Cellular and epigenetic drivers of stem cell ageing

scientific article published on 01 September 2018

Cellular and epigenetic drivers of stem cell ageing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41580-018-0020-3
P698PubMed publication ID29858605

P50authorKarl Lenhard RudolphQ21491023
Francesco NeriQ56812779
Alessandro OriQ42148718
P2093author name stringMaria Ermolaeva
P2860cites workAging of blood can be tracked by DNA methylation changes at just three CpG sitesQ21183983
DNA methylation age of human tissues and cell typesQ21183994
Translating the Histone CodeQ22065840
Epigenetic changes of DNA repair genes in cancerQ22242858
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11Q24298544
Feedback between p21 and reactive oxygen production is necessary for cell senescenceQ24299631
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesQ24307391
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork componentsQ24338173
The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Q24599219
Short-term calorie restriction enhances skeletal muscle stem cell functionQ24628734
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageingQ24649634
Age-related human small intestine methylation: evidence for stem cell nichesQ24815146
The central role of muscle stem cells in regenerative failure with agingQ26801427
The cancer epigenome: its origins, contributions to tumorigenesis, and translational implicationsQ26828751
Hematopoietic stem cell niche maintenance during homeostasis and regenerationQ26865273
Lifespan extension by preserving proliferative homeostasis in DrosophilaQ27345444
A comparison of normalization methods for high density oligonucleotide array data based on variance and biasQ27860710
Wnt/beta-catenin signaling in development and diseaseQ27860784
Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes.Q54700217
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4aQ57277034
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftmentQ58379782
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formationQ60284598
In vitro generation of long-term repopulating hematopoietic stem cells by fibroblast growth factor-1Q72997164
Small bowel enterocyte apoptosis and proliferation are increased in the elderlyQ74254435
Proliferating cell nuclear antigen expression is increased in small bowel epithelium in the elderlyQ77342643
Notch-mediated restoration of regenerative potential to aged muscleQ79331504
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenanceQ81308407
Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell functionQ83344193
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell deathQ84231670
Increased cell-to-cell variation in gene expression in ageing mouse heartQ34540791
In Vivo Amelioration of Age-Associated Hallmarks by Partial ReprogrammingQ34547502
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in miceQ34549707
Human umbilical cord plasma proteins revitalize hippocampal function in aged miceQ34555450
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.Q34558126
Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafishQ34618753
Methylation reveals a niche: stem cell succession in human colon cryptsQ34770573
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.Q34786450
Mitochondrial DNA mutations in disease and agingQ35018267
The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cellsQ35060787
Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanismsQ35080522
Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Q35192737
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiationQ35234787
Epigenetic control of the host gene by commensal bacteria in large intestinal epithelial cellsQ35372167
Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine.Q35437041
Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemnessQ35509884
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PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER StressQ35577504
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.Q35626387
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cellsQ35684586
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrowQ35691159
Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and DiseaseQ35747943
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skinQ35752935
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studiesQ35760749
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen ShockQ35781096
Noncanonical Wnt signaling maintains hematopoietic stem cells in the nicheQ35821670
Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human agingQ35827841
Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewingQ35849317
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.Q35875208
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regenerationQ35883021
The bone marrow niche for haematopoietic stem cellsQ35887876
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenationQ35947877
Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulationQ36002416
The Colonic Crypt Protects Stem Cells from Microbiota-Derived MetabolitesQ36041507
Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional miceQ34348701
The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organismsQ34349039
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemiaQ34403931
Geriatric muscle stem cells switch reversible quiescence into senescence.Q34403951
Rejuvenation of the muscle stem cell population restores strength to injured aged musclesQ34404503
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AAQ34453396
DNMT3A in haematological malignanciesQ34463554
Promoting health and longevity through diet: from model organisms to humansQ34468959
NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in miceQ34524174
Epigenetic control of adult stem cell functionQ34533891
The Wnt signaling pathway in development and diseaseQ27861019
Notch signaling: cell fate control and signal integration in developmentQ27861061
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104pQ27936629
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespanQ28005547
Metabolic consequences of oncogenic IDH mutationsQ28082949
Transcriptional and epigenetic regulation of autophagy in agingQ28083637
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscleQ28239514
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicingQ28249503
Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human diseaseQ28259472
GDF11 Increases with Age and Inhibits Skeletal Muscle RegenerationQ28262319
Impact of genomic damage and ageing on stem cell functionQ28308125
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequenceQ28385712
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesisQ28386212
Age-related clonal hematopoiesis associated with adverse outcomesQ28386602
Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during AgingQ28395874
Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle HypertrophyQ28397839
Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine intestinal developmentQ28504507
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with ageQ28505636
DNA repair is limiting for haematopoietic stem cells during ageingQ28509105
An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fateQ28510030
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in miceQ28511594
Elevated Histone Expression Promotes Life Span ExtensionQ28660674
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsQ29614268
Defining the epithelial stem cell niche in skinQ29614985
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentQ29615250
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiationQ29615366
MLL translocations, histone modifications and leukaemia stem-cell developmentQ29615368
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegansQ29618073
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cellsQ29619410
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosisQ29619965
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancyQ30411786
Structural modulation of gut microbiota in life-long calorie-restricted miceQ30418140
M-CSF instructs myeloid lineage fate in single haematopoietic stem cellsQ30540578
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.Q30582498
H3K4me1 marks DNA regions hypomethylated during aging in human stem and differentiated cellsQ30619629
p53 induces distinct epigenetic states at its direct target promotersQ33376888
Nucleolar expansion and elevated protein translation in premature agingQ41565087
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroQ41770080
A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal.Q42072436
Human mutation rate associated with DNA replication timingQ42085559
Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell CompartmentQ42224471
Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cellsQ42237145
Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion.Q42252666
Autophagy maintains the metabolism and function of young and old stem cells.Q42317229
Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvationQ42359854
Autophagy maintains stemness by preventing senescenceQ42487109
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewalQ42509225
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.Q42708309
Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.Q42776478
Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation PatternsQ42777917
Discrete roles of canonical and non-canonical Wnt signaling in hematopoiesis and lymphopoiesisQ43142247
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cellsQ43505907
Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testisQ43602218
Intestinal label-retaining cells are secretory precursors expressing Lgr5.Q45481109
Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon cryptsQ46129242
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to StressQ46146846
The mitochondrial UPR: mechanisms, physiological functions and implications in ageingQ46256193
Senescence is a developmental mechanism that contributes to embryonic growth and patterningQ46299044
Lifelong dietary intervention does not affect hematopoietic stem cell function.Q46348421
Interplay between metabolic identities in the intestinal crypt supports stem cell functionQ46407355
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.Q46900500
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse DiabetesQ46931622
Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expressionQ47071403
O-GlcNAcylation prevents aggregation of the Polycomb group repressor polyhomeoticQ47072664
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.Q47164905
Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.Q47436464
A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.Q47870632
A CREB-Sirt1-Hes1 Circuitry Mediates Neural Stem Cell Response to Glucose Availability.Q48952399
Shedding light on the cell biology of extracellular vesiclesQ50018560
A subpopulation of adult skeletal muscle stem cells retains all template DNA strands after cell divisionQ50593280
Paternal diet defines offspring chromatin state and intergenerational obesityQ50617301
Programmed cell senescence during mammalian embryonic development.Q50709155
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.Q50759304
Designer matrices for intestinal stem cell and organoid culture.Q51099747
Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells.Q51275474
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.Q51304904
mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.Q51680938
Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.Q51804038
Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.Q51839827
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.Q52715866
Cellular senescence in aging primates.Q53638045
Chaperones convert the energy from ATP into the nonequilibrium stabilization of native proteins.Q53839637
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4aQ36057582
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.Q36069386
Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis.Q36121608
Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and HumansQ36204662
Functions and regulations of fibroblast growth factor signaling during embryonic developmentQ36282338
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosisQ36303447
The p38 MAPK signaling pathway: a major regulator of skeletal muscle developmentQ36462305
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regenerationQ36483525
Nuclear envelope defects cause stem cell dysfunction in premature-aging miceQ36527165
Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction.Q36723446
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elementsQ36745810
Dietary restriction improves repopulation but impairs lymphoid differentiation capacity of hematopoietic stem cells in early agingQ36767454
The asymmetric segregation of damaged proteins is stem cell-type dependentQ36842029
DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in miceQ36908743
DNA double strand break repair, aging and the chromatin connection.Q36952025
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced LongevityQ36956854
Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndromeQ36967122
The Aging EpigenomeQ37029584
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia DevelopmentQ37095702
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cellsQ37117574
Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in miceQ37153111
The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.Q37213960
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognitionQ37279844
Autophagy and aging: keeping that old broom workingQ37321185
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespanQ37465080
Aging is not programmed: genetic pseudo-program is a shadow of developmental growthQ37525814
PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespanQ37591950
Histone chaperone networks shaping chromatin functionQ37656813
Regulation of histone modifying enzymes by the ubiquitin-proteasome systemQ37664744
DNA methylation is required for the control of stem cell differentiation in the small intestineQ37666410
Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolismQ37726260
Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regionsQ37726297
Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cellsQ37734385
Protein homeostasis and aging in neurodegenerationQ37785711
Multi-tissue DNA methylation age predictor in mouseQ33556578
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.Q33567407
Haematopoietic stem cells require a highly regulated protein synthesis rateQ33588717
The role of p38b MAPK in age-related modulation of intestinal stem cell proliferation and differentiation in DrosophilaQ33588784
Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signalsQ33633254
Aging effects on DNA methylation modules in human brain and blood tissueQ33741734
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villusQ33742017
Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in miceQ33787279
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewalQ33804172
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged miceQ33806427
Satellite cells and the muscle stem cell nicheQ33816665
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycleQ33849340
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.Q33858501
Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.Q33918478
Methylation patterns and mathematical models reveal dynamics of stem cell turnover in the human colonQ33943551
NAD+ and sirtuins in aging and diseaseQ33955066
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseasesQ34040980
Ageing as developmental decay: insights from p16(INK4a.).Q34042223
Stem cell aging. A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell agingQ34043513
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in miceQ34045591
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesisQ34076936
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.Q34134909
Regulation of the HIF-1alpha level is essential for hematopoietic stem cellsQ34134916
Dietary restriction enhances germline stem cell maintenanceQ34152458
Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscapeQ34153834
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration.Q34181742
Aging, cellular senescence, and cancerQ34199776
Dnmt3a is essential for hematopoietic stem cell differentiationQ34237926
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.Q34248675
Cancer genetics and epigenetics: two sides of the same coin?Q34287662
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.Q34289997
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesisQ34301317
The aged niche disrupts muscle stem cell quiescence.Q34302715
Alternative splicing: decoding an expansive regulatory layerQ37998762
DNA damage checkpoints in stem cells, ageing and cancer.Q38036830
Non-canonical functions of the DNA methylome in gene regulationQ38089266
The ageing haematopoietic stem cell compartmentQ38098875
Hormonal control of stem cell systemsQ38123197
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regenerationQ38170259
Histone exchange and histone modifications during transcription and agingQ38181507
Genome instability of ageing stem cells--Induction and defence mechanismsQ38350736
Statistical control of peptide and protein error rates in large-scale targeted data-independent acquisition analysesQ38616270
Material Cues as Potent Regulators of Epigenetics and Stem Cell FunctionQ38691260
Intragenic DNA methylation prevents spurious transcription initiationQ38715367
What have we learned on aging from omics studies?Q38718488
Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions.Q38852379
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.Q38903737
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells.Q38905562
HP1 is involved in regulating the global impact of DNA methylation on alternative splicingQ38907065
Total synthesis of 6-deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 cancer cell lineQ38942233
JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut.Q39405395
Sex hormones establish a reserve pool of adult muscle stem cellsQ39466126
Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeresQ39648535
The Janus face of DNA methylation in agingQ39914567
Regulation of life span by the gut microbiota in the short-lived African turquoise killifishQ40085659
Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation.Q40181345
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cellsQ40299682
A mechanism for the segregation of age in mammalian neural stem cellsQ40525711
Tissue-specific mutation accumulation in human adult stem cells during lifeQ40555695
Caloric restriction delays age-related methylation driftQ40638054
Regulation of embryonic stem cell pluripotency by heat shock protein 90Q41096665
Methylation of polycomb target genes in intestinal cancer is mediated by inflammationQ41203475
Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.Q41392338
Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.Q41468517
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptorQ41561672
P433issue9
P304page(s)594-610
P577publication date2018-09-01
P1433published inNature Reviews Molecular Cell BiologyQ1573120
P1476titleCellular and epigenetic drivers of stem cell ageing
P478volume19

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