Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats

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Dopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0168-0102(99)00073-5
P698PubMed publication ID10616914

P2093author name stringT Nagatsu
K Nakajima
M Hashimoto
K Mikoshiba
I Fujimoto
H Hida
H Nishino
Y Shimano
P2860cites workPreparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissueQ29615225
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Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in ratsQ33745707
Cell-specific expression of the mouse glial fibrillary acidic protein gene: identification of the cis- and trans-acting promoter elements for astrocyte-specific expressionQ34975456
Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implantsQ37518848
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinaseQ40396045
Intracerebral grafting of catecholamine producing cells and reconstruction of disturbed brain functionQ40853708
Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neuronsQ40890513
Immune responses to adenovirus vectors in the nervous systemQ40922367
Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson modelQ40941898
Adenoviral vector-mediated GDNF gene therapy in a rodent lesion model of late stage Parkinson's diseaseQ41068462
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Expression of tyrosine hydroxylase in an immortalized human fetal astrocyte cell line; in vitro characterization and engraftment into the rodent striatumQ41222328
Development of cell lines capable of complementing E1, E4, and protein IX defective adenovirus type 5 mutantsQ41263288
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Gene expression of aromatic L-amino acid decarboxylase in cultured rat glial cellsQ41907631
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Direct intracerebral nerve growth factor gene transfer using a recombinant adenovirus: effect on basal forebrain cholinergic neurons during aging.Q42439100
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylaseQ43185222
Long-term survival of grafted cells, dopamine synthesis/release, synaptic connections, and functional recovery after transplantation of fetal nigral cells in rats with unilateral 6-OHDA lesions in the nigrostriatal dopamine pathwayQ44049498
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Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.Q45876510
Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblastsQ45877347
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Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopaQ46578408
Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian ratsQ48242730
A model system for in vivo gene transfer into the central nervous system using an adenoviral vectorQ48325479
Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.Q48876521
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Functional expression of a mammalian odorant receptorQ64382213
Adenovirus gene transfer causes inflammation in the brainQ64383186
Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's diseaseQ64383353
Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine SystemQ64821160
Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplantsQ67019545
Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cellsQ71894853
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P433issue2
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
astrocyteQ502961
P304page(s)101-112
P577publication date1999-11-01
P1433published inNeuroscience ResearchQ15764280
P1476titleDopa-producing astrocytes generated by adenoviral transduction of human tyrosine hydroxylase gene: in vitro study and transplantation to hemiparkinsonian model rats
P478volume35

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cites work (P2860)
Q40775287GDNF is a major component of trophic activity in DA-depleted striatum for survival and neurite extension of DAergic neurons
Q33985663Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders

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