Notch-mediated restoration of regenerative potential to aged muscle

scientific article published on 01 November 2003

Notch-mediated restoration of regenerative potential to aged muscle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.1087573
P698PubMed publication ID14645852

P50authorGayle SmytheQ73547778
Thomas A. RandoQ79331501
P2093author name stringIrina M Conboy
Michael J Conboy
P433issue5650
P407language of work or nameEnglishQ1860
P1104number of pages3
P304page(s)1575-1577
P577publication date2003-11-01
P1433published inScienceQ192864
P1476titleNotch-mediated restoration of regenerative potential to aged muscle
P478volume302

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cites work (P2860)
Q37065378'From death, lead me to immortality' - mantra of ageing skeletal muscle
Q47675142* The Impact of Age on Skeletal Muscle Progenitor Cell Survival and Fate After Injury
Q336879163D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering
Q91894666A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells
Q30582498A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Q42846094A cell-autonomous defect in skeletal muscle satellite cells expressing low levels of survival of motor neuron protein.
Q44829950A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids
Q33571203A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches
Q36294585A murine model of volumetric muscle loss and a regenerative medicine approach for tissue replacement
Q42512299A tale of two niches: differential functions for VCAM-1 in satellite cells under basal and injured conditions
Q42707203Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration
Q34562223Activating Notch signaling post-SCI modulates angiogenesis in penumbral vascular beds but does not improve hindlimb locomotor recovery
Q41858522Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation.
Q40564636Adipose tissue biology in 2014: Advances in our understanding of adipose tissue homeostasis
Q26822437Advancements in stem cells treatment of skeletal muscle wasting
Q36288658Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration
Q40027450Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function
Q38106786Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging
Q41775980Age-associated inflammation inhibits epidermal stem cell function
Q36977666Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells
Q37034374Age-dependent alteration in muscle regeneration: the critical role of tissue niche
Q35088393Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy
Q35375871Age-related Notch-4 quiescence is associated with altered wall remodeling during vein graft adaptation
Q59125244Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Q47131388Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells
Q35055585Age-related impairment of T cell-induced skeletal muscle precursor cell function
Q36681378Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
Q35096716Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells
Q37024979Aged skeletal muscle retains the ability to fully regenerate functional architecture
Q47609609Ageing and the mystery at Arles
Q45826802Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle.
Q28565133Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury
Q37183949Aging and disease as modifiers of efficacy of cell therapy
Q41434529Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats.
Q90538157Aging induces aberrant state transition kinetics in murine muscle stem cells
Q37161623Aging of signal transduction pathways, and pathology
Q38237265Aging of the hematopoietic stem cells niche
Q42252666Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.
Q37083890Altered Ca2+ sparks in aging skeletal and cardiac muscle
Q30587469Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling
Q46032685An Intronic Enhancer Element Regulates Angiotensin II Type 2 Receptor Expression during Satellite Cell Differentiation, and Its Activity Is Suppressed in Congestive Heart Failure.
Q50933925An alternate protocol for establishment of primary caprine fetal myoblast cell culture: an in vitro model for muscle growth study.
Q35180702An overview of notch signaling in adult tissue renewal and maintenance
Q41409749Analysis of αSMA-labeled progenitor cell commitment identifies notch signaling as an important pathway in fracture healing
Q34234465Androgens and skeletal muscle: cellular and molecular action mechanisms underlying the anabolic actions.
Q37099711Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration
Q34248966Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration
Q80434452Antagonism of myostatin enhances muscle regeneration during sarcopenia
Q52695298Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster.
Q41693760Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis.
Q34216980Are human and mouse satellite cells really the same?
Q39783844Arsenic inhibits stem cell differentiation by altering the interplay between the Wnt3a and Notch signaling pathways
Q24320093Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS
Q36145408Attenuation of p38α MAPK stress response signaling delays the in vivo aging of skeletal muscle myofibers and progenitor cells
Q84779715Autografting Satellite Cells to Repair Damaged Muscle Induced by Repeated Compression: An Animal Model
Q64246070Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration
Q37189212Basic biology of skeletal aging: role of stress response pathways
Q59340677Bioinformatics analysis of differentially expressed genes in rotator cuff tear patients using microarray data
Q26863489Biomaterial-based delivery for skeletal muscle repair
Q39346557Biomaterials for skeletal muscle tissue engineering
Q34137578Biophysics and dynamics of natural and engineered stem cell microenvironments
Q92057341Blood autophagy defect causes accelerated non-hematopoietic organ aging
Q36968228Bone and skeletal muscle: neighbors with close ties
Q38359416Bone is Not Alone: the Effects of Skeletal Muscle Dysfunction in Chronic Kidney Disease
Q42520819CD90-positive cells, an additional cell population, produce laminin alpha2 upon transplantation to dy(3k)/dy(3k) mice.
Q38761095Calcium signaling in skeletal muscle development, maintenance and regeneration
Q33753610Cdc42 and aging of hematopoietic stem cells
Q29619469Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Q88955687Cellular and epigenetic drivers of stem cell ageing
Q35725714Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin
Q37701307Cellular mechanisms and local progenitor activation to regulate skeletal muscle mass.
Q37696180Cellular mechanisms of somatic stem cell aging
Q41887477Cellular players in skeletal muscle regeneration
Q24629853Cellular senescence and tumor suppressor gene p16
Q58713722Centronuclear myopathies under attack: A plethora of therapeutic targets
Q64230369Changes in Redox Signaling in the Skeletal Muscle with Aging
Q26778013Changes in Regenerative Capacity through Lifespan
Q37202531Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets
Q34964840Coaxing stem cells for skeletal muscle repair
Q93354244Combination of Coenzyme Q10 Intake and Moderate Physical Activity Counteracts Mitochondrial Dysfunctions in a SAMP8 Mouse Model
Q28547870Combinations of Kinase Inhibitors Protecting Myoblasts against Hypoxia
Q34326261Comparative angiogenic activities of induced pluripotent stem cells derived from young and old mice
Q42196621Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletal muscle satellite cells
Q37019582Control of the adaptive response of the heart to stress via the Notch1 receptor pathway.
Q41813617Correlations between microRNAs and their target genes in skeletal myoblasts cell therapy for myocardial infarction
Q33761360Crystallin-αB regulates skeletal muscle homeostasis via modulation of argonaute2 activity
Q92502907Deiodinases and their intricate role in thyroid hormone homeostasis
Q42987220Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans
Q56911556Delta-like 1 protein, vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis
Q42291306Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c
Q36893184Diabetic mice exhibited a peculiar alteration in body composition with exaggerated ectopic fat deposition after muscle injury due to anomalous cell differentiation
Q33675332Differential genomic responses in old vs. young humans despite similar levels of modest muscle damage after resistance loading
Q37351695Differentiation rather than aging of muscle stem cells abolishes their telomerase activity
Q36812068Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle
Q89964419Divergent Roles of Inflammation in Skeletal Muscle Recovery From Injury
Q33760580Dlk1 is necessary for proper skeletal muscle development and regeneration
Q28389517Donor satellite cell engraftment is significantly augmented when the host niche is preserved and endogenous satellite cells are incapacitated
Q39032912Early gene expression changes in skeletal muscle from SOD1(G93A) amyotrophic lateral sclerosis animal model.
Q35237414Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair.
Q36919044Effects of the activin A-myostatin-follistatin system on aging bone and muscle progenitor cells
Q28743774Efficient generation of iPS cells from skeletal muscle stem cells
Q35403399Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proliferation
Q36764108Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
Q39740143Embryonic anti-aging niche
Q35671770Emerging models and paradigms for stem cell ageing
Q38857342Engineered matrices for skeletal muscle satellite cell engraftment and function
Q97643882Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age
Q37088443Epigenetic drugs in the treatment of skeletal muscle atrophy.
Q26745718Epigenetic perturbations in aging stem cells
Q37858414Epigenetic regulation of aging stem cells
Q33633254Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals
Q96817958Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1
Q92477566Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate
Q42473280Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.
Q37233128Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis
Q35222114Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas
Q38200095Extrinsic Regulation of Satellite Cell Function and Muscle Regeneration Capacity during Aging
Q93023182Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Q36765815Fibroblast growth factor 2-stimulated proliferation is lower in muscle precursor cells from old rats
Q37138197Functional role of Notch signaling in the developing and postnatal heart
Q33682829Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs.
Q36528300Genes and the ageing muscle: a review on genetic association studies
Q35864925Genes invoked in the ovarian transition to menopause
Q35163122Genome instability, cancer and aging
Q39127452Geometric control of myogenic cell fate
Q36357842HEXIM1 controls satellite cell expansion after injury to regulate skeletal muscle regeneration
Q37691004Hemato-vascular origins of endothelial progenitor cells?
Q35693118Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Q36059679Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
Q37789857Heterogeneity in the muscle satellite cell population
Q36446142High glucose induces adipogenic differentiation of muscle-derived stem cells
Q33282298High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny
Q36879972Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles
Q41919865Host tissue response in stem cell therapy
Q33567866Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.
Q35475008Identification of microRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle
Q81510713Identification of novel pathway regulation during myogenic differentiation
Q37574383Identifying and enumerating neural stem cells: application to aging and cancer
Q34786450Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.
Q28308125Impact of genomic damage and ageing on stem cell function
Q57025472Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells
Q37042189Impaired regeneration: A role for the muscle microenvironment in cancer cachexia
Q42793119Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine
Q62661527In vivo GDF3 administration abrogates aging related muscle regeneration delay following acute sterile injury
Q28389659In vivo Monitoring of Transcriptional Dynamics After Lower-Limb Muscle Injury Enables Quantitative Classification of Healing
Q41853105In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma
Q42419013Increased Adipocyte Area in Injured Muscle With Aging and Impaired Remodeling in Female Mice.
Q35752238Increased Stiffness in Aged Skeletal Muscle Impairs Muscle Progenitor Cell Proliferative Activity
Q34317812Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.
Q29615155Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Q52579566Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M.
Q57061866Inflammation-associated miR-155 activates differentiation of muscular satellite cells
Q52571235Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases.
Q34315282Inhibition of JAK-STAT signaling stimulates adult satellite cell function.
Q30427044Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
Q39947147Inhibition of myogenesis by Notch: evidence for multiple pathways
Q36976407Inhibition of myostatin signaling through Notch activation following acute resistance exercise
Q34285424Insulin-like 6 Is Induced by Muscle Injury and Functions as a Regenerative Factor
Q48235527Integrated Analyses Reveal Overexpressed Notch1 Promoting Porcine Satellite Cells' Proliferation through Regulating the Cell Cycle.
Q35907071Integrating physiological regulation with stem cell and tissue homeostasis
Q36100758Interaction between bone and muscle in older persons with mobility limitations
Q47148629Interleukin-1beta (IL-1β)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1β on human dystrophic myogenic cells
Q90612446Interplay between Metabolites and the Epigenome in Regulating Embryonic and Adult Stem Cell Potency and Maintenance
Q36034995Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model
Q52687524Intraoperative delivery of the Notch ligand Jagged-1 regenerates appendicular and craniofacial bone defects.
Q36933565Intrinsic ability of adult stem cell in skeletal muscle: an effective and replenishable resource to the establishment of pluripotent stem cells
Q28084614Intrinsic and extrinsic mechanisms regulating satellite cell function
Q36961239Intrinsic changes and extrinsic influences of myogenic stem cell function during aging
Q33605791Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo
Q42583863Irina Conboy: making the old feel young again. Interview by Kendall Powell
Q50581803Ischaemia-reperfusion modulates inflammation and fibrosis of skeletal muscle after contusion injury.
Q37663796Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle
Q36344905Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype
Q94050448Knocked down a Notch with age
Q89550626Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury
Q82656708Lack of muscle recovery after immobilization in old rats does not result from a defect in normalization of the ubiquitin-proteasome and the caspase-dependent apoptotic pathways
Q35127396Levels of soluble delta-like ligand 1 in the serum and cerebrospinal fluid of tuberculous meningitis patients
Q42733180Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.
Q93233959LncRNAs regulating stemness in aging
Q37625904Long term human reconstitution and immune aging in NOD-Rag (-)-γ chain (-) mice
Q28384001Long-term supplementation with a cystine-based antioxidant delays loss of muscle mass in aging
Q28390560Long-term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in aged mice
Q39587049Losing stem cells in the aged skeletal muscle niche
Q34853001Loss of Notch1 disrupts the barrier repair in the corneal epithelium
Q28273548Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle
Q36117006Loss of stem cell regenerative capacity within aged niches
Q91766490Loss of the adipokine lipocalin-2 impairs satellite cell activation and skeletal muscle regeneration
Q33962042Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations
Q34973330Matrix metalloproteinase-9 inhibition improves proliferation and engraftment of myogenic cells in dystrophic muscle of mdx mice
Q36103986Mechanisms of Cachexia in Chronic Disease States
Q34217593Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis
Q36810649Mechanisms that regulate stem cell aging and life span
Q28511899Megf10 regulates the progression of the satellite cell myogenic program
Q92238221Metabolic Reprogramming Promotes Myogenesis During Aging
Q37315249Methods to promote Notch signaling at the biomaterial interface and evaluation in a rafted organ culture model
Q47440082Methylmercury exposure causes a persistent inhibition of myogenin expression and C2C12 myoblast differentiation
Q38609398MiR-34c represses muscle development by forming a regulatory loop with Notch1
Q28475539Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit
Q33735493Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration
Q36810964Mitophagy is required for mitochondrial biogenesis and myogenic differentiation of C2C12 myoblasts.
Q33349016Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy
Q90334919Moderate Intensity Resistive Training Reduces Oxidative Stress and Improves Muscle Mass and Function in Older Individuals
Q49540642Modulating the metabolism by trimetazidine enhances myoblast differentiation and promotes myogenesis in cachectic tumor-bearing c26 mice
Q30494635Molecular aging and rejuvenation of human muscle stem cells
Q37033031Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease
Q37138465Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia
Q38111713Molecular mechanisms of muscle plasticity with exercise
Q37256787Molecular regulation of stem cell quiescence.
Q50803903Morphological, molecular and functional differences of adult bone marrow- and adipose-derived stem cells isolated from rats of different ages.
Q36519891Mouse model of testosterone-induced muscle fiber hypertrophy: involvement of p38 mitogen-activated protein kinase-mediated Notch signaling
Q36941459Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle
Q26752770Muscle Satellite Cells: Exploring the Basic Biology to Rule Them
Q37270346Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis
Q37002317Muscle development, regeneration and laminopathies: how lamins or lamina-associated proteins can contribute to muscle development, regeneration and disease.
Q54548018Muscle diseases and aging.
Q26770557Muscle memory and a new cellular model for muscle atrophy and hypertrophy
Q33648473Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor- alpha response
Q24815340Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling
Q21131319Muscle satellite cell heterogeneity and self-renewal
Q36802239Muscle satellite cells from GRMD dystrophic dogs are not phenotypically distinguishable from wild type satellite cells in ex vivo culture.
Q30504731Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
Q37364150Muscle-specific deletion of SOCS3 increases the early inflammatory response but does not affect regeneration after myotoxic injury
Q88441149Myeloid Cell Responses to Contraction-induced Injury Differ in Muscles of Young and Old Mice
Q91760092Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers
Q28290654Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining
Q35836830Nestin-GFP reporter expression defines the quiescent state of skeletal muscle satellite cells
Q28564350Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells
Q84454172No change in skeletal muscle satellite cells in young and aging rat soleus muscle
Q36663765Notch Signaling in Meibomian Gland Epithelial Cell Differentiation
Q37785203Notch Signaling in the Regulation of Stem Cell Self-Renewal and Differentiation
Q41464948Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity
Q37766757Notch and Wnt signaling, physiological stimuli and postnatal myogenesis
Q36603527Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Q30482922Notch signaling and Hes labeling in the normal and drug-damaged organ of Corti
Q35946564Notch signaling and cardiac repair
Q33813202Notch signaling and neurogenesis in normal and stroke brain.
Q36903753Notch signaling at a glance
Q38985595Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration
Q33784595Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine
Q36317949Notch signaling in hematopoietic stem cells
Q34480012Notch signaling in pediatric soft tissue sarcomas
Q33784355Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway
Q33649282Notch signalling in ischaemia-induced angiogenesis.
Q37472316Notch-1 signalling is activated in brain arteriovenous malformations in humans
Q37337308Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia
Q85226461Notch3 Null Mutation in Mice Causes Muscle Hyperplasia by Repetitive Muscle Regeneration
Q35829811Novel intriguing strategies attenuating to sarcopenia
Q37319521Numb-deficient satellite cells have regeneration and proliferation defects.
Q98465004Optimizing Skeletal Muscle Anabolic Response to Resistance Training in Aging
Q58547334Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease
Q39052032Outside in: The matrix as a modifier of muscular dystrophy
Q89771836Overview of Basic Mechanisms of Notch Signaling in Development and Disease
Q35883021Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
Q36030982PAX7+ satellite cells in young and older adults following resistance exercise
Q34357219Pericytes at the intersection between tissue regeneration and pathology
Q37729327Pharmacological inhibition of myostatin/TGF-β receptor/pSmad3 signaling rescues muscle regenerative responses in mouse model of type 1 diabetes
Q38738830Phosphatidylserine directly and positively regulates fusion of myoblasts into myotubes
Q50076158Plasticity of the Muscle Stem Cell Microenvironment
Q92856883Podocan Promotes Differentiation of Bovine Skeletal Muscle Satellite Cells by Regulating the Wnt4-β-Catenin Signaling Pathway
Q28509714Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants
Q37454742Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner
Q37845288Primer and interviews: The dynamic stem cell niche
Q23916423Proapoptotic factor Bax is increased in satellite cells in the tibialis anterior muscles of old rats
Q37078868Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
Q47626666Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging.
Q90119945R3hdml regulates satellite cell proliferation and differentiation
Q35670105RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells
Q33949667RNA surveillance-an emerging role for RNA regulatory networks in aging
Q47753820Randomized, four-arm, dose-response clinical trial to optimize resistance exercise training for older adults with age-related muscle atrophy.
Q41170120Reciprocal interaction between TRAF6 and notch signaling regulates adult myofiber regeneration upon injury
Q39059046Redox Control of Skeletal Muscle Regeneration.
Q27318138Reduced Satellite Cell Numbers and Myogenic Capacity in Aging Can Be Alleviated by Endurance Exercise
Q35746503Reflections on lineage potential of skeletal muscle satellite cells: do they sometimes go MAD?
Q34737490Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage
Q24323315Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors
Q38878232Regulation of Skeletal Muscle by microRNAs.
Q37746040Regulation of skeletal myogenesis by Notch
Q95301635Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing
Q39121185Rejuvenating stem cells to restore muscle regeneration in aging
Q29615250Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Q92678605Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age
Q34404503Rejuvenation of the muscle stem cell population restores strength to injured aged muscles
Q35222931Rejuvenation: an integrated approach to regenerative medicine
Q42264762Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses
Q45987864Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans.
Q89022021Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence
Q35335210Role of protein and amino acids in the pathophysiology and treatment of sarcopenia
Q90230822Roles of mTOR Signaling in Tissue Regeneration
Q36028202Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass
Q33706637Sarcopenia: etiology, clinical consequences, intervention, and assessment.
Q36804785Sarcopenic obesity and endocrinal adaptation with age
Q38542445Satellite Cells and Skeletal Muscle Regeneration.
Q33816665Satellite cells and the muscle stem cell niche
Q26777962Satellite cells in human skeletal muscle plasticity
Q37261298Satellite-cell pool size does matter: defining the myogenic potency of aging skeletal muscle
Q37371320Sca-1-expressing nonmyogenic cells contribute to fibrosis in aged skeletal muscle
Q35212612Sculpting chromatin beyond the double helix: epigenetic control of skeletal myogenesis.
Q37596364Self-renewal and differentiation of muscle satellite cells are regulated by the Fas-associated death domain
Q81623652Serum of youth?
Q64914220Shisa2 regulates the fusion of muscle progenitors.
Q29346965Sirt1 increases skeletal muscle precursor cell proliferation
Q33766697Skeletal muscle as a regulator of the longevity protein, Klotho
Q89599729Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation
Q28262423Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise
Q34389066Skeletal muscle satellite cells: mediators of muscle growth during development and implications for developmental disorders
Q36121427Skeletal muscle stem and progenitor cells: reconciling genetics and lineage
Q60300380Skeletal muscle stem cells in comfort and stress
Q37810057Skeletal myoblasts for cardiac repair
Q35167984Slow-adhering stem cells derived from injured skeletal muscle have improved regenerative capacity.
Q36715665Sorting single satellite cells from individual myofibers reveals heterogeneity in cell-surface markers and myogenic capacity
Q41360491Sprouting a new take on stem cell aging.
Q37351564Stage-specific effects of Notch activation during skeletal myogenesis.
Q90190005Stem Cell Aging in Skeletal Muscle Regeneration and Disease
Q40966771Stem Cells and Tissue Niche: Two Faces of the Same Coin of Muscle Regeneration.
Q34402704Stem cell ageing and non-random chromosome segregation.
Q37005066Stem cell ageing: does it happen and can we intervene?
Q34159765Stem cell aging: mechanisms, regulators and therapeutic opportunities
Q34314546Stem cells and aging: a chicken-or-the-egg issue?
Q34450999Stem cells and the niche: a dynamic duo.
Q33616166Stem cells as vehicles for youthful regeneration of aged tissues.
Q35088530Stem cells for skeletal muscle repair
Q36523915Stem cells, ageing and the quest for immortality.
Q33393564Stem cells, their niches and the systemic environment: an aging network
Q47717967Stem cells: Aging and transcriptional fingerprints
Q36118320Stra13 regulates satellite cell activation by antagonizing Notch signaling
Q48325250Sustained Depolarization of the Resting Membrane Potential Regulates Muscle Progenitor Cell Growth and Maintains Stem Cell Properties In Vitro
Q34070002Syndecan-3 and Notch cooperate in regulating adult myogenesis
Q38112137Syndecans in skeletal muscle development, regeneration and homeostasis
Q38625964Systemic Problems: A perspective on stem cell aging and rejuvenation
Q35828481Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal
Q92453264Systemic milieu and age-related deterioration
Q39032975THE RENIN-ANGIOTENSIN SYSTEM AND THE BIOLOGY OF SKELETAL MUSCLE: MECHANISMS OF MUSCLE WASTING IN CHRONIC DISEASE STATES.
Q37153111Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice
Q83987360Taurine postponed the replicative senescence of rat bone marrow-derived multipotent stromal cells in vitro
Q36686910Testosterone improves the regeneration of old and young mouse skeletal muscle
Q34111489Testosterone is essential for skeletal muscle growth in aged mice in a heterochronic parabiosis model
Q33634392Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways
Q51761058The Bioelectric Code: Reprogramming Cancer and Aging From the Interface of Mechanical and Chemical Microenvironments.
Q45833603The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10.
Q51786747The Fountain of Youth: A Tale of Parabiosis, Stem Cells, and Rejuvenation.
Q24307354The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle
Q38671086The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma
Q24306223The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
Q33569692The Notch effector Hey1 associates with myogenic target genes to repress myogenesis.
Q55024852The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
Q90740037The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging
Q35754387The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells
Q39641300The Wnt pathway limits BMP signaling outside of the germline stem cell niche in Drosophila ovaries
Q34302715The aged niche disrupts muscle stem cell quiescence.
Q35105101The altered fate of aging satellite cells is determined by signaling and epigenetic changes
Q26801427The central role of muscle stem cells in regenerative failure with aging
Q33788099The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny
Q47753639The effect of downhill running on Notch signaling in regenerating skeletal muscle.
Q27008819The effect of physiological stimuli on sarcopenia; impact of Notch and Wnt signaling on impaired aged skeletal muscle repair
Q92803290The effects of minodronate and activated vitamin D on bone mineral density and muscle mass in postmenopausal women with osteoporosis
Q37219522The genetics of vertebrate myogenesis
Q36730830The harmonies played by TGF-β in stem cell biology
Q46505558The influence of eccentric exercise on mRNA expression of skeletal muscle regulators
Q26771242The ins and outs of muscle stem cell aging
Q36357449The lymphocyte secretome from young adults enhances skeletal muscle proliferation and migration, but effects are attenuated in the secretome of older adults
Q36971718The microenvironment of the embryonic neural stem cell: lessons from adult niches?
Q39275635The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system
Q34248711The p53 network: cellular and systemic DNA damage responses in aging and cancer
Q26800207The quasi-parallel lives of satellite cells and atrophying muscle
Q35935201The rejuvenating effect of pregnancy on muscle regeneration
Q39924099The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation.
Q34291439The satellite cell in male and female, developing and adult mouse muscle: distinct stem cells for growth and regeneration
Q26827224The stem cell niche in regenerative medicine
Q37068201The therapeutic potential of IGF-I in skeletal muscle repair
Q64894373The transcription factor Slug represses p16Ink4a and regulates murine muscle stem cell aging.
Q37383091The value of mammalian models for duchenne muscular dystrophy in developing therapeutic strategies
Q38208211Therapeutic modulation of Notch signalling--are we there yet?
Q26852708Therapies for sarcopenia and regeneration of old skeletal muscles: more a case of old tissue architecture than old stem cells
Q37429379Tissue resident stem cells: till death do us part
Q92659664Tissue-Resident PDGFRα+ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner
Q34445002Toward molecular understanding of polar overdominance at the ovine callipyge locus
Q50104779Transforming growth factor-β in stem cells and tissue homeostasis
Q53479362Translational strategies and challenges in regenerative medicine.
Q54062963Traumatic muscle fibrosis: From pathway to prevention.
Q39987998Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation
Q48453522Turning neurogenesis up a Notch
Q41021385Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.
Q64236814Unraveling the Paradoxical Action of Androgens on Muscle Stem Cells
Q43299475Up-regulation of calcium-dependent proteolysis in human myoblasts under acute oxidative stress.
Q36867965Vascular endothelial growth factor-A inhibits EphB4 and stimulates delta-like ligand 4 expression in adult endothelial cells.
Q34333066Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old wistar rats
Q21245383What does the concept of the stem cell niche really mean today?
Q26770845When stem cells grow old: phenotypes and mechanisms of stem cell aging
Q33945336Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
Q28588627Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts
Q41440209Young blood heals old muscles
Q36981493hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding
Q37745404miR-127 enhances myogenic cell differentiation by targeting S1PR3.
Q36005429microRNA-206 promotes skeletal muscle regeneration and delays progression of Duchenne muscular dystrophy in mice
Q64241257p16Ink4a Prevents the Activation of Aged Quiescent Dentate Gyrus Stem Cells by Physical Exercise
Q37202809p21 both attenuates and drives senescence and aging in BubR1 progeroid mice
Q33806427p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

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