A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease.

scientific article published on 18 May 2018

A Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease. is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID5961807
P698PubMed publication ID29888052

P50authorKipp W. JohnsonQ52812470
Benjamin S GlicksbergQ56344761
Iftikhar J KulloQ93203286
P2093author name stringJoel T Dudley
Khader Shameer
Ben Readhead
Garrett Dow
Max S Tomlinson
Yi Ze
P2860cites workA dynamic network approach for the study of human phenotypesQ21145365
The human disease networkQ24678240
Network biology: understanding the cell's functional organizationQ27861027
The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association studyQ29417153
Lethality and centrality in protein networksQ29547267
A new method of classifying prognostic comorbidity in longitudinal studies: development and validationQ29547376
A human phenome-interactome network of protein complexes implicated in genetic disordersQ29614448
Personal omics profiling reveals dynamic molecular and medical phenotypesQ29614800
Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex diseaseQ29619085
Computational drug repositioning for peripheral arterial disease: prediction of anti-inflammatory and pro-angiogenic therapeuticsQ30278668
Computational and experimental advances in drug repositioning for accelerated therapeutic stratificationQ30487562
Comorbidity Measures for Use with Administrative DataQ32144770
Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseasesQ33390788
Cardiovascular networks: systems-based approaches to cardiovascular diseaseQ33717801
CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levelsQ33914125
Discovery and preclinical validation of drug indications using compendia of public gene expression dataQ33995422
Understanding protein-nanoparticle interaction: a new gateway to disease therapeutics.Q34025939
Leveraging informatics for genetic studies: use of the electronic medical record to enable a genome-wide association study of peripheral arterial diseaseQ34371896
Protein localization as a principal feature of the etiology and comorbidity of genetic diseasesQ35088894
Exploiting drug-disease relationships for computational drug repositioningQ35109885
Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.Q35463524
Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory.Q35751212
Nitric oxide and arterial diseaseQ35817914
Survival in patients with poorly compressible leg arteriesQ35838381
Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networksQ36053748
Gene expression profiling of peripheral blood mononuclear cells in the setting of peripheral arterial disease.Q36054090
Tracking the epidemiology of human genes in the literature: the HuGE Published Literature databaseQ36461180
Network properties of genes harboring inherited disease mutationsQ36670355
In silico methods for drug repurposing and pharmacologyQ36837816
Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understandingQ36856689
Long-term pleiotropic effect of statins upon nitric oxide and C-reactive protein levels in patients with peripheral arterial diseaseQ36982646
Protein networks in diseaseQ37125547
Genetics of peripheral artery diseaseQ37127078
Cancer metastasis networks and the prediction of progression patternsQ37330786
A systems-based framework for understanding complex metabolic and cardiovascular disordersQ37334581
A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.Q37395737
Evolution of biomolecular networks: lessons from metabolic and protein interactionsQ37620156
Peripheral Artery Disease and Genetics: Is There a Cause-and-Effect Relationship?Q37777012
Addressing the complexity of chronic obstructive pulmonary disease: from phenotypes and biomarkers to scale-free networks, systems biology, and P4 medicineQ37822219
Deciphering the molecular basis of human cardiovascular disease through network biologyQ37989807
An integrative pipeline for multi-modal discovery of disease relationshipsQ38467857
Hubs in biological interaction networks exhibit low changes in expression in experimental asthmaQ42801052
The impact of cellular networks on disease comorbidityQ43125319
A network view of disease and compound screeningQ44111868
Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.Q51376589
A navigator for human genome epidemiologyQ51895975
Enabling Precision Cardiology Through Multiscale Biology and Systems MedicineQ62743772
P4510describes a project that usesCytoscapeQ3699942
P921main subjectdrug repositioningQ5308921
P304page(s)108-117
P577publication date2018-05-18
P1433published inAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational ScienceQ27723308
P1476titleA Network-Biology Informed Computational Drug Repositioning Strategy to Target Disease Risk Trajectories and Comorbidities of Peripheral Artery Disease.
P478volume2017

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Q58739330Pharmacological risk factors associated with hospital readmission rates in a psychiatric cohort identified using prescriptome data miningcites workP2860

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