HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?

scientific article published on 10 December 2018

HIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/BIES.201800128
P932PMC publication ID6545924
P698PubMed publication ID30537007

P50authorEnrique EspinosaQ56853875
P2093author name stringWei Jiang
Amayrani Abrego-Peredo
Juan C Rodríguez-Alba
Carlos Gallardo-Hernández
Jocelyn Pérez-Lara
Wendolaine Santiago-Cruz
P2860cites workMicrobial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapyQ60220163
In vitro modulation of purine enzyme metabolism and lymphocyte surface marker expression by thymosin fraction 5 in homosexual malesQ70101188
Function of NAD glycohydrolase in ADP-ribose uptake from NAD by human erythrocytesQ70469008
T-lymphocytes from AIDS patients are unable to synthesize ribonucleotides de novo in response to mitogenic stimulation. Impaired pyrimidine responses are already evident at early stages of HIV-1 infectionQ70808576
ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADPQ70808763
Elevated relative fluorescence intensity of CD38 antigen expression on CD8+ T cells is a marker of poor prognosis in HIV infection: results of 6 years of follow-upQ71538224
Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activityQ72207085
Comparison of activation marker and TCR V beta gene product expression by CD4+ and CD8+ T cells in peripheral blood and lymph nodes from HIV-infected patientsQ72533164
Investigation of the potential role of membrane CD38 in protection against cell death induced by HIV-1Q73108979
CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytesQ73453098
Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitorsQ73615602
Identification of the enzymatic active site of CD38 by site-directed mutagenesisQ73712748
Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations ofQ73848661
Flow cytometry description of a novel CD3-/CD7+ intraepithelial lymphocyte subset in human duodenal biopsies: potential diagnostic value in coeliac diseaseQ74525669
The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranesQ77526453
T cell dynamics in HIV-1 infectionQ78781458
Bax and the mitochondrial permeability transition cooperate in the release of cytochrome c during endoplasmic reticulum-stress-induced apoptosisQ79434810
CD38: a NAADP degrading enzymeQ82153078
The many faces of sirtuins: Sirtuins and the Warburg effectQ87049820
2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationshipsQ88166495
Intercellular communication in the immune system: differential expression of connexin40 and 43, and perturbation of gap junction channel functions in peripheral blood and tonsil human lymphocyte subpopulationsQ24642743
CD8 T cell persistence in treated HIV infectionQ27014768
CD38 and CD157: a long journey from activation markers to multifunctional moleculesQ28117617
Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily memberQ28268352
Crystal structure of human CD38 extracellular domainQ28271561
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiationQ28280204
Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturityQ28286614
Genenames.org: the HGNC and VGNC resources in 2017Q28584454
Poly(ADP-ribose): novel functions for an old moleculeQ29617735
CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cellsQ30484805
Microbial translocation is associated with increased monocyte activation and dementia in AIDS patientsQ33346244
NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10.Q33748116
CD4+ T lymphocyte subsets express connexin 43 and establish gap junction channel communication with macrophages in vitro.Q33761855
Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiencyQ34055177
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.Q34060896
HIV Infection, Inflammation, Immunosenescence, and AgingQ34150710
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activationQ34242691
Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndromeQ34310880
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO SignalingQ34358623
HIV-associated chronic immune activationQ34653277
Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infectionQ34943158
Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytesQ35112218
Immune activation in the female genital tract during HIV infection predicts mucosal CD4 depletion and HIV sheddingQ35331430
Site-specific differences in T cell frequencies and phenotypes in the blood and gut of HIV-uninfected and ART-treated HIV+ adultsQ35587218
Connexin-43 hemichannels mediate cyclic ADP-ribose generation and its Ca2+-mobilizing activity by NAD+/cyclic ADP-ribose transportQ35639822
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic InflexibilityQ35749984
NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the NucleusQ35805959
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.Q35828692
Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose systemQ36009179
Concentrative influx of functionally active cyclic ADP-ribose in dimethyl sulfoxide-differentiated HL-60 cellsQ42830593
Control of the proliferation of activated CD4+ T cells by connexinsQ43127224
Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communicationQ43548115
Elevation of blood NAD level after moderate exercise in young women and mice.Q43709361
Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodes.Q44403559
CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptorQ44605241
Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort StudyQ44715816
T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).Q45745522
Consideration of diurnal variations in human blood NAD and NADP concentrations.Q45929183
Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA.Q45930407
Whole blood NAD and NADP concentrations are not depressed in subjects with clinical pellagraQ46203412
Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infectionQ46520858
Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation.Q47439250
CD8+ T-lymphocyte activation in HIV-1 disease reflects an aspect of pathogenesis distinct from viral burden and immunodeficiencyQ47684550
Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channelQ48253956
Mechanisms regulating expansion of CD8+ T cells during HIV-1 infectionQ48281703
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell ResponseQ50054341
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levelsQ50328981
NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients.Q50487706
Impaired CD4+ T-cell restoration in the small versus large intestine of HIV-1-positive South Africans receiving combination antiretroviral therapy.Q51872623
Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy.Q51993594
CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.Q52010705
Increased levels of activated subsets of CD4 T cells add to the prognostic value of low CD4 T cell counts in a cohort of HIV-infected drug users.Q52022170
Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics.Q52022757
Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase.Q54570763
Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.Q55399718
CD4+ T-Cell Immunodeficiency Is More Dependent on Immune Activation Than Viral Load in HIV-Infected Children on Highly Active Antiretroviral TherapyQ57276212
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadQ58034113
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 InfectionQ36077705
A transcriptome-based model of central memory CD4 T cell death in HIV infection.Q36201361
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineageQ36360690
Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapyQ36376383
Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.Q36562453
CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease ProgressionQ36731541
CD62L(neg)CD38⁺ expression on circulating CD4⁺ T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controlsQ36966610
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.Q37015205
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.Q37042241
Genetic polymorphisms in the CD14 gene are associated with monocyte activation and carotid intima-media thickness in HIV-infected patients on antiretroviral therapyQ37165196
Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activationQ37262786
Phenotype and function of human T lymphocyte subsets: consensus and issuesQ37266382
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functionsQ37625383
Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approachQ37629663
Metabolism in T cell activation and differentiationQ37699927
Sirtuin 6: a review of biological effects and potential therapeutic propertiesQ38099602
Metabolism of activated T lymphocytes.Q38189903
Rational confederation of genes and diseases: NGS interpretation via GeneCards, MalaCards and VarElectQ38429531
Calcium and mitochondria in the regulation of cell deathQ38496552
SnapShot: ImmunometabolismQ38543884
Current topics in HIV pathogenesis, part 2: Inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjectsQ38725056
Cytochrome c Oxidase Activity Is a Metabolic Checkpoint that Regulates Cell Fate Decisions During T Cell Activation and DifferentiationQ38737991
Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African WomenQ39048750
Persistent immune activation in HIV-1 infection is associated with progression to AIDS.Q39060564
Comparative analysis of T-cell turnover and homeostatic parameters in HIV-infected patients with discordant immune-virological responses to HAART.Q39214123
Metabolic reprograming of anti-tumor immunityQ39244812
The membrane-bound enzyme CD38 exists in two opposing orientationsQ39280765
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming.Q39689532
Distinct aging profiles of CD8+ T cells in blood versus gastrointestinal mucosal compartmentsQ40074042
Analysis of Th17 and Tc17 Frequencies and Antiviral Defenses in Gut-Associated Lymphoid Tissue of Chronic HIV-1 Positive PatientsQ40683781
CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs.Q40771031
The CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells.Q40942972
Activators of TRPM2: Getting it rightQ41030819
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage.Q41611623
Why NAD(+) Declines during Aging: It's DestroyedQ41635896
Activation of NK cells is associated with HIV-1 disease progressionQ42244605
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killingQ42418448
Extracellular NAD+ regulates intracellular free calcium concentration in human monocytesQ42541287
Equilibrative and concentrative nucleoside transporters mediate influx of extracellular cyclic ADP-ribose into 3T3 murine fibroblastsQ42809637
Ligand-induced internalization of CD38 results in intracellular Ca2+ mobilization: role of NAD+ transport across cell membranesQ42819739
P433issue1
P304page(s)e1800128
P577publication date2018-12-10
P1433published inBioEssaysQ4914614
P1476titleHIV Disease Progression: Overexpression of the Ectoenzyme CD38 as a Contributory Factor?
P478volume41

Reverse relations

Q92810397Roles of CD38 in the Immune Response to Infectioncites workP2860

Search more.