Abstract is: Ralph R. Isberg (born January 3, 1955) is a professor at Tufts University School of Medicine known for his contributions to understanding microbial pathogenesis. He is a member of the American National Academy of Sciences and was an investigator of the Howard Hughes Medical Institute for 27 years. A microbiologist, Isberg has published over 185 peer-reviewed articles and is or has been an editor of the Proceedings of the National Academy of Sciences, PLoS Pathogens, and Journal of Experimental Medicine, among others.
| human | Q5 |
| P8179 | Canadiana Name Authority ID | ncf11710068 |
| P2163 | FAST ID | 211864 |
| P2671 | Google Knowledge Graph ID | /g/11gf9mq8m8 |
| P213 | ISNI | 0000000027348841 |
| P244 | Library of Congress authority ID | n87150222 |
| P5380 | National Academy of Sciences member ID | 20020366 |
| P496 | ORCID iD | 0000-0002-8330-3554 |
| P214 | VIAF ID | 60597286 |
| P10832 | WorldCat Entities ID | E39PBJckPXcpCFm9hbcfjBYdcP |
| P27 | country of citizenship | United States of America | Q30 |
| P69 | educated at | Harvard University | Q13371 |
| Oberlin College | Q616591 | ||
| P108 | employer | Tufts Graduate School of Biomedical Sciences | Q7396838 |
| Tufts University School of Medicine | Q7851551 | ||
| Howard Hughes Medical Institute | Q1512226 | ||
| P734 | family name | Isberg | Q27887726 |
| Isberg | Q27887726 | ||
| Isberg | Q27887726 | ||
| P735 | given name | Ralph | Q18156180 |
| Ralph | Q18156180 | ||
| R. | Q19803517 | ||
| R. | Q19803517 | ||
| P463 | member of | National Academy of Sciences | Q270794 |
| P106 | occupation | microbiologist | Q3779582 |
| P21 | sex or gender | male | Q6581097 |
| Q41501952 | A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition |
| Q35161315 | A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death |
| Q49628029 | A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication. |
| Q28253847 | A bifunctional bacterial protein links GDI displacement to Rab1 activation |
| Q54949802 | A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii. |
| Q43215361 | A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth. |
| Q39158220 | A molecular strategy for the study of bacterial invasion |
| Q24533635 | A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association |
| Q41490492 | A region of the Yersinia pseudotuberculosis invasin protein that contributes to high affinity binding to integrin receptors |
| Q41524335 | A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. |
| Q92802394 | Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability |
| Q37190720 | Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen |
| Q41432231 | Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene |
| Q59812944 | An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic |
| Q41509406 | An O antigen can interfere with the function of the Yersinia pseudotuberculosis invasin protein |
| Q37693867 | An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding. |
| Q39515720 | An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors |
| Q81475445 | An open letter to Elias Zerhouni |
| Q39245241 | Analysis of Legionella infection using RNAi in Drosophila cells |
| Q36998388 | Analysis of expression and thermoregulation of the Yersinia pseudotuberculosis inv gene with hybrid proteins |
| Q35550118 | Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis |
| Q38559824 | Analysis of the intracellular fate of Legionella pneumophila mutants |
| Q41490301 | Analysis of the role of invasin during Yersinia pseudotuberculosis infection of mice |
| Q35693357 | Analyzing microbial disease at high resolution: following the fate of the bacterium during infection |
| Q35101682 | Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii |
| Q99248337 | Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope |
| Q36371628 | Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake |
| Q35438605 | Association of Legionella pneumophila with the macrophage endoplasmic reticulum |
| Q102379164 | Author Correction: Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope |
| Q34050049 | Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density |
| Q38237958 | Bacterial pathogen manipulation of host membrane trafficking |
| Q40742836 | Binding and internalization of microorganisms by integrin receptors |
| Q36958405 | Binding of cultured mammalian cells to immobilized bacteria |
| Q41479057 | Border patrols and secret passageways across the intestinal epithelium |
| Q33500145 | CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells |
| Q40643307 | CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity |
| Q36525649 | Cdc42 interacts with the exocyst complex to promote phagocytosis |
| Q33536575 | Cell biology of Legionella pneumophila |
| Q40268692 | Cellular internalization in the absence of invasin expression is promoted by the Yersinia pseudotuberculosis yadA product |
| Q41110911 | Common entry mechanisms. Bacterial pathogenesis |
| Q36347653 | Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack |
| Q40163635 | Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells |
| Q70079406 | Compartmentalization of the proteins encoded by IS50R |
| Q89872282 | Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella-containing vacuole |
| Q54549141 | Conferral of transposable properties to a chromosomal gene in Escherichia coli |
| Q48040136 | Conjugative transfer by the virulence system of Legionella pneumophila |
| Q64937387 | Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses. |
| Q37900141 | Control of host cell phosphorylation by legionella pneumophila |
| Q40238915 | Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: Analysis using platelet-derived growth factor and platelet-poor plasma |
| Q46915760 | Correction for Amyot et al., Poison Domains Block Transit of Translocated Substrates via the Legionella pneumophila Icm/Dot System. |
| Q27619937 | Crystal structure of invasin: a bacterial integrin-binding protein |
| Q33646947 | Cultured mammalian cells attach to the invasin protein of Yersinia pseudotuberculosis |
| Q54514403 | DNA gyrase is a host factor required for transposition of Tn5. |
| Q34768701 | Dancing with the host; flow-dependent bacterial adhesion |
| Q38858511 | Defining heterogeneity within bacterial populations via single cell approaches |
| Q50112238 | Delivering dangerous cargoes |
| Q35111154 | Determinants for thermoinducible cell binding and plasmid-encoded cellular penetration detected in the absence of the Yersinia pseudotuberculosis invasin protein |
| Q43515773 | Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole |
| Q41484495 | Differential effects of integrin alpha chain mutations on invasin and natural ligand interaction |
| Q36495509 | Discrimination Between Intracellular Uptake and Surface Adhesion of Bacterial Pathogens |
| Q41451621 | Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant |
| Q36710716 | Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction |
| Q92024492 | Droplet Tn-Seq combines microfluidics with Tn-Seq for identifying complex single-cell phenotypes |
| Q34119372 | E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates |
| Q40766600 | Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function |
| Q36032337 | Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake |
| Q35947390 | Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9. |
| Q99637082 | Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity |
| Q44534416 | Evidence for pore-forming ability by Legionella pneumophila |
| Q34302151 | Experimental evolution of Legionella pneumophila in mouse macrophages leads to strains with altered determinants of environmental survival |
| Q91148043 | Farewell Stan Stanley Falkow: 1934-2018 |
| Q73341429 | Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growth |
| Q72399097 | Formation of the Legionella pneumophila replicative phagosome |
| Q39398510 | Genetic analysis of bacterial virulence determinants in Bordetella pertussis and the pathogenetic Yersinia |
| Q68217745 | Genetic analysis of cell invasiveness by Yersinia pseudotuberculosis |
| Q34067887 | Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host-pathogen interactions |
| Q35913579 | Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10. |
| Q38126840 | Host signal transduction and protein kinases implicated in Legionella infection |
| Q37523328 | IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole |
| Q44660931 | IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein |
| Q37120240 | Identification and Characterization of a Candidate Wolbachia pipientis Type IV Effector That Interacts with the Actin Cytoskeleton |
| Q35504712 | Identification of Legionella pneumophila mutants that have aberrant intracellular fates. |
| Q72399108 | Identification of Legionella pneumophila promoters regulated by the macrophage intracellular environment |
| Q34372298 | Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes |
| Q34173409 | Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells |
| Q33751274 | Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway |
| Q35111099 | Identification of mammalian proteins that collaborate with type III secretion system function: involvement of a chemokine receptor in supporting translocon activity |
| Q38340751 | Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein |
| Q36371358 | Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response |
| Q46023230 | Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation. |
| Q30973404 | Innate immune recognition of Yersinia pseudotuberculosis type III secretion |
| Q41476997 | Integrin beta1-chain residues involved in substrate recognition and specificity of binding to invasin |
| Q39218893 | Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria |
| Q33898460 | Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions |
| Q35013023 | Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin |
| Q40501278 | Intracellular survival by Legionella. |
| Q35553593 | Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium |
| Q91862887 | Investigation of the host transcriptional response to intracellular bacterial infection using Dictyostelium discoideum as a host model |
| Q28288533 | Involvement of focal adhesion kinase in invasin-mediated uptake |
| Q37129897 | Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila |
| Q92090427 | Iron-Sulfur Cluster Repair Contributes to Yersinia pseudotuberculosis Survival within Deep Tissues |
| Q41501277 | Isolation and identification of eukaryotic receptors promoting bacterial internalization |
| Q39915159 | Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways |
| Q48319960 | Lasker-Koshland Award to 21st century microbe master |
| Q37340940 | Legionella pneumophila Dot/Icm translocated substrates: a sum of parts |
| Q41033239 | Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake |
| Q36964166 | Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages |
| Q36369590 | Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus |
| Q40764000 | Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system |
| Q72399094 | Legionella pneumophila: factors involved in the route and response to an intracellular niche |
| Q77148126 | Legionnaires' disease: the pore macrophage and the legion of terror within |
| Q71867211 | Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13 |
| Q41897005 | LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway |
| Q33530689 | LnaB: a Legionella pneumophila activator of NF-kappaB. |
| Q34125033 | Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth |
| Q37582843 | Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila |
| Q27025164 | Maintenance of vacuole integrity by bacterial pathogens |
| Q38759213 | Mammalian cell adhesion functions and cellular penetration of enteropathogenic Yersinia species |
| Q36987647 | Mapping and topographic localization of epitopes of the Yersinia pseudotuberculosis invasin protein |
| Q38206869 | Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets |
| Q36078970 | MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth |
| Q34680988 | Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells |
| Q35202685 | Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion |
| Q28083042 | Modulation of the host innate immune and inflammatory response by translocated bacterial proteins |
| Q41511934 | Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells |
| Q35554474 | Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer. |
| Q38360033 | Mutations in the cytoplasmic domain of the integrin beta1 chain indicate a role for endocytosis factors in bacterial internalization |
| Q36228869 | NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. |
| Q64082364 | New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems |
| Q36357452 | New gene in Escherichia coli K-12 (drpA): does its product play a role in RNA synthesis? |
| Q36477326 | Non-vertebrate hosts in the analysis of host-pathogen interactions |
| Q91650571 | One for All, but Not All for One: Social Behavior during Bacterial Diseases |
| Q37914725 | Pathways for the penetration of enteroinvasive Yersinia into mammalian cells |
| Q37555597 | Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system |
| Q37460412 | Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade. |
| Q37237972 | Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants |
| Q41382521 | Plague's partners in crime |
| Q37123778 | Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system |
| Q42839563 | QnAs with Ralph R. Isberg |
| Q33241705 | RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics |
| Q41019211 | Recombinant soluble human alpha 3 beta 1 integrin: purification, processing, regulation, and specific binding to laminin-5 and invasin in a mutually exclusive manner |
| Q36389584 | Recombination genes on the Escherichia coli sex factor specific for transposable elements |
| Q67233025 | Regulation of Tn5 by the right-repeat proteins: Control at the level of the transposition reaction? |
| Q72912664 | Replicon fusions promoted by the inverted repeats of Tn5. The right repeat is an insertion sequence |
| Q38317487 | Residues added to the carboxyl terminus of the Yersinia pseudotuberculosis invasin protein interfere with recognition by integrin receptors |
| Q36064532 | Robust bioengineered 3D functional human intestinal epithelium |
| Q41485965 | SWIM analysis allows rapid identification of residues involved in invasin-mediated bacterial uptake |
| Q33885377 | Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). |
| Q34012541 | Signaling and invasin-promoted uptake via integrin receptors |
| Q31667839 | Subversion of integrins by enteropathogenic Yersinia |
| Q40258153 | Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila. |
| Q41773449 | The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02. |
| Q34140790 | The E Block motif is associated with Legionella pneumophila translocated substrates |
| Q92666241 | The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication |
| Q42155652 | The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation |
| Q36918987 | The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity |
| Q47208585 | The Legionella pneumophila IcmR protein exhibits chaperone activity for IcmQ by preventing its participation in high-molecular-weight complexes |
| Q73215694 | The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity |
| Q37326393 | The Legionella pneumophila replication vacuole: making a cosy niche inside host cells |
| Q41507527 | The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor. |
| Q42592086 | The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA |
| Q33946169 | The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines |
| Q36951060 | The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells |
| Q35651739 | The interaction of bacteria with mammalian cells |
| Q92734407 | The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter |
| Q41495118 | The mechanism of phagocytic uptake promoted by invasin-integrin interaction |
| Q41441562 | The polybasic region of Rac1 modulates bacterial uptake independently of self-association and membrane targeting |
| Q34252412 | The protein SdhA maintains the integrity of the Legionella-containing vacuole |
| Q38355971 | The psa locus is responsible for thermoinducible binding of Yersinia pseudotuberculosis to cultured cells. |
| Q89652322 | The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home |
| Q70086841 | Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition |
| Q96435430 | Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites |
| Q39833215 | Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages |
| Q36557111 | Towards a molecular understanding of human diseases using Dictyostelium discoideum |
| Q41488425 | Transcriptional regulation of the Yersinia pseudotuberculosis pH6 antigen adhesin by two envelope-associated components |
| Q54563373 | Transposition of the kanamycin-resistance transposon Tn903. |
| Q72951041 | Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila |
| Q28236482 | Two mammalian cell internalization strategies used by pathogenic bacteria |
| Q40959502 | Uptake of enteropathogenic Yersinia by mammalian cells |
| Q41500768 | Use of Staphylococcus aureus coated with invasin derivatives to assay invasin function |
| Q71969420 | Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages |
| Q36361134 | Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin |
| Q59382609 | Vibrational spectra of cis-dimethyldiazene-d0, -1,1,1-d3, and -d6 |
| Q30656351 | Yersinia entry into host cells requires Rab5-dependent dephosphorylation of PI(4,5)P₂ and membrane scission |
| Q36228677 | Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine |
| Q24811985 | Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. |
| Q37410311 | Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization |
| Q59382606 | cis-Dimethyldiazene |
| Q35208221 | iMAD, a genetic screening strategy for dissecting complex interactions between a pathogen and its host |
| Ralph Isberg | wikipedia |
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