MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases

scientific article published on 01 January 1996

MDR1 expression correlates with mutant p53 expression in colorectal cancer metastases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF01209030
P698PubMed publication ID8898977

P50authorChristian ThiedeQ42323747
P2093author name stringR Herrmann
E de Kant
C F Rochlitz
I Heide
P2860cites workCellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissuesQ24633406
p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expressionQ27853401
Expression of a multidrug-resistance gene in human tumors and tissuesQ34586576
P-glycoprotein is not expressed in a majority of colorectal carcinomas and is not regulated by mutant p53 in vivoQ36081542
Multiple drug resistance gene expression in human renal cell cancer is associated with the histologic subtypeQ39228336
The multidrug transporter, a double-edged swordQ39469668
The region 3' to the major transcriptional start site of the MDR1 downstream promoter mediates activation by a subset of mutant P53 proteinsQ41260571
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motifQ41555610
c-Myc trans-activates the p53 promoter through a required downstream CACGTG motifQ41574272
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.Q41643433
Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activityQ41668137
Constitutive expression of multidrug resistance in human colorectal tumours and cell linesQ42389991
P-glycoprotein, HER-2/neu, and mutant p53 expression in human gynecologic tumorsQ42491214
Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasisQ45020379
Position specificity of Ki-ras oncogene mutations during the progression of colorectal carcinoma.Q53023758
PCR-determined expression of the MDR1 gene in chronic lymphocytic leukemiaQ53024621
Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals.Q53519384
The core promoter region of the P-glycoprotein gene is sufficient to confer differential responsiveness to wild-type and mutant p53.Q54238383
P-glycoprotein associated expression of c-fos and c-jun products in human lung carcinomas.Q54246959
MDR1 gene expression in lung cancer.Q54346895
Down-regulation of ras and myc expression associated with mdr-1 overexpression in adriamycin-resistant tumor cellsQ67890183
Immunocytochemical detection of oncoproteins in animal and human tumor lines with acquired or inherent multidrug resistanceQ67958977
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesisQ68623436
Expression of a multidrug resistance gene in human cancersQ69366790
Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastasesQ71375252
Relationship between p53 gene mutations and multidrug resistance (mdr1) gene expression in myelodysplastic syndromesQ72656838
Wild type p53 stimulates expression from the human multidrug resistance promoter in a p53-negative cell lineQ95822405
P433issue11
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
cancer metastasisQ120912394
P304page(s)671-675
P577publication date1996-01-01
P1433published inJournal of Cancer Research and Clinical OncologyQ2081599
P1476titleMDR1 expression correlates with mutant p53 expression in colorectal cancer metastases
P478volume122

Reverse relations

cites work (P2860)
Q38986437A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels.
Q40077983Ad-PUMA sensitizes drug-resistant choriocarcinoma cells to chemotherapeutic agents
Q49485946Association between MDR1 C3435T polymorphism and colorectal cancer risk: A meta-analysis
Q64086618Glucose starvation induces resistance to metformin through the elevation of mitochondrial multidrug resistance protein 1
Q48168333Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes