CD8+ T cells in HIV control, cure and prevention

scientific article published on 12 February 2020

CD8+ T cells in HIV control, cure and prevention is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/S41577-020-0274-9
P932PMC publication ID7222980
P698PubMed publication ID32051540

P50authorBruce D WalkerQ88402236
P2093author name stringGaurav D Gaiha
David R Collins
P2860cites workDesign and pre-clinical evaluation of a universal HIV-1 vaccineQ21092234
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tractQ22242965
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tractQ22242981
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressorsQ24676982
Cytomegalovirus Infection and Memory T Cell InflationQ26786776
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDSQ28215577
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The major genetic determinants of HIV-1 control affect HLA class I peptide presentationQ29417018
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
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Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study GroupQ29614934
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantationQ29615068
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progressionQ29618956
Evolutionary and immunological implications of contemporary HIV-1 variation.Q30329205
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccineQ30578618
HIV-1 group M conserved elements vaccineQ33308246
Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 studyQ33395678
Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite controlQ33594461
Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variablesQ33614495
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllersQ33630471
Broad, intense anti-human immunodeficiency virus (HIV) ex vivo CD8(+) responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapyQ33648533
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeysQ33712291
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeysQ33712578
HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllersQ37127920
Mucosal immune responses to HIV-1 in elite controllers: a potential correlate of immune controlQ37169129
Influence of HLA-C expression level on HIV controlQ37200459
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing AntibodiesQ37246321
Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activityQ37262408
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
Public clonotype usage identifies protective Gag-specific CD8+ T cell responses in SIV infectionQ37273289
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challengeQ37287080
Efficiency of cell-free and cell-associated virus in mucosal transmission of human immunodeficiency virus type 1 and simian immunodeficiency virusQ37336708
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefitQ37381314
Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.Q37410726
CD8+ T cells from HLA-B*57 elite suppressors effectively suppress replication of HIV-1 escape mutantsQ37427587
Vaccine-induced CD8+ T cells control AIDS virus replicationQ37442789
Simian Immunodeficiency Virus-Producing Cells in Follicles Are Partially Suppressed by CD8+ Cells In VivoQ37448333
Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeysQ37486401
Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllersQ37547677
Dynamics of SIV-specific CXCR5+ CD8 T cells during chronic SIV infection.Q37682298
A systematic review of definitions of extreme phenotypes of HIV control and progressionQ38154750
Multiple Origins of Virus Persistence during Natural Control of HIV InfectionQ38379102
Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort StudyQ38477498
Tissue-resident memory T cells: local specialists in immune defence.Q38674833
Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, UgandaQ38885289
T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.Q39026157
Infrequent recovery of HIV from but robust exogenous infection of activated CD4(+) T cells in HIV elite controllers.Q39112993
Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, ThailandQ39358681
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.Q39362365
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin MiceQ39407795
Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infectionQ40088529
HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapesQ40101982
Demographics and natural history of HIV-1-infected spontaneous controllers of viremiaQ40291456
Higher T-Cell Responses Induced by DNA/rAd5 HIV-1 Preventive Vaccine Are Associated With Lower HIV-1 Infection Risk in an Efficacy TrialQ40332276
Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodiesQ40366328
Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infectionQ40584352
CXCR5(+) follicular cytotoxic T cells control viral infection in B cell folliclesQ40589864
Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressorsQ40615883
Early antibody therapy can induce long-lasting immunity to SHIVQ33762877
Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controllerQ33786447
Elite suppressors harbor low levels of integrated HIV DNA and high levels of 2-LTR circular HIV DNA compared to HIV+ patients on and off HAART.Q33839450
Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
Impaired replication capacity of acute/early viruses in persons who become HIV controllersQ33963989
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.Q34056087
Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollersQ34083315
Copy number variation of KIR genes influences HIV-1 controlQ34090869
A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysisQ34220876
Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodiesQ34229664
Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaQ34332166
Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen designQ34334803
HIV-1 DNA predicts disease progression and post-treatment virological controlQ34350410
Immune clearance of highly pathogenic SIV infectionQ34370314
HIV-1 continues to replicate and evolve in patients with natural control of HIV infectionQ34416428
Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus controlQ34435052
Prolonged control of an HIV type 1 escape variant following treatment interruption in an HLA-B*27-positive patientQ34447772
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.Q34468117
Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virusQ34468698
Intranasal administration of a therapeutic HIV vaccine (Vacc-4x) induces dose-dependent systemic and mucosal immune responses in a randomized controlled trialQ34513477
Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL.Q34550802
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunctionQ34570127
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infectionQ34570624
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI StudyQ34629153
A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replicationQ34646987
Neutralizing antibodies do not mediate suppression of human immunodeficiency virus type 1 in elite suppressors or selection of plasma virus variants in patients on highly active antiretroviral therapyQ34647680
Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trialQ34648825
Transmission of human immunodeficiency virus type 1 from a patient who developed AIDS to an elite suppressorQ34780395
Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipientsQ34874985
Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infectionQ34994754
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccineQ35009558
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllersQ35058635
Reduction of CD4+ T cells in vivo does not affect virus load in macaque elite controllersQ35077809
Coordinate linkage of HIV evolution reveals regions of immunological vulnerabilityQ35105172
Structural topology defines protective CD8+ T cell epitopes in the HIV proteomeQ91711152
Therapeutic Vaccination Refocuses T-cell Responses Towards Conserved Regions of HIV-1 in Early Treated Individuals (BCN 01 study)Q91944005
A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challengeQ91967570
Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cellsQ92094111
HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantationQ92144268
Early evidence of inactivated enterovirus 71 vaccine impact against hand, foot, and mouth disease in a major center of ongoing transmission in China, 2011-2018: a longitudinal surveillance studyQ92268500
Antiretroviral Therapy Reduces T-cell Activation and Immune Exhaustion Markers in Human Immunodeficiency Virus ControllersQ92312862
Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotypeQ92702651
Lessons for general vaccinology research from attempts to develop an HIV vaccineQ93063721
Escape from highly effective public CD8+ T-cell clonotypes by HIVQ35182712
Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infectionQ35241486
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutationsQ35521811
Immunology. Immune activation with HIV vaccinesQ35551760
Beyond adjuvants: immunomodulation strategies to enhance T cell immunityQ35666506
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotypeQ35749755
Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replicationQ35785115
CD8(+) T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen TypesQ35797743
Definition of the viral targets of protective HIV-1-specific T cell responsesQ35800157
HLA B*5701-positive long-term nonprogressors/elite controllers are not distinguished from progressors by the clonal composition of HIV-specific CD8+ T cellsQ35826897
Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.Q35867686
Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV ControlQ35888710
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expressionQ35904453
Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.Q35913945
Comprehensive analysis of unique cases with extraordinary control over HIV replicationQ36010191
Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG bindingQ36172128
The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite ControllersQ36208223
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutationsQ36238124
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
A vaccine strategy that protects against genital herpes by establishing local memory T cellsQ36403540
Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapyQ36498230
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infectionQ36513955
Recent developments in the effort to cure HIV infection: going beyond N = 1.Q36515170
Host factors dictate control of viral replication in two HIV-1 controller/chronic progressor transmission pairsQ36547178
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionQ36547664
Broadly targeted CD8⁺ T cell responses restricted by major histocompatibility complex E.Q36624194
Therapeutic Vaccination With Dendritic Cells Loaded With Autologous HIV Type 1-Infected Apoptotic CellsQ36745227
HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacityQ36827382
Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictableQ36933059
Novel Conserved-region T-cell Mosaic Vaccine With High Global HIV-1 Coverage Is Recognized by Protective Responses in Untreated InfectionQ36951283
Impact of pre-adapted HIV transmission.Q36984267
Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral ReactivationQ37002564
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune controlQ37054526
Safety and comparative immunogenicity of an HIV-1 DNA vaccine in combination with plasmid interleukin 12 and impact of intramuscular electroporation for deliveryQ37070349
PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individualsQ40653907
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllersQ40659603
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosisQ41590197
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
Primary CD8+ T cells from elite suppressors effectively eliminate non-productively HIV-1 infected resting and activated CD4+ T cellsQ41915015
Evaluating the impact of functional genetic variation on HIV-1 controlQ41926563
Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral loadQ42205079
Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parametersQ43070781
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infectionQ43542210
CXCR5+ CCR7- CD8 T cells are early effector memory cells that infiltrate tonsil B cell folliclesQ44152856
Therapeutic dendritic-cell vaccine for chronic HIV-1 infectionQ45165349
Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressorsQ45741753
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cellsQ47199883
Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessmentQ47307973
Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion.Q47349491
Impact of HLA Class I Alleles on Timing of HIV Rebound After Antiretroviral Treatment InterruptionQ47553711
Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individualsQ47555195
Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunizationQ47601205
HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue.Q49748869
T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable.Q50043370
HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy.Q51320237
The Global HIV Epidemic: What Will It Take to Get to the Finish Line?Q51784351
Viral Characteristics Associated with the Clinical Nonprogressor Phenotype Are Inherited by Viruses from a Cluster of HIV-1 Elite Controllers.Q52325888
EFFECT OF SHORT-TERM ART INTERRUPTION ON LEVELS OF INTEGRATED HIV DNA.Q52624999
CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue.Q53551795
Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)Q56911184
Phase I clinical trial of an intranodally administered mRNA based therapeutic vaccine against HIV-1 infectionQ57023723
Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissueQ57225626
Genomewide Association Study of an AIDS‐Nonprogression Cohort Emphasizes the Role Played byHLAGenes (ANRS Genomewide Association Study 02)Q57249723
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopesQ57916541
Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trialQ58587972
Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIVQ59125545
Long-term remission despite clonal expansion of replication-competent HIV-1 isolatesQ59134950
First-in-human randomized controlled trial of an oral, replicating adenovirus 26 vector vaccine for HIV-1Q59351069
Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral reboundQ59355095
HIV-1 latent reservoir size and diversity are stable following brief treatment interruptionQ59358567
HIV Controllers Exhibit Effective CD8 T Cell Recognition of HIV-1-Infected Non-activated CD4 T CellsQ64083948
Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphismQ68184420
Frequency and function of HIV-specific CD8(+) T cellsQ74608670
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral TherapyQ90000752
Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer ImmunologyQ90265999
Accelerating HIV vaccine development using non-human primate modelsQ90334537
HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollersQ90340957
The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical StudiesQ90808810
HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals UntransmittableQ90980677
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responsesQ91044500
Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trialQ91360476
Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacyQ91360501
Topological perspective on HIV escapeQ91711007
P921main subjectCD8-positive T-lymphocytesQ70192767
P577publication date2020-02-12
2020-08-01
P1433published inNature Reviews ImmunologyQ43355
P1476titleCD8+ T cells in HIV control, cure and prevention

Reverse relations

cites work (P2860)
Q96171859Unconventional CD45RA+ memory CD8 T cells to control HIV infection during antiretroviral therapy
Q90634406Virtual memory CD8+ T cells restrain the viral reservoir in HIV-1-infected patients with antiretroviral therapy through derepressing KIR-mediated inhibition

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