IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

scientific article (publication date: 15 August 2005)

IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content is …
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scholarly articleQ13442814

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P8978DBLP publication IDjournals/bioinformatics/DosztanyiCTS05
P356DOI10.1093/BIOINFORMATICS/BTI541
P3181OpenCitations bibliographic resource ID339695
P698PubMed publication ID15955779
P5875ResearchGate publication ID7786631

P2093author name stringSimon I
Csizmok V
Dosztányi Z
Tompa P
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectweb serverQ11288
P304page(s)3433-4
P577publication date2005-08-15
P1433published inBioinformaticsQ4914910
P1476titleIUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
P478volume21

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Q41516577Effects of short indels on protein structure and function in human genomes
Q52325095Ehrlichia chaffeensis TRP120 nucleomodulin binds DNA with disordered tandem repeat domain.
Q90075528Electrostatic Interactions Govern Extreme Nascent Protein Ejection Times from Ribosomes and Can Delay Ribosome Recycling
Q24300745Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies
Q35904221Emergence and evolution of yeast prion and prion-like proteins
Q35739851Environmental Pressure May Change the Composition Protein Disorder in Prokaryotes
Q39005050Erythropoietin and co.: intrinsic structure and functional disorder
Q37243833Essential functions linked with structural disorder in organisms of minimal genome
Q30976509Estimation and efficient computation of the true probability of recurrence of short linear protein sequence motifs in unrelated proteins
Q30392517Estimation of Position Specific Energy as a Feature of Protein Residues from Sequence Alone for Structural Classification
Q34427576Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif?
Q29048164Evaluation of disorder predictions in CASP9
Q64063635Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation
Q33479542Evidence for the concerted evolution between short linear protein motifs and their flanking regions
Q39826674Evidence for the residual tertiary structure in the urea-unfolded form of bacteriophage T5 endolysin
Q42253597Evidence of direct complementary interactions between messenger RNAs and their cognate proteins
Q36381664Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ.
Q28383959Evolution and Spread of Ebola Virus in Liberia, 2014-2015
Q36627901Evolution of disorder in Mediator complex and its functional relevance
Q36799247Evolution of modular intraflagellar transport from a coatomer-like progenitor.
Q96136799Evolution of novel genes in three-spined stickleback populations
Q61806766Evolution of salivary glue genes in Drosophila species
Q42746823Evolution of structurally disordered proteins promotes neostructuralization
Q51099642Evolutionarily conserved and conformationally constrained short peptides might serve as DNA recognition elements in intrinsically disordered regions.
Q91809748Evolutionary Analyses of Sequence and Structure Space Unravel the Structural Facets of SOD1
Q61798267Evolutionary Approach of Intrinsically Disordered CIP/KIP Proteins
Q64064750Evolutionary behaviour of bacterial prion-like proteins
Q47337648Evolutionary rate heterogeneity between multi- and single-interface hubs across human housekeeping and tissue-specific protein interaction network: Insights from proteins' and its partners' properties.
Q42211815Exceptionally abundant exceptions: comprehensive characterization of intrinsic disorder in all domains of life
Q30009908Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome
Q28261787Exonuclease 1-dependent and independent mismatch repair
Q48026313Expediting dynamics approach to understand the influence of 14-3-3ζ causing metastatic cancer through the interaction of YAP1 and β-TRCP.
Q91747308Experimental Insight into the Structural and Functional Roles of the 'Black' and 'Gray' Clusters in Recoverin, a Calcium Binding Protein with Four EF-Hand Motifs
Q28083241Experimental detection of short regulatory motifs in eukaryotic proteins: tips for good practice as well as for bad
Q91663737Exploring Relationships between the Density of Charged Tracts within Disordered Regions and Phase Separation
Q38706805Exploring Short Linear Motifs Using the ELM Database and Tools.
Q46305048Exploring disorder in the human charged biased proteins
Q83275470Extension of the HA-detection based approach: (HCA)CON(CA)H and (HCA)NCO(CA)H experiments for the main-chain assignment of intrinsically disordered proteins
Q36056550Extensive identification and analysis of conserved small ORFs in animals
Q52375447Extreme disorder in an ultrahigh-affinity protein complex.
Q30009321Fast and accurate discovery of degenerate linear motifs in protein sequences
Q64883675Flexibility of the "rigid" classics or rugged bottom of the folding funnels of myoglobin, lysozyme, RNase A, chymotrypsin, cytochrome c, and carboxypeptidase A1.
Q27640764Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins
Q30393337Fluctuations of backbone torsion angles obtained from NMR-determined structures and their prediction
Q47650986Foldability of a Natural De Novo Evolved Protein
Q35536206Folding and self-association of atTic20 in lipid membranes: implications for understanding protein transport across the inner envelope membrane of chloroplasts
Q47988665Folding of intrinsically disordered plant LEA proteins is driven by glycerol-induced crowding and the presence of membranes
Q38840411Fragment-Based NMR Study of the Conformational Dynamics in the bHLH Transcription Factor Ascl1.
Q28730747Free cysteine modulates the conformation of human C/EBP homologous protein
Q44486815From protein sequence to dynamics and disorder with DynaMine
Q54973991Fuento: functional enrichment for bioinformatics.
Q35966468Functional Diversification after Gene Duplication: Paralog Specific Regions of Structural Disorder and Phosphorylation in p53, p63, and p73
Q55311483Functional and structural characterization of osteocytic MLO-Y4 cell proteins encoded by genes differentially expressed in response to mechanical signals in vitro.
Q42872102Functional and structural study of the dimeric inner membrane protein SbmA.
Q37795113Functional classification of scaffold proteins and related molecules
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Q39282756Functional interaction and structural characteristics of unique components of Helicobacter pylori T4SS.
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Q38659937Functionality of Intrinsic Disorder in Tumor Necrosis Factor-α and its Receptors
Q89169733Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics
Q37780480Functions of disordered regions in mammalian early base excision repair proteins
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Q37526122GPS-PAIL: prediction of lysine acetyltransferase-specific modification sites from protein sequences.
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Q31110949Genome-wide analysis of protein disorder in Arabidopsis thaliana: implications for plant environmental adaptation
Q35866476Genomic variation. Impact of regulatory variation from RNA to protein
Q35622751HMMER web server: 2015 update
Q28748436Harnessing disorder: onychophorans use highly unstructured proteins, not silks, for prey capture
Q27677281Helical Repeat Structure of Apoptosis Inhibitor 5 Reveals Protein-Protein Interaction Modules
Q28478955HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization
Q48095729Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase
Q24337888High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1
Q42332214High-Resolution Mapping of RNA-Binding Regions in the Nuclear Proteome of Embryonic Stem Cells.
Q39966175High-order oligomers of intrinsically disordered brain proteins BASP1 and GAP-43 preserve the structural disorder
Q41098679High-resolution structural characterization of Noxa, an intrinsically disordered protein, by microsecond molecular dynamics simulations
Q54940954High-throughput discovery of functional disordered regions: investigation of transactivation domains.
Q36160593High-throughput prediction of RNA, DNA and protein binding regions mediated by intrinsic disorder
Q30009145Highly homologous proteins exert opposite biological activities by using different interaction interfaces
Q40620340How Common Is Disorder? Occurrence of Disordered Residues in Four Domains of Life
Q48043107How Do We Study the Dynamic Structure of Unstructured Proteins: A Case Study on Nopp140 as an Example of a Large, Intrinsically Disordered Protein.
Q37937374How a disordered ubiquitin ligase maintains order in nuclear protein homeostasis
Q38944980How disordered is my protein and what is its disorder for? A guide through the "dark side" of the protein universe
Q28085129How many lives does CLIMP-63 have?
Q50559161How to Predict Disorder in a Protein of Interest.
Q33488516Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1
Q52643023Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p.
Q36095079Human Management of a Wild Plant Modulates the Evolutionary Dynamics of a Gene Determining Recessive Resistance to Virus Infection.
Q33820240Human Nek6 is a monomeric mostly globular kinase with an unfolded short N-terminal domain.
Q46271115Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primate-specific exon included in a novel transcript
Q33842022Human cyclophilin 40 unravels neurotoxic amyloids
Q37256103Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state
Q57753160Human proteins that interact with RNA/DNA hybrids
Q38779773Hydrogel formation by multivalent IDPs: A reincarnation of the microtrabecular lattice?
Q38055634Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins
Q24317710Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein
Q38844519Hypothetical granulin-like molecule from Fasciola hepatica identified by bioinformatics analysis
Q58717213IDP⁻CRF: Intrinsically Disordered Protein/Region Identification Based on Conditional Random Fields
Q55518742IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding.
Q50947442Identification and Evolutionary Characterization of ARGONAUTE-Binding Platforms.
Q39078818Identification and phylogenetic analysis of late embryogenesis abundant proteins family in tomato (Solanum lycopersicum).
Q90647988Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
Q91891728Identification of Intrinsically Disordered Proteins and Regions by Length-Dependent Predictors Based on Conditional Random Fields
Q38762159Identification of Neuregulin-2 as a novel stress granule component
Q28511647Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1
Q28478668Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1)
Q37736698Identification of conserved proteins from diverse shell matrix proteome in Crassostrea gigas: characterization of genetic bases regulating shell formation
Q37333797Identification of unusual E6 and E7 proteins within avian papillomaviruses: cellular localization, biophysical characterization, and phylogenetic analysis
Q40823789Identifying Similar Patterns of Structural Flexibility in Proteins by Disorder Prediction and Dynamic Programming
Q50898025Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach.
Q41633838Identifying intrinsically disordered protein regions likely to undergo binding-induced helical transitions
Q57063936Immunogenicity and Protective Activity of a Chimeric Protein Based on the Domain III of the Tick-Borne Encephalitis Virus E Protein and the OmpF Porin of Incorporated into the TI-Complex
Q35246562Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B.
Q41552179Importin-α-mediated nucleolar localization of potato mop-top virus TRIPLE GENE BLOCK1 (TGB1) protein facilitates virus systemic movement, whereas TGB1 self-interaction is required for cell-to-cell movement in Nicotiana benthamiana.
Q63044066Improved measures for evolutionary conservation that exploit taxonomy distances
Q53477774Improved prediction of residue flexibility by embedding optimized amino acid grouping into RSA-based linear models.
Q24615841Improved sequence-based prediction of disordered regions with multilayer fusion of multiple information sources
Q39067587Improving protein disorder prediction by deep bidirectional long short-term memory recurrent neural networks.
Q35538193Improving protein order-disorder classification using charge-hydropathy plots
Q35539986Improving serodiagnosis of human and canine leishmaniasis with recombinant Leishmania braziliensis cathepsin l-like protein and a synthetic peptide containing its linear B-cell epitope
Q35898819In silico Identification and Validation of a Linear and Naturally Immunogenic B-Cell Epitope of the Plasmodium vivax Malaria Vaccine Candidate Merozoite Surface Protein-9
Q53098617In silico Structural characterization of podocin and assessment of nephrotic syndrome-associated podocin mutants.
Q30400845In silico analysis of five missense mutations in CYP1B1 gene in Pakistani families affected with primary congenital glaucoma
Q92704557In silico prediction of structural changes in human papillomavirus type 16 (HPV16) E6 oncoprotein and its variants
Q50864208In various protein complexes, disordered protomers have large per-residue surface areas and area of protein-, DNA- and RNA-binding interfaces.
Q45914563In-depth analysis of hyaline fibromatosis syndrome frameshift mutations at the same site reveal the necessity of personalized therapy.
Q33935454In-silico prediction of disorder content using hybrid sequence representation
Q47246041InSiDDe: A Server for Designing Artificial Disordered Proteins
Q37836386Inadequate Reference Datasets Biased toward Short Non-epitopes Confound B-cell Epitope Prediction
Q57685595Incipient de novo genes can evolve from frozen accidents that escaped rapid transcript turnover
Q35764718Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms
Q37640420Independent active and thermodynamic processes govern the nucleolus assembly in vivo
Q35838944Independent structural domains in paramyxovirus polymerase protein
Q33962989Influenza virus hemagglutinin spike neck architectures and interaction with model enzymes evaluated by MALDI-TOF mass spectrometry and bioinformatics tools.
Q36554344Inherent relationships among different biophysical prediction methods for intrinsically disordered proteins
Q34162531Inherent structural disorder and dimerisation of murine norovirus NS1-2 protein
Q36101844Initial Molecular Recognition Steps of McjA Precursor during Microcin J25 Lasso Peptide Maturation
Q41890783Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry
Q90835569Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity
Q58621285Interaction modulation through arrays of clustered methyl-arginine protein modifications
Q39378298Interactions of intrinsically disordered Thellungiella salsuginea dehydrins TsDHN-1 and TsDHN-2 with membranes - synergistic effects of lipid composition and temperature on secondary structure
Q30010246Interactome-wide prediction of short, disordered protein interaction motifs in humans
Q51578393Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs.
Q38873802Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions
Q57210036Interplay between sequence, structure and linear motifs in the adenovirus E1A hub protein
Q35656792Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region
Q50559158Intrinsic Disorder and Semi-disorder Prediction by SPINE-D.
Q47351608Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions.
Q38163534Intrinsic Disorder in the Kinesin Superfamily.
Q36140744Intrinsic Disorder of the C-Terminal Domain of Drosophila Methoprene-Tolerant Protein.
Q92444162Intrinsic Disorder-Based Design of Stable Globular Proteins
Q35632957Intrinsic disorder and functional proteomics
Q36604600Intrinsic disorder and multiple phosphorylations constrain the evolution of the flightin N-terminal region.
Q22061745Intrinsic disorder explains diverse nuclear roles of chromatin remodeling proteins
Q37114136Intrinsic disorder in Viral Proteins Genome-Linked: experimental and predictive analyses
Q37649609Intrinsic disorder in biomarkers of insulin resistance, hypoadiponectinemia, and endothelial dysfunction among the type 2 diabetic patients
Q33417626Intrinsic disorder in protein interactions: insights from a comprehensive structural analysis
Q30395169Intrinsic disorder in proteins involved in amyotrophic lateral sclerosis
Q30399043Intrinsic disorder in spondins and some of their interacting partners
Q35146628Intrinsic disorder in the BK channel and its interactome
Q31090109Intrinsic disorder in the Protein Data Bank
Q42613429Intrinsic disorder in the common N-terminus of human adenovirus 5 E1B-55K and its related E1BN proteins indicated by studies on E1B-93R.
Q35044139Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions.
Q53219534Intrinsic disorder of human Yin Yang 1 protein.
Q98775878Intrinsic disorder perspective of an interplay between the renin-angiotensin-aldosterone system and SARS-CoV-2
Q42648353Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity
Q27335553Intrinsic protein disorder in histone lysine methylation
Q47171932Intrinsic protein disorder reduces small-scale gene duplicability
Q33514873Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins
Q91590399Intrinsically Disordered Linkers Impart Processivity on Enzymes by Spatial Confinement of Binding Domains
Q39172489Intrinsically Disordered Regions in Serum Albumin: What Are They For?
Q27926249Intrinsically Disordered Side of the Zika Virus Proteome
Q28542604Intrinsically disordered and pliable Starmaker-like protein from medaka (Oryzias latipes) controls the formation of calcium carbonate crystals
Q40488052Intrinsically disordered caldesmon binds calmodulin via the "buttons on a string" mechanism
Q47140500Intrinsically disordered linkers determine the interplay between phase separation and gelation in multivalent proteins
Q30525528Intrinsically disordered proteins aggregate at fungal cell-to-cell channels and regulate intercellular connectivity
Q57908356Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates
Q33325882Intrinsically disordered proteins display no preference for chaperone binding in vivo
Q35510300Intrinsically disordered proteins in cellular signalling and regulation.
Q47142042Intrinsically disordered proteins in the nucleus of human cells
Q39335014Intrinsically disordered regions in autophagy proteins
Q33640094Intrinsically disordered regions may lower the hydration free energy in proteins: a case study of nudix hydrolase in the bacterium Deinococcus radiodurans
Q37337624Intrinsically semi-disordered state and its role in induced folding and protein aggregation
Q21560973Intrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutations
Q37504397Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.
Q41809419Is Five Percent Too Small? Analysis of the Overlaps between Disorder, Coiled Coil and Collagen Predictions in Complete Proteomes
Q57080287Is there a biological cost of protein disorder? Analysis of cancer-associated mutations
Q44040157IsUnstruct: prediction of the residue status to be ordered or disordered in the protein chain by a method based on the Ising model
Q47553499JABAWS 2.2 Distributed Web Services for Bioinformatics: Protein Disorder, Conservation and RNA Secondary Structure
Q36495406Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy.
Q38511666KEPE--a motif frequently superimposed on sumoylation sites in metazoan chromatin proteins and transcription factors
Q47151585KIXBASE: A comprehensive web resource for identification and exploration of KIX domains.
Q36716505KMAD: knowledge-based multiple sequence alignment for intrinsically disordered proteins.
Q36218605Kinesin tail domains are intrinsically disordered.
Q64083076LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA
Q30899249LCR-eXXXplorer: a web platform to search, visualize and share data for low complexity regions in protein sequences
Q52606714Lactococcus lactis provides an efficient platform for production of disulfide-rich recombinant proteins from Plasmodium falciparum.
Q47229935Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights
Q28275692Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks
Q37383520Large-scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome
Q61805478Leishmania infantum recombinant kinesin degenerated derived repeat (rKDDR): A novel potential antigen for serodiagnosis of visceral leishmaniasis
Q48722775Length-dependent regulation of the Kv1.2 channel activation by its C-terminus.
Q92076216Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor
Q27675570Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding.
Q33728497Library of disordered patterns in 3D protein structures.
Q41164290Limited variation during circulation of a polyomavirus in the human population involves the COCO-VA toggling site of Middle and Alternative T-antigen(s).
Q38943658Linear B-cell epitope mapping of MAPK3 and MAPK4 from Leishmania braziliensis: implications for the serodiagnosis of human and canine leishmaniasis
Q42286181Linear motifs confer functional diversity onto splice variants
Q40767205Linkage and allostery in snRNP protein/RNA complexes
Q38692163Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.
Q30158016Local structural disorder imparts plasticity on linear motifs.
Q38500227Location of disorder in coiled coil proteins is influenced by its biological role and subcellular localization: a GO-based study on human proteome
Q47119424Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization.
Q36694319Looking at the carcinogenicity of human insulin analogues via the intrinsic disorder prism
Q30157992Loop anchor modification causes the population of an alternative native state in an SH3-like domain
Q36548438Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems
Q30369339Low complexity and disordered regions of proteins have different structural and amino acid preferences.
Q91564685Lysine/RNA-interactions drive and regulate biomolecular condensation
Q36278167MAPanalyzer: a novel online tool for analyzing microtubule-associated proteins
Q38779764MFDp2: Accurate predictor of disorder in proteins by fusion of disorder probabilities, content and profiles
Q35008000MFSPSSMpred: identifying short disorder-to-order binding regions in disordered proteins based on contextual local evolutionary conservation
Q37452154MHC class I-associated peptides derive from selective regions of the human genome
Q57461496MRMAssayDB: an integrated resource for validated targeted proteomics assays
Q92663669Macromolecular Interactions of Disordered Proteins
Q56340919Malaria parasite translocon structure and mechanism of effector export
Q27650749Malectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-Glycosylation
Q30430063Malleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome
Q34688655Marked variability in the extent of protein disorder within and between viral families
Q28478338Markov models of amino acid substitution to study proteins with intrinsically disordered regions
Q38728723MatureP: prediction of secreted proteins with exclusive information from their mature regions.
Q34579849McbR/YncC: implications for the mechanism of ligand and DNA binding by a bacterial GntR transcriptional regulator involved in biofilm formation.
Q24658193MeDor: a metaserver for predicting protein disorder
Q47225264Mechanism of intersubunit ketosynthase-dehydratase interaction in polyketide synthases
Q30368617Mechismo: predicting the mechanistic impact of mutations and modifications on molecular interactions.
Q28483943Melanoma-associated cancer-testis antigen 16 (CT16) regulates the expression of apoptotic and antiapoptotic genes and promotes cell survival
Q51491940Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins.
Q21284325MetaDisorder: a meta-server for the prediction of intrinsic disorder in proteins
Q90291222Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles
Q34708119Mining alpha-helix-forming molecular recognition features with cross species sequence alignments
Q30574006Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase
Q30009419MoDPepInt: an interactive web server for prediction of modular domain-peptide interactions
Q34280717MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins
Q47316915Mobi 2.0: an improved method to define intrinsic disorder, mobility and linear binding regions in protein structures.
Q47138466MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins.
Q30355976ModBase, a database of annotated comparative protein structure models and associated resources.
Q35930512Model-Driven Understanding of Palmitoylation Dynamics: Regulated Acylation of the Endoplasmic Reticulum Chaperone Calnexin
Q30366409Modelling and simulation of mutant alleles of breast cancer metastasis suppressor 1 (BRMS1) gene
Q61812303Modulation of Measles Virus N Interactions through Fuzziness and Sequence Features of Disordered Binding Sites
Q40969365Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer
Q92377140Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin
Q41657776Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC.
Q84220622Molecular biology of chronic myeloid leukemia
Q28541190Molecular docking simulations provide insights in the substrate binding sites and possible substrates of the ABCC6 transporter
Q43975421Molecular dynamics simulations of the Bcl-2 protein to predict the structure of its unordered flexible loop domain.
Q34319810Molecular evolution of dihydrouridine synthases
Q57652291Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas
Q35205679Molecular modeling and molecular dynamics simulations based structural analysis of the SG2NA protein variants
Q37746989Molecular simulations of protein disorder
Q48050089More than just tails: intrinsic disorder in histone proteins
Q26741086Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks
Q56881320Multiple Host Factors Interact with Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode
Q35578699Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins
Q93017200Multiple phosphorylations control recruitment of the KMN network onto kinetochores
Q30651045Multisite phosphorylation of the NDC80 complex gradually tunes its microtubule-binding affinity
Q37635085Mutations in γ adducin are associated with inherited cerebral palsy.
Q41089843Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition
Q39123504Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence.
Q33905518NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin
Q102060953NGOME-Lite: Proteome-wide prediction of spontaneous protein deamidation highlights differences between taxa
Q40627988NMR Dynamics of Transmembrane and Intracellular Domains of p75NTR in Lipid-Protein Nanodiscs.
Q56993044NOT THAT RIGID MIDGETS AND NOT SO FLEXIBLE GIANTS: ON THE ABUNDANCE AND ROLES OF INTRINSIC DISORDER IN SHORT AND LONG PROTEINS
Q33292014Natively unstructured loops differ from other loops
Q34665088Natively unstructured regions in proteins identified from contact predictions
Q37075588Natural protein sequences are more intrinsically disordered than random sequences
Q34175008Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway
Q36111854New genes drive the evolution of gene interaction networks in the human and mouse genomes
Q27680795New insights into histidine triad proteins: solution structure of a Streptococcus pneumoniae PhtD domain and zinc transfer to AdcAII
Q41269525Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein
Q48340987Not an exception to the rule: the functional significance of intrinsically disordered protein regions in enzymes.
Q41932793Novel mutations in TSEN54 in pontocerebellar hypoplasia type 2.
Q54294153Novel role for a serine/arginine-rich splicing factor, AdRSZ21 in plant defense and HR-like cell death.
Q57037012Nucleic Acid-Dependent Structural Transition of the Intrinsically Disordered N-Terminal Appended Domain of Human Lysyl-tRNA Synthetase
Q89872460Nucleocytoplasmic transport of intrinsically disordered proteins studied by high-speed super-resolution microscopy
Q44356144Nucleolar scaffold protein, WDR46, determines the granular compartmental localization of nucleolin and DDX21.
Q37578820Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetramer with partly disordered tentacle-like C-terminal segments.
Q37181954Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination
Q41619239Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity
Q99234043ODiNPred: comprehensive prediction of protein order and disorder
Q40235769OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome.
Q41873238Observation selection bias in contact prediction and its implications for structural bioinformatics
Q34051068Occurrence of disordered patterns and homorepeats in eukaryotic and bacterial proteomes
Q91826372On the Need to Develop Guidelines for Characterizing and Reporting Intrinsic Disorder in Proteins
Q41906667On the intrinsic disorder status of the major players in programmed cell death pathways
Q41811100Optimization of linear disorder predictors yields tight association between crystallographic disorder and hydrophobicity
Q28248627Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies
Q37369361Order propensity of an intrinsically disordered protein, the cyclin-dependent-kinase inhibitor Sic1
Q26739978Order, Disorder, and Everything in Between
Q34981100Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology
Q28597043Origin of a folded repeat protein from an intrinsically disordered ancestor
Q35005363Origins of Myc proteins--using intrinsic protein disorder to trace distant relatives
Q27683767Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B
Q37393076Overlapping Regions in HIV-1 Genome Act as Potential Sites for Host-Virus Interaction
Q45965349POODLE-L: a two-level SVM prediction system for reliably predicting long disordered regions.
Q41627029PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.
Q34133671PRO40 is a scaffold protein of the cell wall integrity pathway, linking the MAP kinase module to the upstream activator protein kinase C.
Q30390048PUDGE: a flexible, interactive server for protein structure prediction
Q55100217PVCbase: an integrated web resource for the PVC bacterial proteomes.
Q30008874Paralog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3-SH2-Tyrosine Kinase Protein Family
Q30375382Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods.
Q35154360Performance of protein disorder prediction programs on amino acid substitutions
Q40099941Perturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.
Q28660698Pfam: the protein families database
Q92642717Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation
Q54977608Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.
Q37469773Phenotypic profiling of Mycobacterium tuberculosis EspA point mutants reveals that blockage of ESAT-6 and CFP-10 secretion in vitro does not always correlate with attenuation of virulence.
Q24613280Phospho.ELM: a database of phosphorylation sites--update 2011
Q35252223Phosphorylation of Atg31 is required for autophagy
Q28472246Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factors
Q58114522Physical Background of the Disordered Nature of "Mutual Synergetic Folding" Proteins
Q28545748Physical Features of Intracellular Proteins that Moonlight on the Cell Surface
Q37452497Physical requirements and functional consequences of complex formation between the cytomegalovirus IE1 protein and human STAT2.
Q51587921Physicochemical sequence characteristics that influence S-palmitoylation propensity.
Q43178405Physiological truncation and domain organization of a novel uracil-DNA-degrading factor
Q28261578Physiological, pathological, and structural implications of non-enzymatic protein-protein interactions of the multifunctional human transglutaminase 2
Q50101621Pi-Pi contacts are an overlooked protein feature relevant to phase separation.
Q51596041Picobirnaviruses encode a protein with repeats of the ExxRxNxxxE motif.
Q49968483Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling.
Q92946510Portrait of the Intrinsically Disordered Side of the HTLV-1 Proteome
Q36628432Positional proteomics reveals differences in N-terminal proteoform stability
Q64100465Post-transcriptional regulatory patterns revealed by protein-RNA interactions
Q95272429Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases
Q41660989Potential Roles of Intrinsic Disorder in Maternal-Effect Proteins Involved in the Maintenance of DNA Methylation
Q47710367Potential functions of LEA proteins from the brine shrimp Artemia franciscana - anhydrobiosis meets bioinformatics
Q34135998Power Law Distribution Defines Structural Disorder as a Structural Element Directly Linked with Function
Q92800484Precise Prediction of Calpain Cleavage Sites and Their Aberrance Caused by Mutations in Cancer
Q57471951Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions
Q30418801Predict impact of single amino acid change upon protein structure
Q34418986PredictProtein--an open resource for online prediction of protein structural and functional features
Q36268811Predicting MoRFs in protein sequences using HMM profiles.
Q34982735Predicting binding within disordered protein regions to structurally characterised peptide-binding domains
Q37549950Predicting intrinsic disorder in proteins: an overview
Q35621798Predicting peptide-mediated interactions on a genome-wide scale
Q30614500Predicting sumoylation sites using support vector machines based on various sequence features, conformational flexibility and disorder
Q38673749Predicting the protein half-life in tissue from its cellular properties
Q45046029Prediction of Disordered RNA, DNA, and Protein Binding Regions Using DisoRDPbind
Q48104723Prediction of Disordered Regions and Their Roles in the Anti-Pathogenic and Immunomodulatory Functions of Butyrophilins.
Q35051967Prediction of Intrinsic Disorder in MERS-CoV/HCoV-EMC Supports a High Oral-Fecal Transmission
Q35870617Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder.
Q48347994Prediction of disordered regions in proteins based on the meta approach
Q33282223Prediction of flexible/rigid regions from protein sequences using k-spaced amino acid pairs
Q35872026Prediction of neddylation sites from protein sequences and sequence-derived properties
Q90698804Prediction of polyproline II secondary structure propensity in proteins
Q21145360Prediction of protein binding regions in disordered proteins
Q47596342Prediction of protein disorder based on IUPred
Q100945951Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
Q38647905Predictions of Backbone Dynamics in Intrinsically Disordered Proteins Using De Novo Fragment-Based Protein Structure Predictions
Q33561335Predictors of natively unfolded proteins: unanimous consensus score to detect a twilight zone between order and disorder in generic datasets
Q30009199Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions
Q36101329Prevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers
Q37528739Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein
Q36419279Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.
Q36708196Production of unstable proteins through the formation of stable core complexes
Q34274351Profile-based short linear protein motif discovery
Q28487221Prokaryotic ubiquitin-like protein pup is intrinsically disordered
Q47381502Prolines in Transit Peptides Are Crucial for Efficient Preprotein Translocation into Chloroplasts
Q30376386Protein Misfolding in Lipid-Mimetic Environments.
Q30383384Protein Secondary Structure Prediction Using Deep Convolutional Neural Fields
Q34409863Protein disorder and short conserved motifs in disordered regions are enriched near the cytoplasmic side of single-pass transmembrane proteins
Q34412990Protein disorder in plants: a view from the chloroplast.
Q47250514Protein disorder in the centrosome correlates with complexity in cell types number
Q33481211Protein disorder in the human diseasome: unfoldomics of human genetic diseases
Q33247791Protein disorder prediction by condensed PSSM considering propensity for order or disorder
Q38453597Protein disorder reduced in Saccharomyces cerevisiae to survive heat shock
Q26826940Protein flexibility in the light of structural alphabets
Q30657282Protein functional features are reflected in the patterns of mRNA translation speed
Q26865908Protein intrinsic disorder in plants
Q36675634Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii
Q46324799Protein intrinsic disorder negatively associates with gene age in different eukaryotic lineages
Q81136311Protein robustness promotes evolutionary innovations on large evolutionary time-scales
Q24624818Protein tandem repeats - the more perfect, the less structured
Q30380348Protein unfolding in crowded milieu: what crowding can do to a protein undergoing unfolding?
Q43103613ProteinCCD: enabling the design of protein truncation constructs for expression and crystallization experiments
Q93229444Proteins of generalist and specialist pathogens differ in their amino acid composition
Q35758594Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates.
Q28479221Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis
Q39327102Proteome-wide Structural Analysis of PTM Hotspots Reveals Regulatory Elements Predicted to Impact Biological Function and Disease
Q42673758Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?
Q34635044Proteome-wide subcellular topologies of E. coli polypeptides database (STEPdb).
Q93229314Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
Q30400560Proteus: a random forest classifier to predict disorder-to-order transitioning binding regions in intrinsically disordered proteins
Q36054193Prothymosin-α Variants Elicit Anti-HIV-1 Response via TLR4 Dependent and Independent Pathways
Q30912827QSLiMFinder: improved short linear motif prediction using specific query protein data.
Q64121543Quality and bias of protein disorder predictors
Q58764810Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated
Q34042648Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex
Q27485379RNA chaperoning and intrinsic disorder in the core proteins of Flaviviridae
Q88930935RNA-protein interactions in an unstructured context
Q37163073RNAi Screen Identifies Novel Regulators of RNP Granules in the Caenorhabditis elegans Germ Line
Q35641013Random mutagenesis of the nucleotide-binding domain of NRC1 (NB-LRR Required for Hypersensitive Response-Associated Cell Death-1), a downstream signalling nucleotide-binding, leucine-rich repeat (NB-LRR) protein, identifies gain-of-function mutation
Q34239225Rapid calcium-dependent activation of Aurora-A kinase.
Q34453553Rapid evolution of virus sequences in intrinsically disordered protein regions
Q24289194Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses
Q38954061Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.
Q30387288RaptorX-Property: a web server for protein structure property prediction
Q58702522Recombinant Fusion Protein Joining E Protein Domain III of Tick-Borne Encephalitis Virus and HSP70 of as an Antigen for the TI-Complexes
Q41564363Recombination of strain O segments to HCpro-encoding sequence of strain N of Potato virus Y modulates necrosis induced in tobacco and in potatoes carrying resistance genes Ny or Nc.
Q33658850Reduction in structural disorder and functional complexity in the thermal adaptation of prokaryotes
Q35064474Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1
Q34975931Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
Q36967218Regulation of cell division by intrinsically unstructured proteins: intrinsic flexibility, modularity, and signaling conduits
Q34567970Regulation of protein-protein binding by coupling between phosphorylation and intrinsic disorder: analysis of human protein complexes
Q41367437Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains.
Q33702802Regulatory interplay between TFIID's conformational transitions and its modular interaction with core promoter DNA.
Q39724617Resolving the ambiguity: Making sense of intrinsic disorder when PDB structures disagree
Q30392495Resonance assignment of disordered protein with repetitive and overlapping sequence using combinatorial approach reveals initial structural propensities and local restrictions in the denatured state.
Q92706638Resources to Discover and Use Short Linear Motifs in Viral Proteins
Q57685584Robustness by intrinsically disordered C-termini and translational readthrough
Q37919739Role of an intrinsically disordered conformation in AMPK-mediated phosphorylation of ULK1 and regulation of autophagy
Q36088168Role of mRNA structure in the control of protein folding
Q37922607Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
Q47146412Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation
Q33508587Rules governing selective protein carbonylation
Q36275965SEPIa, a knowledge-driven algorithm for predicting conformational B-cell epitopes from the amino acid sequence
Q58587305SLiM-Enrich: computational assessment of protein-protein interaction data as a source of domain-motif interactions
Q33301323SLiMFinder: a probabilistic method for identifying over-represented, convergently evolved, short linear motifs in proteins.
Q24621848SLiMFinder: a web server to find novel, significantly over-represented, short protein motifs
Q38398397SLiMScape 3.x: a Cytoscape 3 app for discovery of Short Linear Motifs in protein interaction networks.
Q34188209SLiMSearch 2.0: biological context for short linear motifs in proteins
Q58416264SLiMSearch: A Webserver for Finding Novel Occurrences of Short Linear Motifs in Proteins, Incorporating Sequence Context
Q24620741SPINE-D: accurate prediction of short and long disordered regions by a single neural-network based method
Q90337998SPOT-Disorder2: Improved Protein Intrinsic Disorder Prediction by Ensembled Deep Learning
Q34082902SProtP: a web server to recognize those short-lived proteins based on sequence-derived features in human cells
Q52374177SUMO polymeric chains are involved in nuclear foci formation and chromatin organization in Trypanosoma brucei procyclic forms.
Q92930421Sea Urchin Spicule Matrix Proteins Form Mesoscale "Smart" Hydrogels That Exhibit Selective Ion Interactions
Q37377664Secretory granule to the nucleus: role of a multiply phosphorylated intrinsically unstructured domain
Q28476786Segregating variation in the polycomb group gene cramped alters the effect of temperature on multiple traits
Q57214234Self-Coacervation of a Silk-Like Protein and Its Use As an Adhesive for Cellulosic Materials
Q36120393Self-regulation of functional pathways by motifs inside the disordered tails of beta-catenin
Q35110852Sequence complexity of amyloidogenic regions in intrinsically disordered human proteins
Q40626286Sequence determinants of compaction in intrinsically disordered proteins
Q47306170Sequence fingerprints distinguish erroneous from correct predictions of intrinsically disordered protein regions
Q41884903Sequence signatures of direct complementarity between mRNAs and cognate proteins on multiple levels
Q91708289Sequence-Derived Markers of Drug Targets and Potentially Druggable Human Proteins
Q38761956Sequence-based analysis of protein degradation rates.
Q41960876Sequence-derived structural features driving proteolytic processing.
Q28475008Serodiagnosis of Echinococcus spp. infection: explorative selection of diagnostic antigens by peptide microarray
Q34726553Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae
Q34592627Shifts in the host range of a promiscuous plasmid through parallel evolution of its replication initiation protein
Q46211043Single-Cell Alternative Splicing Analysis with Expedition Reveals Splicing Dynamics during Neuron Differentiation
Q90413975Skeletal development in the sea urchin relies upon protein families that contain intrinsic disorder, aggregation-prone, and conserved globular interactive domains
Q41074219Sodium-assisted formation of binding and traverse conformations of the substrate in a neurotransmitter sodium symporter model
Q37603781Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3
Q34045278Spatial structure peculiarities of influenza A virus matrix M1 protein in an acidic solution that simulates the internal lysosomal medium
Q52547079Splicing and transcription touch base: co-transcriptional spliceosome assembly and function.
Q27678435Staphylococcal biofilm-forming protein has a contiguous rod-like structure
Q38136844Stress granules and cell signaling: more than just a passing phase?
Q30375619Structural Analysis of PTM Hotspots (SAPH-ire)--A Quantitative Informatics Method Enabling the Discovery of Novel Regulatory Elements in Protein Families.
Q27312438Structural Aspects of N-Glycosylations and the C-terminal Region in Human Glypican-1.
Q30008904Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2
Q40942320Structural Characterization of Phosducin and Its Complex with the 14-3-3 Protein.
Q36407702Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7.
Q47591898Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry
Q64109378Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level
Q38949313Structural and biochemical analysis of Escherichia coli ObgE, a central regulator of bacterial persistence.
Q39661785Structural and biophysical characterization of murine rif1 C terminus reveals high specificity for DNA cruciform structures.
Q87866577Structural and functional aspects of the interaction partners of the small heat-shock protein in Synechocystis
Q36671880Structural and thermodynamic consequences of b heme binding for monomeric apoglobins and other apoproteins
Q31137865Structural and thermodynamic encoding in the sequence of rat microsomal cytochrome b(5).
Q30413466Structural architecture of the human long non-coding RNA, steroid receptor RNA activator
Q24299239Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease
Q90242836Structural basis for chain release from the enacyloxin polyketide synthase
Q34964228Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection
Q41864504Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus
Q51006190Structural determinants at the interface of the ARC2 and leucine-rich repeat domains control the activation of the plant immune receptors Rx1 and Gpa2.
Q38557562Structural disorder and its role in proteasomal degradation
Q37588016Structural disorder in amyloid fibrils: its implication in dynamic interactions of proteins
Q34230264Structural disorder in eukaryotes
Q59350859Structural disorder in the proteome and interactome of Alkhurma virus (ALKV)
Q55402187Structural disorder of plasmid-encoded proteins in Bacteria and Archaea.
Q33301958Structural disorder promotes assembly of protein complexes
Q34845322Structural disorder provides increased adaptability for vesicle trafficking pathways
Q33640276Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment
Q47562775Structural disorder: a tool for housekeeping proteins performing tissue-specific interactions
Q90053454Structural features of the interaction of MapZ with FtsZ and membranes in Streptococcus pneumoniae
Q42707053Structural flexibility allows the functional diversity of potyvirus genome-linked protein VPg
Q36736139Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor
Q41652019Structural signature of the MYPT1-PP1 interaction.
Q40162625Structural studies of viperin, an antiviral radical SAM enzyme
Q92959479Structure Determination by Single-Particle Cryo-Electron Microscopy: Only the Sky (and Intrinsic Disorder) is the Limit
Q34720695Structure and non-structure of centrosomal proteins.
Q40505556Structure and stability of recombinant bovine odorant-binding protein: I. Design and analysis of monomeric mutants
Q36890749Structure prediction and analysis of DNA transposon and LINE retrotransposon proteins
Q30358932Structure prediction of magnetosome-associated proteins.
Q91641896Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes
Q37060964Structure-function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ
Q34082551Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin
Q38358141Structure-function based molecular relationships in Ewing's sarcoma.
Q41698527Structured States of Disordered Proteins from Genomic Sequences
Q40135382SuccinSite: a computational tool for the prediction of protein succinylation sites by exploiting the amino acid patterns and properties.
Q36406294Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination
Q93040786Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA
Q36287572Systematic analysis of non-structural protein features for the prediction of PTM function potential by artificial neural networks
Q39790685Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development.
Q52639487Systematic characterization of pan-cancer mutation clusters.
Q52365240TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues.
Q33961599TBP binding-induced folding of the glucocorticoid receptor AF1 domain facilitates its interaction with steroid receptor coactivator-1
Q34831850TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA
Q57454682TMEM106B, a risk factor for FTLD and aging, has an intrinsically disordered cytoplasmic domain
Q55113468TOM and SAM Machineries in Mitochondrial Protein Import and Outer Membrane Biogenesis
Q37557027TSTMP: target selection for structural genomics of human transmembrane proteins.
Q26781063Tandem Repeats in Proteins: Prediction Algorithms and Biological Role
Q38510010Tandem and cryptic amino acid repeats accumulate in disordered regions of proteins
Q90950258Tankyrase inhibition preserves osteoarthritic cartilage by coordinating cartilage matrix anabolism via effects on SOX9 PARylation
Q89928713Termination of non-coding transcription in yeast relies on both an RNA Pol II CTD interaction domain and a CTD-mimicking region in Sen1
Q36320807Testis-specific ATP synthase peripheral stalk subunits required for tissue-specific mitochondrial morphogenesis in Drosophila.
Q35054726Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.
Q35669267The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA
Q34510555The Arabidopsis thaliana SERK1 kinase domain spontaneously refolds to an active state in vitro
Q46514569The Argonaute-binding platform of NRPE1 evolves through modulation of intrinsically disordered repeats
Q92411725The Balancing Act of Intrinsically Disordered Proteins: Enabling Functional Diversity while Minimizing Promiscuity
Q34421653The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin
Q47319323The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1.
Q34762803The C-terminus of Bienertia sinuspersici Toc159 contains essential elements for its targeting and anchorage to the chloroplast outer membrane.
Q41120778The C-terminus of ICln is natively disordered but displays local structural preformation
Q57911613The Cyanobacterial Ribosomal-Associated Protein LrtA from sp. PCC 6803 Is an Oligomeric Protein in Solution with Chameleonic Sequence Properties
Q54380629The Dad1 subunit of the yeast kinetochore Dam1 complex is an intrinsically disordered protein
Q55351373The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region.
Q30009088The Disordered Region of the HCV Protein NS5A: Conformational Dynamics, SH3 Binding, and Phosphorylation
Q42279450The DynaMine webserver: predicting protein dynamics from sequence
Q52370659The Enigmatic Alphavirus Non-Structural Protein 3 (nsP3) Revealing Its Secrets at Last.
Q36254755The Goddard and Saturn Genes Are Essential for Drosophila Male Fertility and May Have Arisen De Novo
Q54221608The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA.
Q42732856The Lottia gigantea shell matrix proteome: re-analysis including MaxQuant iBAQ quantitation and phosphoproteome analysis
Q30416170The MULTICOM toolbox for protein structure prediction
Q28646186The Magellania venosa Biomineralizing Proteome: A Window into Brachiopod Shell Evolution
Q34590106The N-terminal intrinsically disordered domain of Mgm101p is localized to the mitochondrial nucleoid
Q39359407The N-terminal region of CXCL11 as structural template for CXCR3 molecular recognition: synthesis, conformational analysis, and binding studies
Q34493766The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila
Q36882704The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells
Q28299026The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy
Q40434276The Proline/Glycine-Rich Region of the Biofilm Adhesion Protein Aap Forms an Extended Stalk that Resists Compaction.
Q34361566The RNA-binding protein repertoire of embryonic stem cells.
Q38814679The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs
Q42129907The RelA nuclear localization signal folds upon binding to IκBα.
Q33947399The SH2 domain interaction landscape
Q42432055The SLiMDisc server: short, linear motif discovery in proteins
Q34026690The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
Q35862448The Schistosome Esophagus Is a 'Hotspot' for Microexon and Lysosomal Hydrolase Gene Expression: Implications for Blood Processing
Q28607872The Skeleton Forming Proteome of an Early Branching Metazoan: A Molecular Survey of the Biomineralization Components Employed by the Coralline Sponge Vaceletia Sp
Q39094581The Structure and Topology of α-Helical Coiled Coils
Q36585939The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.
Q33521382The acidic domains of the Toc159 chloroplast preprotein receptor family are intrinsically disordered protein domains
Q34139157The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality.
Q35927955The contribution of protein intrinsic disorder to understand the role of genetic variants uncovered by autism spectrum disorders exome studies.
Q52354384The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
Q38716767The essential role of guinea pig cytomegalovirus (GPCMV) IE1 and IE2 homologs in viral replication and IE1-mediated ND10 targeting
Q90306924The established and the predicted roles of dynein light chain in the regulation of mitochondrial apoptosis
Q47159538The eukaryotic linear motif resource - 2018 update
Q37125870The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans
Q35092072The extended PP1 toolkit: designed to create specificity
Q28606577The genome of Dasychira pudibunda nucleopolyhedrovirus (DapuNPV) reveals novel genetic connection between baculoviruses infecting moths of the Lymantriidae family
Q34251310The hepatitis E virus polyproline region is involved in viral adaptation
Q30010167The identification of short linear motif-mediated interfaces within the human interactome
Q50223966The intriguing CP12-like tail of adenylate kinase 3 from Chlamydomonas reinhardtii.
Q47687807The intrinsically disordered N-terminal domain of galectin-3 dynamically mediates multisite self-association of the protein through fuzzy interactions
Q43028429The manganese/iron-carboxylate proteins: what is what, where are they, and what can the sequences tell us?
Q64463015The molecular basis of monopolin recruitment to the kinetochore
Q37462521The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome
Q53067378The nucleoporin MEL-28 promotes RanGTP-dependent γ-tubulin recruitment and microtubule nucleation in mitotic spindle formation.
Q37213779The origin recognition complex protein family
Q44777782The origins and evolution of ubiquitination sites
Q35604287The plant Polycomb repressive complex 1 (PRC1) existed in the ancestor of seed plants and has a complex duplication history
Q30379937The protein meta-structure: a novel concept for chemical and molecular biology.
Q24294830The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization
Q39957350The putative HORMA domain protein Atg101 dimerizes and is required for starvation-induced and selective autophagy in Drosophila.
Q35907671The relationship between proteome size, structural disorder and organism complexity
Q30656566The role of balanced training and testing data sets for binary classifiers in bioinformatics
Q42174981The role of intrinsically unstructured proteins in neurodegenerative diseases
Q38481133The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting.
Q42552259The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
Q47693846The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration
Q43208870The spliceosomal proteins PPIH and PRPF4 exhibit bi-partite binding
Q41545354The stability of Fbw7α in M-phase requires its phosphorylation by PKC.
Q42180604The stability of the small nucleolar ribonucleoprotein (snoRNP) assembly protein Pih1 in Saccharomyces cerevisiae is modulated by its C terminus
Q37624303The structurally disordered paramyxovirus nucleocapsid protein tail domain is a regulator of the mRNA transcription gradient
Q24336683The structure and interactions of the proline-rich domain of ASPP2
Q35326762The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.
Q44549934The switches.ELM resource: a compendium of conditional regulatory interaction interfaces
Q39117858The transience of transient overexpression
Q41597233The yeast kinesin-5 Cin8 interacts with the microtubule in a noncanonical manner
Q39175147The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum
Q56774478Thermo-resistant intrinsically disordered proteins are efficient 20S proteasome substrates
Q38453379Time window expansion for HDX analysis of an intrinsically disordered protein
Q39371374To be disordered or not to be disordered: is that still a question for proteins in the cell?
Q26863527Tracking context-specific transcription factors regulating hox activity
Q40422212Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1.
Q47995118Transiently disordered tails accelerate folding of globular proteins.
Q39593473Trehalose induces functionally active conformation in the intrinsically disordered N-terminal domain of glucocorticoid receptor
Q64104376TriPepSVM: de novo prediction of RNA-binding proteins based on short amino acid motifs
Q43065281Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system.
Q61813288Troubleshooting Guide to Expressing Intrinsically Disordered Proteins for Use in NMR Experiments
Q92451154Turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations
Q36218535Two Isoforms of Yersinia pestis Plasminogen Activator Pla: Intraspecies Distribution, Intrinsic Disorder Propensity, and Contribution to Virulence
Q27688964Two potential therapeutic antibodies bind to a peptide segment of membrane-bound IgE in different conformations
Q38378144Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain
Q27324164Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region
Q30401693Tyrosine Regulates β-Sheet Structure Formation in Amyloid-β42: A New Clustering Algorithm for Disordered Proteins
Q30385084Understanding protein non-folding.
Q49759325Understanding the roles of intrinsic disorder in subunits of hemoglobin and the disease process of sickle cell anemia.
Q34502055Unexpected features of the dark proteome
Q41070551Unfoldome variation upon plant-pathogen interactions: strawberry infection by Colletotrichum acutatum
Q38838353Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer
Q36899633Universal allosteric mechanism for Gα activation by GPCRs
Q34474706Unmasking alternative splicing inside protein-coding exons defines exitrons and their role in proteome plasticity.
Q37649607Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs
Q37649606Unreported intrinsic disorder in proteins: Disorder emergency room
Q30375946Unstructural biology of the Dengue virus proteins.
Q34099974Unsupervised Integration of Multiple Protein Disorder Predictors: The Method and Evaluation on CASP7, CASP8 and CASP9 Data
Q42215545Use of host-like peptide motifs in viral proteins is a prevalent strategy in host-virus interactions
Q34314123Using comparative genomics to uncover new kinds of protein-based metabolic organelles in bacteria
Q37388968Using the ubiquitin-modified proteome to monitor protein homeostasis function
Q34609175Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder
Q35064280Visualization of the nanospring dynamics of the IkappaBalpha ankyrin repeat domain in real time
Q46534990Wider than Thought Phylogenetic Occurrence of Apicortin, A Characteristic Protein of Apicomplexan Parasites
Q36126137Yersinia pestis Caf1 Protein: Effect of Sequence Polymorphism on Intrinsic Disorder Propensity, Serological Cross-Reactivity and Cross-Protectivity of Isoforms
Q54989440Young Genes are Highly Disordered as Predicted by the Preadaptation Hypothesis of De Novo Gene Birth.
Q92256630bHLH-PAS Proteins: Their Structure and Intrinsic Disorder
Q47204147fDETECT webserver: fast predictor of propensity for protein production, purification, and crystallization.
Q44194295fLPS: Fast discovery of compositional biases for the protein universe
Q41850199iELM--a web server to explore short linear motif-mediated interactions
Q35914230iPDA: integrated protein disorder analyzer
Q94948361mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1
Q28079390p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept
Q58090467qPhos: a database of protein phosphorylation dynamics in humans
Q33520352svmPRAT: SVM-based protein residue annotation toolkit

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