinsically disordered proteins induces stepwise target recognition.
Q34076768Structural genomics: an overview
Q55261718Structural insights and characterization of human Npas4 protein.
Q52629670Structural mechanisms of CFTR function and dysfunction.
Q31032929Structural plasticity in influenza virus protein NS2 (NEP).
Q57904165Structural properties of semenogelin I
Q38906195Structural studies on Laz, a promiscuous anticancer Neisserial protein
Q34366754Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA.
Q43510587Structural transformations accompanying the assembly of bacteriophage P22 portal protein rings in vitro
Q80385150Structure and function of a mitochondrial late embryogenesis abundant protein are revealed by desiccation
Q30476133Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition
Q24296040Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6
Q37173275Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system
Q36890749Structure prediction and analysis of DNA transposon and LINE retrotransposon proteins
Q36638977Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc
Q37772334Structure-switching biosensors: inspired by Nature.
Q34325473Structured disorder and conformational selection
Q51306890Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1.
Q49571797Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
Q91866615Studies on Molecular Dynamics of Intrinsically Disordered Proteins and Their Fuzzy Complexes: A Mini-Review
Q33851690SubVis: an interactive R package for exploring the effects of multiple substitution matrices on pairwise sequence alignment
Q47942511Supercharging SpyCatcher toward an intrinsically disordered protein with stimuli-responsive chemical reactivity
Q36607866Surface adhesins of Staphylococcus aureus
Q33583570Synonymous constraint elements show a tendency to encode intrinsically disordered protein segments
Q35458552Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma
Q37178764TOP-IDP-scale: a new amino acid scale measuring propensity for intrinsic disorder
Q38510010Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins
Q36291452Target binding to S100B reduces dynamic properties and increases Ca(2+)-binding affinity for wild type and EF-hand mutant proteins
Q36020398Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept
Q35835558Targeting intrinsically disordered proteins in rational drug discovery
Q37847584Targeting p27Kip1 protein: its relevance in the therapy of human cancer.
Q36919983Targeting the human cancer pathway protein interaction network by structural genomics
Q53113316Temperature and urea have opposing impacts on polyproline II conformational bias.
Q46279441Testing the transferability of a coarse-grained model to intrinsically disordered proteins
Q27932062The 'interactome' of the Knr4/Smi1, a protein implicated in coordinating cell wall synthesis with bud emergence in Saccharomyces cerevisiae.
Q43094965The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA.
Q44746385The C-terminal domain of measles virus nucleoprotein belongs to the class of intrinsically disordered proteins that fold upon binding to their physiological partner
Q45728875The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein
Q28545811The Dimerization State of the Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2)
Q42279450The DynaMine webserver: predicting protein dynamics from sequence
Q30373133The GTOP database in 2009: updated content and novel features to expand and deepen insights into protein structures and functions.
Q36227793The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea Virus
Q33445480The K-segment of maize DHN1 mediates binding to anionic phospholipid vesicles and concomitant structural changes
Q93222971The Klotho proteins in health and disease
Q50198142The Mcm2-7-interacting domain of human mini-chromosome maintenance 10 (Mcm10) protein is important for stable chromatin association and origin firing.
Q42121729The N(0)-binding region of the vesicular stomatitis virus phosphoprotein is globally disordered but contains transient α-helices
Q34590106The N-terminal intrinsically disordered domain of Mgm101p is localized to the mitochondrial nucleoid
Q39752522The Oligomerization Domain of VP3, the Scaffolding Protein of Infectious Bursal Disease Virus, Plays a Critical Role in Capsid Assembly
Q28909797The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling
Q40434276The Proline/Glycine-Rich Region of the Biofilm Adhesion Protein Aap Forms an Extended Stalk that Resists Compaction.
Q57825646The RING Domain of the Scaffold Protein Ste5 Adopts a Molten Globular Character with High Thermal and Chemical Stability
Q44121413The Subsequence Composition of Polypeptides
Q34538440The TFE-induced transient native-like structure of the intrinsically disordered σ₄⁷⁰ domain of Escherichia coli RNA polymerase
Q47796874The Thermodynamic Basis of the Fuzzy Interaction of an Intrinsically Disordered Protein.
Q39013660The Transactivation Domains of the p53 Protein
Q38779767The alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins
Q30402098The alphabet of intrinsic disorder: II. Various roles of glutamic acid in ordered and intrinsically disordered proteins
Q34472057The amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling
Q39142387The binding of maize DHN1 to lipid vesicles. Gain of structure and lipid specificity
Q34027894The blast resistance gene Pi54of cloned from Oryza officinalis interacts with Avr-Pi54 through its novel non-LRR domains
Q41915186The calponin regulatory region is intrinsically unstructured: novel insight into actin-calponin and calmodulin-calponin interfaces using NMR spectroscopy
Q28080017The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
Q34102257The coronavirus nucleocapsid is a multifunctional protein.
Q37808166The critical protein interactions and structures that elicit growth deregulation in cancer and viral replication
Q27656662The crystal structure of the TolB box of colicin A in complex with TolB reveals important differences in the recruitment of the common TolB translocation portal used by group A colicins
Q42103648The effect of an ionic detergent on the natively unfolded beta-dystroglycan ectodomain and on its interaction with alpha-dystroglycan
Q26862004The ensemble nature of allostery
Q28660725The eukaryotic linear motif resource ELM: 10 years and counting
Q27645697The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue
Q42277084The heterogeneous structural behavior of E7 from HPV16 revealed by NMR spectroscopy
Q34232501The human genome: an immuno-centric view of evolutionary strategies
Q33566030The importance of being flexible: the case of basic region leucine zipper transcriptional regulators
Q28776125The importance of intrinsic disorder for protein phosphorylation
Q39850928The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment
Q30399038The intrinsic disorder alphabet. III. Dual personality of serine
Q42223133The intrinsic disorder status of the human hepatitis C virus proteome
Q36518053The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct sites and remains predominantly unfolded
Q42560984The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer
Q41940615The intrinsically disordered TC-1 interacts with Chibby via regions with high helical propensity
Q35305255The intrinsically disordered regions of the Drosophila melanogaster Hox protein ultrabithorax select interacting proteins based on partner topology
Q34598286The inverted chevron plot measured by NMR relaxation reveals a native-like unfolding intermediate in acyl-CoA binding protein
Q38105815The most important thing is the tail: multitudinous functionalities of intrinsically disordered protein termini
Q38527462The multifaceted roles of intrinsic disorder in protein complexes
Q37462521The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome
Q43258539The nanny model for IDPs.
Q26751488The new (dis)order in RNA regulation
Q33594094The p53 core domain is a molten globule at low pH: functional implications of a partially unfolded structure.
Q30413242The plant proteome folding project: structure and positive selection in plant protein families
Q34046537The protein kingdom extended: ordered and intrinsically disordered proteins, their folding, supramolecular complex formation, and aggregation.
Q30379937The protein meta-structure: a novel concept for chemical and molecular biology.
Q52055900The protein trinity--linking function and disorder.
Q74763080The regions of securin and cyclin B proteins recognized by the ubiquitination machinery are natively unfolded
Q41774157The relationship between relative solvent accessible surface area (rASA) and irregular structures in protean segments (ProSs)
Q42924615The role of disorder in interaction networks: a structural analysis
Q37462213The role of disordered ribosomal protein extensions in the early steps of eubacterial 50 S ribosomal subunit assembly
Q34978182The role of the LH subdomain in the function of the Cip/Kip cyclin-dependent kinase regulators
Q54343211The roles of intrinsic disorder in orchestrating the Wnt-pathway.
Q47693846The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Q27637582The solution structure of acyl carrier protein from Mycobacterium tuberculosis
Q42217044The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation
Q47197538The structural basis of the TIM10 chaperone assembly.
Q24306374The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain
Q24336683The structure and interactions of the proline-rich domain of ASPP2
Q44549934The switches.ELM resource: a compendium of conditional regulatory interaction interfaces
Q27691999The tandem β-zipper: modular binding of tandem domains and linear motifs.
Q40895923The twilight zone between protein order and disorder
Q33184245The ubiquitous nature of RNA chaperone proteins
Q30372413The unfoldomics decade: an update on intrinsically disordered proteins.
Q35837347The unstructured C-terminus of the tau subunit of Escherichia coli DNA polymerase III holoenzyme is the site of interaction with the alpha subunit
Q62099176Theoretical Study of the Raman Optical Activity Spectra of 310-Helical Polypeptides
Q34355349Therapeutic strategies to inhibit MYC
Q41774237Thermal unfolding of the N-terminal region of p53 monitored by circular dichroism spectroscopy
Q30164730Thermally induced structural changes in glycinin, the 11S globulin of soya bean (Glycine max)--an in situ spectroscopic study.
Q56774478Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates
Q37310615Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors
Q36137400Thermodynamic dissection of the intrinsically disordered N-terminal domain of human glucocorticoid receptor
Q28910365Thermodynamics of the Op18/stathmin-tubulin interaction
Q47701859Thermotoga maritima IscU. Structural characterization and dynamics of a new class of metallochaperone
Q34212956Thymosin beta 4 interactions
Q34890013Tight regulation of unstructured proteins: from transcript synthesis to protein degradation
Q38453379Time window expansion for HDX analysis of an intrinsically disordered protein
Q43105053To be folded or to be unfolded?
Q53079816Topology-based modeling of intrinsically disordered proteins: balancing intrinsic folding and intermolecular interactions.
Q30382415Toward a quantitative theory of intrinsically disordered proteins and their function
Q34989905Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins
Q27641495Towards an understanding of the poliovirus replication complex: the solution structure of the soluble domain of the poliovirus 3A protein
Q43227326Transfer of flexibility between ankyrin repeats in IkappaB* upon formation of the NF-kappaB complex
Q36326844Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations
Q37890142Transient protein-protein interactions.
Q44222230Transient structure formation in unfolded acyl-coenzyme A-binding protein observed by site-directed spin labelling
Q37854496Translating DRiPs: progress in understanding viral and cellular sources of MHC class I peptide ligands
Q88030587Translational Control by Prion-like Proteins
Q45966104Trimethylamine-N-oxide-induced folding of alpha-synuclein.
Q61813288Troubleshooting Guide to Expressing Intrinsically Disordered Proteins for Use in NMR Experiments
Q28216160Truncation of amino-terminal tail stimulates activity of human endonuclease III (hNTH1)
Q90003817Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions
Q36218535Two Isoforms of Yersinia pestis Plasminogen Activator Pla: Intraspecies Distribution, Intrinsic Disorder Propensity, and Contribution to Virulence
Q50064138Two possible improvements for mass spectrometry analysis of intact biomolecules.
Q24646890Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity
Q28290917Ubiquitin-independent proteasomal degradation
Q50919522Under-folded proteins: Conformational ensembles and their roles in protein folding, function, and pathogenesis.
Q97878176Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
Q36336728Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses
Q30385084Understanding protein non-folding.
Q47218534Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV.
Q49759325Understanding the roles of intrinsic disorder in subunits of hemoglobin and the disease process of sickle cell anemia.
Q36821293Understanding the structural ensembles of a highly extended disordered protein
Q34989888Unfolded proteins studied by Raman optical activity
Q33481254Unfoldomics of human diseases: linking protein intrinsic disorder with diseases
Q47226964Unified understanding of folding and binding mechanisms of globular and intrinsically disordered proteins
Q34398554Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides
Q41492486Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map.
Q30375946Unstructural biology of the Dengue virus proteins.
Q93050870Untangling the Conformational Polymorphism of Disordered Proteins Associated With Neurodegeneration at the Single-Molecule Level
Q43057974Urea-induced denaturation of apolipoprotein serum amyloid A reveals marginal stability of hexamer
Q38044420Using NMR chemical shifts to calculate the propensity for structural order and disorder in proteins.
Q93048656Using Small-Angle Scattering Data and Parametric Machine Learning to Optimize Force Field Parameters for Intrinsically Disordered Proteins
Q37649680Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure
Q37633034Utilization of protein intrinsic disorder knowledge in structural proteomics
Q30155273VAPC, an human endogenous inhibitor for hepatitis C virus (HCV) infection, is intrinsically unstructured but forms a "fuzzy complex" with HCV NS5B.
Q37451071Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated Plasmodium falciparum protein PFF0165c
Q46735392VirtualSpectrum, a tool for simulating peak list for multi-dimensional NMR spectra
Q45399479Virulence factor of potato virus Y, genome-attached terminal protein VPg, is a highly disordered protein.
Q36630637What drives proteins into the major or minor grooves of DNA?
Q27012942What macromolecular crowding can do to a protein
Q33656573What's in a name? Why these proteins are intrinsically disordered: Why these proteins are intrinsically disordered
Q60302049Where differences resemble: sequence-feature analysis in curated databases of intrinsically disordered proteins
Q42216042Wide-open flaps are key to urease activity
Q27000495Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators
Q28909275Yeast cox17 solution structure and Copper(I) binding
Q36126137Yersinia pestis Caf1 Protein: Effect of Sequence Polymorphism on Intrinsic Disorder Propensity, Serological Cross-Reactivity and Cross-Protectivity of Isoforms
Q89208629Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity
Q28202577Zinc and copper bind to unique sites of histatin 5
Q27641221Zinc-Mediated Helix Capping in A Triple-Helical Protein,
Q33745509iMethyl-PseAAC: identification of protein methylation sites via a pseudo amino acid composition approach
Q35914230iPDA: integrated protein disorder analyzer
Q37588275iPhos-PseEn: identifying phosphorylation sites in proteins by fusing different pseudo components into an ensemble classifier
Q28910366p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
Q28079390p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept
Q34153187p53 contains large unstructured regions in its native state
Q34351764pH dependence of amide chemical shifts in natively disordered polypeptides detects medium-range interactions with ionizable residues
Q60917799pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain
Q36640696pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation.
Q38272154pH-induced folding of an apoptotic coiled coil
Q41989778sgTarget: a target selection resource for structural genomics.

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