Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

scientific article published on 26 June 2017

Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JACBTS.2016.11.010
P932PMC publication ID6034501
P698PubMed publication ID30062151

P50authorKipp W. JohnsonQ52812470
Benjamin S GlicksbergQ56344761
P2093author name stringJoel T Dudley
Partho P Sengupta
Khader Shameer
Johan L M Björkegren
Jason C Kovacic
Ben Readhead
P2860cites workFive years of GWAS discoveryQ24610574
Clinical assessment incorporating a personal genomeQ24612653
The failure of torcetrapib: what have we learned?Q24652526
Evolution of biological complexityQ24679232
Precision medicine in NSCLC and pathology: how does ALK fit in the pathway?Q26738390
The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular diseaseQ26748869
Colchicine and the heart: pushing the envelopeQ27001634
Genome-wide association studies of late-onset cardiovascular diseaseQ27012711
Shifting from the single to the multitarget paradigm in drug discoveryQ27144242
Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic DataQ27301054
Genomic medicine--an updated primerQ27691437
Network biology: understanding the cell's functional organizationQ27861027
Ockham's razor for the MET-driven invasive growth linking idiopathic pulmonary fibrosis and cancerQ28067777
Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disordersQ28082561
Quinupristin/dalfopristin: a therapeutic reviewQ28202172
DeepChrome: deep-learning for predicting gene expression from histone modificationsQ28223334
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics dataQ28266682
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control studyQ28281870
Network pharmacology: the next paradigm in drug discoveryQ28297997
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic applicationQ28300751
Multi-target drugs: the trend of drug research and developmentQ28480888
EHDViz: clinical dashboard development using open-source technologiesQ28601874
The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing dataQ28649714
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and futureQ28674604
Systems biology approaches to adverse drug effects: the example of cardio-oncologyQ38606067
Drug repurposing in oncology--patient and health systems opportunities.Q38611707
The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association studyQ29417153
A new initiative on precision medicineQ29615654
Interactome networks and human diseaseQ29615773
2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)Q29617334
Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart AssociationQ30080021
Medical student preparedness for an era of personalized medicine: findings from one US medical schoolQ30151843
Precision medicine in cardiologyQ30249224
Using recurrent neural network models for early detection of heart failure onset.Q30358244
Computational and experimental advances in drug repositioning for accelerated therapeutic stratificationQ30487562
Clinical implications of chronic heart failure phenotypes defined by cluster analysisQ30604593
Unsupervised feature construction and knowledge extraction from genome-wide assays of breast cancer with denoising autoencodersQ30616727
Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial)Q30731532
Visual analytics in healthcare education: exploring novel ways to analyze and represent big data in undergraduate medical educationQ30874069
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.Q30990302
Topological data analysis for discovery in preclinical spinal cord injury and traumatic brain injury.Q31004909
Big data analytics to improve cardiovascular care: promise and challengesQ31062479
Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human RecombinationQ31110726
An electronic clinical decision support tool to assist primary care providers in cardiovascular disease risk management: development and mixed methods evaluationQ33575307
Pharmaco-miR: linking microRNAs and drug effectsQ33920265
Insights into Protein Sequence and Structure-Derived Features Mediating 3D Domain Swapping Mechanism using Support Vector Machine Based Approach.Q33983023
Discovery and preclinical validation of drug indications using compendia of public gene expression dataQ33995422
Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics.Q34025939
Antihypertensive medication classes used among medicare beneficiaries initiating treatment in 2007-2010.Q34084060
History of the design of captopril and related inhibitors of angiotensin converting enzymeQ34097139
The design and rationale of a multicenter clinical trial comparing two strategies for control of systolic blood pressure: the Systolic Blood Pressure Intervention Trial (SPRINT)Q34145516
Phenomics: the next challengeQ34150453
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancerQ34276296
Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango).Q34416426
The precision medicine initiative: a new national effortQ34474452
Trimethoprim-sulfamethoxazole revisitedQ34648327
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart AssociationQ34741065
Genomic medicine--a primerQ34992066
Effective diagnosis of genetic disease by computational phenotype analysis of the disease-associated genomeQ35237812
Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid ArthritisQ35891702
Drug response prediction by inferring pathway-response associations with kernelized Bayesian matrix factorizationQ38748583
Heart Failure Update: Diagnosis and ClassificationQ38773646
Pharmacogenetics of Lipid-Lowering Agents: Precision or Indecision Medicine?Q38780996
The Next Era: Deep Learning in Pharmaceutical ResearchQ38823933
Pleiotropic effects of statins: new therapeutic targets in drug designQ38825843
Cholesteryl Ester Transfer Protein Inhibitors: Trials and TribulationsQ38832478
Moving beyond regression techniques in cardiovascular risk prediction: applying machine learning to address analytic challengesQ38902965
Cholesteryl Ester Transfer Protein Inhibition Is Not Yet Dead--ProQ38911754
Deep Learning in Drug Discovery.Q38918718
Lung cancer: current therapies and new targeted treatmentsQ38940816
Genetics and Genomics of Coronary Artery DiseaseQ38944185
Cardiovascular precision medicine: hope or hype?Q38995650
Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD scoreQ39135665
Machine-Learning Algorithms to Automate Morphological and Functional Assessments in 2D EchocardiographyQ39156139
Digital mammographic tumor classification using transfer learning from deep convolutional neural networksQ39407913
Multiparametric Non-Negative Matrix Factorization for Longitudinal Variations Detection in White-Matter Fiber Bundles.Q39499411
Prolongation of survival in congestive cardiomyopathy by beta-receptor blockadeQ39550779
Recent Trends in Cardiovascular Mortality in the United States and Public Health GoalsQ39580505
Combining deep learning and level set for the automated segmentation of the left ventricle of the heart from cardiac cine magnetic resonance.Q39596050
Escaping the EHR Trap — The Future of Health ITQ39603584
Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and SwedenQ39703517
Opportunities for the Cardiovascular Community in the Precision Medicine InitiativeQ39877605
PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportabilityQ39879045
The Impact of Biochemical Markers on Major Adverse Cardiovascular Events and Contralateral Carotid Artery Stenosis Progression Following Carotid InterventionsQ40613045
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.Q40615674
Healthcare and the information age: implications for medical educationQ40860303
Network medicine in disease analysis and therapeuticsQ41890269
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study GroupQ42556789
The US Cancer Moonshot initiativeQ45036066
3dswap-pred: Prediction of 3D Domain Swapping from Protein Sequence Using Random Forest ApproachQ45961910
Cost-effectiveness of pharmacogenetics-guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation.Q46008192
Developing New Treatments for Heart Failure: Focus on the HeartQ48115739
Back to the future: improving the use of guidelines-recommended coronary disease secondary prevention at the dawn of the precision medicine era.Q48528410
Ensembles of Deep Learning Architectures for the Early Diagnosis of the Alzheimer's DiseaseQ48593607
Oncology Nurses and the Cancer Moonshot 2020.Q48612847
The heterogeneity of heart failure: will enhanced phenotyping be necessary for future clinical trial success?Q48694284
The role of serum levels of microRNA-21 and matrix metalloproteinase-9 in patients with acute coronary syndromeQ51535970
Association of Soluble Fibrinogen-like Protein 2 with the Severity of Coronary Artery DiseaseQ51540421
Whole exome sequencing implicates an INO80D mutation in a syndrome of aortic hypoplasia, premature atherosclerosis, and arterial stiffnessQ52652833
Plasma MicroRNA-126-5p is Associated with the Complexity and Severity of Coronary Artery Disease in Patients with Stable Angina PectorisQ52982596
Decline in Rates of Death and Heart Failure in Acute Coronary Syndromes, 1999-2006Q57243464
The effect of beta adrenergic blockade on patterns of urinary sodium excretion. Studies in normal subjects and in patients with heart diseaseQ72846401
Cyclic-GMP-Binding, Cyclic-GMP-Specific Phosphodiesterase (PDE5) Gene Expression Is Regulated during Rat Pulmonary DevelopmentQ74220192
Realism in drug discovery—could Cassandra be right?Q77317501
Medication nonadherence is associated with a broad range of adverse outcomes in patients with coronary artery diseaseQ80969615
Modern management of acute myocardial infarctionQ84289643
Translating the effects of statins: from redox regulation to suppression of vascular wall inflammationQ84749257
Planning for US Precision Medicine Initiative underwayQ85489836
Challenges and opportunities of drug repositioningQ86587232
Pharmacogenetic-guided selection of warfarin versus novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: a cost-effectiveness analysisQ86606402
Applying cluster analysis to data of previously published chronic heart failure trialsQ87000142
Systems biology and clinical phenotypes of heart failure syndromeQ87000143
Reply: applying cluster analysis to data of previously published chronic heart failure trials: systems biology and clinical phenotypes of heart failure syndromeQ87000146
Cost-effectiveness of hypertension therapy according to 2014 guidelinesQ87165889
The emergence of cardiovascular imaging as a subspecialty and individualized treatment of coronary artery disease: two related trendsQ95801973
Sildenafil in the treatment of pulmonary hypertensionQ36013070
Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networksQ36053748
A Multimodal Data Analysis Approach for Targeted Drug Discovery Involving Topological Data Analysis (TDA).Q36057399
DL-ADR: a novel deep learning model for classifying genomic variants into adverse drug reactionsQ36100724
Serum levels of mitochondrial inhibitory factor 1 are independently associated with long-term prognosis in coronary artery disease: the GENES StudyQ36110734
Classification of breast cancer patients using somatic mutation profiles and machine learning approaches.Q36121092
Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons.Q36145457
GWASdb v2: an update database for human genetic variants identified by genome-wide association studiesQ36435017
Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.Q36554423
Identification of type 2 diabetes subgroups through topological analysis of patient similarityQ36659399
Multi-target therapeutics: when the whole is greater than the sum of the partsQ36697412
In silico methods for drug repurposing and pharmacologyQ36837816
Cross-Tissue Regulatory Gene Networks in Coronary Artery DiseaseQ36865220
Deep Patient: An Unsupervised Representation to Predict the Future of Patients from the Electronic Health Records.Q36906830
Genetic loci associated with ideal cardiovascular health: A meta-analysis of genome-wide association studiesQ36918961
Pathogenesis of essential hypertension: historical paradigms and modern insightsQ37094953
Bioinformatics and medical informatics: collaborations on the road to genomic medicine?Q37101286
Deep learning for digital pathology image analysis: A comprehensive tutorial with selected use casesQ37161047
Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approachQ37170587
Predicting the risk of cardiovascular comorbidities in adult cancer survivorsQ37247981
The digital revolution in phenotypingQ37284033
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertensionQ37324554
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effectsQ37432574
Cognitive Machine-Learning Algorithm for Cardiac Imaging: A Pilot Study for Differentiating Constrictive Pericarditis From Restrictive CardiomyopathyQ37660478
Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high-risk patients harboring neck lymph node extracapsular extensionQ37665255
The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in cardiovascular disease: a comprehensive reviewQ37798424
The productivity crisis in pharmaceutical R&D.Q37883027
Pharmacogenetics and cost-effectiveness analysis: a two-way streetQ37929355
Pleiotropic Effects of Statins: The Role of Eicosanoid ProductionQ37979644
Drug repositioning for Alzheimer's disease.Q38057607
Social Network Analysis: Foundations and Frontiers on AdvantageQ38071130
The disconnect between phase II and phase III trials of drugs for heart failureQ38072257
Coronary stents: historical development, current status and future directionsQ38093501
Cardiovascular drug development: is it dead or just hibernating?Q38424497
An integrative pipeline for multi-modal discovery of disease relationshipsQ38467857
Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General PopulationQ38503734
P433issue3
P407language of work or nameEnglishQ1860
P921main subjecttranslational bioinformaticsQ7834541
precision medicineQ17075943
P304page(s)311-327
P577publication date2017-06-26
P1433published inJACC. Basic to Translational ScienceQ27727237
P1476titleEnabling Precision Cardiology Through Multiscale Biology and Systems Medicine
P478volume2

Reverse relations

cites work (P2860)
Q55257457A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease.
Q92280999A transcriptomic model to predict increase in fibrous cap thickness in response to high-dose statin treatment: Validation by serial intracoronary OCT imaging
Q92877426Artificial Intelligence: Practical Primer for Clinical Research in Cardiovascular Disease
Q91879187Deep learning cardiac motion analysis for human survival prediction
Q64039509Exploiting machine learning for end-to-end drug discovery and development
Q92409586Relevance of Multi-Omics Studies in Cardiovascular Diseases
Q90019228The 'Digital Twin' to enable the vision of precision cardiology

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