Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients

scientific article

Transmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PPAT.1004565
P932PMC publication ID4287535
P698PubMed publication ID25569444
P5875ResearchGate publication ID270651315

P50authorJianming TangQ45997233
Beatrice H. HahnQ55293537
Alan S. PerelsonQ55719625
Etienne KaritaQ72386151
George M. ShawQ78514357
Paul A GoepfertQ87472808
Ruy M. RibeiroQ30504775
P2093author name stringRong Rong
Jill Gilmour
Eric Hunter
Cynthia A Derdeyn
Susan A Allen
Daniel T Claiborne
Jessica L Prince
Ling Yue
Cecilia Chui
Katja J Pfafferott
Joshua Baalwa
Emmanuel Cormier
Karen Conrod
Catherine C Dong
P2860cites workHLA allele sharing and HIV type 1 viremia in seroconverting Zambians with known transmitting partnersQ46171893
HIV evolution: CTL escape mutation and reversion after transmissionQ47211742
Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmissionQ47878972
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomesQ48088168
Elite control of HIV infection: implications for vaccine designQ56994404
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
Long-term survivors with HIV-1 infection: incubation period and longitudinal patterns of CD4+ lymphocytesQ72112068
Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversionQ72624142
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDSQ73034306
Neutralizing antibodies are positively associated with CD4+ T-cell counts and T-cell function in long-term AIDS-free infectionQ77386243
A longitudinal study of neutralizing antibodies and disease progression in HIV-1-infected subjectsQ77399464
Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infectionQ80819695
Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infectionQ83862341
Common genetic variation and the control of HIV-1 in humansQ21092450
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndromeQ24648628
The Antibody Response against HIV-1Q27000889
Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization BreadthQ27676728
Long-term HIV-1 infection without immunologic progressionQ28242263
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virusQ28302762
Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infectionQ28304764
Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationshipsQ28394085
Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral loadQ28475652
Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cellsQ28748976
The major genetic determinants of HIV-1 control affect HLA class I peptide presentationQ29417018
Antibody neutralization and escape by HIV-1Q29547345
A whole-genome association study of major determinants for host control of HIV-1Q29614891
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
Rapid evolution of the neutralizing antibody response to HIV type 1 infectionQ29618603
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionQ29619510
Optimized determination of T cell epitope responsesQ31133720
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantageQ33325923
Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1Q33402461
Elite suppressor-derived HIV-1 envelope glycoproteins exhibit reduced entry efficiency and kineticsQ33429049
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathwaysQ33504599
HIV-1 transmitting couples have similar viral load set-points in Rakai, UgandaQ33576652
Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infectionQ33828583
Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.Q33915790
HIV RNA level in early infection is predicted by viral load in the transmission sourceQ33921382
Impaired replication capacity of acute/early viruses in persons who become HIV controllersQ33963989
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
Additive contribution of HLA class I alleles in the immune control of HIV-1 infectionQ34120809
Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infectionQ34228730
Impact of MHC class I diversity on immune control of immunodeficiency virus replicationQ34235198
Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infectionQ34295972
Molecular epidemiology of human immunodeficiency virus type 1 transmission in a heterosexual cohort of discordant couples in ZambiaQ34327190
Specificity of the autologous neutralizing antibody responseQ34415389
HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replicationQ34448446
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.Q34468117
The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverterQ34485260
Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesisQ34499377
Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1Q34648079
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionQ37273195
Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703-positive individuals and their transmission recipientsQ37273283
Escape from CD8(+) T cell responses in Mamu-B*00801(+) macaques differentiates progressors from elite controllersQ37442895
T cell immunity in acute HIV-1 infection.Q37789345
HIV-1 replicative fitness in elite controllersQ37856676
Phylogenetic evaluation of Kenyan HIV type 1 isolatesQ38558632
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120Q39612212
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllersQ40659603
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytesQ40669542
Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine designQ41338220
The characterization of non-progressors: long-term HIV-1 infection with stable CD4+ T-cell levels.Q41531784
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte [corrected] recognitionQ41966337
The rate of immune escape vanishes when multiple immune responses control an HIV infectionQ42277067
Continuous viral escape and selection by autologous neutralizing antibodies in drug-naive human immunodeficiency virus controllersQ43215260
Chronic HIV infection affects the expression of the 2 transcription factors required for CD8 T-cell differentiation into cytolytic effectors.Q44179257
Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history studyQ44429168
Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort StudyQ45743784
Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressorsQ45772545
The natural history of HIV-1 infection: virus load and virus phenotype independent determinants of clinical course?Q45783098
Elucidating the elite: mechanisms of control in HIV-1 infectionQ35008384
Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.Q35076519
Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infectionQ35274776
Role of donor genital tract HIV-1 diversity in the transmission bottleneckQ35558621
Definition of the viral targets of protective HIV-1-specific T cell responsesQ35800157
Impact of HLA-B*81-associated mutations in HIV-1 Gag on viral replication capacityQ35826266
HIV and SIV CTL escape: implications for vaccine designQ35852284
Clade-specific differences between human immunodeficiency virus type 1 clades B and C: diversity and correlations in C3-V4 regions of gp120.Q35857408
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infectionQ35947590
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escapeQ36000736
Fine-mapping classical HLA variation associated with durable host control of HIV-1 infection in African AmericansQ36231666
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutationsQ36238124
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.Q36315572
Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.Q36368095
Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte responseQ36399559
Vertical T cell immunodominance and epitope entropy determine HIV-1 escapeQ36497283
HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44Q36498061
Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clonesQ36532973
Cumulative impact of host and viral factors on HIV-1 viral-load control during early infectionQ36559632
Evidence for rapid disappearance of initially expanded HIV-specific CD8+ T cell clones during primary HIV infectionQ36576849
Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsQ36639954
Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaquesQ36702206
Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteinsQ36759719
Autologous neutralizing humoral immunity and evolution of the viral envelope in the course of subtype B human immunodeficiency virus type 1 infectionQ36845710
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changesQ36845893
Specific N-linked and O-linked glycosylation modifications in the envelope V1 domain of simian immunodeficiency virus variants that evolve in the host alter recognition by neutralizing antibodiesQ36884458
Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapyQ36950611
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyQ37033224
HLA-associated alterations in replication capacity of chimeric NL4-3 viruses carrying gag-protease from elite controllers of human immunodeficiency virus type 1.Q37033250
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodiesQ37033269
Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune controlQ37054526
HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703Q37081581
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.Q37099792
Influence of HLA-C expression level on HIV controlQ37200459
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectHIV transmissionQ49029021
P304page(s)e1004565
P577publication date2015-01-08
P1433published inPLOS PathogensQ283209
P1476titleTransmitted virus fitness and host T cell responses collectively define divergent infection outcomes in two HIV-1 recipients
P478volume11

Reverse relations

cites work (P2860)
Q30381208A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.
Q47548907Alterations of HIV-1 envelope phenotype and antibody-mediated neutralization by signal peptide mutations.
Q59356540Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection
Q37221660Broad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults
Q35697246CD4:CD8 lymphocyte ratio as a quantitative measure of immunologic health in HIV-1 infection: findings from an African cohort with prospective data
Q89686737CD8+ T cells in HIV control, cure and prevention
Q30381239Composite Sequence-Structure Stability Models as Screening Tools for Identifying Vulnerable Targets for HIV Drug and Vaccine Development.
Q64068820Defining Kinetic Properties of HIV-Specific CD8⁺ T-Cell Responses in Acute Infection
Q37252894Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection
Q36194234Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth
Q33809708Factors Associated With the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller
Q58085173HIV control: Is getting there the same as staying there?
Q26765966HIV-Host Interactions: Implications for Vaccine Design
Q35778333Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance
Q92883461Identification of Immunodominant HIV-1 Epitopes Presented by HLA-C*12:02, a Protective Allele, Using an Immunopeptidomics Approach
Q35694015Infection of ectocervical tissue and universal targeting of T-cells mediated by primary non-macrophage-tropic and highly macrophage-tropic HIV-1 R5 envelopes.
Q36223864New prospects for a preventive HIV-1 vaccine
Q39735439Notwithstanding Circumstantial Alibis, Cytotoxic T Cells Can Be Major Killers of HIV-1-Infected Cells.
Q40349815Replication Capacity of Viruses from Acute Infection Drives HIV-1 Disease Progression
Q37612507Resistance to type 1 interferons is a major determinant of HIV-1 transmission fitness
Q26772713Role of HLA Adaptation in HIV Evolution
Q38491191Success and failure of the cellular immune response against HIV-1.
Q40091554The HIV Genomic Incidence Assay Meets False Recency Rate and Mean Duration of Recency Infection Performance Standards
Q30240629Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity
Q52325888Viral Characteristics Associated with the Clinical Nonprogressor Phenotype Are Inherited by Viruses from a Cluster of HIV-1 Elite Controllers.
Q39400038Virus-Host Gene Interactions Define HIV-1 Disease Progression.

Search more.