TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.

scientific article published on 27 August 2018

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI99005
P932PMC publication ID6159955
P698PubMed publication ID30148455

P50authorGiuseppe PantaleoQ88061163
P2093author name stringQi Wang
Zheng Zhang
Lishan Su
Liang Cheng
Yves Levy
Guangming Li
Gerard Zurawski
Haisheng Yu
Jianping Ma
Fumihiko Yasui
Matthieu Perreau
Riddhima Banga
Sandra Zurawski
P2860cites workCD40 AND CD154 IN CELL-MEDIATED IMMUNITYQ22255634
HIV therapeutic vaccines: moving towards a functional cureQ27002180
Delivering HIV Gagp24 to DCIR Induces Strong Antibody Responses In VivoQ27300713
Immunopathogenesis and immunotherapy in AIDS virus infectionsQ28183667
Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremiaQ28254584
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infectionQ28304764
Dendritic cells: specialized and regulated antigen processing machinesQ29617085
Taking dendritic cells into medicineQ29619243
New CD4+ and CD8+ T cell responses induced in chronically HIV type-1-infected patients after immunizations with an HIV type 1 lipopeptide vaccineQ33249455
Multiepitopic B- and T-cell responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccineQ33797285
Immunologic strategies for HIV-1 remission and eradicationQ33896523
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.Q33902330
The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cellsQ33902379
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cellsQ33902421
HIV Infection, Inflammation, Immunosenescence, and AgingQ34150710
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized miceQ34180174
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
Dendritic-cell-based therapeutic cancer vaccinesQ34360094
HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replicationQ34448446
Humanized mice in translational biomedical researchQ34607151
Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates.Q34880294
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersQ35058635
Eradicating HIV-1 infection: seeking to clear a persistent pathogenQ35252186
Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus MacaquesQ35989484
Vaccine Adjuvants: Putting Innate Immunity to WorkQ36168232
Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell toleranceQ36376611
Clinical safety of HIV lipopeptides used as vaccines in healthy volunteers and HIV-infected adultsQ36444377
In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase InhibitorsQ36523946
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionQ36547664
Functional Specialty of CD40 and Dendritic Cell Surface Lectins for Exogenous Antigen Presentation to CD8(+) and CD4(+) T CellsQ36754182
The histone deacetylase inhibitor, romidepsin, suppresses cellular immune functions of cutaneous T-cell lymphoma patientsQ36802272
Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentationQ36822696
Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapyQ36950611
The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus EradicationQ37034469
Humanized mice for immune system investigation: progress, promise and challengesQ37111994
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirsQ37273652
Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulationQ37305160
Targeting concatenated HIV antigens to human CD40 expands a broad repertoire of multifunctional CD4+ and CD8+ T cellsQ37385041
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirsQ37545050
HIV-1 immunopathogenesis in humanized mouse modelsQ37676228
Dendritic cell-targeted vaccinesQ38218671
Superiority in Rhesus Macaques of Targeting HIV-1 Env gp140 to CD40 versus LOX-1 in Combination with Replication-Competent NYVAC-KC for Induction of Env-Specific Antibody and T Cell ResponsesQ38757011
Therapeutic vaccines and immunological intervention in HIV infection: a paradigm changeQ38949441
Humanized Mouse Models for Human Immunodeficiency Virus Infection.Q39459609
The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon.Q40098403
Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infectionQ40160105
Toll-like receptor 3 activation selectively reverses HIV latency in microglial cellsQ40343146
Characterization of a multi-lipopeptides mixture used as an HIV-1 vaccine candidateQ40795438
Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cellsQ40952120
Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral loadQ42205079
Lipopeptides induce cell-mediated anti-HIV immune responses in seronegative volunteersQ42653193
Dendritic cell-targeted vaccines--hope or hype?Q42696952
Immunological and virological efficacy of a therapeutic immunization combined with interleukin-2 in chronically HIV-1 infected patients.Q44142940
Studies in subjects with long-term nonprogressive human immunodeficiency virus infectionQ44369963
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune systemQ49663116
Delivery of antigen to CD40 induces protective immune responses against tumors.Q51976812
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.Q53592113
HIV: Shock and kill.Q55056512
Selective transduction of dendritic cells in human lymph nodes and superior induction of high-avidity melanoma-reactive cytotoxic T cells by a CD40-targeted adenovirusQ64374855
Infection of the SCID-hu mouse by HIV-1Q67985380
A potent adjuvant effect of CD40 antibody attached to antigenQ73303811
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantationQ82252349
Sustained control of viremia following therapeutic immunization in chronically HIV-1-infected individualsQ82389408
Internalization and endosomal degradation of receptor-bound antigens regulate the efficiency of cross presentation by human dendritic cellsQ84569562
P433issue10
P304page(s)4387-4396
P577publication date2018-08-27
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleTLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.
P478volume128

Reverse relations

cites work (P2860)
Q92667638A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection
Q93196555Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination
Q60909641Application of built-in adjuvants for epitope-based vaccines
Q89694033HIV infection suppresses TLR3 activation-mediated antiviral immunity in microglia and macrophages
Q60048646HIV-1 T cell epitopes targeted to Rhesus macaque CD40 and DCIR: A comparative study of prototype dendritic cell targeting therapeutic vaccine candidates
Q61812881The Incorporation of Host Proteins into the External HIV-1 Envelope

Search more.