Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis

scientific article

Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00018-016-2416-6
P8608Fatcat IDrelease_hqyej2hzyjay3iio277qqxgjli
P698PubMed publication ID27838743

P50authorVladimir N. UverskyQ59698496
P2093author name stringLeonid Breydo
Maria Harreguy Alfonso
Marwa Alhothali
Nikolas Santamaria
P2860cites workPrediction of protein binding regions in disordered proteinsQ21145360
Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 ConceptQ22061726
Classification of intrinsically disordered regions and proteinsQ22061736
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregationQ24324878
The Protein Data BankQ24515306
Alternative splicing in concert with protein intrinsic disorder enables increased functional diversity in multicellular organismsQ24548466
hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase IIQ24562004
UniProt: the Universal Protein knowledgebaseQ24598826
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional studyQ24600803
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scoredQ24607390
Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALSQ24608159
Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosisQ24619298
The IntAct molecular interaction database in 2012Q24621004
Protein tandem repeats - the more perfect, the less structuredQ24624818
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTDQ24634583
DisProt: the Database of Disordered ProteinsQ24675789
Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?Q26777971
Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisQ26863439
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsQ27000495
Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein foldingQ27641822
Structures of mouse SOD1 and human/mouse SOD1 chimerasQ27664114
Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43Q27687574
The TDP-43 N-terminal domain structure at high resolutionQ27703592
Determination and analysis of the 2 A-structure of copper, zinc superoxide dismutaseQ27729237
Crystallization and structure determination of bovine profilin at 2.0 A resolutionQ27730841
The crystal structure of a major allergen from plantsQ27734729
Functional roles of transiently and intrinsically disordered regions within proteinsQ28085662
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosisQ28131672
Intrinsically disordered proteinQ28191444
The Database of Interacting Proteins: 2004 updateQ28234998
The BioGRID interaction database: 2015 updateQ28252221
Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cellsQ28254284
Comprehensive large-scale assessment of intrinsic protein disorderQ60787508
Characterization of renatured profilin purified by urea elution from poly-L-proline agarose columnsQ69425510
Crystallographic characterization of recombinant human CuZn superoxide dismutaseQ69663958
Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongationQ70802575
An essential role for the conserved Glu-133 in the anion interaction with superoxide dismutaseQ72217950
Predicting Protein Disorder for N-, C-, and Internal RegionsQ73174432
SnapShot: Cellular bodiesQ79385899
Role of intrinsic disorder in transient interactions of hub proteinsQ79416219
Intrinsic disorder in yeast transcriptional regulatory networkQ80353265
Optimizing long intrinsic disorder predictors with protein evolutionary informationQ81484824
Familial versus sporadic amyotrophic lateral sclerosis--a false dichotomy?Q82333999
Disordered domains and high surface charge confer hubs with the ability to interact with multiple proteins in interaction networksQ82855583
C9orf72 hexanucleotide repeat expansions as the causative mutation for chromosome 9p21-linked amyotrophic lateral sclerosis and frontotemporal dementiaQ84958100
Domain architectures and characterization of an RNA-binding protein, TLSQ28276007
The RCSB Protein Data Bank: views of structural biology for basic and applied research and educationQ28650443
Pfam: the protein families databaseQ28660698
A decade and a half of protein intrinsic disorder: biology still waits for physicsQ28681184
Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosisQ28730723
The importance of intrinsic disorder for protein phosphorylationQ28776125
Human Protein Reference Database--2009 updateQ29547392
Intrinsically unstructured proteinsQ29614784
Stress granules: the Tao of RNA triageQ29615263
Protein disorder prediction: implications for structural proteomicsQ29615736
GlobPlot: Exploring protein sequences for globularity and disorderQ29615737
Why are "natively unfolded" proteins unstructured under physiologic conditions?Q29615739
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigmQ29615865
IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy contentQ29615888
Intrinsic disorder and protein functionQ29616415
Natively unfolded proteins: a point where biology waits for physicsQ29616416
Sequence complexity of disordered proteinQ29616420
Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.Q30276728
Comparing and combining predictors of mostly disordered proteins.Q30350136
Exploiting heterogeneous sequence properties improves prediction of protein disorder.Q30351476
Flexible nets. The roles of intrinsic disorder in protein interaction networks.Q30351593
Length-dependent prediction of protein intrinsic disorder.Q30353929
Understanding protein non-folding.Q30385084
Intrinsically disordered proteins: a 10-year recapQ30421421
Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomesQ33252616
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosisQ33649745
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulationQ33675114
PONDR-FIT: a meta-predictor of intrinsically disordered amino acidsQ33902242
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesQ33909288
A method for simultaneous alignment of multiple protein structuresQ33978603
FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosisQ34118590
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicityQ34141572
MINT, the molecular interaction database: 2012 updateQ34233947
Structure and mechanism of copper, zinc superoxide dismutaseQ34255150
MobiDB: a comprehensive database of intrinsic protein disorder annotations.Q34278790
D²P²: database of disordered protein predictionsQ34314929
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.Q34326849
Alternative splicing of intrinsically disordered regions and rewiring of protein interactionsQ38109334
Intrinsically disordered proteins and intrinsically disordered protein regionsQ38194194
Introducing protein intrinsic disorderQ38205058
Subclassifying disordered proteins by the CH-CDF plot method.Q38499397
SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS.Q38632098
Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral SclerosisQ38666305
Dancing Protein Clouds: The Strange Biology and Chaotic Physics of Intrinsically Disordered ProteinsQ38724766
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to StressQ38781435
Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansionsQ38789426
Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studiesQ38866202
A majority of the cancer/testis antigens are intrinsically disordered proteinsQ39063386
On the complementarity of the consensus-based disorder prediction.Q39675172
Structural diversity and functional implications of the eukaryotic TDP gene familyQ40608660
Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosisQ40737530
Profilin 1 mutants form aggregates that induce accumulation of prion-like TDP-43Q41596094
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.Q41628256
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networksQ41884066
RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLDQ42011097
C9ORF72 interaction with cofilin modulates actin dynamics in motor neuronsQ42425843
PrDOS: prediction of disordered protein regions from amino acid sequenceQ42431942
What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?Q42625650
The structural and functional signatures of proteins that undergo multiple events of post-translational modificationQ42663688
Characterization of the dipeptide repeat protein in the molecular pathogenesis of c9FTD/ALS.Q42693496
Refined solution structure of human profilin I.Q42844645
ESpritz: accurate and fast prediction of protein disorderQ44385437
Mutation analysis of PFN1 in familial amyotrophic lateral sclerosis patients.Q45907822
Faster superoxide dismutase mutants designed by enhancing electrostatic guidanceQ45965859
The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysisQ46281486
Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregationQ46591159
Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosisQ46599359
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteinsQ46797980
Intrinsic disorder in pathogenic and non-pathogenic microbes: discovering and analyzing the unfoldomes of early-branching eukaryotesQ47702038
Coupled folding and binding with alpha-helix-forming molecular recognition elementsQ48122045
Disorder and sequence repeats in hub proteins and their implications for network evolution.Q52673882
The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins.Q52974739
Phosphorylated TDP-43 becomes resistant to cleavage by calpain: A regulatory role for phosphorylation in TDP-43 pathology of ALS/FTLD.Q53227139
Identification of the poly-L-proline-binding site on human profilin.Q54738745
A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts.Q55056826
Accurate prediction of disorder in protein chains with a comprehensive and empirically designed consensusQ56992931
Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type EnzymesQ57909227
Analysis of theC9orf72Gene in Patients with Amyotrophic Lateral Sclerosis in Spain and Different Populations WorldwideQ58006957
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALSQ58477808
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactinQ59080539
Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.Q34424308
RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteinsQ34425242
MobiDB 2.0: an improved database of intrinsically disordered and mobile proteinsQ34445775
The BioPlex Network: A Systematic Exploration of the Human InteractomeQ34485581
What does it mean to be natively unfolded?Q34488954
APID interactomes: providing proteome-based interactomes with controlled quality for multiple species and derived networks.Q34524369
Mining alpha-helix-forming molecular recognition features with cross species sequence alignmentsQ34708119
Identification and functions of usefully disordered proteinsQ34989882
Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disordersQ35135581
Improving protein order-disorder classification using charge-hydropathy plotsQ35538193
Protein folding revisited. A polypeptide chain at the folding ? misfolding ? nonfolding cross-roads: which way to go?Q35549177
C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral SclerosisQ35643260
Clinical characteristics of patients with familial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeat expansion of C9ORF72.Q35776923
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.Q35886826
Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) conceptQ36020398
Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72.Q36304922
Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulationQ36588602
The neuropathology of FTD associated With ALS.Q37036221
CDF it all: consensus prediction of intrinsically disordered proteins based on various cumulative distribution functionsQ37195737
ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamicsQ37256571
Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALSQ37316045
C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.Q37316053
ANCHOR: web server for predicting protein binding regions in disordered proteins.Q37381486
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementiaQ37409251
Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseasesQ37409270
Reduced C9orf72 protein levels in frontal cortex of amyotrophic lateral sclerosis and frontotemporal degeneration brain with the C9ORF72 hexanucleotide repeat expansionQ37706316
Unusual biophysics of intrinsically disordered proteinsQ38069936
P433issue7
P921main subjectamyotrophic lateral sclerosisQ206901
P304page(s)1297-1318
P577publication date2016-11-12
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleIntrinsic disorder in proteins involved in amyotrophic lateral sclerosis
P478volume74

Reverse relations

cites work (P2860)
Q47276758Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions
Q47351608Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.
Q64263070Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis
Q89818887Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons
Q41660989Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation
Q89602412The Order-Disorder Continuum: Linking Predictions of Protein Structure and Disorder through Molecular Simulation
Q64054884The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
Q92317999The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension
Q47693846The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

Search more.