Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse

scientific article published on 01 March 1998

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0165-0173(97)00055-6
P698PubMed publication ID9600623

P50authorBernardo CastellanoQ37843102
José Miguel VelaQ56947146
Berta GonzálezQ59564318
P2860cites workMyelin Basic Protein Deposition in the Optic and Sciatic Nerves of Dysmyelinating Mutants Quaking, Jimpy, Trembler, MLD, and Shiverer During DevelopmentQ72712550
Biochemical Expression of Mosaicism in Female Mice Heterozygous for the Jimpy GeneQ72723128
Assembly of CNS myelin in the absence of proteolipid proteinQ73016640
Abnormal expression of the proliferating cell nuclear antigen (PCNA) in the spinal cord of the hypomyelinated Jimpy mutant miceQ73093917
Jimpy, a new totally sex-linked gene in the house mouseQ78609651
Hypomyelination and recovery of the myelin deficit in heterozygous jimpy miceQ87976727
Myelination in the jimpy mouse in the absence of proteolipid proteinQ93513727
Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expressionQ28511941
MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEMQ28590426
Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid proteinQ34334046
Aberrant splicing of proteolipid protein mRNA in the dysmyelinating jimpy mutant mouseQ34603372
Macrophages and microglia in the nervous systemQ34660547
Oligodendroglial cell death induced by oxygen radicals and its protection by catalaseQ34853603
Morphology of demyelination in the human central nervous systemQ35513515
The role of macrophages in demyelinationQ35513547
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient miceQ35931734
Inflammatory cytokines within the central nervous system: sources, function, and mechanism of actionQ36347725
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.Q36437643
Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicingQ36458669
Structure and Function of Myelin Protein GenesQ36649406
The pH of jimpy glia is increased: intracellular measurements using fluorescent laser cytometryQ36764700
Microglial cell reaction in the gray and white matter in spinal cords from jimpy mice. An enzyme histochemical study at the light and electron microscope levelQ36839371
Molecular biology of myelin proteins from the central nervous systemQ38189000
Refined genetic mapping and proteolipid protein mutation analysis in X-linked pure hereditary spastic paraplegiaQ38929854
Cellular and molecular aspects of myelin protein gene expressionQ39581704
Contribution of transplantations to the understanding of the role of the PLP geneQ40395804
Immunocytochemical investigations of murine leukodystrophies. A study of the mutants 'jimpy' (jp) and 'myelin deficient' (mld).Q48795511
Effects of colony stimulating factors on isolated microglia in vitroQ48846984
GFAP immunoreactivity reveals astrogliosis in females heterozygous for jimpyQ48882804
Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpyQ48895293
The fine structure of the cerebella of jimpy mice and their "normal" litter matesQ49012729
Quaking*jimpy double mutant mice: additional evidence for independence of primary deficits in jimpyQ49049451
The microglial reaction in spinal cords of jimpy mice is related to apoptotic oligodendrocytes.Q49060147
Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C.Q49101442
Selective degeneration of oligodendrocytes mediated by reactive oxygen species.Q50884032
Abnormal glial maturation in the white matter in Jimpy mice. An optical study.Q51108049
Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.Q52054165
A case of Pelizaeus-Merzbacher disease showing increased dosage of the proteolipid protein gene.Q52209396
Jimpy mutation affects astrocytes: lengthening of the cell cycle in vitro.Q52228368
[Ultrastructural study of the corpus callosum in Jimpy mice].Q54096881
Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein geneQ57043289
Expression of macrophage colony-stimulating factor gene in the mouse brain during developmentQ57267765
Myelin deficit in the Jimpy mouse may be due to cellular abnormalities in astrogliaQ59086257
Oligodendrocyte development and differentiation in the rumpshaker mutationQ59782506
Stimulation of in vitro myelin synthesis by microgliaQ60641821
Paralytic tremor (pt) rabbit: a sex-linked mutation affecting proteolipid protein-gene expressionQ62035802
Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd miceQ67653573
Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF betaQ67902817
Macromolecular structure of axonal membrane in the optic nerve of the jimpy mouseQ67934282
Expression of galactocerebroside in developing normal and jimpy oligodendrocytes in situQ67971685
Cell kinetics and cell death in the optic nerve of the myelin deficient ratQ68002740
Astroglial plasticity in hemizygous and heterozygous jimpy miceQ68009693
Arrest of proteolipid transport through the Golgi apparatus in Jimpy brainQ68182648
Differences in levels of neuroglial cell death in jimpy male mice and carrier femalesQ68841619
[Quantitative study of myelination and axonal growth in corpus callosum and posterior columns of spinal cord in the Jimpy mouse (author's transl)]Q68867924
Glial fibrillary acidic protein in mutant mice with deficiency of myelination: Quaking and jimpyQ69360883
Oligodendroglial cell death in jimpy mice: an explanation for the myelin deficitQ69622249
Expression of the jimpy gene in the spinal cords of heterozygous female mice. 2. Oligodendroglial and endothelial cell hyperplasiaQ69637327
Dysmyelination in "jimpy" mouse. Electron microscopic studyQ69782011
Oligodendroglial structures and distribution shown by carbonic anhydrase immunostaining in the spinal cords of developing normal and shiverer miceQ69969966
Colony-stimulating factors as promoters of ameboid microgliaQ70229709
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitroQ70392550
Accumulation of GFA, the monomeric precursor of the gliofilaments, during development in normal mice and dysmyelinating mutantsQ70655680
Shaking pups: a disorder of central myelination in the Spaniel dog. Part 1. Clinical, genetic and light-microscopical observationsQ70666322
Expression of mosaicism in females heterozygous for JimpyQ70755463
Neuropathology and genetics of Pelizaeus-Merzbacher diseaseQ70785121
Programmed cell death in the dysmyelinating mutantsQ70785128
Fine structure of the central myelin sheath in the myelin deficient mutant Shiverer mouse, with special reference to the pattern of myelin formation by oligodendrogliaQ70866299
Radioautographic evidence for the protracted proliferation of glial cells in the central nervous system of jimpy miceQ70937395
Isolation and characterization of defective jimpy oligodendrocytes in cultureQ70938835
Oligodendroglial precursor cell susceptibility to hypoxia is related to poor ability to cope with reactive oxygen speciesQ70951131
Abnormal cell relationships in Jimpy mice: electron microscopic and immunocytochemical findingsQ71106623
Abnormal metabolic response to excess potassium in astrocytes from the Jimpy mouse, a convulsing neurological mutantQ71128922
Hypomyelinated mutant mice: description of jpmsd and comparison with jp and qk on their present genetic backgroundsQ71235075
Hypomyelinated mutant mice. III. Increased myelination in mutant cerebellum co-cultured with normal optic nerveQ71507120
Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar developmentQ71543637
Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouseQ71567360
Myelin structure in proteolipid protein (PLP)-null mouse spinal cordQ71603477
A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouseQ71638166
Isolation and identification of proteolipid proteins in jimpy mouse brainQ71664227
Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheathsQ71706053
Overexpression of DM20 messenger RNA in two brothers with Pelizaeus-Merzbacher diseaseQ71778448
Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp geneQ71914971
Apoptosis occurs in the oligodendroglial lineage, and is prevented by basic fibroblast growth factorQ72225206
Expression of cytokines during glial differentiationQ72368141
Immunohistochemical localization of the myelin basic protein and of the glial fibrillary acidic protein: Comparative study in normal, quaking and jimpy miceQ72622821
Cytokines in cerebral ischemia: expression of transforming growth factor beta-1 (TGF-beta 1) mRNA in the postischemic adult rat hippocampusQ72643380
Regional distribution of myelin basic protein in the central nervous system of quaking, jimpy, and normal mice during development and agingQ72650189
Genetics of Pelizaeus-Merzbacher diseaseQ40397095
Cell-mediated cytotoxicity: contact and secreted factorsQ40488888
Neurological mouse mutants and the genes of myelinQ40561097
Cytotoxicity of microgliaQ40870381
Oxygen free radicals and metallothioneinQ40889930
Transgenic systems in studying myelin gene expressionQ40939826
Temperature-dependent regulation of PLP/DM20 and CNP gene expression in two conditionally-immortalized jimpy oligodendrocyte cell linesQ41118714
Regulation of oligodendrocyte development and CNS myelination by growth factors: prospects for therapy of demyelinating diseaseQ41157691
Ciliary neurotrophic factor selectively protects human oligodendrocytes from tumor necrosis factor-mediated injuryQ41232387
Jimpy mouse myelin revisited with freeze-fractureQ41433616
Regulation of an oligodendrocyte progenitor cell line by the interleukin-6 family of cytokinesQ41440638
Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transport.Q41478756
Brain peptides and glial growth. I. Glia-promoting factors as regulators of gliogenesis in the developing and injured central nervous systemQ41500473
Effect of the Jimpy Mutation on Expression of Myelin Proteins in Heterozygous and Hemizygous Mouse BrainQ41545300
Neurons and astrocytes influence the development of purified O-2A progenitor cellsQ41704584
Fibronectin and laminin regulate the in vitro differentiation of microglial cellsQ41966365
Myelin proteolipid protein gene structure and its regulation of expression in normal and jimpy mutant miceQ42638631
Myelin basic protein is affected by reduced synthesis of myelin proteolipid protein in the jimpy mouseQ42794199
Immunohistochemical studies on cross-transplantations between jimpy, shiverer, and normal newborn miceQ43514731
Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein geneQ43605216
Gene expression in the jimpy mutant: evidence for fewer oligodendrocytes expressing myelin protein genes and impaired translocation of myelin basic protein mRNA.Q43768343
Death of individual oligodendrocytes in jimpy brain precedes expression of proteolipid proteinQ44063104
Myelin proteolipid protein gene expression in jimpy and jimpy(msd) miceQ44286193
Oligodendroglial cell development in jimpy mice and controls. An electron-microscopic study in the optic nerveQ44306073
Glial conditioned medium enables jimpy oligodendrocytes to express properties of normal oligodendrocytes: production of myelin antigens and membranesQ44489386
Tumour necrosis factor causes an increase in axonal transport of protein and demyelination in the mouse optic nerveQ44635103
Developmental expression of glial fibrillary acidic protein and glutamine synthetase mRNAs in normal and jimpy miceQ44914504
Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivoQ45132323
Comparative immunocytochemistry of Pelizaeus-Merzbacher disease, the jimpy mouse, and the myelin-deficient rat.Q46014404
CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death.Q46020332
Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosageQ46440780
Paralytic tremor (pt): a new allele of the proteolipid protein gene in rabbits.Q48077825
Fate of jimpy-type oligodendrocytes in jimpy heterozygote.Q48137303
The ontogeny of ultrasonic vocalizations and other behaviors in male jimpy (jp/Y) mice and their normal male littermatesQ48160340
A defect in the cell cycle of neuroglia in the myelin deficient jimpy mouseQ48197121
Developmental expression of the myelin proteolipid protein and basic protein mRNAs in normal and dysmyelinating mutant miceQ48204702
Neuronal abnormalities associated with impaired myelination during brain development: a golgi study of neocortex in the Jimpy mouseQ48212983
Antigen presentation and tumor cytotoxicity by interferon-gamma-treated microglial cellsQ48215877
The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant miceQ48262095
Biochemical correlates of myelination in brain and spinal cord of mice heterozygous for the jimpy geneQ48274896
Expression of the jimpy gene in the spinal cords of heterozygous female mice. I. An early myelin deficit followed by compensationQ48292872
Appearance of hematogenous cells in the white matter of myelin-deficient Jimpy mice.Q48312242
Jimpy mice: quantitation of myelin-associated glycoprotein and other proteinsQ48331187
The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy miceQ48334404
A single nucleotide difference in the gene for myelin proteolipid protein defines the jimpy mutation in mouseQ48334787
An AG----GG transition at a splice site in the myelin proteolipid protein gene in jimpy mice results in the removal of an exonQ48335699
Shiverer jimpy double mutant mice. II. Morphological evidence supports reciprocal intergenic suppressionQ48342788
Shiverer jimpy double mutant mice. I. Biochemical evidence for reciprocal intergenic suppressionQ48342960
Regional and developmental variations of GFAP and actin mRNA levels in the CNS of jimpy and shiverer mutant miceQ48382385
Expression of myelin proteolipid protein and basic protein in normal and dysmyelinating mutant miceQ48384472
Characterization of interleukin-1 production by microglia in cultureQ48430990
Selective expression of DM-20, an alternatively spliced myelin proteolipid protein gene product, in developing nervous system and in nonglial cellsQ48476911
DM-20 mRNA Is Expressed During the Embryonic Development of the Nervous System of the MouseQ48511250
Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cordQ48589841
Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouseQ48595546
Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine productionQ48661807
Developmental expression of myelin protein genes in dysmyelinating mutant mice: analysis by nuclear run-off transcription assay, in situ hybridization, and immunohistochemistryQ48789070
Myelination of jp,jpmsd, and qk axons by normal glia in vitro: ultrastructural and autoradiographic evidenceQ48795322
P433issue1
P304page(s)29-42
P577publication date1998-03-01
P1476titleUnderstanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse
P478volume26

Reverse relations

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