Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin

scientific article published on 01 March 2020

Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JTH.14724
P932PMC publication ID7080319
P698PubMed publication ID32112532

P50authorAlireza R RezaieQ88924052
P2093author name stringHemant Giri
P2860cites workHuman myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase NQ24317442
Syndecan-4 signaling at a glanceQ26865478
Structure of beta-antithrombin and the effect of glycosylation on antithrombin's heparin affinity and activityQ27640482
CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell linesQ28115250
Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancementQ28274243
IREM-1 is a novel inhibitory receptor expressed by myeloid cellsQ28294075
Antiangiogenic activity of the cleaved conformation of the serpin antithrombinQ33874343
A peptide of heparin cofactor II inhibits endotoxin-mediated shock and invasive Pseudomonas aeruginosa infection.Q33927961
Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signallingQ34038099
Therapeutic rationale for antithrombin III in sepsisQ34046668
Molar antithrombin concentration in normal human plasmaQ34265854
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trialQ34518326
Interaction of antithrombin III with bovine aortic segments. Role of heparin in binding and enhanced anticoagulant activityQ34524635
Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasisQ34889931
Antithrombin: a new look at the actions of a serine protease inhibitorQ35004303
CD13 restricts TLR4 endocytic signal transduction in inflammationQ35472323
Proteolytic activation transforms heparin cofactor II into a host defense moleculeQ36914757
Mutagenesis studies toward understanding the intracellular signaling mechanism of antithrombinQ37287790
Molecular mechanisms of antithrombin-heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors.Q37777806
Anticoagulant heparan sulfate to not clot--or not?Q37784309
Partial glycosylation of antithrombin III asparagine-135 is caused by the serine in the third position of its N-glycosylation consensus sequence and is responsible for production of the beta-antithrombin III isoform with enhanced heparin affinityQ38293560
Comparison of biological activities of human antithrombins with high-mannose or complex-type nonfucosylated N-linked oligosaccharidesQ38294435
Importance of a 3-O-sulfate group in a heparin pentasaccharide for antithrombotic activityQ38345840
Role of ternary complexes, in which heparin binds both antithrombin and proteinase, in the acceleration of the reactions between antithrombin and thrombin or factor Xa.Q38350190
CD300F blocks both MyD88 and TRIF-mediated TLR signaling through activation of Src homology region 2 domain-containing phosphatase 1.Q39549619
Localization of anticoagulantly active heparan sulfate proteoglycans in vascular endothelium: antithrombin binding on cultured endothelial cells and perfused rat aortaQ41197917
Antimicrobial effects of helix D-derived peptides of human antithrombin IIIQ41747279
Helix D elongation and allosteric activation of antithrombin.Q43821727
The serpins: nature's molecular mousetrapsQ45303721
High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safetyQ46902575
Antithrombin prevents endotoxin-induced pulmonary vascular injury by inhibiting leukocyte activationQ47851749
Antithrombin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study.Q51076281
Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells.Q52541786
Antithrombin up-regulates AMP-activated protein kinase signalling during myocardial ischaemia/reperfusion injury.Q54321477
Anticoagulantly active heparin-like molecules from vascular tissueQ72814587
Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coliQ73426853
Antithrombin inhibits lipopolysaccharide-induced tissue factor and interleukin-6 production by mononuclear cells, human umbilical vein endothelial cells, and whole bloodQ73436045
Antithrombin III inhibits nuclear factor kappaB activation in human monocytes and vascular endothelial cellsQ74097923
Antithrombin III (AT III) prevents LPS-induced pulmonary vascular injury: novel biological activity of AT IIIQ74196820
Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclinQ77720659
Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cellsQ79175826
Syndecan-4-dependent signaling in the inhibition of endotoxin-induced endothelial adherence of neutrophils by antithrombinQ79339933
Local administration of recombinant human antithrombin in a mouse model of peritoneal sepsisQ80086709
A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infectionQ90243063
P433issue3
P921main subjectanticoagulantQ215118
P304page(s)528-533
P577publication date2020-03-01
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleAntithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin
P478volume18

Reverse relations

Q96028621Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Researchcites workP2860

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