Abstract is: Reverse cholesterol transport is a multi-step process resulting in the net movement of cholesterol from peripheral tissues back to the liver first via entering the lymphatic system, then the bloodstream. Cholesterol from non-hepatic peripheral tissues is transferred to HDL by the ABCA1 (ATP-binding cassette transporter). Apolipoprotein A1 (ApoA-1), the major protein component of HDL, acts as an acceptor, and the phospholipid component of HDL acts as a sink for the mobilised cholesterol.The cholesterol is converted to cholesteryl esters by the enzyme LCAT (lecithin-cholesterol acyltransferase).The cholesteryl esters can be transferred, with the help of CETP (cholesterylester transfer protein) in exchange for triglycerides, to other lipoproteins (such as LDL and VLDL), and these lipoproteins can be taken up by secreting unesterified cholesterol into the bile or by converting cholesterol to bile acids. Adiponectin induces ABCA1-mediated reverse cholesterol transport from macrophages by activation of PPAR-γ and LXRα/β. Uptake of HDL2 is mediated by hepatic lipase, a special form of lipoprotein lipase found only in the liver. Hepatic lipase activity is increased by androgens and decreased by estrogens, which may account for higher concentrations of HDL2 in women. Discoidal (Nascent) HDL:Initially, HDL is discoidal in shape because it lacks esterified cholesterol but as it keeps accumulating free cholesterol in it, the enzyme LCAT keeps esterifying the free cholesterol. When the HDL molecule is cholesterol rich, its shape is changed into more spherical and it becomes less dense (HDL 2). This is carried to the liver to release all the esterified cholesterol into the liver.
P2888 | exact match | http://purl.obolibrary.org/obo/GO_0043691 |
P646 | Freebase ID | /m/09rwcxv |
P686 | Gene Ontology ID | GO:0043691 |
P6366 | Microsoft Academic ID | 110459506 |
P10283 | OpenAlex ID | C110459506 |
P2892 | UMLS CUI | C2248593 |
Q14916272 | APOC2 |
Q14910515 | APOC3 |
Q21115210 | ATP binding cassette subfamily A member 1 |
Q21115253 | ATP binding cassette subfamily A member 5 |
Q21113668 | ATP binding cassette subfamily G member 1 |
Q21491072 | ATP binding cassette subfamily G member 1 |
Q21494758 | ATP-binding cassette, sub-family A (ABC1), member 1 |
Q21494762 | ATP-binding cassette, sub-family A (ABC1), member 5 |
Q14910072 | Apolipoprotein A-I |
Q21499493 | Apolipoprotein A-II |
Q21201272 | Apolipoprotein A-IV |
Q21499492 | Apolipoprotein A-IV |
Q29822762 | Apolipoprotein A-IV a |
Q29823799 | Apolipoprotein A-IV b, tandem duplicate 1 |
Q29823666 | Apolipoprotein A-IV b, tandem duplicate 3 |
Q29823500 | Apolipoprotein A-Ib |
Q21980338 | Apolipoprotein A-V |
Q1316030 | Apolipoprotein A1 |
Q28560424 | Apolipoprotein A1 |
Q21154572 | Apolipoprotein A2 |
Q28559398 | Apolipoprotein A2 |
Q28558120 | Apolipoprotein A4 |
Q55203937 | Apolipoprotein A4 |
Q28559375 | Apolipoprotein A5 |
Q3445743 | Apolipoprotein C2 |
Q21416505 | Apolipoprotein E |
Q28562617 | Apolipoprotein E |
Q29827348 | Apolipoprotein Eb |
Q21173371 | Apolipoprotein M |
Q21982759 | Apolipoprotein M |
Q28559187 | Apolipoprotein M |
Q55204420 | Apolipoprotein M |
Q24224251 | Blr5887 |
Q29823063 | Cholesteryl ester transfer protein, plasma |
Q4223101 | Clusterin |
Q21983331 | HNF1 homeobox A |
Q28556371 | HNF1 homeobox A |
Q14905444 | LCAT |
Q29520346 | Lecithin cholesterol acyltransferase |
Q55200036 | Lecithin-cholesterol acyltransferase |
Q908765 | Lipase C, hepatic type |
Q22676900 | Lipase G, endothelial type |
Q28560448 | Lipase G, endothelial type |
Q21987586 | Lipase, endothelial |
Q21108841 | Scavenger receptor class B member 1 |
Q21988081 | Scavenger receptor class B, member 1 |
Q28560248 | Scavenger receptor class B, member 1 |
Q29825084 | Si:dkey-7f3.14 |
Q21173178 | apolipoprotein A5 |
Q4068038 | apolipoprotein C3 |
Q424728 | apolipoproteins E |
Q424706 | cholesteryl ester transfer protein |
Q14905448 | lecithin cholesterol acyltransferase |
Q424716 | lecithin-cholesterol acyltransferase |
Q24336518 | A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells |
Q24300472 | A protein cofactor of lecithin:cholesterol acyltransferase |
Q24299006 | Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis |
Q64237421 | Cholesterol: Can't Live With It, Can't Live Without It |
Q24302828 | Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice |
Q64123064 | Effects of pemafibrate (K-877) on cholesterol efflux capacity and postprandial hyperlipidemia in patients with atherogenic dyslipidemia |
Q24297088 | Hepatic lipase mutation may reduce vascular disease prevalence in hemodialysis patients with high CETP levels |
Q64277669 | Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice |
Q24306389 | Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice |
Q40526401 | Molecular physiology of reverse cholesterol transport |
Q22010457 | Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency |
Q34291776 | Myeloperoxidase, inflammation, and dysfunctional high-density lipoprotein |
Q64237412 | Revisiting Reverse Cholesterol Transport in the Context of High-Density Lipoprotein Free Cholesterol Bioavailability |
Q41348534 | The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor |
Q24313050 | Triglycerides Are Major Determinants of Cholesterol Esterification/Transfer and HDL Remodeling in Human Plasma |
Reverser Cholesterintransport | wikipedia | |
Reverse cholesterol transport | wikipedia | |
Trasporto inverso del colesterolo | wikipedia | |
Obrnuti transport holesterola | wikipedia |
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