Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation

scientific article published on 12 January 2006

Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2005-11-4388
P698PubMed publication ID16410443

P2093author name stringYong-Guang Yang
Shumei Wang
Akira Shimizu
Ping Lan
Noriko Tonomura
P433issue2
P304page(s)487-492
P577publication date2006-01-12
P1433published inBloodQ885070
P1476titleReconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation
P478volume108

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cites work (P2860)
Q93051913A Caulobacter crescentus Microbicide Protects from Vaginal Infection with HIV-1JR-CSF in Humanized Bone Marrow-Liver-Thymus Mice
Q90121995A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Q49990668A Hitchhiker's Guide to Humanized Mice: new pathways to studying viral infections.
Q52724272A Humanized Mouse Model Generated Using Surplus Neonatal Tissue.
Q33697336A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model
Q36969230A model for personalized in vivo analysis of human immune responsiveness
Q37664268A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production
Q36811931APOBEC3G and APOBEC3F Act in Concert To Extinguish HIV-1 Replication
Q37342291Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy
Q36989415Activation of Human T Cells in Hypertension: Studies of Humanized Mice and Hypertensive Humans
Q57062356Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1
Q59126043Advanced model systems and tools for basic and translational human immunology
Q41537754Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics
Q35826239Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice
Q35091621An AAV vector-mediated gene delivery approach facilitates reconstitution of functional human CD8+ T cells in mice
Q34039500An effective approach to prevent immune rejection of human ESC-derived allografts
Q28743012Analysis of the CD1 antigen presenting system in humanized SCID mice
Q34267776Animal models for viral infection and cell exhaustion
Q26853069Animal models in HIV cure research
Q37041160Animal models to achieve an HIV cure
Q36528798Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model
Q91907826Antigen-specific therapeutic approaches for autoimmunity
Q21144657Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
Q33652103Antithymocyte globulin treatment at the time of transplantation impairs donor hematopoietic stem cell engraftment
Q92620214Application of Highly Immunocompromised Mice for the Establishment of Patient-Derived Xenograft (PDX) Models
Q38779010Autologous reconstitution of human cancer and immune system in vivo.
Q95941885Autologously Humanized Mice for Immune-Oncologic Studies
Q35998374BLT humanized mice as a small animal model of HIV infection
Q37254470BLT humanized mice as model to study HIV vaginal transmission
Q37390234BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection
Q36777155CD19xCD3 DART protein mediates human B-cell depletion in vivo in humanized BLT mice
Q37781118CD47 in xenograft rejection and tolerance induction
Q34433569CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
Q53140630Cancer stem cell definitions and terminology: the devil is in the details.
Q26779931Cancer stem cell targeted therapy: progress amid controversies.
Q64100649Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice
Q83133198Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice
Q84040857Co-transplantation of fetal bone tissue facilitates the development and reconstitution in human B cells in humanized NOD/SCID/IL-2Rγnull (NSG) mice
Q42084230Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts
Q42376396Complement Depletion Improves Human Red Blood Cell Reconstitution in Immunodeficient Mice
Q90629204Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Q30664978Conserved and divergent aspects of human T-cell development and migration in humanized mice
Q30361201Construction of a live-attenuated HIV-1 vaccine through genetic code expansion
Q37049642Cryptopatches are essential for the development of human GALT.
Q34474320Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis
Q33596915Development and function of human innate immune cells in a humanized mouse model
Q38884521Development of Humanized Mice in the Age of Genome Editing.
Q53504782Development of functional human immune system with the transplantations of human fetal liver/thymus tissues and expanded hematopoietic stem cells in RAG2-/-gamma(c)-/- MICE.
Q98164359Development of the FAST-DOSE assay system for high-throughput biodosimetry and radiation triage
Q36984469Durable knockdown and protection from HIV transmission in humanized mice treated with gel-formulated CD4 aptamer-siRNA chimeras
Q27314724EBV promotes human CD8 NKT cell development
Q39491833Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice
Q56898421Efficient peripheral construction of functional human regulatory CD4(+)CD25(high)Foxp3(+) T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34(+) cells
Q27331060Electron tomography of HIV-1 infection in gut-associated lymphoid tissue
Q38926281Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector
Q21133769Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice
Q37734869Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics
Q35252186Eradicating HIV-1 infection: seeking to clear a persistent pathogen
Q64947234Evaluation of the biocompatibility and stability of allogeneic tissue-engineered cartilage in humanized mice.
Q35691125Evaluation of the efficiency of human immune system reconstitution in NSG mice and NSG mice containing a human HLA.A2 transgene using hematopoietic stem cells purified from different sources
Q58612483Exploring immunomodulatory features of Mesenchymal Stromal Cells in humanized mouse models
Q41919588Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System
Q33911359Expression of HLA class II molecules in humanized NOD.Rag1KO.IL2RgcKO mice is critical for development and function of human T and B cells
Q33721886Failure of effector function of human CD8+ T Cells in NOD/SCID/JAK3⁻/⁻ immunodeficient mice transplanted with human CD34+ hematopoietic stem cells
Q36194261Full reconstitution of human platelets in humanized mice after macrophage depletion
Q27022347Gene therapy strategies for HIV/AIDS: preclinical modeling in humanized mice
Q35666126Generation of HIV latency in humanized BLT mice
Q37608438Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells
Q34135605Generation of improved humanized mouse models for human infectious diseases
Q91292201Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors
Q49990061HIV replication and latency in a humanized NSG mouse model during suppressive oral combinational ART.
Q37676228HIV-1 immunopathogenesis in humanized mouse models
Q35007831HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells
Q37254475HIV-specific CD8⁺ T-cell immunity in humanized bone marrow-liver-thymus mice
Q39024287HTLV-1 Infection and Neuropathogenesis in the Context of Rag1-/-γc-/- (RAG1-Hu) and BLT Mice.
Q90440739HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia
Q56334018Healthy Donor Polyclonal IgM's Diminish B Lymphocyte Autoreactivity, Enhance Treg Generation, and Reverse T1D in NOD Mice
Q98196708Highly synergistic drug combination prevents vaginal HIV infection in humanized mice
Q34914050Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs
Q33681388Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice
Q52579149Human Immune System Mice for the Study of Human Immunodeficiency Virus-Type 1 Infection of the Central Nervous System.
Q98177696Human Thymic Involution and Aging in Humanized Mice
Q33995307Human hemato-lymphoid system mice: current use and future potential for medicine
Q38102807Human immune responses and potential for vaccine assessment in humanized mice
Q42254467Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells
Q37981545Human lymphohematopoietic reconstitution and immune function in immunodeficient mice receiving cotransplantation of human thymic tissue and CD34(+) cells
Q40043435Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice
Q35446761Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model
Q89755936Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease and Regenerative Medicine
Q55190039Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy.
Q61800042Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8 T Cells
Q50146682Humanized Mice as Unique Tools for Human-Specific Studies
Q92881586Humanized Mice for Live-Attenuated Vaccine Research: From Unmet Potential to New Promises
Q42560779Humanized Mice--A Neoteric Animal Disease Model for Ebola Virus?
Q92177909Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells
Q39459609Humanized Mouse Models for Human Immunodeficiency Virus Infection.
Q38640208Humanized Mouse Models for Transplant Immunology
Q59350579Humanized Mouse Models for the Study of Infection and Pathogenesis of Human Viruses
Q37614202Humanized Mouse Models of Clinical Disease
Q64228779Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies
Q33634034Humanized Mouse Models of Staphylococcus aureus Infection.
Q26771440Humanized hemato-lymphoid system mice
Q38838864Humanized mice for HIV and AIDS research
Q35027512Humanized mice for studying human leukocyte integrins in vivo
Q37179146Humanized mice for the study of infectious diseases
Q55039176Humanized mice reveal an essential role for human hepatocytes in the development of the liver immune system.
Q46145863Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials.
Q37089865Humanized mouse models of HIV infection
Q36142747Humanized mouse models of human cytomegalovirus infection
Q52634041Humanizing the mouse immune system to study splanchnic organ inflammation.
Q43041962Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells
Q37254488Humoral immunity in humanized mice: a work in progress
Q59349136Hypercholesterolemia induces T cell expansion in humanized immune mice
Q35291397Hypogammaglobulinemia in BLT humanized mice--an animal model of primary antibody deficiency.
Q36972070IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice
Q89137790IXA Honorary Member Lecture, 2017: The long and winding road to tolerance
Q27692578Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection
Q92376487Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia
Q35765555Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development
Q37467601Improved B cell development in humanized NOD-scid IL2Rγnull mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3
Q39315707In Vivo Models of Human Immunodeficiency Virus Persistence and Cure Strategies
Q35848314In vivo analysis of Nef's role in HIV-1 replication, systemic T cell activation and CD4(+) T cell loss
Q30009533In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis
Q36515119In vivo platforms for analysis of HIV persistence and eradication
Q36651190Increasing hematopoietic stem cell yield to develop mice with human immune systems
Q37363576Induction of human T-cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system
Q37247943Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice
Q39134077Influence of human myasthenia gravis thymus on the differentiation of human cord blood stem cells in SCID mice
Q89460612Intra-bone Bone Marrow Transplantation in Pig-to-Nonhuman Primates for the Induction of Tolerance Across Xenogeneic Barriers
Q92366030Long-term survival and differentiation of human thymocytes in human thymus-grafted immunodeficient mice
Q37682792Longitudinal imaging of HIV-1 spread in humanized mice with parallel 3D immunofluorescence and electron tomography
Q35585979Macrophages prevent human red blood cell reconstitution in immunodeficient mice
Q35040650Modeling EBV infection and pathogenesis in new-generation humanized mice
Q50054545Modeling Human Antitumor Responses In Vivo Using Umbilical Cord Blood-Engrafted Mice
Q37221363Modeling Human Leukemia Immunotherapy in Humanized Mice
Q64907480Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemia.
Q36879075Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation
Q88885438Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Q34590684Mouse models with human immunity and their application in biomedical research
Q91813244Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies
Q36923075Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice
Q47151028Multidimensional Analysis Integrating Human T-Cell Signatures in Lymphatic Tissues with Sex of Humanized Mice for Prediction of Responses after Dendritic Cell Immunization
Q26823568Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
Q36112824Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes.
Q98896077Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus
Q27014786New generation humanized mice for virus research: comparative aspects and future prospects
Q37337138No irradiation required: The future of humanized immune system modeling in murine hosts
Q33898447Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells
Q37084504Novel humanized murine models for HIV research
Q35140303One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates
Q35035610PD-1 blockade in chronically HIV-1-infected humanized mice suppresses viral loads
Q58770106Potential Pitfalls of the Humanized Mice in Modeling Sepsis
Q97884890Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies
Q40062702Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice
Q89492422Production of Humanized Mice through Stem Cell Transfer
Q33766637Production of bone marrow, liver, thymus (BLT) humanized mice on the C57BL/6 Rag2(-/-)γc(-/-)CD47(-/-) background
Q38409791Propagating Humanized BLT Mice for the Study of Human Immunology and Immunotherapy
Q47103891Prospects for combined use of oncolytic viruses and CAR T-cells
Q53837345Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice.
Q33730699RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice
Q36936058Rapid evolution of HIV-1 to functional CD8⁺ T cell responses in humanized BLT mice
Q92543466Recent Advances in Allergy Research Using Humanized Mice
Q37254480Recent advances in humanized mice: accelerating the development of an HIV vaccine
Q28488527Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice
Q90359789Reduced positive selection of a human TCR in a swine thymus using a humanized mouse model for xenotolerance induction
Q37600607Renaissance for mouse models of human hematopoiesis and immunobiology
Q91752345SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2
Q90430180SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model
Q42591008Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice
Q40616678Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
Q26849806Studies of retroviral infection in humanized mice
Q35154146Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ(-/-) (NSG) BLT mice.
Q28472590Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice
Q92008485T Lymphocyte Development and Activation in Humanized Mouse Model
Q64991307TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.
Q40734424Th1 and Th17 immunocompetence in humanized NOD/SCID/IL2rgammanull mice
Q93084382The Preconditioning of Busulfan Promotes Efficiency of Human CD133+ Cells Engraftment in NOD Shi-SCID IL2Rγcnull (NOG) Mice via Intra-Bone Marrow Injection
Q55078034The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer.
Q61800463The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate
Q92914944The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice
Q34175149The use of BLT humanized mice to investigate the immune reconstitution of the gastrointestinal tract
Q54244413The use of humanized mice for studies of viral pathogenesis and immunity.
Q47152294Tolerance in xenotransplantation
Q50055147Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes.
Q47569628Type 1 diabetes induction in humanized mice.
Q52647754Ultra-Sensitive HIV-1 Latency Viral Outgrowth Assays Using Humanized Mice.
Q92092011Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes
Q35738486Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases
Q36185583XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer
Q37137178Xenotransplantation as a model of integrated, multidisciplinary research
Q36850147Xenotransplantation: current status and a perspective on the future
Q47197092Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model
Q86848619[Development of immunodeficient mice/humanized mouse models and their applications in hematology research]

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