The Role of RNA in Biological Phase Separations

scientific article published on 10 May 2018

The Role of RNA in Biological Phase Separations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2018.05.003
P932PMC publication ID6204303
P698PubMed publication ID29753780

P2093author name stringPaul J Anderson
Marta M Fay
P2860cites workThe Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor PhosphorylationQ24297656
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspecklesQ24310786
ZBP1 regulates mRNA stability during cellular stressQ24314843
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayQ24316111
A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stabilityQ24522539
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic fociQ24540163
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structuresQ24543188
Stress granule assembly is mediated by prion-like aggregation of TIA-1Q24559953
Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAsQ24623900
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALSQ24633692
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTDQ24634583
MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspecklesQ24646100
Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNAQ24648896
Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic nuclear structureQ24651270
The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acidsQ24651464
MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspecklesQ24651886
Stress granules and processing bodies are dynamically linked sites of mRNP remodelingQ24678779
G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunitsQ27309029
Characterizing mRNA interactions with RNA granules during translation initiation inhibitionQ27342467
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiaeQ27930894
ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.Q27936710
Phase separation in biology; functional organization of a higher orderQ28071484
Regulation of translation initiation in eukaryotes: mechanisms and biological targetsQ28111696
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulationQ28118784
Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress GranulesQ49649749
Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule AssemblyQ50098070
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies.Q50209860
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.Q50963829
The coilin interactome identifies hundreds of small noncoding RNAs that traffic through Cajal bodies.Q51502949
RNA catalysis through compartmentalization.Q53356383
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.Q53368534
Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophyQ55670526
RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptomeQ60017421
Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3' end of a transcript encoding a protein kinase family memberQ68100373
Myotonic dystrophy in transgenic mice expressing an expanded CUG repeatQ74281230
De novo formation of a subnuclear bodyQ79696419
Phase Transitions in the Assembly and Function of Human miRISCQ88167003
Vinca alkaloid drugs promote stress-induced translational repression and stress granule formationQ37327483
RNA Controls PolyQ Protein Phase Transitions.Q37573060
Repeat expansion disease: progress and puzzles in disease pathogenesisQ37696972
Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein InteractionsQ37747172
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9Q28210917
The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAsQ28214585
Stress granules: sites of mRNA triage that regulate mRNA stability and translatabilityQ28215404
The translational regulator CPEB1 provides a link between dcp1 bodies and stress granulesQ28236721
Identifying and quantifying in vivo methylation sites by heavy methyl SILACQ28241075
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory rolesQ28247080
Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodiesQ28270553
Regulating gene expression through RNA nuclear retentionQ28278213
A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assemblyQ28294112
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposureQ28305175
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillizationQ28588090
Paraspeckles are subpopulation-specific nuclear bodies that are not essential in miceQ28591342
A muscleblind knockout model for myotonic dystrophyQ28592365
The regulated retrotransposon transcriptome of mammalian cellsQ29614444
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogelsQ29614781
Processing bodies require RNA for assembly and contain nontranslating mRNAsQ29615264
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granulesQ29615265
Protein arginine methylation in mammals: who, what, and whyQ29617309
Eukaryotic stress granules: the ins and outs of translationQ29619569
Arginine Demethylation of G3BP1 Promotes Stress Granule AssemblyQ30008866
Viral and cellular proteins containing FGDF motifs bind G3BP to block stress granule formationQ30009233
Both G3BP1 and G3BP2 contribute to stress granule formationQ30009952
Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylationQ30010053
Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granulesQ30014820
Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granulesQ30014821
RNA phase transitions in repeat expansion disordersQ30224330
Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism.Q30313887
RNA seeds higher-order assembly of FUS proteinQ30457170
Nucleic acid-binding specificity of human FUS proteinQ30459673
G-quadruplex RNA structure as a signal for neurite mRNA targetingQ30502060
Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domainsQ30577537
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).Q30663823
Cloning of the essential myotonic dystrophy region and mapping of the putative defectQ30985550
Targeting vertebrate intron-encoded box C/D 2'-O-methylation guide RNAs into the Cajal body.Q33698657
C9orf72 nucleotide repeat structures initiate molecular cascades of disease.Q33715387
The amyloid state of proteins in human diseasesQ37994283
Cajal bodies: where form meets functionQ38050096
Protein arginine methyltransferases and cancerQ38067063
Unusual biophysics of intrinsically disordered proteinsQ38069936
Stress granules and cell signaling: more than just a passing phase?Q38136844
Liquid-liquid phase separation in biologyQ38257388
TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells.Q38326803
Stress-specific differences in assembly and composition of stress granules and related fociQ38720884
Protein methylation and stress granules: posttranslational remodeler or innocent bystander?Q38755430
Unusual semi-extractability as a hallmark of nuclear body-associated architectural noncoding RNAsQ38839533
Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storageQ38965527
Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structuresQ38976436
c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA.Q38993039
Biomolecular condensates: organizers of cellular biochemistryQ39146409
Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm.Q39265687
Unravelling the ultrastructure of stress granules and associated P-bodies in human cells.Q39297506
Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.Q39349822
The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains.Q39396328
Alu element-mediated gene silencingQ39408863
Characterization and prediction of protein nucleolar localization sequences.Q39675144
mRNA escape from stress granule sequestration is dictated by localization to the endoplasmic reticulumQ39706103
A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs.Q39831945
A conserved charged single α-helix with a putative steric role in paraspeckle formation.Q40475971
Poly(ADP-ribose): an organizer of cellular architectureQ40485657
Phase transition of a disordered nuage protein generates environmentally responsive membraneless organellesQ41277254
Nuclear speckles: molecular organization, biological function and role in diseaseQ41924562
Granules harboring translationally active mRNAs provide a platform for P-body formation following stress.Q42115920
Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodiesQ42119478
Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granulesQ42208957
Adaptation to Stressors by Systemic Protein Amyloidogenesis.Q42373056
C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms RNA G-quadruplexesQ42424866
Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs.Q42636887
P-body formation is a consequence, not the cause, of RNA-mediated gene silencingQ42738042
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinaseQ42833009
The long noncoding RNA Neat1 is required for mammary gland development and lactation.Q43015249
An improved MS2 system for accurate reporting of the mRNA life cycleQ45072785
Coilin-dependent snRNP assembly is essential for zebrafish embryogenesisQ47073237
Paraspeckles: Where Long Noncoding RNA Meets Phase Separation.Q47242675
ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in CellsQ47270745
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution.Q47352667
The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress GranulesQ47411868
P-Body Purification Reveals the Condensation of Repressed mRNA RegulonsQ47665335
Nanoscale Analysis Reveals the Maturation of Neurodegeneration-Associated Protein Aggregates: Grown in mRNA Granules then Released by Stress Granule ProteinsQ48058822
p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosisQ33921377
Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granulesQ33983718
Cajal bodies: the first 100 yearsQ34059715
Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2.Q34094021
Angiogenin-induced tRNA fragments inhibit translation initiationQ34209434
Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodiesQ34313582
Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.Q34512451
Coexisting Liquid Phases Underlie Nucleolar SubcompartmentsQ34527840
Mechanistic insights into mammalian stress granule dynamics.Q34544246
Programmable RNA Tracking in Live Cells with CRISPR/Cas9.Q34676404
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytesQ34694194
NOPdb: Nucleolar Proteome Database--2008 updateQ34872544
Relationship of GW/P-bodies with stress granules.Q35049975
Compromised paraspeckle formation as a pathogenic factor in FUSopathiesQ35066217
An overview of pre-ribosomal RNA processing in eukaryotesQ35180630
P-body assembly requires DDX6 repression complexes rather than decay or Ataxin2/2L complexesQ35849087
ALS-Causing Mutations Significantly Perturb the Self-Assembly and Interaction with Nucleic Acid of the Intrinsically Disordered Prion-Like Domain of TDP-43.Q35886826
Modified deoxyoligonucleotides stable to exonuclease degradation in serumQ35913882
Phase transitions in the assembly of multivalent signalling proteinsQ35932499
Prion-like domains in RNA binding proteins are essential for building subnuclear paraspecklesQ35965458
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding ProteinsQ36172705
A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tailsQ36374180
RNA-mediated neuromuscular disordersQ36507582
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.Q36673676
The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structuresQ36742244
Translationally repressed mRNA transiently cycles through stress granules during stress.Q36914216
Mammalian stress granules and processing bodiesQ36965220
Interleukin-1β induced Stress Granules Sequester COX-2 mRNA and Regulates its Stability and Translation in Human OA ChondrocytesQ36980832
Repeat-associated non-ATG (RAN) translation in neurological diseaseQ37195032
Uncoupling stress granule assembly and translation initiation inhibitionQ37207715
Distinct stages in stress granule assembly and disassemblyQ37238978
Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA.Q37282006
Structural, super-resolution microscopy analysis of paraspeckle nuclear body organizationQ37285424
P433issue23
P1104number of pages17
P304page(s)4685-4701
P577publication date2018-05-10
P1433published inJournal of Molecular BiologyQ925779
P1476titleThe Role of RNA in Biological Phase Separations
P478volume430

Reverse relations

cites work (P2860)
Q92683542A unified mechanism for LLPS of ALS/FTLD-causing FUS as well as its modulation by ATP and oligonucleic acids
Q92656727Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles
Q91767779Chromosome-associated RNA-protein complexes promote pairing of homologous chromosomes during meiosis in Schizosaccharomyces pombe
Q91143116Dynamics of mRNA entry into stress granules
Q91588167Long Noncoding RNAs and Stress Response in the Nucleolus
Q57793886Molecular dissection of nuclear paraspeckles: towards understanding the emerging world of the RNP milieu
Q91869139Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies
Q101403041Phase separation by the polyhomeotic sterile alpha motif compartmentalizes Polycomb Group proteins and enhances their activity
Q91986309RNA promotes phase separation of glycolysis enzymes into yeast G bodies in hypoxia
Q92570860The Nucleolus: A Multiphase Condensate Balancing Ribosome Synthesis and Translational Capacity in Health, Aging and Ribosomopathies
Q59798011UPA-seq: prediction of functional lncRNAs using differential sensitivity to UV crosslinking

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