Oncogenic Y68 frame shift mutation of PTEN represents a mechanism of docetaxel resistance in endometrial cancer cell lines

scientific article published in Scientific Reports

Oncogenic Y68 frame shift mutation of PTEN represents a mechanism of docetaxel resistance in endometrial cancer cell lines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-38585-9
P932PMC publication ID6375989
P698PubMed publication ID30765787

P2093author name stringHe Zhu
Song Wang
Haiyang Zhang
Gottfried Konecny
Mitchell Kamrava
Nicholas Cacalano
Qiuju Liu
Michael Xie
Shunzi Jin
P2860cites workAdjuvant paclitaxel and carboplatin chemotherapy with involved field radiation in advanced endometrial cancer: a sequential approachQ79329241
Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer: a gynecologic oncology group studyQ81780938
The xCELLigence system for real-time and label-free monitoring of cell viabilityQ83790178
(S034) Pilot Phase II Trial of "Sandwich" Radiation and Combination Carboplatin and Paclitaxel Chemotherapy in Patients With High-Risk Endometrial CancerQ95368961
PTEN regulatory functions in tumor suppression and cell biologyQ28284719
Integrated genomic characterization of endometrial carcinomaQ28289962
ras oncogenes in human cancer: a reviewQ29547769
The functions and regulation of the PTEN tumour suppressorQ29615536
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial CarcinomaQ33180279
Pilot phase II trial of radiation "sandwiched" between combination paclitaxel/platinum chemotherapy in patients with uterine papillary serous carcinoma (UPSC).Q33377350
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activityQ33774967
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromesQ33855646
Signalling pathways in endometrial cancerQ34721660
The benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysisQ34786625
High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stabilityQ35275603
Sequential chemotherapy and radiotherapy in the sandwich method for advanced endometrial cancer: a meta-analysisQ35612775
G2 checkpoint abrogator abates the antagonistic interaction between antimicrotubule drugs and radiation therapyQ36176979
Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cellsQ36510153
Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer--results from two randomised studiesQ36554430
Dynamic and label-free cell-based assays using the real-time cell electronic sensing systemQ36658140
Drug-sensitive FGFR2 mutations in endometrial carcinomaQ36735178
PI3K pathway dependencies in endometrioid endometrial cancer cell linesQ36980561
The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapiesQ37349623
Emerging therapeutic targets in endometrial cancerQ37827340
Contemporary management of endometrial cancerQ37996608
Markers for individualised therapy in endometrial carcinomaQ38030768
The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancerQ38053414
Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancerQ38242086
PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer.Q38882236
Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cellsQ39188104
Cell cycle-dependent antagonistic interactions between paclitaxel and gamma-radiation in combination therapyQ40532790
Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group StudyQ40533016
Combined treatment with chemotherapy and radiotherapy in high-risk FIGO stage III-IV endometrial cancer patientsQ40535566
A single institution experience using sequential multi-modality adjuvant chemotherapy and radiation in the "sandwich" method for high risk endometrial carcinomaQ43104465
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdocetaxelQ420436
endometrial cancerQ944777
P304page(s)2111
P577publication date2019-02-14
P1433published inScientific ReportsQ2261792
P1476titleOncogenic Y68 frame shift mutation of PTEN represents a mechanism of docetaxel resistance in endometrial cancer cell lines
P478volume9

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Q90179383Cyclooxygenase-2 and β-Catenin as Potential Diagnostic and Prognostic Markers in Endometrial Cancercites workP2860

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