T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation

scientific article published on 11 March 2020

T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1901484
P1325external data available at URLhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE138222
P932PMC publication ID7325601
P698PubMed publication ID32161096

P50authorJune L RoundQ87779262
Jared RutterQ87804805
Huseyin Atakan EkizQ89788054
Micah J DrummondQ89880322
Soh-Hyun LeeQ90062541
Andrew G RamsteadQ106585015
Dinesh S RaoQ46191684
P2093author name stringRuozhen Hu
Ryan M O'Connell
Kaylyn M Bauer
Jared A Wallace
Morgan C Nelson
P2860cites workmiR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in miceQ24595073
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell developmentQ24620604
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 proteinQ24641913
Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorderQ24649158
MicroRNA-155 is induced during the macrophage inflammatory responseQ24683841
An Update on Inflamm-Aging: Mechanisms, Prevention, and TreatmentQ26738759
T cell metabolism drives immunityQ26799575
Fueling immunity: insights into metabolism and lymphocyte functionQ27025284
The role of the T cell in age-related inflammationQ27026492
MiR-155 Enhances Insulin Sensitivity by Coordinated Regulation of Multiple Genes in MiceQ27307894
A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humansQ27931310
Metabolic pathways in T cell activation and lineage differentiationQ28078955
RAG-1-deficient mice have no mature B and T lymphocytesQ28592133
Follicular helper CD4 T cells (TFH)Q29615063
Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adultsQ33684572
Chronic inflammation (inflammaging) and its potential contribution to age-associated diseasesQ34040980
The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjectsQ34106521
microRNA regulation of inflammatory responsesQ34245279
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling.Q34280968
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responsesQ34626052
Age-related autoimmunityQ34654906
Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and diseaseQ34670001
A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growthQ34718277
miR-155 gene: a typical multifunctional microRNA.Q34958384
NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignanciesQ35022054
Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in AgingQ35858488
A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cellsQ35931759
Exosome-delivered microRNAs modulate the inflammatory response to endotoxinQ36018633
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T CellsQ36199966
Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic diseaseQ64232914
Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiencyQ64234120
Integrating single-cell transcriptomic data across different conditions, technologies, and speciesQ88243551
The effect of cellular context on miR-155-mediated gene regulation in four major immune cell typesQ91495449
miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and SurvivalQ92751166
Inflammaging decreases adaptive and innate immune responses in mice and humansQ36225887
Causes, consequences, and reversal of immune system agingQ36638131
MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in miceQ36864863
Regulation of immune responses and tolerance: the microRNA perspective.Q36934845
Nature and functions of autoantibodiesQ37243935
B cells and aging: molecules and mechanismsQ37398750
miR-146a-mediated suppression of the inflammatory response in human adipocytesQ37475995
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acidsQ37495470
Exploiting and antagonizing microRNA regulation for therapeutic and experimental applicationsQ37553909
B cell repertoire and ageingQ37764152
MicroRNA control in the development of systemic autoimmunityQ38078996
Metabolic pathways in immune cell activation and quiescenceQ38100361
Metabolic regulation of immune responsesQ38198155
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolismQ38622483
Immunometabolism: Cellular Metabolism Turns Immune RegulatorQ38624726
T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesisQ38650724
Specific and Complex Reprogramming of Cellular Metabolism in Myeloid Cells during Innate Immune ResponsesQ38661944
Age-associated B cells: key mediators of both protective and autoreactive humoral responsesQ38673417
Bcl-6 directly represses the gene program of the glycolysis pathwayQ38959240
Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunityQ39234961
Metabolic Instruction of Immunity.Q39286043
Macrophages in age-related chronic inflammatory diseasesQ39443058
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.Q39689532
mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation.Q40537683
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory developmentQ40760682
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.Q41052928
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cellsQ41427795
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivoQ41530637
Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus NephritisQ42059217
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.Q42182457
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cellsQ42476602
miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammationQ42631760
T Follicular Helper Cells and B Cell Dysfunction in Aging and HIV-1 Infection.Q44174979
A description of the Molecular Signatures Database (MSigDB) Web siteQ46317320
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammationQ46425558
Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade.Q47799445
miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.Q52587340
microRNA-155 positively regulates glucose metabolism via PIK3R1-FOXO3a-cMYC axis in breast cancer.Q54982268
Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cellsQ57804782
MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancersQ64066398
P4510describes a project that usesspleenQ9371
10x Genomics ChromiumQ105426347
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectlifetimeQ22675021
single cell transcriptomicsQ105406038
P304page(s)2064-2075
P577publication date2020-03-11
P1433published inJournal of ImmunologyQ3521441
P1476titleT Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation
P478volume204

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cites work (P2860)
Q99635028Aryl Hydrocarbon Receptor Role in Co-Ordinating SARS-CoV-2 Entry and Symptomatology: Linking Cytotoxicity Changes in COVID-19 and Cancers; Modulation by Racial Discrimination Stress
Q98465623microRNAs Shape Myeloid Cell-Mediated Resistance to Cancer Immunotherapy

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