Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

scientific article published on 01 September 2007

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1038378473
P356DOI10.1007/S11064-007-9471-1
P698PubMed publication ID17763943

P50authorHelle S. WaagepetersenQ37377430
Lasse K. BakQ38543717
Arne SchousboeQ56446698
Jan AlbrechtQ68085265
P2093author name stringElzbieta Ziemińska
P2860cites workProtein measurement with the Folin phenol reagentQ20900776
Preparation and properties of mitochondria derived from synaptosomesQ28565988
Metabolic distinction between vesicular and cytosolic GABA in cultured GABAergic neurons using 13C magnetic resonance spectroscopyQ31913177
Kinetics and localization of brain phosphate activated glutaminaseQ34464779
Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological toolsQ36347960
Synaptic and non-synaptic mitochondria from rat brain: isolation and characterizationQ39145317
Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytesQ41504615
Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivoQ42113965
Metabolic flux analysis as a tool for the elucidation of the metabolism of neurotransmitter glutamate.Q44568917
Evaluation of brain mitochondrial glutamate and alpha-ketoglutarate transport under physiologic conditionsQ45159490
Analysis of glutamine accumulation in rat brain mitochondria in the presence of a glutamine uptake inhibitor, histidine, reveals glutamine pools with a distinct access to deamidationQ45232656
Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neuronsQ46514981
Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neuronsQ46935651
Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellumQ48205811
Complex glutamate labeling from [U-13C]glucose or [U-13C]lactate in co-cultures of cerebellar neurons and astrocytesQ48403996
NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brainQ48489904
Glutamate uptake is inhibited by L-arginine in mitochondria isolated from rat cerebrumQ48659501
The orientation of phosphate activated glutaminase in the inner mitochondrial membrane of synaptic and non-synaptic rat brain mitochondria.Q52521607
Role of plasma membrane transport in hepatic glutamine metabolismQ69871404
Evidence that aspartate aminotransferase activity and ketodicarboxylate carrier function are essential for biosynthesis of transmitter glutamateQ69919248
Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analoguesQ73583754
Properties and submitochondrial localization of pig and rat renal phosphate-activated glutaminaseQ74172736
P433issue2
P304page(s)273-278
P577publication date2007-09-01
P1433published inNeurochemical ResearchQ15716728
P1476titleMetabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix
P478volume33

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Q48417506Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle
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