Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors

scientific article published on 01 March 2018

Enhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOODADVANCES.2017010975
P932PMC publication ID5873227
P698PubMed publication ID29545255

P2093author name stringMortimer Poncz
Vincent Hayes
Rodney M Camire
Karen K Vo
Randolph B Lyde
Danuta Jarocha
P2860cites workApoptosis and megakaryocytic differentiation during ex vivo expansion of human cord blood CD34+ cells using thrombopoietinQ73942243
Stromal cell-derived factor-1 and macrophage-derived chemokine: 2 chemokines that activate plateletsQ73984172
Secretable human platelet-derived factor V originates from the plasma poolQ77459128
Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet releaseQ77535996
Megakaryocytes endocytose and subsequently modify human factor V in vivo to form the entire pool of a unique platelet-derived cofactorQ81479235
Dysmegakaryopoiesis of FPD/AML pedigrees with constitutional RUNX1 mutations is linked to myosin II deregulated expressionQ84812579
Rho kinase inhibition drives megakaryocyte polyploidization and proplatelet formation through MYC and NFE2 downregulationQ87023629
The selectivity of protein kinase inhibitors: a further updateQ24654622
Understanding platelet generation from megakaryocytes: implications for in vitro-derived plateletsQ26770860
Phosphatidylserine exposure is required for ADAM17 sheddase functionQ27317119
Why has demand for platelet components increased? A reviewQ28249969
Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesisQ28505080
Infusion of mature megakaryocytes into mice yields functional plateletsQ30497158
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cellsQ30657328
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse plateletsQ33349386
Flow cytometric analysis of thiazole orange uptake by platelets: a diagnostic aid in the evaluation of thrombocytopenic disordersQ33372140
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cellsQ33392928
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitorsQ33440323
The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet productionQ33491220
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living miceQ33789872
Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functionalQ34293080
Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte developmentQ34425414
Understanding Cytokinesis FailureQ34717820
Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary taleQ35692415
Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.Q36358673
Flow cytometric analysis of normal human megakaryocytesQ36450722
High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombastheniaQ37535262
In vitro megakaryocyte production and platelet biogenesis: state of the artQ37644828
Challenges and promises for the development of donor-independent platelet transfusionsQ38074224
Ex vivo production of platelets from stem cellsQ38187494
Distinct functional effects for dynamin 3 during megakaryocytopoiesisQ39407130
Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase.Q39929394
Ex vivo large-scale generation of human platelets from cord blood CD34+ cellsQ40290226
Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function.Q40328019
A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cellsQ40415814
Induction of polyploidization in leukemic cell lines and primary bone marrow by Src kinase inhibitor SU6656.Q40464481
Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase.Q40465579
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivoQ41460916
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivoQ45042577
Megakaryocytes express functional Aurora-B kinase in endomitosisQ46768355
Binding of Platelets to Lymphocytes: A Potential Anti-Inflammatory Therapy in Rheumatoid ArthritisQ48176964
Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach.Q51999245
Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process.Q53318623
Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling.Q53461749
Optimizing megakaryocyte polyploidization by targeting multiple pathways of cytokinesis.Q53734886
Megakaryocyte polyploidization is associated with a functional gene amplificationQ57082825
Unilineage megakaryocytic proliferation and differentiation of purified hematopoietic progenitors in serum-free liquid cultureQ71789377
P433issue6
P304page(s)597-606
P577publication date2018-03-01
P1476titleEnhancing functional platelet release in vivo from in vitro-grown megakaryocytes using small molecule inhibitors
P478volume2

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cites work (P2860)
Q92219763Enabling Large-Scale Ex Vivo Production of Megakaryocytes from CD34+ Cells Using Gas-Permeable Surfaces
Q110698426Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain
Q89521706Interplay between the tyrosine kinases Chk, Csk and phosphatase PTPRJ is critical for regulating platelets in mice
Q92756639Mesenchymal stromal cells lower platelet activation and assist in platelet formation in vitro

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