Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma

Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1113160233
P356DOI10.1186/S40169-019-0226-9
P932PMC publication ID6441665
P698PubMed publication ID30931508

P2093author name stringK M Sullivan
V G Pillarisetty
K P Labadie
S K Daniel
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Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signalingQ34654565
Increased circulating Th17 cells after transarterial chemoembolization correlate with improved survival in stage III hepatocellular carcinoma: a prospective study.Q34658445
Hypoxia and lineage specification of cell line-derived colorectal cancer stem cellsQ34693614
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Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunctionQ34873308
Prognostic value of PDL1 expression in pancreatic cancerQ37687595
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.Q37688914
Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR.Q37697031
Targeted delivery of chemotherapy using HSP90 inhibitor drug conjugates is highly active against pancreatic cancer modelsQ37706198
CD20+ B cells: the other tumor-infiltrating lymphocytesQ37801779
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Twist promotes angiogenesis in pancreatic cancer by targeting miR-497/VEGFA axisQ37295501
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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolismQ37378754
Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancerQ37588378
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Impeding macrophage entry into hypoxic tumor areas by Sema3A/Nrp1 signaling blockade inhibits angiogenesis and restores antitumor immunity.Q46373208
Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancerQ46453398
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Targeted depletion of an MDSC subset unmasks pancreatic ductal adenocarcinoma to adaptive immunity.Q35121535
CD25 blockade depletes and selectively reprograms regulatory T cells in concert with immunotherapy in cancer patientsQ35588533
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Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabineQ36156256
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Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancerQ36260673
HLA-G impairs host immune response and predicts poor prognosis in pancreatic cancerQ36309539
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaQ36339991
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4Q36413897
Hypoxia signalling in cancer and approaches to enforce tumour regressionQ36488739
HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancerQ36543040
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer.Q36617328
Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancerQ36663615
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.Q36664869
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma.Q36673245
Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.Q36821138
CD39 and CD73 in immunity and inflammationQ36906658
Normalizing the environment recapitulates adult human immune traits in laboratory miceQ36912671
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.Q36971755
Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent mannerQ36976060
Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunityQ36996588
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.Q37084096
Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancerQ37195134
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A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic AdenocarcinomaQ38961784
Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxiaQ38978138
L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progressionQ39003009
Hypoxia-inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascinQ39018300
Novel bispecific antibodies increase γδ T-cell cytotoxicity against pancreatic cancer cellsQ39032241
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cellsQ39043650
HIF1 contributes to hypoxia-induced pancreatic cancer cells invasion via promoting QSOX1 expressionQ39099627
Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminaseQ39101616
Making Mouse Models That Reflect Human Immune ResponsesQ39119729
Myeloid-derived suppressor cells suppress antitumor immune responses through IDO expression and correlate with lymph node metastasis in patients with breast cancerQ39188755
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
MYC and HIF in shaping immune response and immune metabolismQ39211916
Aberrant elevated microRNA-146a in dendritic cells (DC) induced by human pancreatic cancer cell line BxPC-3-conditioned medium inhibits DC maturation and activationQ39400542
Autophagy mediates survival of pancreatic tumour-initiating cells in a hypoxic microenvironmentQ39409332
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.Q39507131
The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor modelQ39604863
Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontinQ39796201
Selective killing of hypoxia-inducible factor-1-active cells improves survival in a mouse model of invasive and metastatic pancreatic cancerQ39856479
Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancerQ39893068
Differential regulation of hypoxia-induced CXCR4 triggering during B-cell development and lymphomagenesisQ40079539
Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activationQ40124587
Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cellsQ40241550
Pancreatic cancer: Update on immunotherapies and algenpantucel-L.Q40261599
Hypoxia requires notch signaling to maintain the undifferentiated cell stateQ40356897
Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.Q40412450
IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancerQ40503359
Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabineQ40568618
A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model.Q41202462
Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma.Q41330055
Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.Q41367891
Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinomaQ41514095
The impact of hypoxia on tumor-associated macrophagesQ41678839
Peroxisome proliferator-activated receptors (PPARs) are potential drug targets for cancer therapyQ41694098
Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinomaQ41768958
Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cellsQ41866335
The pancreatic cancer microenvironment: an immunologic battlegroundQ41970901
Current progress in immunotherapy for pancreatic cancerQ42086309
PanIN-specific regulation of Wnt signaling by HIF2α during early pancreatic tumorigenesisQ42119856
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancerQ42289841
HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expressionQ42335712
The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic reviewQ42600273
Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.Q42682218
HIF-1alpha expression regulates the bactericidal capacity of phagocytesQ42876119
HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxiaQ43258538
Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functionsQ44359280
Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and functionQ44869825
P433issue1
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
immunotherapyQ1427096
pancreatic adenocarcinomaQ18556189
P304page(s)10
P577publication date2019-04-01
P1433published inClinical and translational medicineQ27724586
P1476titleHypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma
P478volume8

Reverse relations

cites work (P2860)
Q91639548CXCL12 and Its Isoforms: Different Roles in Pancreatic Cancer?
Q89713724Effect of Hypercapnia, an Element of Obstructive Respiratory Disorder, on Pancreatic Cancer Chemoresistance and Progression
Q90193029Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
Q94481939Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models
Q92504704Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Q92541764Ping-Pong-Tumor and Host in Pancreatic Cancer Progression
Q95273159Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
Q90098490Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy
Q90677037The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier
Q64278826The ionophore antibiotic gramicidin A inhibits pancreatic cancer stem cells associated with CD47 down-regulation

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