| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S1569-2566(06)05012-5 |
| P50 | author | Jussi Pihlajamäki | Q42169304 |
| P2093 | author name string | Mary Elizabeth Patti | |
| P2860 | cites work | Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | Q22250892 |
| The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes | Q24290189 | ||
| The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha | Q24292329 | ||
| Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator | Q24294798 | ||
| Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha | Q24300512 | ||
| Potentiation of liver X receptor transcriptional activity by peroxisome-proliferator-activated receptor gamma co-activator 1 alpha | Q24535642 | ||
| AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation | Q24541475 | ||
| Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise | Q24546790 | ||
| Pgc-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells | Q24550957 | ||
| Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators | Q24557011 | ||
| Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle | Q24561461 | ||
| Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins | Q24561604 | ||
| Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle | Q24564824 | ||
| The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis | Q24564869 | ||
| Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK | Q24598689 | ||
| Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity | Q24673585 | ||
| Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 | Q24679555 | ||
| Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action | Q24803901 | ||
| Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents | Q24812499 | ||
| A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis | Q27860471 | ||
| Cloning and mRNA tissue distribution of human PPARgamma coactivator-1. | Q27863664 | ||
| Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1 | Q28131760 | ||
| Activation of PPARgamma coactivator-1 through transcription factor docking | Q28137806 | ||
| Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1 | Q28138472 | ||
| Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance | Q28186874 | ||
| PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma | Q28187874 | ||
| Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP | Q28203891 | ||
| Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance | Q28207189 | ||
| Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor | Q28208668 | ||
| Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1 | Q28212805 | ||
| A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes | Q28213832 | ||
| Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus | Q28215672 | ||
| Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1 | Q28216275 | ||
| Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha | Q28218141 | ||
| SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha} | Q28235481 | ||
| Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 | Q28237795 | ||
| Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro | Q28269790 | ||
| Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha | Q28279733 | ||
| Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1) | Q28298538 | ||
| Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes | Q28508812 | ||
| PGC-1beta in the regulation of hepatic glucose and energy metabolism | Q28566796 | ||
| PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes | Q29547229 | ||
| Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres | Q29555845 | ||
| Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice | Q29614547 | ||
| Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes | Q29614548 | ||
| CREB regulates hepatic gluconeogenesis through the coactivator PGC-1 | Q29615692 | ||
| Metabolic control through the PGC-1 family of transcription coactivators | Q29616509 | ||
| Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes | Q29616567 | ||
| Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity | Q29619156 | ||
| SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes | Q29619456 | ||
| Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction | Q29619822 | ||
| Identification of a specific molecular repressor of the peroxisome proliferator-activated receptor gamma Coactivator-1 alpha (PGC-1alpha). | Q31115376 | ||
| p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene | Q33199648 | ||
| p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis | Q33226681 | ||
| Calpain 10 and type 2 diabetes: are we getting closer to an explanation? | Q33341230 | ||
| Fatty acids, lipotoxicity and insulin secretion | Q33537945 | ||
| Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation | Q33855408 | ||
| Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans | Q33909623 | ||
| Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice | Q34075210 | ||
| Transcriptional activators and coactivators in the nuclear control of mitochondrial function in mammalian cells | Q34122975 | ||
| The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes | Q34457979 | ||
| Nuclear activators and coactivators in mammalian mitochondrial biogenesis | Q34657768 | ||
| Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5 | Q34761571 | ||
| Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand | Q34829404 | ||
| Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis | Q34920348 | ||
| Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. | Q35041054 | ||
| An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle | Q35163135 | ||
| Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study | Q44081023 | ||
| A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians | Q44329016 | ||
| Acquirement of brown fat cell features by human white adipocytes | Q44478768 | ||
| Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity | Q44527020 | ||
| Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity | Q44575204 | ||
| Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. | Q44666324 | ||
| Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner | Q44730585 | ||
| A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population. | Q44816769 | ||
| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. | Q44859720 | ||
| Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle | Q44865473 | ||
| Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region | Q44865544 | ||
| Complex haplotypes of the PGC-1alpha gene are associated with carbohydrate metabolism and type 2 diabetes | Q44865559 | ||
| Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study | Q44883814 | ||
| The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations | Q44898189 | ||
| Cold-induced PGC-1alpha expression modulates muscle glucose uptake through an insulin receptor/Akt-independent, AMPK-dependent pathway. | Q44912758 | ||
| Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study | Q45173682 | ||
| Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial | Q45183730 | ||
| Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. | Q45244060 | ||
| Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. | Q46466747 | ||
| Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes | Q46506222 | ||
| Short-term inhibition of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice. | Q46605088 | ||
| Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha | Q46669140 | ||
| PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle | Q46735110 | ||
| PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max. | Q47346085 | ||
| Real-time imaging of peroxisome proliferator-activated receptor-gamma coactivator-1alpha promoter activity in skeletal muscles of living mice | Q47582415 | ||
| Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle | Q47755014 | ||
| A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression. | Q51024981 | ||
| Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol. | Q51507753 | ||
| Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise. | Q51519056 | ||
| The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes. | Q51521612 | ||
| Peroxisome proliferator-activated receptor gamma coactivator 1 alpha promoter polymorphisms are associated with early-onset type 2 diabetes mellitus in the Korean population. | Q53620678 | ||
| Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. | Q53848758 | ||
| A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. | Q53853490 | ||
| Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. | Q54095921 | ||
| Expression of the thermogenic nuclear hormone receptor coactivator PGC-1α is reduced in the adipose tissue of morbidly obese subjects | Q58035875 | ||
| Lipid Infusion Decreases the Expression of Nuclear Encoded Mitochondrial Genes and Increases the Expression of Extracellular Matrix Genes in Human Skeletal Muscle | Q58451168 | ||
| Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM | Q73497254 | ||
| Modulation of estrogen receptor-alpha transcriptional activity by the coactivator PGC-1 | Q73626496 | ||
| Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b | Q74306436 | ||
| Regulation of mitochondrial biogenesis in skeletal muscle by CaMK | Q77932716 | ||
| Polyunsaturated fatty acid regulation of gene expression | Q80892046 | ||
| Conversion from white to brown adipocytes: a strategy for the control of fat mass? | Q35595288 | ||
| Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise | Q35855948 | ||
| Tissue-specific regulation of metabolic pathways through the transcriptional coactivator PGC1-alpha | Q36042273 | ||
| Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: evidence from the Finnish Diabetes Prevention Study | Q36162756 | ||
| Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review | Q36281375 | ||
| A major predisposition locus for severe obesity, at 4p15-p14 | Q37217251 | ||
| A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus | Q37377734 | ||
| An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians | Q37381130 | ||
| Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis | Q37526796 | ||
| Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice | Q37692671 | ||
| Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism. | Q38337494 | ||
| Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain | Q38358588 | ||
| The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes | Q39451469 | ||
| Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure | Q39996386 | ||
| Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway | Q40446884 | ||
| Free fatty acids increase PGC-1alpha expression in isolated rat islets. | Q40454071 | ||
| Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells | Q40649634 | ||
| PPARγ coactivator-1α expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations | Q40649637 | ||
| The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). | Q40678460 | ||
| Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. | Q40763964 | ||
| R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1. | Q40878732 | ||
| A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes | Q42450726 | ||
| Reduced Expression of FOXC2 and Brown Adipogenic Genes in Human Subjects with Insulin Resistance | Q42451614 | ||
| PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells | Q42478723 | ||
| Suppression of beta cell energy metabolism and insulin release by PGC-1alpha | Q42799597 | ||
| Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients | Q43603786 | ||
| Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study | Q43667504 | ||
| Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment | Q44007240 | ||
| P921 | main subject | insulin resistance | Q1053470 |
| type 2 diabetes | Q3025883 | ||
| preproinsulin | Q7240673 | ||
| P1104 | number of pages | 21 | |
| P304 | page(s) | 233-253 | |
| P577 | publication date | 2006-01-01 | |
| P1476 | title | Chapter 12 Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: Functional implications |
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