Divide or Commit - Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis

Divide or Commit - Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis is …
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scholarly articleQ13442814

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P356DOI10.3389/FCELL.2019.00055
P932PMC publication ID6491688
P698PubMed publication ID31069222

P2093author name stringOtto W Witte
Anja Urbach
P2860cites workCdk6-dependent regulation of G(1) length controls adult neurogenesisQ24293050
Beyond the cell cycle: a new role for Cdk6 in differentiationQ24295941
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?Q24301459
Expression of cyclin-dependent kinase 6, but not cyclin-dependent kinase 4, alters morphology of cultured mouse astrocytesQ24308801
The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulationQ64380599
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-betaQ71995235
p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cellsQ74190453
Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brainQ74233473
LIF and BMP signaling generate separate and discrete types of GFAP-expressing cellsQ81545462
Fibroblast growth factor-2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor-2Q84618128
The regulatory mechanism of neurogenesis by IGF-1 in adult miceQ87774677
Distinct Molecular Signatures of Quiescent and Activated Adult Neural Stem Cells Reveal Specific Interactions with Their MicroenvironmentQ89462315
Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH)Q90821321
Effects of p21 on adult hippocampal neuronal development after irradiationQ91419874
pRb-E2F signaling in life of mesenchymal stem cells: Cell cycle, cell fate, and cell differentiationQ91792029
Brain-derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cellsQ93233254
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb functionQ24311568
New functional activities for the p21 family of CDK inhibitorsQ24313427
The decision to enter mitosis: feedback and redundancy in the mitotic entry networkQ24315132
Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signalingQ24322974
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complexQ24336704
Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitorsQ24597269
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylationQ24607335
Adult neurogenesis in the mammalian brain: significant answers and significant questionsQ24628935
Signaling mechanisms regulating adult neural stem cells and neurogenesisQ24633503
Neurons born in the adult dentate gyrus form functional synapses with target cellsQ24648754
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6Q24652510
Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf ExpressionQ24658265
In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampusQ24683755
Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after InjuryQ26746964
Molecular mechanisms underlying RB protein functionQ27003956
BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in miceQ27339382
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
Transcriptional control of stem cell fate by E2Fs and pocket proteinsQ28082523
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotersQ28140428
The INK4 family of cell cycle inhibitors in cancerQ28145080
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathwayQ28182285
Mitotic kinases as regulators of cell division and its checkpointsQ28202545
Cyclin A in cell cycle control and cancerQ28205375
Tumor suppression by Ink4a-Arf: progress and puzzlesQ28207959
Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathwayQ28237113
Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brainQ28240882
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrestQ28258615
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrestQ28270478
In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehogQ28275763
Cdks, cyclins and CKIs: roles beyond cell cycle regulationQ28294632
A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesisQ28296641
Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6Q28296993
How proteolysis drives the cell cycleQ28297983
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.Q28505355
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrusQ28505756
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryQ28509466
Smoothened controls cyclin D2 expression and regulates the generation of intermediate progenitors in the developing cortexQ28511154
Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesisQ28511326
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cellsQ28512856
Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiationQ28513619
Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivoQ28572747
Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogeneQ28576833
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivoQ28577046
VEGF links hippocampal activity with neurogenesis, learning and memoryQ28578381
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressantsQ28579192
Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the p19ARF-p53 pathwayQ28581842
Generation of neurons by transient expression of neural bHLH proteins in mammalian cellsQ28588730
Primary cilia regulate proliferation of amplifying progenitors in adult hippocampus: implications for learning and memoryQ28590555
Impaired long-term memory retention: common denominator for acutely or genetically reduced hippocampal neurogenesis in adult miceQ28591779
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinaseQ28612948
p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activityQ28647314
Mechanisms and functional implications of adult neurogenesisQ29547295
Principles of CDK regulationQ29547820
D-type cyclin-dependent kinase activity in mammalian cellsQ29614966
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageingQ29615155
For the long run: maintaining germinal niches in the adult brainQ29615156
G1 phase progression: cycling on cueQ29615162
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumorsQ29616203
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint controlQ29616465
Wnt signalling regulates adult hippocampal neurogenesisQ29619688
Runx transcription factors and the developmental balance between cell proliferation and differentiation.Q30332928
A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration.Q30476691
p27kip1 Is Required for Functionally Relevant Adult Hippocampal Neurogenesis in Mice.Q48452944
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.Q48473013
RB regulates the production and the survival of newborn neurons in the embryonic and adult dentate gyrus.Q48473533
Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain.Q48513149
The cyclin-dependent kinase inhibitor p27 kip1 regulates radial stem cell quiescence and neurogenesis in the adult hippocampus.Q48566419
Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development.Q48571923
Predicting stem cell fate changes by differential cell cycle progression patterns.Q48750437
Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex.Q48861138
Differential expression of D-type G1 cyclins during mouse development and liver regeneration in vivo.Q49015677
Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation.Q49031578
Increased cyclin E expression may obviate the role of cyclin D1 during brain development in cyclin D1 knockout mice.Q49042683
Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus.Q49084529
Multipotential stem cells from the adult mouse brain proliferate and self-renew in response to basic fibroblast growth factor.Q49159036
Live imaging of neurogenesis in the adult mouse hippocampus.Q50034921
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.Q50335523
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.Q50420534
p21Cip restrains hippocampal neurogenesis and protects neuronal progenitors from apoptosis during acute systemic inflammationQ34223531
Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiationQ34256767
Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2.Q34260459
Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cellsQ34277057
Acute effects of wheel running on adult hippocampal precursor cells in mice are not caused by changes in cell cycle length or S phase lengthQ34292051
New roles of cyclin D1.Q34352513
Running rescues defective adult neurogenesis by shortening the length of the cell cycle of neural stem and progenitor cells.Q34408836
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndromeQ34413824
BRG-1 is required for RB-mediated cell cycle arrestQ34509523
Hedgehog-Gli signalling and the growth of the brain.Q34514462
The restriction point of the cell cycleQ34528876
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.Q34656077
Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cellsQ34657898
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortexQ34666832
Cdk2 loss accelerates precursor differentiation and remyelination in the adult central nervous systemQ34825266
Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brainQ34973654
Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms.Q34989521
Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficitsQ35041002
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristicsQ35072024
Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent mannerQ35105147
The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursorsQ35111678
Not(ch) just development: Notch signalling in the adult brainQ35175155
Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesisQ35208724
Roles of p53 and p27(Kip1) in the regulation of neurogenesis in the murine adult subventricular zoneQ35545392
A niche for adult neural stem cellsQ35556003
Development of the adult neurogenic niche in the hippocampus of miceQ35580113
p57(KIP2) regulates radial glia and intermediate precursor cell cycle dynamics and lower layer neurogenesis in developing cerebral cortexQ35655615
Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampusQ35776311
Loss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formationQ35792968
Milestones of neuronal development in the adult hippocampusQ35844478
Living with or without cyclins and cyclin-dependent kinasesQ35951291
Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexesQ36058266
Unique processing during a period of high excitation/inhibition balance in adult-born neurons.Q36064695
Mammalian G1 cyclins and cell cycle progressionQ40983870
Epidermal growth factor induces cyclin D1 in a human prostate cancer cell lineQ41046866
Cell division and the nervous system: regulating the cycle from neural differentiation to deathQ41120777
Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cellsQ41138641
The role of controlled proteolysis in cell-cycle regulationQ41139575
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.Q41559119
Regulation of CDK/cyclin complexes during the cell cycleQ41639250
The tumor suppressor protein p16INK4a.Q41673713
Cdk1 is sufficient to drive the mammalian cell cycleQ41791627
Neural stem and progenitor cells shorten S-phase on commitment to neuron productionQ41963873
p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.Q42109916
CDK Substrate Phosphorylation and Ordering the Cell CycleQ42350856
Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.Q42459454
Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells.Q42505393
Differences in cyclin D2 and D1 protein expression distinguish forebrain progenitor subsetsQ42683659
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacityQ42705690
The critical role of cyclin D2 in adult neurogenesisQ42916216
Seizures increase cell proliferation in the dentate gyrus by shortening progenitor cell-cycle lengthQ42949393
Cyclin D2 knockout mice with depleted adult neurogenesis learn Barnes maze task.Q43661449
Astrocytes give rise to new neurons in the adult mammalian hippocampus.Q43732532
Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity.Q43906964
Lack of the cell-cycle inhibitor p27Kip1 results in selective increase of transit-amplifying cells for adult neurogenesis.Q43918838
Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampusQ44086931
Mcl1 regulates the terminal mitosis of neural precursor cells in the mammalian brain through p27Kip1.Q44251281
Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged miceQ44526579
IGF-I has a direct proliferative effect in adult hippocampal progenitor cellsQ44612681
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesisQ44660997
The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivoQ44864628
Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrusQ45071634
Overexpression of p27 Kip 1, probability of cell cycle exit, and laminar destination of neocortical neuronsQ45221848
Basic fibroblast growth factor exhibits dual and rapid regulation of cyclin D1 and p27 to stimulate proliferation of rat cerebral cortical precursorsQ45265181
Altered patterns of neuron production in the p27 knockout mouseQ45265185
New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning.Q45954233
Preferences for phosphorylation sites in the retinoblastoma protein of D-type cyclin-dependent kinases, Cdk4 and Cdk6, in vitroQ46421360
Intermediate progenitors in adult hippocampal neurogenesis: Tbr2 expression and coordinate regulation of neuronal outputQ46667144
CDK2 is dispensable for adult hippocampal neurogenesisQ46855317
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus.Q46881337
Enhanced production and dendritic growth of new dentate granule cells in the middle-aged hippocampus following intracerebroventricular FGF-2 infusions.Q46990503
Notch activity levels control the balance between quiescence and recruitment of adult neural stem cells.Q47073573
Cyclin D/CDK4/6 activity controls G1 length in mammalian cells.Q47194463
IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cellsQ47920201
Review: adult neurogenesis contributes to hippocampal plasticityQ47945182
The retinoblastoma gene family: cousins with overlapping interestsQ47945692
Lack of cyclin D2 impairing adult brain neurogenesis alters hippocampal-dependent behavioral tasks without reducing learning abilityQ48028352
G1-phase regulators, cyclin D1, cyclin D2, and cyclin D3: up-regulation at gastrulation and dynamic expression during neurulationQ48036033
Autocrine action of BDNF on dendrite development of adult-born hippocampal neuronsQ48145817
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.Q48199490
Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and agingQ48207817
Proliferation and differentiation of neural stem cells are selectively regulated by knockout of cyclin D1.Q48215680
Cerebellar histogenesis is disturbed in mice lacking cyclin D2.Q48249499
Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytesQ48264885
Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brainsQ48283634
Brief report: Adult hippocampal precursor cells shorten S-phase and total cell cycle length during neuronal differentiation.Q48372802
Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment.Q48397095
p57kip2 regulates glial fate decision in adult neural stem cells.Q48416197
Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis.Q48426963
Biochemical and cellular mechanisms of mammalian CDK inhibitors: a few unresolved issuesQ36101745
The retinoblastoma tumor suppressor and stem cell biologyQ36110891
Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zoneQ36274559
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrusQ36300108
p107 regulates neural precursor cells in the mammalian brainQ36322017
p27(KIP1) regulates neurogenesis in the rostral migratory stream and olfactory bulb of the postnatal mouseQ36368949
Vascular endothelial growth factor receptor 3 controls neural stem cell activation in mice and humansQ36387982
Regenerative response in ischemic brain restricted by p21cip1/waf1Q36399429
p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampusQ36446238
p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation.Q36546981
Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulbQ36548691
Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesisQ36602402
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin DQ36603861
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesisQ36739553
Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2.Q36771257
Non-canonical functions of cell cycle cyclins and cyclin-dependent kinasesQ36827351
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signalingQ36861834
The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrusQ36892213
Notch activates cell cycle reentry and progression in quiescent cardiomyocytes.Q36917080
Cell fate determination during G1 phase progressionQ36949844
RB1, development, and cancerQ36950978
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.Q36994927
Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expressionQ37023123
CDK inhibitors: cell cycle regulators and beyondQ37081857
Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus.Q37119855
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatmentQ37127162
Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic originQ37137169
Fine processes of Nestin-GFP-positive radial glia-like stem cells in the adult dentate gyrus ensheathe local synapses and vasculatureQ37173116
Molecular regulation of stem cell quiescence.Q37256787
Differential regulation of cyclin-dependent kinase 4 (CDK4) and CDK6, evidence that CDK4 might not be activated by CDK7, and design of a CDK6 activating mutation.Q37275203
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cellsQ37302213
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexesQ37375698
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.Q37393033
BMP signaling regulates the tempo of adult hippocampal progenitor maturation at multiple stages of the lineage.Q50684187
RB and RB2/P130 genes cooperate with extrinsic signals to promote differentiation of rat neural stem cells.Q50912886
Neurogenesis in the Adult Hippocampus.Q51787496
RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.Q51897964
Mouse development and cell proliferation in the absence of D-cyclins.Q52088064
The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus.Q52112242
Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity.Q52178920
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.Q52526599
Human Hippocampal Neurogenesis Persists throughout Aging.Q52602379
Radial glial cells in the adult dentate gyrus: what are they and where do they come from?Q52641494
Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain.Q52724659
Human Adult Neurogenesis: Evidence and Remaining QuestionsQ52804530
A growth-promoting signaling component cyclin D1 in neural stem cells has antiastrogliogenic function to execute self-renewal.Q53080235
Role of the INK4a locus in tumor suppression and cell mortality.Q53455197
The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors.Q53533279
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.Q54048106
Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice.Q54955875
Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity.Q54979714
INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice.Q55002768
BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells.Q55286264
Epidermal growth factor receptor and Ink4a/ArfQ57277079
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndromeQ58236969
Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through expressionQ58733466
The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wallQ64117434
p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical ExerciseQ64241257
An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorantsQ64265315
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behaviorQ30483856
Forced G1-phase reduction alters mode of division, neuron number, and laminar phenotype in the cerebral cortex.Q30492178
Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates.Q30513948
Selective cortical interneuron and GABA deficits in cyclin D2-null mice.Q30520114
Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesisQ30651624
Hippocampal bone morphogenetic protein signaling mediates behavioral effects of antidepressant treatmentQ30843800
Reliable activation of immature neurons in the adult hippocampusQ30862067
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.Q32062012
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosisQ33560182
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cellsQ33589421
Cyclin D2 is critical for intermediate progenitor cell proliferation in the embryonic cortexQ33609469
Cyclins and cell cycle checkpointsQ33636687
Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.Q33692299
Genetic replacement of cyclin D1 function in mouse development by cyclin D2.Q33714058
The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesisQ33723574
Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.Q33730685
Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosisQ33799210
Cyclin D activates the Rb tumor suppressor by mono-phosphorylationQ33827900
Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewalQ33894555
Cyclin-dependent kinasesQ33900533
Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampusQ34072691
Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycleQ34076834
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cellsQ34112161
Smoothened agonist augments proliferation and survival of neural cellsQ34124154
Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampusQ34125376
The Ink4a/Arf locus is a barrier to direct neuronal transdifferentiationQ34162817
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiationQ34194645
Endogenous Wnt signaling maintains neural progenitor cell potencyQ37436994
The cell-cycle state of stem cells determines cell fate propensity.Q37504042
Signaling in adult neurogenesis.Q37540178
Concise Review: Control of Cell Fate Through Cell Cycle and Pluripotency NetworksQ37546242
Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylationQ37627255
Cell cycle control of mammalian neural stem cells: putting a speed limit on G1.Q37691982
Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factorsQ37713598
Cdks and cyclins link G1 length and differentiation of embryonic, neural and hematopoietic stem cellsQ37740912
Maintenance and differentiation of neural stem cellsQ37808164
Adult neurogenesis and the plasticity of the dentate gyrus network.Q37852097
Concise review: Quiescent and active states of endogenous adult neural stem cells: identification and characterizationQ37873886
The multiple roles of the cyclin-dependent kinase inhibitory protein p57(KIP2) in cerebral cortical neurogenesisQ37955145
Wnt signaling in the regulation of adult hippocampal neurogenesisQ38117365
Neurogenesis in neurological and psychiatric diseases and brain injury: from bench to bedside.Q38175268
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct mannerQ38325589
Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.Q38347118
Adult neurogenesis: a substrate for experience-dependent change.Q38365236
The vascular niche in adult neurogenesisQ38535525
Cdk4 regulates adult neural stem cell proliferation and differentiation in response to insulin-IRS2 signalsQ38611877
Epilepsy and Adult NeurogenesisQ38629077
Control of Adult Neurogenesis by Short-Range Morphogenic-Signaling MoleculesQ38659223
Transcriptional repression of Bmp2 by p21(Waf1/Cip1) links quiescence to neural stem cell maintenanceQ39085673
Jagged1 is necessary for postnatal and adult neurogenesis in the dentate gyrusQ39205699
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitorsQ39444740
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexesQ39574223
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical developmentQ39647556
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.Q39743667
p27Kip1 and p21Cip1 Are Not Required for the Formation of Active D Cyclin-cdk4 ComplexesQ40015617
Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transitionQ40142298
Growth factor-regulated G1 cyclins.Q40494043
p19ARF directly and differentially controls the functions of c-Myc independently of p53.Q40516548
Noggin expands neural stem cells in the adult hippocampusQ40629552
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsQ40967344
Cyclin dependent kinase regulationQ40974421
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectneurogenesisQ1456827
ProliferationQ25096177
Neural stem cellsQ28202913
cyclinsQ62287157
P304page(s)55
P577publication date2019-01-01
P1433published inFrontiers in Cell and Developmental BiologyQ27725488
P1476titleDivide or Commit - Revisiting the Role of Cell Cycle Regulators in Adult Hippocampal Neurogenesis
P478volume7

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