The Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella

scientific article published on 13 March 2018

The Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.RA117.001421
P932PMC publication ID5925794
P698PubMed publication ID29535187

P50authorEnrique Rudiño-PiñeraQ74251283
Gilberto Valdes-GarciaQ85655292
P2093author name stringVíctor H Bustamante
Víctor R Juárez-González
Claudia C Paredes-Amaya
P2860cites workI-TASSER server for protein 3D structure predictionQ21284202
I-TASSER: a unified platform for automated protein structure and function predictionQ24605680
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatusQ24651984
The cost of virulence: retarded growth of Salmonella Typhimurium cells expressing type III secretion system 1Q27349314
A Salmonella small non-coding RNA facilitates bacterial invasion and intracellular replication by modulating the expression of virulence factorsQ27349443
A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helixQ27660705
Structural Basis for the Secretion of EvpC: A Key Type VI Secretion System Protein from Edwardsiella tardaQ27664835
Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal OmegaQ27860809
ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activityQ28492626
Arac/XylS family of transcriptional regulatorsQ28776772
Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion systemQ29346800
A bacterial two-hybrid system based on a reconstituted signal transduction pathwayQ29617862
Crystal Structure of Hcp from Acinetobacter baumannii: A Component of the Type VI Secretion SystemQ30152905
A large family of anti-activators accompanying XylS/AraC family regulatory proteinsQ30277050
DNA-binding activities of the HilC and HilD virulence regulatory proteins of Salmonella enterica serovar TyphimuriumQ30309622
Role of nucleoid-associated proteins Hha and H-NS in expression of Salmonella enterica activators HilD, HilC, and RtsA required for cell invasionQ30443796
In silico clustering of Salmonella global gene expression data reveals novel genes co-regulated with the SPI-1 virulence genes through HilD.Q31144688
The role of coupled positive feedback in the expression of the SPI1 type three secretion system in SalmonellaQ33649749
Identification of the domains of UreR, an AraC-like transcriptional regulator of the urease gene cluster in Proteus mirabilisQ33996633
Salmonella: a model for bacterial pathogenesis.Q34131975
Salmonella pathogenicity islands encoding type III secretion systemsQ34288964
Salmonella enterica serovar Typhimurium skills to succeed in the host: virulence and regulationQ34336985
Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substratesQ34364793
FliT selectively enhances proteolysis of FlhC subunit in FlhD4C2 complex by an ATP-dependent protease, ClpXP.Q34552812
Degradation of the HilC and HilD regulator proteins by ATP-dependent Lon protease leads to downregulation of Salmonella pathogenicity island 1 gene expressionQ34554341
Patterns of expression and translocation of the ubiquitin ligase SlrP in Salmonella enterica serovar TyphimuriumQ34593329
Salmonella infections: an update on epidemiology, management, and preventionQ34633936
HilE interacts with HilD and negatively regulates hilA transcription and expression of the Salmonella enterica serovar Typhimurium invasive phenotype.Q34714166
Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilDQ35049823
A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimuriumQ35162771
Lateral gene transfer in SalmonellaQ35206858
Mlc regulation of Salmonella pathogenicity island I gene expression via hilE repressionQ35804589
The two-component system CpxR/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilDQ35921961
The Impact of 18 Ancestral and Horizontally-Acquired Regulatory Proteins upon the Transcriptome and sRNA Landscape of Salmonella enterica serovar Typhimurium.Q36114219
Functional domains of the AraC proteinQ36367901
Coordinate regulation of Salmonella pathogenicity island 1 (SPI1) and SPI4 in Salmonella enterica serovar TyphimuriumQ36483666
Intestinal Long-Chain Fatty Acids Act as a Direct Signal To Modulate Expression of the Salmonella Pathogenicity Island 1 Type III Secretion SystemQ36577171
The intestinal fatty acid propionate inhibits Salmonella invasion through the post-translational control of HilDQ36636799
Formate acts as a diffusible signal to induce Salmonella invasionQ36747272
HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2.Q36936468
Salmonellae interplay with host cellsQ37008201
Mapping the Regulatory Network for Salmonella enterica Serovar Typhimurium InvasionQ37236308
In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genesQ37545958
Identification of HilD-regulated genes in Salmonella enterica serovar Typhimurium.Q37643366
The Salmonella Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.Q37713164
The type VI secretion system: a multipurpose delivery system with a phage-like machineryQ37848429
Salmonella T3SSs: successful mission of the secret(ion) agents.Q38072180
A view to a kill: the bacterial type VI secretion systemQ38170842
Delineation of the Salmonella enterica serovar Typhimurium HilA regulon through genome-wide location and transcript analysisQ38302051
Butyrate specifically down-regulates salmonella pathogenicity island 1 gene expression.Q38317128
The Type VI Secretion System: A Dynamic System for Bacterial Communication?Q38626632
Evidence for multimerization of neu proteins involved in polysialic acid synthesis in Escherichia coli K1 using improved LexA-based vectorsQ39500773
Integrating global regulatory input into the Salmonella pathogenicity island 1 type III secretion systemQ39694438
Bile Acids Function Synergistically To Repress Invasion Gene Expression in Salmonella by Destabilizing the Invasion Regulator HilD.Q39761480
HilD, HilC and RtsA constitute a feed forward loop that controls expression of the SPI1 type three secretion system regulator hilA in Salmonella enterica serovar Typhimurium.Q40402350
Lon protease activity causes down-regulation of Salmonella pathogenicity island 1 invasion gene expression after infection of epithelial cells.Q40574768
Intestinal short-chain fatty acids alter Salmonella typhimurium invasion gene expression and virulence through BarA/SirA.Q40687509
Virulence Gene Regulation by L-Arabinose in Salmonella entericaQ41215879
The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cellsQ41469984
Fur regulates expression of the Salmonella pathogenicity island 1 type III secretion system through HilD.Q41911664
Two-component regulators control hilA expression by controlling fimZ and hilE expression within Salmonella enterica serovar Typhimurium.Q41982767
FliZ Regulates Expression of theSalmonellaPathogenicity Island 1 Invasion Locus by Controlling HilD Protein Activity inSalmonella entericaSerovar TyphimuriumQ42162171
Evolution of Salmonella-Host Cell Interactions through a Dynamic Bacterial GenomeQ42369791
Negative and positive regulation of the non-osmoregulated ompS1 porin gene in Salmonella typhi: a novel regulatory mechanism that involves OmpR.Q42600595
HilD induces expression of Salmonella pathogenicity island 2 genes by displacing the global negative regulator H-NS from ssrAB.Q43044995
Anti-activator ExsD forms a 1:1 complex with ExsA to inhibit transcription of type III secretion operons.Q43096524
AraC/XylS family members, HilC and HilD, directly bind and derepress the Salmonella typhimurium hilA promoterQ43970346
The bundle-forming pili of enteropathogenic Escherichia coli: transcriptional regulation by environmental signalsQ46411600
Characterization of functional domains of the Vibrio cholerae virulence regulator ToxT.Q46785725
Crystal structure of the putative cytoplasmic protein STM0279 (Hcp2) from Salmonella typhimuriumQ47991289
HilE Regulates HilD by Blocking DNA Binding in Salmonella enterica serovar TyphimuriumQ49597228
Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by the LysR-type regulator LeuO.Q50004550
A new LexA-based genetic system for monitoring and analyzing protein heterodimerization in Escherichia coliQ74272835
P433issue17
P407language of work or nameEnglishQ1860
P1104number of pages15
P304page(s)6578-6592
P577publication date2018-03-13
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella
P478volume293

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cites work (P2860)
Q93197826Molecular Characterization of SehB, a Type II Antitoxin of Salmonella enterica Serotype Typhimurium: Amino Acid Residues Involved in DNA-Binding, Homodimerization, Toxin Interaction, and Virulence
Q92715663Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network

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