Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration

scientific article published on 01 May 2019

Automated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S42003-019-0411-9
P932PMC publication ID6494885
P698PubMed publication ID31069265

P50authorTomasz NowakowskiQ63170360
Jeremy W LinsleyQ91869268
P2093author name stringSteven Finkbeiner
Irina Epstein
Ashkan Javaherian
Siddharth Samsi
Galina Schmunk
Viral Oza
Mariya Barch
Elliot Mount
Atmiyata Tripathi
Matthew Campioni
P2860cites workDevelopment and evolution of the human neocortexQ22337363
Mutant LRRK2 toxicity in neurons depends on LRRK2 levels and synuclein but not kinase activity or inclusion bodiesQ24318474
Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disordersQ26850298
Self-propagation of pathogenic protein aggregates in neurodegenerative diseasesQ26996441
Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomersQ88959344
Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neuronsQ38975954
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosisQ39255266
Genetically Encoded Calcium Indicators as Probes to Assess the Role of Calcium Channels in Disease and for High-Throughput Drug DiscoveryQ39320565
Live-cell imaging of cell signaling using genetically encoded fluorescent reportersQ39371960
Mitotic spindle orientation predicts outer radial glial cell generation in human neocortexQ39837321
Biolistic transfection of neuronal cultures using a hand-held gene gun.Q40150089
Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke.Q41508786
Organotypic slice cultures: a technique has come of age.Q41623986
Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex DevelopmentQ41625328
Nrf2 mitigates LRRK2- and α-synuclein-induced neurodegeneration by modulating proteostasis.Q41827284
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic miceQ41841473
Cocultured, but not isolated, cortical explants display normal dendritic development: a long-term quantitative studyQ42529071
Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assayQ42741104
An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice cultureQ42930740
Assembly of functionally integrated human forebrain spheroidsQ43487488
Imaging neurite development of adult-born granule cellsQ44222842
Monitoring aggregate formation in organotypic slice cultures from transgenic miceQ45293912
A one-hit model of cell death in inherited neuronal degenerationsQ45300872
Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutationQ45302975
Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortexQ46852287
The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic ImplicationsQ47102449
Imaging organoids: a bright future ahead.Q47753249
Long-term live imaging of neuronal circuits in organotypic hippocampal slice culturesQ48218820
A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuitQ48537370
Organotypic monolayer cultures of nervous tissueQ49146386
Cell-based screening: extracting meaning from complex dataQ27305816
Zika virus cell tropism in the developing human brain and inhibition by azithromycinQ28119685
Huntington's diseaseQ28284355
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal deathQ28287762
High-throughput screening in primary neuronsQ28709230
A simple method for organotypic cultures of nervous tissueQ29614375
Computer control of microscopes using µManagerQ29615172
Neurogenic radial glia in the outer subventricular zone of human neocortexQ29616182
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's diseaseQ30080016
Serine 421 regulates mutant huntingtin toxicity and clearance in mice.Q30355064
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosisQ30575638
Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement ActivationQ30754508
Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesisQ30986761
Variables with time-varying effects and the Cox model: some statistical concepts illustrated with a prognostic factor study in breast cancerQ33541305
Neuronal loss in the hippocampus in Huntington's disease: a comparison with HIV infectionQ33591131
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosisQ33649745
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.Q33930825
Seizures and epilepsy in Alzheimer's diseaseQ34070798
Modifications to the hand-held Gene Gun: improvements for in vitro biolistic transfection of organotypic neuronal tissueQ34097933
Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminencesQ34314170
Organotypic brain slice cultures of adult transgenic P301S mice--a model for tauopathy studiesQ34416323
Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.Q34508992
Genetically Encoded Voltage Indicators: Opportunities and Challenges.Q34541461
Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platformQ34691557
Atg4b-dependent autophagic flux alleviates Huntington's disease progressionQ34827331
Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synucleinQ35063363
Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1.Q35796020
A three-groups model for high-throughput survival screens.Q35907530
Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice culturesQ36102782
Late-onset Parkinsonism in NFκB/c-Rel-deficient miceQ36218699
Computational method for calculating fluorescence intensities within three-dimensional structures in cellsQ36714563
Internal regulation of neurite plasticity: A general model.Q37590139
Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade.Q37719047
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathologyQ38134459
Modeling Human Neurological and Neurodegenerative Diseases: From Induced Pluripotent Stem Cells to Neuronal Differentiation and Its Applications in NeurotraumaQ38745828
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautomationQ184199
P304page(s)155
P577publication date2019-05-01
P1433published inCommunications BiologyQ60029756
P1476titleAutomated four-dimensional long term imaging enables single cell tracking within organotypic brain slices to study neurodevelopment and degeneration
P478volume2

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cites work (P2860)
Q99723633Functional genomics, genetic risk profiling and cell phenotypes in neurodegenerative disease
Q98158672Low-cost calcium fluorometry for long-term nanoparticle studies in living cells

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